Gene GK149 (G.lamblia)

GK149

Species: G.lamblia
Alias: GK149
External Links:
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GK149.AA Protein None 683 None Fasta, JSON
GK149.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of GK149.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GK149.AA Pkinase 73-302 19 4.1e-21 75.73 Pfam 28-293 (293) Show / Hide 
Range on Protein: 73-302
Range on HMM: 28-293/293
Sequence Identity: 19% (54 aa)

AVKEIRLDGLDQHSVDAIRRR---LTVLLGTLHPDVLKYHQVLMDDNTILVVTDRC-CG----DLRQFITDYRDIHEPI--PSKLVLSLLGQLAGALAHL
|||.|...  . ...| ..||   . ...   || ..... . .|.. | .|.. | .|    ||  .|.   . | ..  . . . . . |.. .|...
AVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYC

HGLSRGAHNGLPSSVV---LEPDNIMFAGDGRR---VVLADFGFCE---GISSGAAK--AGDPAYMAPETLL-CGDTTAASDVWSLGAVAYELATLRKPD
|            ...   | |.||..  .|     | ..|||...     ... ..  .| | ||||| .. . . . ..|.||.| . ||... ..| 
HSM----------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPP

FLGG------REPAEVFVDGWRPDLSGVA----------------------DDLARSVLERMLVLDPAERPTARRLARL--L
| |       .. . .. ....|  .                         .. ........| .||..||||. .     .
FPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GK149.AA AGC 181-245 21 4.2e-16 36.66 In-house 183-300 (395) Show / Hide 
Range on Protein: 181-245
Range on HMM: 183-300/395
Sequence Identity: 21% (26 aa)

PDNIMFAGDGRRVVLADFGFCEGISSGA----------------------------------------------------AK--AG--DPAYMAPETLLC
|.||..  |   . |.|||.|  . ..                                                     ..   |   | ||||| |  
PENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--

GDTTAASDVWS--LGAVAYELAT
   . | | ||  ||.. ||. |
--YGKACDWWSFGLGCLMYEMLT
S_TKc GK149.AA S_TKc 49-305 22 1e-15 53.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-305
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

RRLGNMLSKDAHGAVYSLRGCP---YLAVKEIRLDGLDQHSVDAIRRRLTVLLGTLHPDVLKYHQVLMDDNTILVVTDRCCG---DLRQFITDYRD--IH
 .... . | | | ||  |      . |.|.|.         . ||| . .|    || . |.. |  | . . .|.. | |   ||...| ...    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

EPIPSKLVLSLLGQLAGALAHLHGLSRGAHNGLPSSVV---LEPDNIMFAGDGRRVVLADFGFCEGISSGAAKAGDPAYMAPETLLCGDTTAASDVWSLG
 |.|   . ... |.. ||...| .           ..   | |.||..     .. ..|||..  .       | | ||||| |  | .....|.||.|
FPFPE-HARFYMYQICCALEYCHSHG----------IIHRDLKPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL--GYGKCKCDWWSCG

AVAYELATLRKPDFLGGREPAEVFVDGWRPDLSGVADDLARSVLERMLVLDPAERPTARRLAR------LLRRL
 . ||... ..| |    .....|            .. |.. ....|. ||..||||  . .      .   .
CILYEMLC-GYPPFP---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GK149.AA STE 181-298 21 8.5e-15 48.79 In-house 180-351 (359) Show / Hide 
Range on Protein: 181-298
Range on HMM: 180-351/359
Sequence Identity: 21% (38 aa)

PDNIMFAGDGRRVVLADFGFCEGISSGAA----------------K----AGDPAYMAPETLLC------GDTTAASDVWSLGAVAYELATLRKP----D
|.||..      | |.|||.|  ...  |                |    .| | .|||| ...      .. .. .|.|||| .. |.|| . |     
PANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMH

FLGGREPAE------------VFVDGWRPDLSGVAD-------------------DLARSVLERMLVLDPAERPTARRL
 .    ..               |.|  | |    .                   .  .  ... |. || .||||  |
PMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQL
Kinase GK149.AA NEK6 102-249 30 3.7e-13 39.41 In-house 58-202 (252) Show / Hide 
Range on Protein: 102-249
Range on HMM: 58-202/252
Sequence Identity: 30% (47 aa)

HPDVLKYHQVLMDDNTILVVTDRC-CGDLRQFITDYRDIHEPIPSKLVLSLLGQLAGALAHLHGLSRGAHNGLPSSVVLEPDNIMFAGDGRRVVLADFGF
||.|.|| .  ...| . .| .    ||. . |  ..     || . .     ||. ||.|.|   |  |        . | |.   ..|  | | | | 
HPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMH-SKRVMHRD------IKPANVFITANG-IVKLGDLGL

CEGISSGAAKA----GDPAYMAPETLLCGDTTAASDVWSLGAVAYELATLRKP
    ||    |    | | ||.|| .        ||.|||| . ||.| |  |
GRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSP
Kinase GK149.AA TK 186-302 18 7.9e-12 35.16 In-house 283-486 (486) Show / Hide 
Range on Protein: 186-302
Range on HMM: 283-486/486
Sequence Identity: 18% (38 aa)

FAGDGRRVVLADFGFC---------------EGISSGAAKAGDPA-----------------------YMAPETLL---------CGDTTAASDVWSLGA
| |.|. . .|||| .               .  ...  ..|.|.                       .||||.|.          |  | .|||||.| 
FDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV

VAYELATLRKPDFLGG------------REPAEVFVDG---------------WRPDLSGVAD-------------DLARSVLERMLVLDPAERPTARRL
. .|. |. .  . ||            .|  |  ..|                .|   .  |             ..   .. .   .||..||| . |
LMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQL

ARLL
 . |
HEQL
Kinase GK149.AA Fer 216-303 20 1.2e-11 36.09 In-house 184-283 (283) Show / Hide 
Range on Protein: 216-303
Range on HMM: 184-283/283
Sequence Identity: 20% (20 aa)

YMAPETLLCGDTTAASDVWSLGAVAYELATLRKPDFLG-----------GREPAEVFVDGWRPDLS-GVADDLARSVLERMLVLDPAERPTARRLARLLR
..||||.  | .. ..|||| | ...|  |  . ...|           ..  . . ..| .. .  ........ ....  . || .|||.  . . |.
WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase GK149.AA TKL 181-302 15 1.5e-11 37.82 In-house 168-364 (364) Show / Hide 
Range on Protein: 181-302
Range on HMM: 168-364/364
Sequence Identity: 15% (30 aa)

PDNIMFAGDGR-------------RVVLADFGFCEGISSGAA-----------------------KAGDPAYMAPETLL----------------CGDTT
..||.   ...             .. ..|||..  .|                           . | |..|||| |                 ... .
SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

AASDVWSLGAVAYELATLRKPDF-LGGREPA---------EVFVD-GWRPDLS------------GVADDLARSVLERMLVLDPAERPTARRLARLL
 ..||.| | | .|..| ..| . .. ...          .. .| | || .               ...  .. ...    || .||.. ..   |
EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GK149.AA Ciliate-E2 181-249 21 1.7e-11 35.71 In-house 189-295 (365) Show / Hide 
Range on Protein: 181-249
Range on HMM: 189-295/365
Sequence Identity: 21% (24 aa)

PDNIMFAGDGRRVVLADFGFCEGISS--------GAAK---------------------------AGDPAYMAPETLLCGD---------TTAASDVWSL
|.||.|      . ..|||..  ..           .|                           .| | ||||| |  ..          . ..|.|||
PENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GAVAYELATLRKP
| . ||. . . |
GVILYEMLFGKPP
Kinase GK149.AA Ciliate-E2-Unclassified 179-249 24 5.3e-11 34.42 In-house 170-269 (352) Show / Hide 
Range on Protein: 179-249
Range on HMM: 170-269/352
Sequence Identity: 24% (24 aa)

LEPDNIMFAGDGR--RVVLADFGFCEGISS-------------------GAAKAGDPAYM----APETLLCGDTT----AASDVWSLGAVAYELATLRKP
. |.||.|  .|.  .. ..|||..  . .                      ..| | ||    ||| |           ..|.|||| ..||. . . |
IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
TyrKc GK149.AA TyrKc 49-302 19 2.5e-10 -55.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 49-302
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

RRLGNMLSKDAHGAVYS--LRGCPYL-AVKEIRLDGLDQHSVDAIRRRLTVLLGT--LHPDVLKYHQVLMDD-------NTILVVTDRCC-GDLRQFITD
 .|| .|   | | ||   ..   .  ||| .. |      . ...| . ..      || ... . | ...         ...|.  .. |||.... .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

YRDIHEPIPSKLVLSLLGQLAGALAHLHGLSRGAHNGLPSSVV---LEPDNIMFAGDGRRVVLADFGFCEGISSG--------AAKA----GDP-----A
.|.    .. |  ||   | |   ..||             ..   |   |.. . .. .|  .||| .  | ..          ..    |        
HRPK---LCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YMAPETLLCGDTTAASDVWSLGAVAYELATLRKPDFLGG----REPAEVF---VDGWRPDLSGV---------ADDLARSVLERMLVLDPAERPTARRLA
 ||||..  |  | .||||| | . .|. |. ..   |      ...||.    .| |..              |.. . . ..    ||..||| . . 
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIH

RLL
...
ECF
Kinase GK149.AA TK-Unique 215-302 28 2.5e-09 28.43 In-house 201-294 (294) Show / Hide 
Range on Protein: 215-302
Range on HMM: 201-294/294
Sequence Identity: 28% (27 aa)

AYMAPETLL--CGDT-TAASDVWSLGAVAYELATLRKPDFLGG--REPAEVFVDGWRPDLSGVA-DDLARSVLERMLVLDPAERPTARRLARLL
..|||| |.   |   |  |||||.| . .|..|| .... |   ... | . || |...      .  ...... . ..| |||. | ..  |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase GK149.AA CAMK 181-241 17 2.9e-09 25.25 In-house 207-325 (425) Show / Hide 
Range on Protein: 181-241
Range on HMM: 207-325/425
Sequence Identity: 17% (21 aa)

