Gene GL50803_36783 (G.lamblia)
GL50803_36783
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_36783.AA | Protein | None | 645 | None | Fasta, JSON |
| GL50803_36783.kin_dom | Protein Kinase Domain | None | 244 | None | Fasta, JSON |
Protein domains of GL50803_36783.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_36783.AA | TKL | 116-201 | 18 | 9.8e-11 | 34.89 | In-house | 137-283 (364) | Show / Hide |
Range on Protein: 116-201 Range on HMM: 137-283/364 Sequence Identity: 18% (28 aa) ILSQISMGLAYLHT--P---AGKGVILHRNLTPANVLVVANGA--------------IKLSDIRLGPLFDDDE--------------------------- . .|. |..|||. | | |.||.|...|.|| |. .|..| | .. .. WALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCG PTAFRAPELRS----------------SGSFSAKTDIYSMGRIIAELC ... |||. ....| |.|.||.| .. |.. TPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL |
|||||||||
| S_TKc | GL50803_36783.AA | S_TKc | 9-252 | 21 | 3.3e-10 | -27.25 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 9-252 Range on HMM: 1-231/231 Sequence Identity: 21% (57 aa) YSDIHEVSQKRWWTSYYAYRADSTRKVVLKRIDLSNLKTRESNTLVWAYSQLRDLSNIYVVRCSVVHYAPGDSLLLESPFEEG--CNLIDYVKRSCA--S | . .. . . | .. .. |.| .|.|. . || . | ..|.. | . |.| . . .| .| || |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--------HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL CEPVSEEALWPILSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSD----IRLGPLFDDDEPTAFRAPELRSSGSFSA-KTDIYSMGRIIAE . | .| . .. || .|.|.| | |.|| | |.|.|. ||..| .| ..|||. ... | |..| | |..| RFPFPE-HARFYMYQICCALEYCHSH-G---IIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE LCIAGPLSAETITRSALESHGYTSVFATLLHACLDPDPSKRPTAWDIAE-------QSTL .. |. .. | .. . .. ||. ||.||||| .. . . MLCGYPPFP--QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | GL50803_36783.AA | PEK | 173-252 | 19 | 6.7e-09 | 26.35 | In-house | 555-655 (655) | Show / Hide |
Range on Protein: 173-252 Range on HMM: 555-655/655 Sequence Identity: 19% (20 aa) FRAPELRSSG-----SFSAKTDIYSMGRIIAELCIAGPLSA-ETITRSALESH------GYTS---------VFATLLHACLDPDPSKRPTAWDIAEQST ...||. | . . |.|.||.| |..|... . | .. | . ..|.... .|..||..||.| .| .. . YMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEF L . F |
|||||||||
| Kinase | GL50803_36783.AA | nmo | 117-200 | 36 | 5.7e-08 | 19.94 | In-house | 108-197 (292) | Show / Hide |
Range on Protein: 117-200 Range on HMM: 108-197/292 Sequence Identity: 36% (34 aa) LSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSDIRLGPLFDDDEPTA---------FRAPE-LRSSGSFSAKTDIYSMGRIIAEL | || || |||. |||| . | |.|| .| .|. | | . |. .|||| | . ... ||.|.| | ||| LYQILRGLKYLHSAN----ILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAEL |
|||||||||
| Kinase | GL50803_36783.AA | PEK | 90-158 | 18 | 1.2e-07 | 21.95 | In-house | 366-475 (655) | Show / Hide |
Range on Protein: 90-158 Range on HMM: 366-475/655 Sequence Identity: 18% (21 aa) EGCNLIDYVKRSC----------------------------------------ASCEPVSEEALWPILSQISMGLAYLHTPAGKGVILHRNLTPANVLVV |...| |. .... . |. .... .| |..|| ||.|.| ..| . || |.|.|... EKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIH---SQG-MIHRDLKPSNIFLD ANGA-----IKLSD .| .| | CDGQHHQMQVKIGD |
|||||||||
| Kinase | GL50803_36783.AA | CDC2 | 92-158 | 26 | 1.2e-07 | 19.01 | In-house | 84-146 (301) | Show / Hide |
Range on Protein: 92-158 Range on HMM: 84-146/301 Sequence Identity: 26% (18 aa) CNLIDYVKRSCASCEPVSEEALWPILSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSD ..| | ..| . ........ .. || |....|. |.||.| | | |. ..|.||..| MDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRR----IMHRDLKPQNILIDKKGNIKIAD |
|||||||||
| Kinase | GL50803_36783.AA | Ciliate-E2 | 116-194 | 20 | 2e-06 | 17.96 | In-house | 150-283 (365) | Show / Hide |
Range on Protein: 116-194
Range on HMM: 150-283/365
Sequence Identity: 20% (29 aa)
ILSQIS---------------MGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSDIRLGPLFDDDE-------------------------------
| || .| ||| |. |.||.. | |.|. ||..| | .|||.
