Gene GL50803_17231 (G.lamblia)
GL50803_17231
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_17231.AA | Protein | None | 1006 | None | Fasta, JSON |
| GL50803_17231.kin_dom | Protein Kinase Domain | None | 266 | None | Fasta, JSON |
Protein domains of GL50803_17231.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_17231.AA | S_TKc | 10-275 | 18 | 8.6e-13 | 10.65 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-275 Range on HMM: 1-231/231 Sequence Identity: 18% (53 aa) YTVRHAIEEGSESTWYSVERKNDGLPFSCREYSVRHLDSGYNGFDHASIKELLSIVHPYMLRVMEIIYDQEVQKVYVVTELNSH--NNLRYMIDAYWK-- |.. | .|. .. | . |. . |.. . .. . .| . ||. . ....| ...|.|.|. .. .|. .|. . . YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--EHIRREIQILKK---HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG SREQIGEGTIIRIIGELAEALKYYHTGVRPGMLPSTPNHYRTLTPASVLVTKDGVYKI---DTSRIEHILDPGYMAKASAKSV-----YTAPEVFEGANP | .. | .. ... ....||.| | . | . .| | |. .|... . || .|. ... | ||||. LRFPFPE-HARFYMYQICCALEYCHS--H-GII------HRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GY SE-RSDIWSLGCITYELATLQAFVKNPTAEDARTQVQAVLPNLRLPGYSREFADLIRRMLCIDPRSRASVTYICG-------LEPV . ..|.||.||| ||... . |.|... ... |.|. |.||..|. ||. | .. . . . GKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_17231.AA | STE | 186-267 | 22 | 4.6e-12 | 39.01 | In-house | 228-349 (359) | Show / Hide |
Range on Protein: 186-267 Range on HMM: 228-349/359 Sequence Identity: 22% (27 aa) YTAPEVFEGANPS------ERSDIWSLGCITYELATLQAFVKNPTAEDARTQVQAV--------------LPNLRLPG--------------------YS . |||| .. . . ...||||||| |.|| . . . | . . | .|| .| WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWS REFADLIRRMLCIDPRSRASVT || | |.. | .||. |.... PEFKDFINKCLQKDPNKRPTAS |
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| Kinase | GL50803_17231.AA | ULK | 186-265 | 28 | 5.3e-12 | 38.27 | In-house | 217-319 (329) | Show / Hide |
Range on Protein: 186-265 Range on HMM: 217-319/329 Sequence Identity: 28% (30 aa) YTAPEVFE----GANPSER-SDIWSLGCITYELATLQ-AFVKNPTAEDARTQVQAVLPN------------LRLPG------YSREFADLIRRMLCIDPR | ||.... . .... .|||||||| ||. . . |... .. ..| . | |. | | |. |||||||..|.. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK SRAS | | DRIS |
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| Kinase | GL50803_17231.AA | Ciliate-E2-Unclassified | 174-263 | 23 | 1.7e-11 | 36.12 | In-house | 226-340 (352) | Show / Hide |
Range on Protein: 174-263 Range on HMM: 226-340/352 Sequence Identity: 23% (29 aa) PGYMAKASAKSVYTAPEVFEGANPSER----SDIWSLGCITYELATLQAFVKNPTAED----------------ARTQVQA--VLPNLRLP-----GYSR |.|| ||||||..| |.... .||||||.| ||. . . . .. |. . . .. . . . . | PNYMP-Q-----YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSP EFADLIR----RMLCIDPRSR | .|.|. .|| .| .| EAKDFINDLLQKMLKKNPNKR |
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| Kinase | GL50803_17231.AA | Ciliate-E2 | 186-263 | 25 | 2.3e-11 | 35.22 | In-house | 253-352 (365) | Show / Hide |
Range on Protein: 186-263 Range on HMM: 253-352/365 Sequence Identity: 25% (28 aa) YTAPEVFEGAN---------PSERSDIWSLGCITYELATLQA-FVKNPTAEDARTQVQAVLPNLRLP-------------------GYSREFADLIRR-- | |||...| . .. .||||||.| ||. . . | | | ....| | | |||.. YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFG --MLCIDPRSR ||. || | KRMLQKDPEKR |
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| Kinase | GL50803_17231.AA | ULK | 186-265 | 28 | 5e-11 | 35.43 | In-house | 213-314 (324) | Show / Hide |
