Gene GL50803_30354 (G.lamblia)

GL50803_30354

Species: G.lamblia
Alias: GK146, GL50803_30354
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_30354.AA Protein None 709 None Fasta, JSON
GL50803_30354.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of GL50803_30354.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_30354.AA S_TKc 50-306 20 1.2e-12 8.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 50-306
Range on HMM: 1-231/231
Sequence Identity: 20% (55 aa)

RCLGDVLSKDAYSTIYSLKGYP---HLAAKEIRPDDPDQYSVDAAKLKLVALPNTSYPDVLSCGKIIKSRNTIFIIMDRRCG---DLQQLITNYRE--TH
  ..... | |... |  .      . | |.|.    ..     . ||         | .  .  .. . . ....|.   |   || ..| ...   ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

KPIPKRLVLSLVRDLANCLIYLHDPINGVHGSLFPGVIFKPDNILFTENRRHIVLANFELCMGMSSWATKTGDPAYMAPETLLRGIITP-ASNIWSIGAI
.|.|   . .... ... | |.|.  . .|  |      ||.|||..|   || .. | |.  .    |  | | ||||| |     .. .. .||.| |
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDL------KPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

AYELATLRKPDFLGGREPEDVFVDGWRPDLSGITDGFIKSVLERIFVLDPERRPTARGLVR------LLQML
 ||... ..| |      ...  .  .      .. ..   ...... |||.||||  . .      . . .
LYEMLC-GYPPFP----QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_30354.AA CAMK 181-242 19 1.9e-10 29.11 In-house 206-325 (425) Show / Hide 
Range on Protein: 181-242
Range on HMM: 206-325/425
Sequence Identity: 19% (23 aa)

KPDNILFTENR----------------RHIVLANFELCMGMSS---------------------------WATKTGDPAYMA-PETLLRGI---------
||.|||...|                   | .. | .   . .                             |  | |.||| || |..           
KPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATD

-----ITPASNIWSIGAIAY
     ..|.. .||.| | |
EEKPYYGPKCDMWSCGVILY
Kinase GL50803_30354.AA AGC 181-246 23 4.5e-10 20.72 In-house 182-300 (395) Show / Hide 
Range on Protein: 181-246
Range on HMM: 182-300/395
Sequence Identity: 23% (29 aa)

KPDNILFTENRRHIVLANFELCMGMSS----------------------------------------------------WATKT--G--DPAYMAPETLL
||.|||..|.  || |. | ||  . .                                                      |.|  |   | ||||| | 
KPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-

RGIITPASNIWS--IGAIAYELAT
    ..|  .||   |.. ||. |
---YGKACDWWSFGLGCLMYEMLT
Kinase GL50803_30354.AA Ciliate-E2 181-250 21 8.7e-10 29.76 In-house 188-295 (365) Show / Hide 
Range on Protein: 181-250
Range on HMM: 188-295/365
Sequence Identity: 21% (25 aa)

KPDNILFTENRRHIVLANFELCM------------GMSSWATKTG------------------------DPAYMAPETLLRGI---------ITPASNIW
||.||||      | .. | |.              .. | .  .                         | ||||| | ..           . .. ||
KPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW

SIGAIAYELATLRKP
|.| | ||. . . |
SLGVILYEMLFGKPP
Kinase GL50803_30354.AA Ciliate-E2-Unclassified 181-250 26 2.8e-09 28.36 In-house 171-269 (352) Show / Hide 
Range on Protein: 181-250
Range on HMM: 171-269/352
Sequence Identity: 26% (26 aa)

KPDNILFTENRR--HIVLANFELCM-------------------GMSSWATKTGDPAYM----APETLLRGIIT----PASNIWSIGAIAYELATLRKP
||.||||..| .  .| .. | ...                         |..| | ||    ||| | .         .. ||| | |.||. . . |
KPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase GL50803_30354.AA TKL 181-303 16 8.5e-09 27.81 In-house 167-364 (364) Show / Hide 
Range on Protein: 181-303
Range on HMM: 167-364/364
Sequence Identity: 16% (33 aa)

KPDNILFTENRRH-------------IVLANFELCM------GMSSWAT-----------------KTGDPAYMAPETLL----------------RGII
|..|||  || ..             . .. | |.       .|. ..|                 . | |..|||| |                  .  
KSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEY

TPASNIWSIGAIAYELATLRKPDF-LGGREPE---------DVFVD-GWRPDLS---------GITDGF---IKSVLERIFVLDPERRPTARGLVRLL
.... ..| | . .|..| ..| . .. ....          . .| | || .             . .   .|. ...    ||| ||..  ..  |
SEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_30354.AA CAMK-Unique 181-246 21 1.1e-08 24.54 In-house 184-288 (363) Show / Hide 
Range on Protein: 181-246
Range on HMM: 184-288/363
Sequence Identity: 21% (23 aa)

KPDNILFTEN---------------RRHIVLANFELCMGMSSWATKT------GDPAYMAP--------------ETLL-RGIITPAS---NIWSIGAIA
|..||.. ..               . ||.|..| ||   ..    .      | | ||||              |..  ...  . |    |||.|.|.
KLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIM

YELAT
|....
YYMLC
Kinase GL50803_30354.AA Fer 217-304 22 5.6e-08 23.38 In-house 184-283 (283) Show / Hide 
Range on Protein: 217-304
Range on HMM: 184-283/283
Sequence Identity: 22% (22 aa)

YMAPETLLRGIITPASNIWSIGAIAYELATLRKPDFLG-----------GREPEDVFVDGWRPDLSGITDGFIKSVLE-RIFVLDPERRPTARGLVRLLQ
..||||.  || .|.. .|| |  ..|  |  . ...|           ..  . . ..| .. .   .  .|..... .... ||| |||.  ... | 
WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase GL50803_30354.AA TK-Unique 216-303 25 7.5e-08 23.28 In-house 201-294 (294) Show / Hide 
Range on Protein: 216-303
Range on HMM: 201-294/294
Sequence Identity: 25% (24 aa)

AYMAPETLL--RGII-TPASNIWSIGAIAYELATLRKPDFLGG--REPEDVFVDGWRPDLSGIT-DGFIKSVLERIFVLDPERRPTARGLVRLL
..|||| |.  .|.. |. |..|| | . .|..|| .... |   ..... . || |...        . ..... . ..|| ||. | ..  |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase GL50803_30354.AA RTKK 216-303 34 1.8e-07 21.14 In-house 183-272 (272) Show / Hide 
Range on Protein: 216-303
Range on HMM: 183-272/272
Sequence Identity: 34% (32 aa)

AYMAPETLLRGIITPASNIWSIGAIAYEL-ATLRKPDFLGGREPEDVFVD---GWRPDLSGITDGFIKSVLERIFVLDPERRPTARGLVRLL
. |.|| |      ||| .|| |  | |  .    |   .|.||.|.      | || ..      | |.| |   .|| .|| ||  |  |
PWMSPESLIHRRFSPASDVWSLGMTAWEICSNGQRP--WEGMEPQDIMLAVHRGQRPVIQNNWPPQIQSLLRRVWERDPNKRPSARDYVSKL
Kinase GL50803_30354.AA Pkinase 212-305 20 7.7e-07 25.26 Pfam 172-293 (293) Show / Hide 
Range on Protein: 212-305
Range on HMM: 172-293/293
Sequence Identity: 20% (25 aa)

TGDPAYMAPETLL-RGIITPASNIWSIGAIAYELATLRKPDFLGG------REPEDVFVDGWRPDLSGITDG----------------------FIKSVL
.| | ||||| .. .  ..|.. .||.| | ||... ..| | |       .. . .. ....|  . .                           |...
CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI

ERIFVLDPERRPTARGLVRLLQM
.... .||..||||. ..    .
KWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_30354.AA STE 181-248 24 2e-06 18.97 In-house 179-265 (359) Show / Hide 
Range on Protein: 181-248
Range on HMM: 179-265/359
Sequence Identity: 24% (23 aa)

KPDNILFTENRRHIVLANFELCMGMSS-WA-------------------TKTGDPAYMAPETLLRGI------ITPASNIWSIGAIAYELATLR
||.|||.      . |..| .|  ...  |                   | .| | .|||| ....        .  . |||.|  . |.|| .
KPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
TyrKc GL50803_30354.AA TyrKc 50-303 16 4e-06 -123.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 50-303
Range on HMM: 1-280/280
Sequence Identity: 16% (53 aa)

RCLGDVLSKDAYSTIYSLKGYPHLAAKEIRPDDPDQYSVDAA--KLKLVALPNTSYPDVLSCGKIIKSR------------------------NTIFIIM
  ||..|   |. ..|  . .                 .. |  .||  |       | ..  .| ..                           ..|.|
ITLGKKLGEGAFGEVYKGTWK-----------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVM

D--RRCGDLQQLITNYRETHKPIPKRLVLSLVRDLANCLIYLHDPINGVHGSLFPGVI---FKPDNILFTENRRHIVLANFELCMGMSSW-------ATK
      |||.. . ..|..   .. .  ||   . |.   |||.           ..|       |.| .||. ..  . | |.    .         ..
EYMPH-GDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYY

T-----GDP-----AYMAPETLLRGIITPASNIWSIGAIAYELATLRKPDFLGG----REPEDVF---VDGWRPDLSGI--------TDGFIKSVLERIF
.     |         ||||..  |. |..| .|| |   .|. |. ..   |      ....|.    .| |..                . .. ..  
RKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCW

VLDPERRPTARGLVRLL
  ||| ||| . .....
HEDPEDRPTFSEIHECF
Kinase GL50803_30354.AA Ciliate-E2-Unclassified 114-164 18 0.242275 0.44 In-house 91-160 (352) Show / Hide 
Range on Protein: 114-164
Range on HMM: 91-160/352
Sequence Identity: 18% (13 aa)

KSRNTIFIIMDR-RCGDLQQLITNY-------------RETHKPIPKRLVL-----SLVRDLANCLIYLH
.....|.|.|.  . |||.| |...             ... | .. . ..      . . . ..| |||
QDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH
Ank GL50803_30354.AA Ank 425-441 35 41.491427 1.04 Pfam 6-22 (33) Show / Hide 
Range on Protein: 425-441
Range on HMM: 6-22/33
Sequence Identity: 35% (6 aa)

LMRAVDRNDVEAVKTLI
|. |. ....| || |.
LHLACRCGHTEVVKMLL
Ank GL50803_30354.AA Ank 461-484 45 0.00257 16.22 Pfam 1-24 (33) Show / Hide 
Range on Protein: 461-484
Range on HMM: 1-24/33
Sequence Identity: 45% (11 aa)

CGGTALMRAAIHGHTELVGLLLEK
.| |.|. |...|||| | .||..
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_30354.AA Ank 492-515 37 0.000176 20.42 Pfam 1-24 (33) Show / Hide 
Range on Protein: 492-515
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

SGWTALIWAARTGHIDCLELLLER
 |.|.| .|.| ||......||..
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_30354.AA Ank 554-577 37 0.000369 19.26 Pfam 1-24 (33) Show / Hide 
Range on Protein: 554-577
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

NGTTALMAAAGRGYTDCVKLLMKK
.| |.|. |. .|.|..||.|...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_30354.AA Ank 523-553 24 0.064571 11.17 Pfam 1-33 (33) Show / Hide 
Range on Protein: 523-553
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

NGGTALMATVGNGYSNCARSLLR--KEICMQDN
.| |.|.  . .|. .... ||    ....||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_30354.AA Ank 585-607 39 1.9e-05 23.94 Pfam 1-23 (33) Show / Hide 
Range on Protein: 585-607
Range on HMM: 1-23/33
Sequence Identity: 39% (9 aa)

NGWTALMCAAELGRTDCVKLLVE
.|.|.|..|.. |.|..||.|..
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_30354.AA Ank 616-641 34 4e-06 26.54 Pfam 1-26 (33) Show / Hide 
Range on Protein: 616-641
Range on HMM: 1-26/33
Sequence Identity: 34% (9 aa)

DGMTALMWAAQNRHVDCVRLLVDKEA
||.|.|..|... |...|..|... |
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank GL50803_30354.AA Ank 647-676 27 0.002792 16.09 Pfam 1-33 (33) Show / Hide 
Range on Protein: 647-676
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

TGWTALMFAMKIGSIDCVKLLVR---EKSLRDS
 |.|.|. | . |....||.|.    .  ..| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD