Gene GL50803_16879 (G.lamblia)
GL50803_16879
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_16879.AA | Protein | None | 958 | None | Fasta, JSON |
| GL50803_16879.kin_dom | Protein Kinase Domain | None | 265 | None | Fasta, JSON |
Protein domains of GL50803_16879.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_16879.AA | NEK1 | 189-272 | 37 | 5.2e-15 | 48.66 | In-house | 187-270 (276) | Show / Hide |
Range on Protein: 189-272 Range on HMM: 187-270/276 Sequence Identity: 37% (32 aa) YCAPEILLHLQYSDKSEMWSLGCILYELCTLKR-FIEDPNPMLVRNQAEAAENRIVLPGYSEDICNLLNGLLRYEPGNRYSAEYI | ||| . | || .|||||.||||||||. | . || . .. |. | ||... .|. ... |..| |. | YLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIP-PHYSYELQSLVSQMFKRNPRHRPSVNQI |
|||||||||
| Kinase | GL50803_16879.AA | NEK8 | 188-221 | 52 | 3.8e-13 | 33.77 | In-house | 187-220 (278) | Show / Hide |
Range on Protein: 188-221 Range on HMM: 187-220/278 Sequence Identity: 52% (18 aa) CYCAPEILLHLQYSDKSEMWSLGCILYELCTLKR .| ||. .| || ||.|||.|||.|.||| YYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKR |
|||||||||
| S_TKc | GL50803_16879.AA | S_TKc | 14-281 | 18 | 1.7e-12 | 6.36 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 14-281 Range on HMM: 1-231/231 Sequence Identity: 18% (56 aa) YRFCSEVPQSGYDKVYRVESKHGGNFYTCREISYSNIVQDSIAIDPGIFTALLAIEHPCIAKIYDIYHDTTTKKLYIVTELLED--STLETLVAAHLR-- |.. .. . .. |||.. |. | . . .|. . | | || | |.||...| ..||.|.|... .| .. . | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG TNESMIEEVVWRVAAYLSSALYY---------------FLFQFQKKSICAIFKRFITPQDCVVCRTGLVKLLLTDLIFIVNPNYAKLMSHQKQC----YC .. . | ....... . .|| | |. .| || ..| .| |. LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------------HIKICDFGLARQL------------------TTFCGTPWYM APEILLHLQYSD-KSEMWSLGCILYELCTLKRFIEDPNPMLVRNQAEAAENRIVLPGYSEDICNLLNGLLRYEPGNRYSAEYICS----IKQCTLV |||.| .|. |. .||.||||||... . . | .. ..|. |.. .......|...| .|..| . ||. . APEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | GL50803_16879.AA | NEK | 188-221 | 50 | 4.8e-11 | 35.54 | In-house | 189-224 (286) | Show / Hide |
Range on Protein: 188-221 Range on HMM: 189-224/286 Sequence Identity: 50% (18 aa) CYCAPEILLHLQYSDKSEMWSLGCILYELCTL--KR .| .||.. . |. || .|||||.|||.||| |. YYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKH |
|||||||||
| Kinase | GL50803_16879.AA | NEK2 | 189-220 | 43 | 6.9e-11 | 32.78 | In-house | 230-261 (319) | Show / Hide |
Range on Protein: 189-220 Range on HMM: 230-261/319 Sequence Identity: 43% (14 aa) YCAPEILLHLQYSDKSEMWSLGCILYELCTLK | || . . |..|| ||.||..||.|.|. YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALH |
|||||||||
| Kinase | GL50803_16879.AA | STE | 189-270 | 19 | 7.4e-11 | 34.7 | In-house | 228-349 (359) | Show / Hide |