Range on Protein: 186-265 Range on HMM: 213-314/324 Sequence Identity: 28% (29 aa) YTAPEVFE----GANPSER-SDIWSLGCITYELATLQ-AFVKN-PTAE----------------DARTQVQAVLPNLRLPGYSREFADLIRRMLCIDPRS | ||.... . .... .|||||||| ||. . . |... . . ...| .|. | | |. |||||||..|.. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKD RAS | | RIS |
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| Kinase | GL50803_17231.AA | Pkinase | 186-270 | 21 | 6.3e-10 | 36.19 | Pfam | 177-288 (293) | Show / Hide |
Range on Protein: 186-270 Range on HMM: 177-288/293 Sequence Identity: 21% (24 aa) YTAPEVFE-GANPSERSDIWSLGCITYELATLQAFVKNP----TAEDARTQVQAVLPNLRLPGYS-----------------------REFADLIRRMLC | |||| | . ..|.||.||| ||... . .. . | . .. ... .. .|. |.|...|| YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC IDPRSRASVTYIC || .| . . |. KDPKKRPTAEQIL |
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| Kinase | GL50803_17231.AA | NEK2 | 186-216 | 48 | 1.2e-09 | 28.49 | In-house | 230-260 (319) | Show / Hide |
Range on Protein: 186-216 Range on HMM: 230-260/319 Sequence Identity: 48% (15 aa) YTAPEVFEGANPSERSDIWSLGCITYELATL | ||. .| .|.|||||.||. ||...| YMSPEQMHGQKYNEKSDIWSVGCLIYEMCAL |
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| Kinase | GL50803_17231.AA | NEK | 186-217 | 50 | 1.8e-09 | 29.93 | In-house | 190-221 (286) | Show / Hide |
Range on Protein: 186-217 Range on HMM: 190-221/286 Sequence Identity: 50% (16 aa) YTAPEVFEGANPSERSDIWSLGCITYELATLQ | .|||... ...||||||||. ||..||. YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLK |
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| Kinase | GL50803_17231.AA | NEK-Unclassified | 186-219 | 45 | 1.8e-09 | 27.23 | In-house | 163-197 (258) | Show / Hide |
Range on Protein: 186-219 Range on HMM: 163-197/258 Sequence Identity: 45% (16 aa) YTAPEVFEGANPSERSDIWSLGCITYELATLQ-AF . .||| . .|||.|||||| ||..| .| WMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFF |
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| Kinase | GL50803_17231.AA | TKL | 186-273 | 17 | 2.7e-09 | 29.61 | In-house | 239-364 (364) | Show / Hide |
Range on Protein: 186-273 Range on HMM: 239-364/364 Sequence Identity: 17% (22 aa) YTAPEVFEGA----------------NPSERSDIWSLGCITYELATLQAFVKNPTAEDARTQ-------VQAVLPNLRL---------------PGYSRE . ||||..|. ||..|..| | . .|..| . ... .. | ..... .||. | .. WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPS FADLIRRMLCIDPRSRASVTYICGLE ...|. . ||..| | . | MKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | GL50803_17231.AA | AGC | 186-215 | 40 | 5.4e-09 | 17.85 | In-house | 273-300 (395) | Show / Hide |
Range on Protein: 186-215 Range on HMM: 273-300/395 Sequence Identity: 40% (13 aa) YTAPEVFEGANPSERSDIWS--LGCITYELAT | |||.. . |.|| |||. ||. | YMAPEIL----YGKACDWWSFGLGCLMYEMLT |
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| Kinase | GL50803_17231.AA | AGC | 238-263 | 29 | 0.000359 | 5.1 | In-house | 337-373 (395) | Show / Hide |
Range on Protein: 238-263 Range on HMM: 337-373/395 Sequence Identity: 29% (11 aa) NLRLP-----------GYSREFADLIRRMLCIDPRSR ....| | | |||...|| ||. | KVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKR |
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| TyrKc | GL50803_17231.AA | TyrKc | 10-279 | 13 | 0.000377 | -155.53 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-279
Range on HMM: 1-280/280
Sequence Identity: 13% (44 aa)
YTVRHAIEEGS-----ESTWYSVERKNDGLPF-----SCREYSVRHLDSGYNGFDHASIKELLS-------I--VHPYMLRVMEIIYDQ-----EVQKVY
| . . || . ||. ...|.. ...... . || .| .. .| ... ..
