Gene GL50803_17299 (G.lamblia)

GL50803_17299

Species: G.lamblia
Alias: GK306, GL50803_17299
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17299.AA Protein None 1182 None Fasta, JSON
GL50803_17299.kin_dom Protein Kinase Domain None 337 None Fasta, JSON

Protein domain

Protein domains of GL50803_17299.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_17299.AA S_TKc 22-360 15 1.4e-10 -21.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-360
Range on HMM: 1-231/231
Sequence Identity: 15% (57 aa)

RDEVGLVGTG------LVRKKGLGLMTTILVVPLHQHPPEVQIKIAHAMRDCLNIT--NPYLASYVDVTHSMREAKLTIETEFFGR--GSLRKKIDSHFK
 . . ..| |      ..|.|. |    | ...             |..|         |..  . || ..    .| . .|. .   |.|.. |... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

HGLI--FPEAEIWNVVAHIAAGLAYLHSPLPLPGKKAGFLLHLGLSPDSLMVYSDAEYKLTAYSIRQLLFRPIPPAEYARIIGIESENARWYMAPELRRA
|||   ||| ... ... |. .|.|.||            .|  | |. ... .  . |..   .  .|           ..|      .||||||.   
HGLRFPFPE-HARFYMYQICCALEYCHS--------H-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCG-----TPWYMAPEVL--

FSRYGSLCQLST-KCDIWSLGILLLDMVS-LALYRDNTSDPSTELVKNDSTIPAVIILPNDDRPLRVKMDDLSEEHNNSTDDEDAKRVSTTSLSSSVDYH
        . .. |||.||.|..|  |..   ...  . .   ....                                                     
--------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------------------------------------------

GFCHPPRSLLKTLLDDGLDTPYSKELITLIKQCVSEDPSERPSATIICK-------LPSV
                      |.|.. .|..|   ||..||.|  . .        | .
----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_17299.AA TKL 201-352 14 3.1e-09 29.44 In-house 239-358 (364) Show / Hide 
Range on Protein: 201-352
Range on HMM: 239-358/364
Sequence Identity: 14% (26 aa)

YMAPELRRAFSRYGSLC---------QLSTKCDIWSLGILLLDMVSLALYRDNTSDPSTELVKNDSTIPAVIILPNDDRPLRVKMDDLSEEHNNSTDDED
.||||. |    | . .         . |.|||..| ||.|  ...  .                                                   
WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---------------------------------------------------

AKRVSTTSLSSSVDYHGFCHPPRSLL-------KTLLDDGLD----------------TPYSKELITLIKQCVSEDPSERPSAT
              |... ..|. .        .   |.||                 ..  .... |...| ..||..|||..
-------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQ
Kinase GL50803_17299.AA NEK8 328-360 39 2.1e-07 17.04 In-house 246-278 (278) Show / Hide 
Range on Protein: 328-360
Range on HMM: 246-278/278
Sequence Identity: 39% (13 aa)

PYSKELITLIKQCVSEDPSERPSATIICKLPSV
.||.|.. |. .| . ||  ||||  | . | .
HYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase GL50803_17299.AA NEK 329-360 40 2.8e-07 22.13 In-house 255-286 (286) Show / Hide 
Range on Protein: 329-360
Range on HMM: 255-286/286
Sequence Identity: 40% (13 aa)

YSKELITLIKQCVSEDPSERPSATIICKLPSV
||..|  || |.   ||..|||.. | ..| .
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_17299.AA WEE 89-137 29 1e-06 18.16 In-house 79-129 (297) Show / Hide 
Range on Protein: 89-137
Range on HMM: 79-129/297
Sequence Identity: 29% (15 aa)

KLTIETEFFGRGS--LRKKIDSHFKHGLIFPEAEIWNVVAHIAAGLAYLHS
.. | .|.  .||  | . | .. . . ..||..||..  .|. ||...||
HMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHS
Kinase GL50803_17299.AA NEK1 329-360 37 1e-06 19.53 In-house 245-276 (276) Show / Hide 
Range on Protein: 329-360
Range on HMM: 245-276/276
Sequence Identity: 37% (12 aa)