PDNIMFAGDG----------------RRVVLADFGFCEGISSGA---------------------------AKAGDPAYMA-PETLLC------------
|.||..  ..                  . ..||||   . .|                               | |.||| || |.             
PENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDE

--GDTTAASDVWSLGAVAY
     . ..|.||.| . |
EKPYYGPKCDMWSCGVILY
Kinase GK149.AA CAMK 270-295 21 0.012693 3.47 In-house 384-416 (425) Show / Hide 
Range on Protein: 270-295
Range on HMM: 384-416/425
Sequence Identity: 21% (7 aa)

SGVADD-------LARSVLERMLVLDPAERPTA
... |.        ... . .||. || .|.|.
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTI
Kinase GK149.AA TK 102-163 11 0.012737 3.75 In-house 102-251 (486) Show / Hide 
Range on Protein: 102-163
Range on HMM: 102-251/486
Sequence Identity: 11% (17 aa)

HPDVLKYHQVLMDDNT------------ILVVTDRCC-GD----LRQFITDYR-----------------------------------------------
|| ... . | ... .            ...|.  .. ||    ||..  . |                                               
HPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYD

-----DIHEPIPSKLVLS-------------------LLGQLAGALAHLH
     |. .|.. |  |.                      |.| ....||
DDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLH
Kinase GK149.AA Ciliate-E2-Unclassified 268-295 32 0.222518 0.57 In-house 316-343 (352) Show / Hide 
Range on Protein: 268-295
Range on HMM: 316-343/352
Sequence Identity: 32% (9 aa)

DLSGVADDLARSVLERMLVLDPAERPTA
..|  | |. .  | .||. .| .|.|.
HWSPEAKDFINDLLQKMLKKNPNKRITF
Kinase GK149.AA Ciliate-E2 102-163 21 0.242764 0.34 In-house 91-177 (365) Show / Hide 
Range on Protein: 102-163
Range on HMM: 91-177/365
Sequence Identity: 21% (19 aa)

HPDVLKYHQVLM--DDNTILVVTDRCCG-DLRQFITDYRDIHEPIPS-------KLVLSLLGQLAG---------------ALAHLH
|| ..|.. .    |||.|  |.. | | ||...| . .  .  ...       | .. .  |..                || .||
HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH
Ank GK149.AA Ank 409-425 35 50.875765 0.72 Pfam 6-22 (33) Show / Hide 
Range on Protein: 409-425
Range on HMM: 6-22/33
Sequence Identity: 35% (6 aa)

LMKAVDRNDVEAVKALI
|. |. ....| || |.
LHLACRCGHTEVVKMLL
Ank GK149.AA Ank 445-465 38 1.256871 6.52 Pfam 1-21 (33) Show / Hide 
Range on Protein: 445-465
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

YEGTALIRAAVYGYTEIVELL
.  |.|  |. .|.||.|..|
DGFTPLHLACRCGHTEVVKML
Ank GK149.AA Ank 476-499 33 0.000248 19.88 Pfam 1-24 (33) Show / Hide 
Range on Protein: 476-499
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

NGWTALMYTARTGRADCLKLLLEK
.|.|.|.. .| |.....|.||..
DGFTPLHLACRCGHTEVVKMLLQH
Ank GK149.AA Ank 507-537 39 1e-06 28.52 Pfam 1-33 (33) Show / Hide 
Range on Protein: 507-537
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

KGRTALMSAASAGHLECIKLLLK--NEVGMQDN
 |.|.|. |.. ||.|..|.||.   .| .||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GK149.AA Ank 538-568 36 1e-05 24.91 Pfam 1-33 (33) Show / Hide 
Range on Protein: 538-568
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

DGETALMAAAGNGHRDCVELLLE--REGGIQDN
||.|.|. |. .|| ..|..||.   .  .||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GK149.AA Ank 569-592 25 0.005186 15.12 Pfam 1-24 (33) Show / Hide 
Range on Protein: 569-592
Range on HMM: 1-24/33
Sequence Identity: 25% (6 aa)

SKWTALMIAAERGEAGCVELLVEK
  .|.|..|...| . .|..|...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GK149.AA Ank 600-623 37 6e-07 29.31 Pfam 1-24 (33) Show / Hide 
Range on Protein: 600-623
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

DGWTALMWAAKNGHASCVRLLVEK
||.|.|..|...||...|..|...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GK149.AA Ank 631-660 27 0.001916 16.68 Pfam 1-33 (33) Show / Hide 
Range on Protein: 631-660
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

DGWPALTVAAQSGYVECARLLVR---EKNIRDN
||. .| .|...|..|....|.    . |..|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GK149.AA Ank 661-681 23 41.491427 1.04 Pfam 1-21 (33) Show / Hide 
Range on Protein: 661-681
Range on HMM: 1-21/33
Sequence Identity: 23% (5 aa)

MDETALDMAKLWRRHEIIALL
. .|.| .| .. ..|.. .|
DGFTPLHLACRCGHTEVVKML