Gene GL50803_95549 (G.lamblia)
GL50803_95549
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_95549.AA | Protein | None | 771 | None | Fasta, JSON |
| GL50803_95549.kin_dom | Protein Kinase Domain | None | 259 | None | Fasta, JSON |
Protein domains of GL50803_95549.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_95549.AA | S_TKc | 11-270 | 18 | 2.1e-12 | 4.95 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 11-270 Range on HMM: 1-231/231 Sequence Identity: 18% (52 aa) YTITEPIKEIPVGCVARAQSHMDGSEHCCVIIRYTDMVPANYTRLMSLVSIVSEMRHPNICTLREYVLNVDEKVLCIIVEDYPG--RSLLDLVRGNIFLY |.| ..| . |.| ... . .| . . ||. .... ..| .. .||||..| .. . . |... | .| .|.|. . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG N---FDPWEITRIGVAILDALEYLHNPFTTGGSIVHLGVSLEHIYVTPTGVPMLS------ILPLFWSLGLNKIVNYAPDLTL-YRSPQILRSTPFSS-L . |.. .. .. |..||||.|. |.| . | | .. . ... .| . |. |..| .| ... LRFPFPE-HARFYMYQICCALEYCHSHG-----IIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCK ADIWSLGLVLYFLLQGEVLLTNDNVSSIVFRADFPVFTITGPAPLQTTLTHMLSKDEDSRVTARELLR-Y-----KPFL .|.||.| .|| .| |. . .. . . . .. . ..| || . | || |.|. |.. CDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_95549.AA | Ciliate-E2 | 183-269 | 21 | 1.6e-09 | 28.81 | In-house | 253-365 (365) | Show / Hide |
Range on Protein: 183-269 Range on HMM: 253-365/365 Sequence Identity: 21% (25 aa) YRSPQILRSTP---------FSSLADIWSLGLVLYFLLQGEVLLTNDNVSSIVFRADFPVF---------------TITGPAPLQTTLTH----MLSKDE | .|.||.. . . .|||||| .||..| |. . ||| . . . . . || ||. YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDP DSRVT-ARELLRYKPF . | | . ..| . | EKRITGWEQILNHPWF |
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| Kinase | GL50803_95549.AA | Pkinase | 59-141 | 24 | 7.3e-09 | 32.41 | Pfam | 51-131 (293) | Show / Hide |
Range on Protein: 59-141 Range on HMM: 51-131/293 Sequence Identity: 24% (22 aa) VSIVSEMRHPNICTLREYVLNVDEKVLCIIVEDYPGR----SLLDLVR--GNIFLYNFDPWEITRIGVAILDALEYLHNPFTTGGSIVH ..| ...||||..|.... . .. .... | .| .| |... . .| |..||. .. || .|||.|. .|.| IQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSM-----GIIH |
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| Kinase | GL50803_95549.AA | ULK | 182-215 | 41 | 1.2e-08 | 26.86 | In-house | 212-250 (324) | Show / Hide |
Range on Protein: 182-215 Range on HMM: 212-250/324 Sequence Identity: 41% (16 aa) LYRSPQILR----STPFSSL-ADIWSLGLVLYFLLQGEV || .|||| |... .|||||| ..| .| |.. LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKY |
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| Kinase | GL50803_95549.AA | ULK | 182-215 | 41 | 1.2e-08 | 26.36 | In-house | 216-254 (329) | Show / Hide |
Range on Protein: 182-215 Range on HMM: 216-254/329 Sequence Identity: 41% (16 aa) LYRSPQILR----STPFSSL-ADIWSLGLVLYFLLQGEV || .|||| |... .|||||| ..| .| |.. LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKP |
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| Kinase | GL50803_95549.AA | Ciliate-E2b | 186-215 | 31 | 3.6e-07 | 18.02 | In-house | 174-208 (272) | Show / Hide |
Range on Protein: 186-215 Range on HMM: 174-208/272 Sequence Identity: 31% (11 aa) PQILR-----STPFSSLADIWSLGLVLYFLLQGEV |.|. . . .||||.| .||... | | PEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYV |
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| Kinase | GL50803_95549.AA | Pkinase | 183-269 | 18 | 3.7e-07 | 26.4 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 183-269 Range on HMM: 177-293/293 Sequence Identity: 18% (22 aa) YRSPQILR-STPFSSLADIWSLGLVLYFLLQGEVLLTND------NVSSIVFRADFPVFTITGP-----------------------APLQTTLTHMLSK |..| ..| ... .. .|.||.|..|| .| |. . .. . ...| | . | ... .. .| | YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK DEDSRVTARELLRYKPF | .| ||...| . | DPKKRPTAEQILQHPWF |
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| Kinase | GL50803_95549.AA | STE | 198-270 | 17 | 7.2e-07 | 20.42 | In-house | 249-359 (359) | Show / Hide |
Range on Protein: 198-270 Range on HMM: 249-359/359 Sequence Identity: 17% (19 aa) ADIWSLGLVLYFLLQGEVLLTNDNVSSIVFRAD----------------FPVFTITGP---------------------APLQTTLTHMLSKDEDSRVTA .||||||... .. |.. . . . . |.. .| .. . ... . . | || . | || CDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA RELLRY-KPFL .||. ||. SQLLKSEHPFI |
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| Kinase | GL50803_95549.AA | MARK | 183-213 | 46 | 9e-06 | 14.98 | In-house | 171-202 (262) | Show / Hide |
Range on Protein: 183-213 Range on HMM: 171-202/262 Sequence Identity: 46% (15 aa) YRSPQILRSTPFS-SLADIWSLGLVLYFLLQG | .|.|. . | .|||||| ||||...| YMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCG |
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| Kinase | GL50803_95549.AA | DyrkP | 183-241 | 37 | 1.6e-05 | 13.45 | In-house | 171-225 (323) | Show / Hide |
Range on Protein: 183-241 Range on HMM: 171-225/323 Sequence Identity: 37% (22 aa) YRSPQILRSTPFSSLADIWSLGLVLYFLLQGEVLLTNDNVSSIVFRADFPVFTITGPAP || | .. . |.|||| .| | | || |||. .. | | | || | YRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGLLAR----VIGIIGPFP |
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| Kinase | GL50803_95549.AA | MELK | 198-270 | 28 | 1.7e-05 | 14.39 | In-house | 181-254 (254) | Show / Hide |
Range on Protein: 198-270 Range on HMM: 181-254/254 Sequence Identity: 28% (22 aa) ADIWSLGLVLYFLLQGEVLLTNDNVSSI---VFRADFPVFTITGPAPLQTTLTHMLSKDEDSRVTARELLRYKPFL ||.||.|..|| |. | . ||.. . . . . . | | | ||| | . |. ..|| |.. ADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQ-LLRHMLQVDPKKRISMKNLLNH-PWV |
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| Kinase | GL50803_95549.AA | CAMK | 185-214 | 22 | 2.7e-05 | 12.24 | In-house | 287-331 (425) | Show / Hide |
Range on Protein: 185-214 Range on HMM: 287-331/425 Sequence Identity: 22% (10 aa) S-PQILRS--------------TPFSSLADIWSLGLVLYFLLQGE . | .|.. .. . .|.||.| .||..| |. AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGY |
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| Kinase | GL50803_95549.AA | PLK | 183-213 | 39 | 4.5e-05 | 12.57 | In-house | 166-198 (258) | Show / Hide |
Range on Protein: 183-213 Range on HMM: 166-198/258 Sequence Identity: 39% (13 aa) YRSPQIL--RSTPFSSLADIWSLGLVLYFLLQG | .| .| .. | .|.|||| ..| || | YIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIG |
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| Kinase | GL50803_95549.AA | Ciliate-E2 | 55-131 | 21 | 0.012984 | 4.77 | In-house | 60-178 (365) | Show / Hide |
Range on Protein: 55-131
Range on HMM: 60-178/365
Sequence Identity: 21% (25 aa)
LMSLVSIVSEMR-------------------HPNICTLREYVLNVDEKVLCIIVEDYPGRSLLDLVRGNIFLYNFDPW--------EITRIGVAILD---
. .. .. ..|| ||||. . |. . |.. . .. | . | .|.|. . | |. . || .| ||.
IEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFK
------------ALEYLHN
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TKAEFYIACIILALEYLHS
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| Kinase | GL50803_95549.AA | PLK | 246-270 | 32 | 0.037208 | 2.94 | In-house | 235-258 (258) | Show / Hide |
Range on Protein: 246-270 Range on HMM: 235-258/258 Sequence Identity: 32% (8 aa) LTHMLSKDEDSRVTARELLRYKPFL ...||... |.| |. ..|.. ||. IQKMLNWNPDERPTIDQILQH-PFF |
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| Kinase | GL50803_95549.AA | CAMK | 43-131 | 17 | 0.03767 | 1.92 | In-house | 66-197 (425) | Show / Hide |
Range on Protein: 43-131
Range on HMM: 66-197/425
Sequence Identity: 17% (24 aa)
RYTDMVPANYTRLMSLVSIVSE-------MRHPNICTLREYVL------------NVD------EKVLCIIV---EDYPGR----SLLDLV--RGN----
||... | . .... ..| . ..||||. | |. . . .| .... | .| |.| . .|.
RYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEE
-----IFLYN--FDPWEITRIGVAILDALEYLHN
| . |. .| |. |..|..|.|.
FDQFDIV-ERGRFTEREARRYFRQICSAVHYCHS
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| Kinase | GL50803_95549.AA | STE | 54-131 | 21 | 0.065166 | 2.69 | In-house | 74-170 (359) | Show / Hide |
Range on Protein: 54-131 Range on HMM: 74-170/359 Sequence Identity: 21% (21 aa) RLMSLVSIVSEMR--HPNICTLREYVLNVD-----EKVLCIIVEDYPGRSLLDLVRGNIFLYN-----------FDPWEITRIGVAILDA-LEYLHN ... ..| .... |||| . . .. . . |.|. | .| || |... . . |. .| .| ..|| . |.|||. QILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS |
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| Ank | GL50803_95549.AA | Ank | 363-385 | 34 | 0.003092 | 15.93 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 363-385 Range on HMM: 1-23/33 Sequence Identity: 34% (8 aa) VGRTALMYAAFLGNYAMAKRLLK |.|.|..|.. |.. ..| ||. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_95549.AA | Ank | 394-415 | 45 | 8.3e-05 | 21.59 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 394-415 Range on HMM: 1-22/33 Sequence Identity: 45% (10 aa) HGCTALYYAARGGHKSIVSLLL .|.|.| .|.| ||...|..|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_95549.AA | Ank | 456-486 | 30 | 0.002619 | 16.19 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 456-486 Range on HMM: 1-33/33 Sequence Identity: 30% (10 aa) LGLTALMVAATDNDIEAVEFLLN--YEANQKDK | |.|..|. ...| |..||. . | .|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_95549.AA | Ank | 487-508 | 27 | 0.080225 | 10.83 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 487-508 Range on HMM: 1-22/33 Sequence Identity: 27% (6 aa) YGWTALMYAIKSNSCYVLQQLV .|.|.|..|..... |.. |. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_95549.AA | Ank | 518-539 | 27 | 0.16717 | 9.68 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 518-539 Range on HMM: 1-22/33 Sequence Identity: 27% (6 aa) DGVTPLMISASVNNVPALTALI || |||.. .. ... .. |. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_95549.AA | Ank | 613-643 | 36 | 2.4e-05 | 23.55 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 613-643 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) EGKTALMHAAIAGNAECVKLLLL--SETGAIDN .| |.|. |.. |..|.||.|| . | |. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_95549.AA | Ank | 644-667 | 45 | 0.000236 | 19.96 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 644-667 Range on HMM: 1-24/33 Sequence Identity: 45% (11 aa) DDYTALMRAVEKGHREVVDLLLEA | .|.|. |...|| ||| .||.. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_95549.AA | Ank | 549-581 | 27 | 0.023549 | 12.75 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 549-581 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) RGRTALMYGAMKGSVEATELMVQGTQELGAQDT |.|.|.. ...|..| .. .| .. ||| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_95549.AA | Ank | 582-612 | 24 | 0.47024 | 8.06 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 582-612 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) MGFTSLMYAAVNNAIALLPTLLS--GERCKRDR .||| |..|. .. . . ||. . . .|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_95549.AA | Ank | 705-737 | 27 | 0.178191 | 9.58 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 705-737 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) SGECACMLALQANNLSVAKELLVHEVHLHNKDG |. . .|| . ....|.|.|| | .. .| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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