YSKELITLIKQCVSEDPSERPSATIICKLPSV
||.||  |..|  . .|. |||.. | . |..
YSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_17299.AA NAK 326-358 24 1e-05 14.99 In-house 267-299 (299) Show / Hide 
Range on Protein: 326-358
Range on HMM: 267-299/299
Sequence Identity: 24% (8 aa)

DTPYSKELITLIKQCVSEDPSERPSATIICKLP
.. ||.... ||. .  .||..||.   .... 
NSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase GL50803_17299.AA TKL-ciliate1 329-357 26 4.1e-05 13.44 In-house 250-279 (279) Show / Hide 
Range on Protein: 329-357
Range on HMM: 250-279/279
Sequence Identity: 26% (8 aa)

YSKELITLIKQCVSEDPSERPSAT-IICKL
.. ....|.. | ...|  ||..  ||  |
CPQNFHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase GL50803_17299.AA NAK-Unclassified 329-350 50 7.9e-05 12.49 In-house 374-395 (405) Show / Hide 
Range on Protein: 329-350
Range on HMM: 374-395/405
Sequence Identity: 50% (11 aa)

YSKELITLIKQCVSEDPSERPS
||  |. ||| .. |||..||.
YSNQLHNLIKIMLNEDPIQRPN
Kinase GL50803_17299.AA Pkinase 199-237 35 0.000102 17.77 Pfam 175-207 (293) Show / Hide 
Range on Protein: 199-237
Range on HMM: 175-207/293
Sequence Identity: 35% (14 aa)

RWYMAPELRRAFSRYGSLCQLSTKCDIWSLGILLLDMVS
.||||||. |      .    ..|.|.||.|..|  |..
PWYMAPEVIR------GGQYYGPKVDMWSCGCILYEMLC
Kinase GL50803_17299.AA WEE 325-360 33 0.0002 10.84 In-house 262-297 (297) Show / Hide 
Range on Protein: 325-360
Range on HMM: 262-297/297
Sequence Identity: 33% (12 aa)

LDTPYSKELITLIKQCVSEDPSERPSATIICKLPSV
.| ..|.||  |||.   .||. ||..  . . | .
FDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase GL50803_17299.AA NEK 99-137 32 0.000237 11.68 In-house 90-132 (286) Show / Hide 
Range on Protein: 99-137
Range on HMM: 90-132/286
Sequence Identity: 32% (14 aa)

R-GSLRKKIDS--HFKH-GLIFPEAEIWNVVAHIAAGLAYLHS
. | | .|| |  . |. |  |.| .||.. .... .| |.|.
GGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHD
Kinase GL50803_17299.AA STE 201-236 38 0.000364 10.75 In-house 228-262 (359) Show / Hide 
Range on Protein: 201-236
Range on HMM: 228-262/359
Sequence Identity: 38% (14 aa)

YMAPELRRAFSRYGSLCQLSTKCDIWSLGILLLDMV
.||||  .  ..  .  . .|||||||||.... |.
WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMA
Kinase GL50803_17299.AA TKL-Unique 336-357 56 0.000829 9.52 In-house 268-290 (290) Show / Hide 
Range on Protein: 336-357
Range on HMM: 268-290/290
Sequence Identity: 56% (13 aa)

LIKQCVSEDPSERPS-ATIICKL
||.||   |||.|||  .|| .|
LIQQCWHHDPSQRPSFDEIIHRL
Kinase GL50803_17299.AA STE 329-352 37 0.005468 6.54 In-house 326-349 (359) Show / Hide 
Range on Protein: 329-352
Range on HMM: 326-349/359
Sequence Identity: 37% (9 aa)

YSKELITLIKQCVSEDPSERPSAT
.|.|..  |..|   ||..||.|.
WSPEFKDFINKCLQKDPNKRPTAS
Kinase GL50803_17299.AA TKL-Unique 201-232 45 0.005483 6.59 In-house 192-218 (290) Show / Hide 
Range on Protein: 201-232
Range on HMM: 192-218/290
Sequence Identity: 45% (15 aa)