Range on Protein: 189-270 Range on HMM: 228-349/359 Sequence Identity: 19% (24 aa) YCAPEILLH------LQYSDKSEMWSLGCILYELCTLKRFIEDPNPMLVRNQAEAA--------------ENRIVLPG--------------------YS . |||... .|. |. .||||| . |..| | | .|| . .. .. || .| WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWS EDICNLLNGLLRYEPGNRYSAE .. .. .| |...| .| .|. PEFKDFINKCLQKDPNKRPTAS |
|||||||||
| Kinase | GL50803_16879.AA | NEK-Unclassified | 188-278 | 30 | 1.3e-10 | 31.04 | In-house | 162-258 (258) | Show / Hide |
Range on Protein: 188-278 Range on HMM: 162-258/258 Sequence Identity: 30% (30 aa) CYCAPEILLHLQYSDKSEMWSLGCILYELCTLKRFIEDPNPMLVRNQAEAAENRI------VLPGYSEDICNLLNGLLRYEPGNRYSAEYICSIKQC |. .||.. | ..| ||||||.||.|| |. | | .||. | || | ... .|| .. | || | . CWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI |
|||||||||
| Kinase | GL50803_16879.AA | Ciliate-E2 | 189-270 | 17 | 2.5e-09 | 28.15 | In-house | 253-357 (365) | Show / Hide |
Range on Protein: 189-270
Range on HMM: 253-357/365
Sequence Identity: 17% (23 aa)
YCAPEILLHLQ---------YSDKSEMWSLGCILYELCTLKR-FIEDPNPMLVRNQAEAAENRIVLPGYSEDIC--------------------------
| ||||| . |. |. .||||.||||... |. | . . .
YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKK
------NLLNG----LLRYEPGNRYS-AE
.|.. .| ..| .|.. .|
WSQECKDLIKKFGKRMLQKDPEKRITGWE
|
|||||||||
| Kinase | GL50803_16879.AA | Ciliate-E2-Unclassified | 189-270 | 21 | 5.6e-09 | 27.31 | In-house | 232-344 (352) | Show / Hide |
Range on Protein: 189-270 Range on HMM: 232-344/352 Sequence Identity: 21% (24 aa) YCAPEILLHLQYSDK----SEMWSLGCILYELCTLKRFIEDPNPML----------------VRNQAEA-------AENR---IVLPGYSEDICN-LLNG | |||.| .|... . .||||.||||... .. .|.| .... . .... .. .|..| || YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK LLRYEPGNRYSAE .| . |..|...| MLKKNPNKRITFE |
|||||||||
| Kinase | GL50803_16879.AA | Pkinase | 189-218 | 48 | 1.2e-08 | 31.7 | Pfam | 177-207 (293) | Show / Hide |
Range on Protein: 189-218 Range on HMM: 177-207/293 Sequence Identity: 48% (15 aa) YCAPEILL-HLQYSDKSEMWSLGCILYELCT |.|||... . |. |. |||.||||||... YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC |
|||||||||
| Kinase | GL50803_16879.AA | ULK | 189-268 | 27 | 1.3e-08 | 26.75 | In-house | 213-314 (324) | Show / Hide |
Range on Protein: 189-268 Range on HMM: 213-314/324 Sequence Identity: 27% (28 aa) YCAPEILL----HLQYSDK-SEMWSLGCILYELCTLK-----RFIEDPNP---MLVRN----QAEAAENRIVLP------GYSEDICNLLNGLLRYEPGN | ||.|| . .|.|. . .||||||.||. . | . ..| . |..| | . | | |... .|. ..| |.. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKD RYS | | RIS |
|||||||||
| Kinase | GL50803_16879.AA | CAMK | 188-214 | 33 | 1.8e-07 | 19.36 | In-house | 284-325 (425) | Show / Hide |
Range on Protein: 188-214 Range on HMM: 284-325/425 Sequence Identity: 33% (14 aa) CYCA-PEILLH--------------LQYSDKSEMWSLGCILY .|.| ||.|. |. |. |||.|.||| EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY |
|||||||||
| Kinase | GL50803_16879.AA | Ciliate-E2-Unclassified | 68-101 | 26 | 4e-06 | 17.42 | In-house | 76-109 (352) | Show / Hide |
Range on Protein: 68-101 Range on HMM: 76-109/352 Sequence Identity: 26% (9 aa) IEHPCIAKIYDIYHDTTTKKLYIVTELLEDSTLE . ||.. .....|........|||.|..|. .|. LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLW |
|||||||||
| Kinase | GL50803_16879.AA | CAMK | 68-96 | 24 | 5e-06 | 14.52 | In-house | 95-143 (425) | Show / Hide |
Range on Protein: 68-96 Range on HMM: 95-143/425 Sequence Identity: 24% (12 aa) IEHPCIAKIYDIYHD-----------TTTK-------KLYIVT---ELLE . ||.| |.|..| | | .| ..|.|. |. . LDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCS |
|||||||||
| Kinase | GL50803_16879.AA | Ciliate-E2 | 70-132 | 17 | 2e-05 | 14.54 | In-house | 91-175 (365) | Show / Hide |
Range on Protein: 70-132 Range on HMM: 91-175/365 Sequence Identity: 17% (15 aa) HPCIAKIYDIYHDTTTKKLYIVTELLEDSTLETLVA--AHLRTNE-----SMIEEVVWRVAAYLSS---------------ALYY || | |.|. . .......|.|.|... .|. . . |..| .. |. . .. ... . || | HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEY |
|||||||||
| Kinase | GL50803_16879.AA | NEK | 65-132 | 26 | 0.003233 | 7.64 | In-house | 57-129 (286) | Show / Hide |
Range on Protein: 65-132 Range on HMM: 57-129/286 Sequence Identity: 26% (19 aa) LLA-IEHPCIAKIYDIYHDTTTKKLYIVTELLE-DSTLETL---VAAHLRTNESMIEEVVWRVAAYLSSALYY .|. . || | | || . . .|.|| | | .|. . . .. . ||..|.. . ...||.| ILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKY |
|||||||||
| Kinase | GL50803_16879.AA | ULK | 68-103 | 28 | 0.005319 | 6.56 | In-house | 70-107 (324) | Show / Hide |
Range on Protein: 68-103 Range on HMM: 70-107/324 Sequence Identity: 28% (11 aa) IEHPC--IAKIYDIYHDTTTKKLYIVTELLEDSTLETL . || | | ||.. ... . .||..|. .. .||.. LKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQY |
|||||||||
| Kinase | GL50803_16879.AA | CAMK | 248-270 | 26 | 0.01989 | 2.83 | In-house | 395-417 (425) | Show / Hide |
Range on Protein: 248-270 Range on HMM: 395-417/425 Sequence Identity: 26% (6 aa) SEDICNLLNGLLRYEPGNRYSAE |.. .|....|...| .|...| SQECKDLIRKMLQVDPEKRMTIE |
|||||||||
| Kinase | GL50803_16879.AA | NEK | 244-278 | 28 | 0.033126 | 4.04 | In-house | 249-286 (286) | Show / Hide |
Range on Protein: 244-278 Range on HMM: 249-286/286 Sequence Identity: 28% (11 aa) LP-G--YSEDICNLLNGLLRYEPGNRYSAEYICSIKQC .| ||.| ||.. .|. .| .|.|.. | . .. IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
|||||||||
| Kinase | GL50803_16879.AA | Pkinase | 70-96 | 37 | 0.476056 | 4.79 | Pfam | 59-83 (293) | Show / Hide |
Range on Protein: 70-96 Range on HMM: 59-83/293 Sequence Identity: 37% (10 aa) HPCIAKIYDIYHDTTTKKLYIVTELLE ||.| ..||...| ...|.|.|..| HPNIVRLYDWFED--KDHIYMVMEYCE |
|||||||||
| Kinase | GL50803_16879.AA | Pkinase | 243-273 | 25 | 8.139783 | 0.43 | Pfam | 259-288 (293) | Show / Hide |
Range on Protein: 243-273 Range on HMM: 259-288/293 Sequence Identity: 25% (8 aa) VLPGYSEDICNLLNGLLRYEPGNRYSAEYIC . . ||. . .....|.. | |..|| |. F-HNWSEECKDFIKWCLCKDPKKRPTAEQIL |
|||||||||
| Ank | GL50803_16879.AA | Ank | 612-635 | 29 | 0.694139 | 7.45 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 612-635 Range on HMM: 1-24/33 Sequence Identity: 29% (7 aa) EGVSALMLAASVGNTYAIRSILER .| ..|.||.. |.| .. |.. DGFTPLHLACRCGHTEVVKMLLQH |
|||||||||
| Ank | GL50803_16879.AA | Ank | 651-676 | 38 | 0.012596 | 13.73 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 651-676 Range on HMM: 1-26/33 Sequence Identity: 38% (10 aa) NGKTALMYAVEGQHEEAVDVLAKHEA .| |.|..|.. |.| | | .| | DGFTPLHLACRCGHTEVVKMLLQHGA |
|||||||||
| Ank | GL50803_16879.AA | Ank | 682-702 | 47 | 0.000592 | 18.52 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 682-702 Range on HMM: 1-21/33 Sequence Identity: 47% (10 aa) DGTTALMLAAVRENVEIVKRL || |.|.||. . ..|.|| | DGFTPLHLACRCGHTEVVKML |
|||||||||
| Ank | GL50803_16879.AA | Ank | 713-733 | 28 | 8.919674 | 3.45 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 713-733 Range on HMM: 1-21/33 Sequence Identity: 28% (6 aa) IGRTALMHAMGIHNYKAVSIL |.|.|. | ... |. | DGFTPLHLACRCGHTEVVKML |
|||||||||
| Ank | GL50803_16879.AA | Ank | 744-764 | 42 | 0.005055 | 15.16 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 744-764 Range on HMM: 1-21/33 Sequence Identity: 42% (9 aa) NGLTPLMIAAKVGDNELVDIL .| |||..|.. |. | | | DGFTPLHLACRCGHTEVVKML |
|||||||||
| Ank | GL50803_16879.AA | Ank | 775-795 | 38 | 0.03432 | 12.16 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 775-795 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) AGETALMAAAAAGHVAVCRTL |.|.|. |. ||. |.. | DGFTPLHLACRCGHTEVVKML |
|||||||||
| Ank | GL50803_16879.AA | Ank | 806-827 | 40 | 0.000147 | 20.7 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 806-827 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) IGMTALMYAAEAGHEEICEALL |.|.|..|.. ||.|... || DGFTPLHLACRCGHTEVVKMLL |
|||||||||
| Ank | GL50803_16879.AA | Ank | 837-860 | 33 | 0.004337 | 15.4 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 837-860 Range on HMM: 1-24/33 Sequence Identity: 33% (8 aa) AGRTALMYAASTGQVGCVRKLLHA |.|.|..|.. |.. .|. || . DGFTPLHLACRCGHTEVVKMLLQH |
|||||||||
| Ank | GL50803_16879.AA | Ank | 868-893 | 42 | 0.05793 | 11.34 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 868-893 Range on HMM: 1-26/33 Sequence Identity: 42% (11 aa) DGSTALIIAAELGFTAVVAELVTREA || |.| .|.. | | || .|. . | DGFTPLHLACRCGHTEVVKMLLQHGA |
|||||||||
| Ank | GL50803_16879.AA | Ank | 899-922 | 25 | 0.159864 | 9.75 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 899-922 Range on HMM: 1-24/33 Sequence Identity: 25% (6 aa) SDETALSMAIMNNRRDCVQLLLKA .|.| .|..... ..|..||.. DGFTPLHLACRCGHTEVVKMLLQH |
|||||||||