IMKQILQGFKTKAEFYIACIILALEYLHS---KNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQ
--------PTAFRAPELRSSGS---------FSAKTDIYSMG
. ||| .... . | ||.|.|
NMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG
|
|||||||||
| Kinase | GL50803_36783.AA | NEK | 106-158 | 27 | 4e-06 | 17.89 | In-house | 109-166 (286) | Show / Hide |
Range on Protein: 106-158 Range on HMM: 109-166/286 Sequence Identity: 27% (16 aa) EPVSEEALWPILSQISMGLAYLH--TPAGKGVILHRNLTPANVLVVANGA----IKLSD .. .|| | .. |....| |.| ... |||| . |.|. .|. .|. | KYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGD |
|||||||||
| Kinase | GL50803_36783.AA | NAK | 221-250 | 30 | 5e-06 | 16.05 | In-house | 270-299 (299) | Show / Hide |
Range on Protein: 221-250 Range on HMM: 270-299/299 Sequence Identity: 30% (9 aa) YTSVFATLLHACLDPDPSKRPTAWDIAEQS |.. . | ..|.|||..||. ... .| YSQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
|||||||||
| TyrKc | GL50803_36783.AA | TyrKc | 25-252 | 16 | 7e-06 | -127.59 | SMART | 16-280 (280) | Show / Hide |
Range on Protein: 25-252 Range on HMM: 16-280/280 Sequence Identity: 16% (47 aa) YAYRADSTRKVVLKRIDLSNLKTRESNTLVWAYSQLRD-------L--SNIYVVRCSVVHYAPG------DSLLLESPFEEGCNLIDYVKRSCASCEPVS | ... ..| | . . ... | .. .||. | .| . |.. . .. .| || ... .. YKGTWK--IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LC EEALWPILSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSD------IRLG-------PLFD------DD--EPTAFRAPELRSSGSFSAKT . | . ||. | .||| . || | |.|| .|. .| || | . . . | ||| | |. |. MKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS D----------IYSMGRIIAEL-----CIAGPLSAETITRSALESHGY---------TSVFATLLHACLDPDPSKRPTAWDIAEQSTL | |.. | . . . . . .. .. . .. .. | . ||..||| ..| . . DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
|||||||||
| Kinase | GL50803_36783.AA | MLK | 119-158 | 34 | 2e-05 | 14.93 | In-house | 132-176 (291) | Show / Hide |
Range on Protein: 119-158 Range on HMM: 132-176/291 Sequence Identity: 34% (16 aa) QISMGLAYLHTPAGKGVILHRNLTPANVLVVA------NGAIKLSD |.. |..||| | | | || | . |.|. . .| | .| QCARGMHYLHSMAPK-PIIHRDLKSHNILIDEICHDMHHGTLKICD |
|||||||||
| Kinase | GL50803_36783.AA | GCN2 | 107-158 | 33 | 6.5e-05 | 12.67 | In-house | 303-351 (511) | Show / Hide |
Range on Protein: 107-158 Range on HMM: 303-351/511 Sequence Identity: 33% (18 aa) PVSEEA-LWPILSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAIKLSD ...... || ...|| ||.|.| .|.| || | |.|... ..| .| .| WCMDHDELWRYFRQILEGLNYIH---SQGMI-HRDLKPSNIFLDCCGNVKIGD |
|||||||||
| Kinase | GL50803_36783.AA | NEK | 228-252 | 32 | 8.2e-05 | 13.32 | In-house | 262-286 (286) | Show / Hide |
Range on Protein: 228-252 Range on HMM: 262-286/286 Sequence Identity: 32% (8 aa) LLHACLDPDPSKRPTAWDIAEQSTL |.. .| .||..||....| |.. . LISQMLQKDPEQRPSCNQILEMPFI |
|||||||||
| Kinase | GL50803_36783.AA | STE-Unique | 110-158 | 32 | 0.000119 | 11.79 | In-house | 403-453 (616) | Show / Hide |
Range on Protein: 110-158 Range on HMM: 403-453/616 Sequence Identity: 32% (18 aa) EEALWPILSQISMGLAYLHTPAGKG-VILHRNLTPANVLVVANG-----AIKLSD .|..| .. || || |||. .. |.||.| |.|.. | .|..| TEVIW-YTYQILEGLEYLHS---QHNPIIHRDLKPHNIFCMQDGKGRVCKVKICD |
|||||||||
| Kinase | GL50803_36783.AA | NAK | 107-158 | 25 | 0.000175 | 10.79 | In-house | 115-169 (299) | Show / Hide |
Range on Protein: 107-158 Range on HMM: 115-169/299 Sequence Identity: 25% (14 aa) PVSEEALWPILSQISMGLAYLHTPA-GKGVILHRNLTPANVLVV---ANGAIKLSD ...|. . |.... |....|.. |. | || ... |.| ..| .|| | CFTEDEILQIFCDVCEGVQAMHQCQPPKPII-HRDIKIENILLSESHHDGNYKLCD |
|||||||||
| Kinase | GL50803_36783.AA | GCN2 | 225-252 | 32 | 0.000184 | 11.06 | In-house | 484-511 (511) | Show / Hide |
Range on Protein: 225-252 Range on HMM: 484-511/511 Sequence Identity: 32% (9 aa) FATLLHACLDPDPSKRPTAWDIAEQSTL ...... ||..||.|||.| .. . ..| QQDMIRWCLNHDPQKRPSAQQLLQHEFL |
|||||||||
| Kinase | GL50803_36783.AA | STE-Unique | 225-252 | 25 | 0.000263 | 10.55 | In-house | 589-616 (616) | Show / Hide |
Range on Protein: 225-252 Range on HMM: 589-616/616 Sequence Identity: 25% (7 aa) FATLLHACLDPDPSKRPTAWDIAEQSTL .. .. .||...|..||.| . .. .| QQQFIEKCLERNPHHRPSAHQLLHHFWL |
|||||||||
| Kinase | GL50803_36783.AA | Pkinase | 173-243 | 17 | 0.000775 | 14.65 | Pfam | 177-284 (293) | Show / Hide |
Range on Protein: 173-243 Range on HMM: 177-284/293 Sequence Identity: 17% (19 aa) FRAPELRS-SGSFSAKTDIYSMGRIIAELCIAGPLSAET----------ITRSALE-----SHGYT---------------------SVFATLLHACLDP ..|||. . . | |..|.| |..|.. |. . . . .. . .. . . .. ||.. YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK DPSKRPTA ||.||||| DPKKRPTA |
|||||||||
| Kinase | GL50803_36783.AA | MLK | 225-250 | 30 | 0.002717 | 7.43 | In-house | 266-291 (291) | Show / Hide |
Range on Protein: 225-250 Range on HMM: 266-291/291 Sequence Identity: 30% (8 aa) FATLLHACLDPDPSKRPTAWDIAEQS .. |.. | ..||.|||. | .. WKKLMKQCWNQDPHKRPSFRQIVQHL |
|||||||||
| Kinase | GL50803_36783.AA | TKL | 225-250 | 34 | 0.005086 | 6.73 | In-house | 339-364 (364) | Show / Hide |
Range on Protein: 225-250 Range on HMM: 339-364/364 Sequence Identity: 34% (9 aa) FATLLHACLDPDPSKRPTAWDIAEQS .. |. | |.||.|||.. .| .. MKKLMQDCWDHDPEKRPSFQEILKRL |
|||||||||
| Kinase | GL50803_36783.AA | Ciliate-E2 | 228-252 | 26 | 0.029085 | 3.55 | In-house | 336-365 (365) | Show / Hide |
Range on Protein: 228-252 Range on HMM: 336-365/365 Sequence Identity: 26% (8 aa) LLHA----CLDPDPSKRPT-AWDIAEQSTL |. .|. ||.||.| ...| . . LIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
| Kinase | GL50803_36783.AA | MLK | 172-192 | 33 | 0.170523 | 1.11 | In-house | 198-221 (291) | Show / Hide |
Range on Protein: 172-192 Range on HMM: 198-221/291 Sequence Identity: 33% (8 aa) AFRAPELR---SSGSFSAKTDIYS |..||| . .. .| | |..| AWMAPEVIQQFRCEKYSEKCDVWS |
|||||||||
| Kinase | GL50803_36783.AA | Pkinase | 116-158 | 38 | 0.949376 | 3.73 | Pfam | 113-155 (293) | Show / Hide |
Range on Protein: 116-158 Range on HMM: 113-155/293 Sequence Identity: 38% (18 aa) ILSQISMGLAYLHTPAGKGVILHRNLTPANVLVVANGAI----KLSD .. || ||.|.| |.|| | |.|.|.. || | |..| YMYQILRGLEYCHS-M---GIIHRDLKPENILIDNNGHIDACVKICD |
|||||||||