YMAPELRRA-FSRYGSLCQLSTKCDIWSLGILL
.||||. |  |      || |.|.|..| || |
WMAPEVLRMNF------CQYSEKSDVYSFGIVL
Kinase GL50803_17299.AA NAK-Unclassified 217-232 50 0.006363 5.72 In-house 319-334 (405) Show / Hide 
Range on Protein: 217-232
Range on HMM: 319-334/405
Sequence Identity: 50% (8 aa)

CQLSTKCDIWSLGILL
|... | |||.||..|
CPIDEKIDIWALGCFL
Kinase GL50803_17299.AA NAK 217-232 50 0.006495 5.47 In-house 216-231 (299) Show / Hide 
Range on Protein: 217-232
Range on HMM: 216-231/299
Sequence Identity: 50% (8 aa)

CQLSTKCDIWSLGILL
|.  .| |||.||..|
CPIDEKVDIWALGCML
Kinase GL50803_17299.AA STE 95-137 31 0.007259 6.1 In-house 117-170 (359) Show / Hide 
Range on Protein: 95-137
Range on HMM: 117-170/359
Sequence Identity: 31% (17 aa)

EFFGRGSLRKKIDSHFKHGL----------IFPEAEIWNVVAHIAAG-LAYLHS
|. . |||.. |.. ...|            ||| .|  ..  |  | |.||||
EYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS
Kinase GL50803_17299.AA TKL-ciliate1 201-232 32 0.018588 4.22 In-house 180-209 (279) Show / Hide 
Range on Protein: 201-232
Range on HMM: 180-209/279
Sequence Identity: 32% (11 aa)

YMAPELRR--AFSRYGSLCQLSTKCDIWSLGILL
.||||  .   |. |    . ..| ||...||..
WMAPEQMDPHIFPNY----PINEKIDIYAYGIVM
Kinase GL50803_17299.AA TKL-Unique 94-137 20 0.031064 3.9 In-house 79-128 (290) Show / Hide 
Range on Protein: 94-137
Range on HMM: 79-128/290
Sequence Identity: 20% (10 aa)

TEFFGRGSLRKKID------SHFKHGLIFPEAEIWNVVAHIAAGLAYLHS
.|.. .|||.. ..         .  . .. . . . .  || |. |||.
MEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHH
Kinase GL50803_17299.AA NEK 222-238 58 0.049454 3.42 In-house 204-220 (286) Show / Hide 
Range on Protein: 222-238
Range on HMM: 204-220/286
Sequence Identity: 58% (10 aa)

KCDIWSLGILLLDMVSL
|.|||||| .|  |..|
KSDIWSLGCVLYEMCTL
Kinase GL50803_17299.AA Pkinase 330-360 38 0.087565 7.39 Pfam 263-293 (293) Show / Hide 
Range on Protein: 330-360
Range on HMM: 263-293/293
Sequence Identity: 38% (12 aa)

SKELITLIKQCVSEDPSERPSATIICKLPSV
|.|.. .|| |   ||..||.|. |.. | .
SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_17299.AA Pkinase 116-137 40 1.124522 3.47 Pfam 105-126 (293) Show / Hide 
Range on Protein: 116-137
Range on HMM: 105-126/293
Sequence Identity: 40% (9 aa)

FPEAEIWNVVAHIAAGLAYLHS
|.| |. ...  |. ||.|.||
FSEWECKFYMYQILRGLEYCHS
Ank GL50803_17299.AA Ank 478-504 36 0.001447 17.12 Pfam 4-33 (33) Show / Hide 
Range on Protein: 478-504
Range on HMM: 4-33/33
Sequence Identity: 36% (11 aa)

TALMMAAREGNTECIKLLLA---EVGIVTA
|.|..|.| |.||..|.||    .| ... 
TPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_17299.AA Ank 505-526 31 0.002722 16.13 Pfam 1-22 (33) Show / Hide 
Range on Protein: 505-526
Range on HMM: 1-22/33
Sequence Identity: 31% (7 aa)

KGETALMYAAQNGCLAATQLLL
 |.|.|..|...|..   ..||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_17299.AA Ank 535-555 33 0.001844 16.74 Pfam 1-21 (33) Show / Hide 
Range on Protein: 535-555
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