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM
VVTELNSHNNLRYMIDAYWKSREQIGEGTIIRIIGELAEALKYYHTGVRPGMLPSTPNHYRTLTPAS----------VLVTKDGVYKIDT----SRIEHI
.|.|. .| .|. . .. . . . . . |. | | .||..... || . || .
IVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-------------------NCIHRDLAARNCLVGENHTVKI-SDFGLSRDIYD
L------DPGYMAKA--SAKSV----YTAPEVFEGANPSERSDIWSLGCITYELATL-QAFVKN-----PTAEDARTQVQAVLPNLRLPG--------YS
. |..| ..|.. .|||.. .. ||.|| | .|. |. | . ...... .|.. . | .
DDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP
REFADLIRRMLCIDPRSRASVTYICGLEPVVNIM
| ..... || .| . . | . ..
DEMYQIMKQCWHEDPEDRPTFSEI------HECF
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| Kinase | GL50803_17231.AA | NEK | 240-275 | 30 | 0.001142 | 9.25 | In-house | 248-286 (286) | Show / Hide |
Range on Protein: 240-275 Range on HMM: 248-286/286 Sequence Identity: 30% (12 aa) RLP-G--YSREFADLIRRMLCIDPRSRASVTYICGLEPV ..| ||.. .||..||. || .| |.. | . . PIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_17231.AA | Ciliate-E2-Unclassified | 25-130 | 14 | 0.005887 | 6.12 | In-house | 62-160 (352) | Show / Hide |
Range on Protein: 25-130 Range on HMM: 62-160/352 Sequence Identity: 14% (18 aa) YSVERKNDGLPFSCREYSVRHLDSGYNGFDHASIKELLS---IVHPYMLRVMEIIYDQEVQKVYVVTELNSHNNLRYMIDAYWK-------------SRE |... | .. .. . || ..| .. ..| |..| |.|. ...|...| ..| .|. YHQR-K---------------------------YNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRK QIGEGTII-----RIIGELAEALKYYH .. | .. ... .. ..|.|.| IFTEQQAKYKKAKFYFAQILQGLEYLH |
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| Kinase | GL50803_17231.AA | NEK2 | 244-276 | 30 | 0.007536 | 5.29 | In-house | 288-319 (319) | Show / Hide |
Range on Protein: 244-276 Range on HMM: 288-319/319 Sequence Identity: 30% (10 aa) YSREFADLIRRMLCIDPRSRASVTYICGLEPVV |||. ..| .|. .|...| |. | . .| . YSRHLNEIIHFMINVDHYHRPSIEEILQ-HPQI |
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| Kinase | GL50803_17231.AA | Ciliate-E2 | 59-130 | 20 | 0.009707 | 5.21 | In-house | 83-177 (365) | Show / Hide |
Range on Protein: 59-130 Range on HMM: 83-177/365 Sequence Identity: 20% (19 aa) KELLSIV-HPYMLRVMEIIYDQEVQKVYVVTELNSHNNLRYMIDAYWKSR-------EQIGEGTIIRIIGELAE---------------ALKYYH |..|... ||. .. | ... ...| |.|. ....|.. | .|.| ... | |..|. .... ||.| | KNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH |
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| Kinase | GL50803_17231.AA | NEK-Unclassified | 244-275 | 31 | 0.03192 | 2.81 | In-house | 227-258 (258) | Show / Hide |
Range on Protein: 244-275 Range on HMM: 227-258/258 Sequence Identity: 31% (10 aa) YSREFADLIRRMLCIDPRSRASVTYICGLEPV || ..|| || .. | | | | .. . YSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI |
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| Ank | GL50803_17231.AA | Ank | 641-659 | 36 | 0.113973 | 10.28 | Pfam | 1-19 (33) | Show / Hide |
Range on Protein: 641-659 Range on HMM: 1-19/33 Sequence Identity: 36% (7 aa) DGTTPLMKAVIRDDMRLVQ || |||. |....... |. DGFTPLHLACRCGHTEVVK |
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| Ank | GL50803_17231.AA | Ank | 672-695 | 29 | 0.002995 | 15.98 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 672-695 Range on HMM: 1-24/33 Sequence Identity: 29% (7 aa) RGVTALMLAAYFDNFDAIQLLLDK | |.|.||.. .. . ...||.. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_17231.AA | Ank | 703-728 | 38 | 0.01932 | 13.06 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 703-728 Range on HMM: 1-26/33 Sequence Identity: 38% (10 aa) AGMTALMYAAHKGNTNSVVQLYTHEA |.|.|..|...|.|. | | | | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_17231.AA | Ank | 734-755 | 36 | 0.005671 | 14.98 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 734-755 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) KGVTALMIAAECGWVDIVRTLM | |.|..|..|| ...|. |. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_17231.AA | Ank | 765-790 | 42 | 0.000258 | 19.82 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 765-790 Range on HMM: 1-26/33 Sequence Identity: 42% (11 aa) FGNTALIYACKAGRASVVQELLEYEA |.|.| .||. |...||..||.. | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_17231.AA | Ank | 796-819 | 25 | 0.023399 | 12.76 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 796-819 Range on HMM: 1-24/33 Sequence Identity: 25% (6 aa) DEWTALMISAKMGFAQITNLLLER | .|.|.. ...| ... .||.. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_17231.AA | Ank | 827-849 | 26 | 0.004743 | 15.26 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 827-849 Range on HMM: 1-23/33 Sequence Identity: 26% (6 aa) AGLTALMIAAANNRPDIANTLLK | |.|..|. ....... ||. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_17231.AA | Ank | 858-880 | 30 | 0.132 | 10.05 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 858-880 Range on HMM: 1-23/33 Sequence Identity: 30% (7 aa) HEETAMMKAAALGAYDVVKVLID . .|. . |. | ..||| |.. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_17231.AA | Ank | 889-906 | 38 | 0.007368 | 14.57 | Pfam | 1-18 (33) | Show / Hide |
Range on Protein: 889-906 Range on HMM: 1-18/33 Sequence Identity: 38% (7 aa) DGKTALMCAADAGYADIV || |.|..|. |....| DGFTPLHLACRCGHTEVV |
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| Ank | GL50803_17231.AA | Ank | 920-942 | 47 | 1.3e-05 | 24.55 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 920-942 Range on HMM: 1-23/33 Sequence Identity: 47% (11 aa) DGTTALMYATERGHTECVRLLVE || |.|..| ..||||.|..|.. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_17231.AA | Ank | 951-974 | 37 | 0.000135 | 20.83 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 951-974 Range on HMM: 1-24/33 Sequence Identity: 37% (9 aa) NGETALMIAVCRGLVDCVKILADH .|.|.|..|...| ...|| | .| DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_17231.AA | Ank | 982-1002 | 38 | 1.785566 | 5.97 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 982-1002 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) DGTSVMDIASQTGNQEVIKCL || . .|.. |. ||.|.| DGFTPLHLACRCGHTEVVKML |
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