Gene GL50803_41369 (G.lamblia)
GL50803_41369
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_41369.AA | Protein | None | 1136 | None | Fasta, JSON |
| GL50803_41369.kin_dom | Protein Kinase Domain | None | 267 | None | Fasta, JSON |
Protein domains of GL50803_41369.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_41369.AA | ULK | 187-276 | 25 | 2.8e-15 | 49.89 | In-house | 217-329 (329) | Show / Hide |
Range on Protein: 187-276 Range on HMM: 217-329/329 Sequence Identity: 25% (29 aa) YLAPEVIA----EQTVSDK-SDVWSMGVIFYELCT-LTP----LLPLL-QGN-ELIDN-------INILRTHISVPG----YSFDMCDVINGMLSREPLH | ||... .. .|. .|.||.|.||||. . .| .. |.. .||.| |. . . .| | .. | | .|| ... YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKD RFSTYELLHHERI |.| ||..|. . RISWEELFNHPWF |
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| S_TKc | GL50803_41369.AA | S_TKc | 25-276 | 21 | 1.3e-14 | 37.14 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 25-276 Range on HMM: 1-231/231 Sequence Identity: 21% (60 aa) YDAVRIDGPGTFTYLELCYAKA----------FQISVLPTLDALEDFQRLRHPSIVPILEIVYDPSSGIVGILVEQITD--MTLRDLMDDFIRHKLS--L |. .|. | |.| .|. | .... .. |. .|| || .... .| . . . | . .|.|.... ||.| . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF PEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVRVG-------FPELSFLLGCIKASDLSPGIQRYLAPEVIAEQTVSD-KS || ... ...|...|..||| ...||| | | ||... .. .. . . | |.||||. . |. PE-HARFYMYQICCALEYCH---------SHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKC DVWSMGVIFYELCTLTPLLPLLQGNELIDNINILRTHISVPGYSFDMCDVINGMLSREPLHRFSTYELLH-------HERI |.|| |.|.||... |. | | ......| | ...| |...| ..| .| . |.|. |. . DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_41369.AA | ULK | 187-276 | 21 | 1.5e-13 | 44.53 | In-house | 213-324 (324) | Show / Hide |
Range on Protein: 187-276 Range on HMM: 213-324/324 Sequence Identity: 21% (24 aa) YLAPEVIA----EQTVSDK-SDVWSMGVIFYELCT-LTP----LLPLL------------QGNELIDNINILRTHI--SVPGYSFDMCDVINGMLSREPL | ||... .. .|. .|.||.|.||||. . .| .. | ... . . .. . . | | .. | | .|| ... YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQ--QIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEK HRFSTYELLHHERI |.| |...|. . DRISWEEIFNHPWF |
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| Kinase | GL50803_41369.AA | Ciliate-E2-Unclassified | 89-276 | 16 | 1e-12 | 40.43 | In-house | 101-352 (352) | Show / Hide |
Range on Protein: 89-276
Range on HMM: 101-352/352
Sequence Identity: 16% (46 aa)
EQITDMTLRDLMDDFIR----------HKLS---LPEEQVW-----DIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVRVGFPELSF
|.. . .|.. . .. .... ..|.|. .. ||.... .|.| ... .||| . |.||... .|
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH-------HKN-NIIHRDIKPENILFDNNGK----------
LLGCIKASDLSP------------------------------GIQRYL----APEVIAEQTVSDK----SDVWSMGVIFYELCTLTPLLPLLQGNE----
..|| .|.. | .|. ||||. .| ... .|.||.|||.||... .. . . ..
-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQL
------------LIDNINILRTHISV-------PGYSFDMCDVIN----GMLSREPLHRFSTYELLHHERI
|..||. . .. . |. | || || | | . ..| | .
ITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
|
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| Kinase | GL50803_41369.AA | Pkinase | 186-276 | 23 | 1.5e-12 | 45.48 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 186-276 Range on HMM: 176-293/293 Sequence Identity: 23% (28 aa) RYLAPEVIA-EQTVSDKSDVWSMGVIFYELCTLTPLLPLL------QGNELIDNINILRTHISVPGYS--------------------FDMCDVINGMLS .|.||||| | . |.|.||.|.|.||... |. | ...|..| ..| . | . ...|.|...| WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC REPLHRFSTYELLHHERI . | | . ..|.|. . KDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_41369.AA | NEK6 | 103-217 | 31 | 2.4e-12 | 36.7 | In-house | 93-199 (252) | Show / Hide |
Range on Protein: 103-217 Range on HMM: 93-199/252 Sequence Identity: 31% (37 aa) FIRHKLSLPEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVRVGFPELS-FLLGCIKASDLSPGIQRYLAPEVIAEQTVSDK | . | .|| .| |. .|.. | .||.|| . | |.|. | | |..| | | | | |..|| | |. | FKKQKRLIPERTIWKYFVQLCSALEHMH---------SKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFK SDVWSMGVIFYELCTL ||.||.| . ||. | SDIWSLGCLLYEMAAL |
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| Kinase | GL50803_41369.AA | NEK1 | 187-276 | 32 | 9e-12 | 37.27 | In-house | 187-276 (276) | Show / Hide |
Range on Protein: 187-276 Range on HMM: 187-276/276 Sequence Identity: 32% (30 aa) YLAPEVIAEQTVSDKSDVWSMGVIFYELCTLTPLLPLLQGNELIDNIN-ILRTHIS--VPGYSFDMCDVINGMLSREPLHRFSTYELLHHERI || || . . |||.|| |.. ||||||. .| ..| . .. |.. ... .| || . . |..| | ||.|. .| | YLSPEICQNKPYNNKSDIWSLGCVLYELCTLK--HP-FEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | GL50803_41369.AA | CDC2 | 64-164 | 25 | 1.5e-11 | 31.27 | In-house | 57-145 (301) | Show / Hide |
Range on Protein: 64-164 Range on HMM: 57-145/301 Sequence Identity: 25% (26 aa) LR-HPSIVPILEIVYDPSSGIVGILVEQITDMTLRDLMDDFIRHKLSLPEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVR |. || || . .... .| || |. .|| | . ..|.. | .. | .... .|| ||..|| | | ||.....|... LKDHPNIVKLHDVIHQ----NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCH---------QRRIMHRDLKPQNILIDKKGNIK VG .. IA |
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| Kinase | GL50803_41369.AA | NEK-Unclassified | 187-221 | 45 | 1.7e-10 | 30.66 | In-house | 163-197 (258) | Show / Hide |
Range on Protein: 187-221 Range on HMM: 163-197/258 Sequence Identity: 45% (16 aa) YLAPEVIAEQTVSDKSDVWSMGVIFYELCTLTPLL ...|||. .| ..|||||.| | ||.|| | . WMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFF |
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| Kinase | GL50803_41369.AA | NEK2 | 187-219 | 45 | 6.3e-10 | 29.48 | In-house | 230-262 (319) | Show / Hide |
Range on Protein: 187-219 Range on HMM: 230-262/319 Sequence Identity: 45% (15 aa) YLAPEVIAEQTVSDKSDVWSMGVIFYELCTLTP | ||.. | ..|||.||.| . ||.|.| | YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHP |
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| Kinase | GL50803_41369.AA | NEK | 187-219 | 42 | 2.8e-09 | 29.24 | In-house | 190-224 (286) | Show / Hide |
Range on Protein: 187-219 Range on HMM: 190-224/286 Sequence Identity: 42% (15 aa) YLAPEVIAEQTVSDKSDVWSMGVIFYELCTL--TP |..|||. .. . |||.|| |.. ||.||| . YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKH |
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| Kinase | GL50803_41369.AA | PEK | 185-276 | 26 | 1.2e-08 | 25.45 | In-house | 553-655 (655) | Show / Hide |
Range on Protein: 185-276 Range on HMM: 553-655/655 Sequence Identity: 26% (29 aa) QRYLAPEVIAEQ-----TVSDKSDVWSMGVIFYELCTLTPLLPLLQGN-ELIDNINILRT-HISVPGYSF---------DMCDVINGMLSREPLHRFSTY ..| .||.. | |.|..|.|.|| |.. | . | .. ...||. | || . . .| |. |||. | | |. CLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMW-----YPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQ ELLHHERI ..| || . QILQHEFF |
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| Kinase | GL50803_41369.AA | NEK | 100-164 | 25 | 6.6e-08 | 24.34 | In-house | 94-165 (286) | Show / Hide |
Range on Protein: 100-164 Range on HMM: 94-165/286 Sequence Identity: 25% (19 aa) MDDF---IRHKL----SLPEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGT----VRVG .... | .. ..|||.||. .| ..|..|.| . |...|| . |.||| ..... |..| LYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP---QRKILHRDIKPQNIFLTKNNNDYHNVKIG |
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| Kinase | GL50803_41369.AA | NEK2 | 110-157 | 28 | 8.7e-08 | 22.17 | In-house | 101-160 (319) | Show / Hide |
Range on Protein: 110-157 Range on HMM: 101-160/319 Sequence Identity: 28% (17 aa) LPEEQVWDIVAQVVKAMQYCHL------------AYKPGSQNLRRVIHRCLHPNNIFVSA ..|| .| | .| | | || || . . . ..|| . | ||| .. MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDY |
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| Pkinase | GL50803_41369.AA | Pkinase | 62-164 | 23 | 9.6e-08 | 28.47 | Pfam | 55-154 (293) | Show / Hide |
Range on Protein: 62-164 Range on HMM: 55-154/293 Sequence Identity: 23% (27 aa) QRLRHPSIVPILEIVYDPSSGIVGILVEQITDMTLRDLMDDF--IR--HKLSL--PEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFV .||.|| || ......| .. | .| ...| .|| | |. . .. .|... ... |......||| ..||| | | ||.. KRLNHPNIVRLYDWFED-KDHIY--MVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILI SASGTV----RVG . |.. ... DNNGHIDACVKIC |
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| TyrKc | GL50803_41369.AA | TyrKc | 25-276 | 20 | 4.2e-07 | -107.77 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 25-276
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)
YDAVRIDGPGTFTYLELCYAKAFQISVL------PTLDALEDFQR-------L--RHPSIVPILEIVYDP-----SSGIVGILVEQITDMTLRDLMDDFI
.. | | | .. .| | | . .||| | | .|| || .. .. .. ... . |..| | . || .|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY---MPHGDL-KDYL
-RHKLSLPEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVRVGFPELSFLLGCI----------KASD--LSP--GIQRYLA
.|. |. .. .. |. . |.| | ..||| | |. |.. .||... || .. ... . | .|
RKHRPKLCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA
PEVIAEQTVSDKSDVWSMGVIFYELCTLTPLLPL------LQGNELIDNINILRTHISVPG--------YSFDMCDVINGMLSREPLHRFSTYELLHHER
||.| . . . |||||| || .|..|. . . |.| .. . | . .| ... ..| | . |. ||.
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC
I
.
F
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| Kinase | GL50803_41369.AA | PEK | 95-164 | 19 | 1.4e-05 | 14.58 | In-house | 369-474 (655) | Show / Hide |
Range on Protein: 95-164 Range on HMM: 369-474/655 Sequence Identity: 19% (22 aa) TLRDLMDD----------------------------------------FIRHKLSLPEEQVWDIVAQVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIF ||||..|. . . ......|.|.| .|......| | . .||| | | ||| TLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIH---------SQGMIHRDLKPSNIF VSASGT-----VRVG .. .|. |..| LDCDGQHHQMQVKIG |
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| Kinase | GL50803_41369.AA | Pkinase_Tyr | 186-217 | 43 | 0.000143 | 16.1 | Pfam | 179-210 (270) | Show / Hide |
Range on Protein: 186-217 Range on HMM: 179-210/270 Sequence Identity: 43% (14 aa) RYLAPEVIAEQTVSDKSDVWSMGVIFYELCTL . .|||.|.. . |||||| || .|..|. KWMAPECINYGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | GL50803_41369.AA | NEK-Unclassified | 245-276 | 37 | 0.000515 | 8.84 | In-house | 227-258 (258) | Show / Hide |
Range on Protein: 245-276 Range on HMM: 227-258/258 Sequence Identity: 37% (12 aa) YSFDMCDVINGMLSREPLHRFSTYELLHHERI || |. .|| || |.. | | |.. . | YSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI |
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| Kinase | GL50803_41369.AA | NEK2 | 245-276 | 34 | 0.000828 | 8.57 | In-house | 288-319 (319) | Show / Hide |
Range on Protein: 245-276 Range on HMM: 288-319/319 Sequence Identity: 34% (11 aa) YSFDMCDVINGMLSREPLHRFSTYELLHHERI || . ..| |. . || |. |.| | .| YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
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| Kinase | GL50803_41369.AA | NEK-Unclassified | 121-164 | 38 | 0.001109 | 7.72 | In-house | 105-139 (258) | Show / Hide |
Range on Protein: 121-164 Range on HMM: 105-139/258 Sequence Identity: 38% (17 aa) QVVKAMQYCHLAYKPGSQNLRRVIHRCLHPNNIFVSASGTVRVG | . |.|| | |..||| | | ||| . || | QMIMAVQYIH---------QRKIIHRDLKPQNIFLTDDDTVSMG |
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| Kinase | GL50803_41369.AA | CDC2 | 203-220 | 47 | 0.003779 | 4.94 | In-house | 188-208 (301) | Show / Hide |
Range on Protein: 203-220 Range on HMM: 188-208/301 Sequence Identity: 47% (10 aa) DVWSMGVIFYEL---CTLTPL |.|| | ||.|. .| || DMWSIGCIFAEMFMDVTKKPL |
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| Kinase | GL50803_41369.AA | NEK | 242-276 | 31 | 0.010758 | 5.78 | In-house | 249-286 (286) | Show / Hide |
Range on Protein: 242-276 Range on HMM: 249-286/286 Sequence Identity: 31% (12 aa) VP-G--YSFDMCDVINGMLSREPLHRFSTYELLHHERI .| || |. ..|. || ..| .| |. ..| . | IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_41369.AA | NEK1 | 141-164 | 21 | 0.019575 | 4.46 | In-house | 123-163 (276) | Show / Hide |
Range on Protein: 141-164 Range on HMM: 123-163/276 Sequence Identity: 21% (9 aa) RRVIHRCLHPNNIFVS--ASG---------------TVRVG |...|| . . ||| . .| .|..| RKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLG |
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| Ank | GL50803_41369.AA | Ank | 801-822 | 45 | 0.000351 | 19.34 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 801-822 Range on HMM: 1-22/33 Sequence Identity: 45% (10 aa) HGVTALMFAAAAGHLSVVETLL .| |.|. |. ||..||. || DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_41369.AA | Ank | 770-800 | 25 | 10.198843 | 3.24 | Pfam | 1-31 (33) | Show / Hide |
Range on Protein: 770-800 Range on HMM: 1-31/33 Sequence Identity: 25% (8 aa) IEYTNLMKAATLGDIDKVKLLISLEANITTR .| |. |. |... ||.|.. |.. . DGFTPLHLACRCGHTEVVKMLLQHGADVNAQ |
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| Ank | GL50803_41369.AA | Ank | 832-852 | 38 | 1.179141 | 6.62 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 832-852 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) DGLPALSYAVKGGHAEISRVL || .| .|.. ||.|. . | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_41369.AA | Ank | 863-887 | 28 | 0.008533 | 14.34 | Pfam | 1-25 (33) | Show / Hide |
Range on Protein: 863-887 Range on HMM: 1-25/33 Sequence Identity: 28% (7 aa) NGLSPLMIACDYNQVAIASILKEYG .| .||..|| .... ... | ..| DGFTPLHLACRCGHTEVVKMLLQHG |
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| Ank | GL50803_41369.AA | Ank | 894-924 | 21 | 0.113248 | 10.29 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 894-924 Range on HMM: 1-33/33 Sequence Identity: 21% (7 aa) SGTTALMRAAQRNSYPLCKTLFD--VEAAMQNN | |.|. |...... .| | . . .|.. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_41369.AA | Ank | 925-945 | 23 | 0.237494 | 9.13 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 925-945 Range on HMM: 1-21/33 Sequence Identity: 23% (5 aa) AGETAMLIAAKQNYVQIVELL |.|. .|.. .....|..| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_41369.AA | Ank | 956-976 | 33 | 0.003793 | 15.61 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 956-976 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) QGTTALMIAASKNFVEIVRLL | |.|..|.... .|.|..| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_41369.AA | Ank | 987-1012 | 26 | 0.075263 | 10.93 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 987-1012 Range on HMM: 1-26/33 Sequence Identity: 26% (7 aa) YNETALMKAAKAGALDAAALLLEAEA . .|.|. |.. | .. . .||.. | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_41369.AA | Ank | 1018-1041 | 33 | 0.001891 | 16.7 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 1018-1041 Range on HMM: 1-24/33 Sequence Identity: 33% (8 aa) DGKTAMMCAAEMDRMEMVDLLLKK || |. ..|......|.| .||.. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_41369.AA | Ank | 1049-1069 | 42 | 9.3e-05 | 21.42 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 1049-1069 Range on HMM: 1-21/33 Sequence Identity: 42% (9 aa) DGTTALMLAAQKGHRRIIQLL || |.|.||...|| .....| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_41369.AA | Ank | 1080-1112 | 24 | 1e-05 | 24.9 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 1080-1112 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) SGETALMLAIRHQNVDAIEDLINYEGDIDMYNG |.|.|.||.|. ... ...|... |... . DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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