YGETALMYAVQNGFVHIVNLL
.|.|.|..|...| . .| .|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_17299.AA Ank 566-591 42 0.003651 15.67 Pfam 1-26 (33) Show / Hide 
Range on Protein: 566-591
Range on HMM: 1-26/33
Sequence Identity: 42% (11 aa)

DGLTALMLAAKLGRGRCVAILMHHEA
|| |.|.||.. |. ..|  |. | |
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank GL50803_17299.AA Ank 597-620 33 6.822392 3.87 Pfam 1-24 (33) Show / Hide 
Range on Protein: 597-620
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

LGETALELALKYRHGHCADLLLDY
 |.|.| || .. |  .. .||..
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_17299.AA Ank 628-650 39 8.584585 3.51 Pfam 1-23 (33) Show / Hide 
Range on Protein: 628-650
Range on HMM: 1-23/33
Sequence Identity: 39% (9 aa)

NGASPLRFAVDNGAIKVVPRLLY
.| .||  |. .| ..||  ||.
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_17299.AA Ank 835-860 34 0.012279 13.77 Pfam 1-25 (33) Show / Hide 
Range on Protein: 835-860
Range on HMM: 1-25/33
Sequence Identity: 34% (9 aa)

GNDTALLLAAKNHHFDCIKLLLCEQG
  .|.| ||... | ...|.||  .|
DGFTPLHLACRCGHTEVVKMLLQ-HG
Ank GL50803_17299.AA Ank 865-886 36 0.473252 8.05 Pfam 1-22 (33) Show / Hide 
Range on Protein: 865-886
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

DCVTALMVTACKGDVESLKLLL
|  |.|.. ...|..| .|.||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_17299.AA Ank 895-918 37 6.8e-05 21.9 Pfam 1-24 (33) Show / Hide 
Range on Protein: 895-918
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

DGNSALMLAAEAGHDACVQLLIKR
||...|.||.. ||  .|..|...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_17299.AA Ank 926-946 28 1.643366 6.1 Pfam 1-21 (33) Show / Hide 
Range on Protein: 926-946
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

AGRTALIRAAEACNLSTVNLL
 |.|.|  |..  ... | .|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_17299.AA Ank 983-1008 42 1.4e-05 24.37 Pfam 1-25 (33) Show / Hide 
Range on Protein: 983-1008
Range on HMM: 1-25/33
Sequence Identity: 42% (11 aa)

CGWTALMFAAKAGHVKCVELLLQEAG
.|.|.|. |.. ||...|..||| .|
DGFTPLHLACRCGHTEVVKMLLQ-HG
Ank GL50803_17299.AA Ank 1013-1039 33 0.021673 12.88 Pfam 1-26 (33) Show / Hide 
Range on Protein: 1013-1039
Range on HMM: 1-26/33
Sequence Identity: 33% (9 aa)

DERTAIFMAAKQGHKECIELLFDKEGA
| .|.  .|.. ||.|....| .  ||
DGFTPLHLACRCGHTEVVKMLLQ-HGA
Ank GL50803_17299.AA Ank 1044-1061 44 0.278591 8.88 Pfam 1-18 (33) Show / Hide 
Range on Protein: 1044-1061
Range on HMM: 1-18/33
Sequence Identity: 44% (8 aa)

DGWTILMATAYGGHAECV
||.| |.  .. ||.|.|
DGFTPLHLACRCGHTEVV
Ank GL50803_17299.AA Ank 1089-1114 50 8.7e-07 28.73 Pfam 1-26 (33) Show / Hide 
Range on Protein: 1089-1114
Range on HMM: 1-26/33
Sequence Identity: 50% (13 aa)

DGRTALMLAADQGHAQCVKLLLEKEA
||.|.|.||.  ||...||.||.. |
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank GL50803_17299.AA Ank 1120-1152 24 0.07623 10.91 Pfam 1-33 (33) Show / Hide 
Range on Protein: 1120-1152
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

LGESALFKAVRWEHPDCVTLLAPYEAQLTNKNN
 |...|  |.|. |...|..|  . | .  ...
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD