Gene GL50803_16802 (G.lamblia)

GL50803_16802

Species: G.lamblia
Alias: GL50803_16802, GK023
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK5

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16802.AA Protein None 291 None Fasta, JSON
GL50803_16802.kin_dom Protein Kinase Domain None 282 None Fasta, JSON

Protein domain

Protein domains of GL50803_16802.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_16802.AA CDK5 8-289 55 2.6e-170 542.77 In-house 1-287 (287) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-287/287
Sequence Identity: 55% (160 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENADEGIPATAIREIAILKEMKHKNVVDLLSVIHTEAKLTLVFEYLDMDLKKYIDSKQGKLTPKEV
||..  .||||||.|.||..|||. ||||||.||.. |||.|.||||||..|||.||||.| |  |||.| |||||||..| |||||.|| .|.. .. .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPVRSYTHEVVTLWYRCPSVLLGCRKYGGALDIWSCGCIFYECV-TGKPLF
|||| ||. || . |...||||||||||||.   | |||||||||| .||||| |.||||||||| | ||.| ..|    |.||||||| | . .|.|||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PAKTEKDELIKIFKTLGTPDKQSWPDVDTLPQWQ---KDFPVYPGIN-VAELLPTLDEAGRDLFSKMMALDPSKRPSARDCLKHPYF
|   ..|.| .||| .|||   .|| .  ||...   ...|.||.    ... | ||| |.|| .||. ..| .| || . |.||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase GL50803_16802.AA CDC2 8-289 52 9.90000000001e-168 520.02 In-house 1-301 (301) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-301/301
Sequence Identity: 52% (159 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENADEG--IPATAIREIAILKEMK-HKNVVDLLSVIHTEAKLTLVFEYLDMDLKKYID---SKQGK
|..|. .||||||||.|.||..|.||||||.||||. |||  .| |||||| .|||.| |.|.| |  |||   || .|||||||||||| |   .|. .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LTPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPVRSYT--HEVVTLWYRCPSVLLGCRKYGGALDIWSCGCIFYEC
..|  |||.| |.  |. . | .|..||||||||.|. ..| .|.|||||||  |||.| ||  ||||||||| | .||||..|  . |.|| ||||.| 
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---VTGKPLFPAKTEKDELIKIFKTLGTPDKQSWPDVDTLPQWQKDFPVYPGINVAELLPT---------LDEAGRDLFSKMMALDPSKRPSARDCLKHP
   || ||||... | |.| |||..||||. |.||.|. || .. .|| .. ..  ...|          ||. |.|| ..| ..||.|| ||.. |.||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase GL50803_16802.AA CDK 8-289 46 7.29999999999e-160 515.28 In-house 1-284 (284) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-284/284
Sequence Identity: 46% (148 aa)

YERIQGLGEGTYGVVFKAKDKETG-----QIVALKRIRLEN-----ADEGIPATAIREIAILKEMKHKNVVDLLSVIHTE-----------AKLTLVFEY
||... .||||||||.||.||.||     ||||||.||.||     ..||.| ||||||..|||. |.|.| |. |.||.            ||..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDMDLKKYIDSKQGKLTPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGL-----LKLADFGLARGSGI------PVRSYTHEVVTLWYRCPS
.|.|||||.|          .|..| ||. || |.| ....||||||||.|... |      ||.|||||||  ||      |.| ||||||||||| | 
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLGCRKYG--GALDIWSCGCIFYECVT---GKPLFPAKTEKDELIKIFKTLGTPDKQSWPDVDTLPQWQKDFPVYPGINVAELLPTLDEAGRDLFSKMM
.|||...|.   . |.||.||||.| .|   .||||| ..| | | |||...|||. ..||.|  || .                        || .||.
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKML

ALDPSKRPSARDCLKHPYF
..||.|| || ..|.||||
CYDPKKRISAEQALQHPYF
Kinase GL50803_16802.AA CDK7 8-289 43 2.8e-135 362.89 In-house 1-288 (288) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-288/288
Sequence Identity: 43% (127 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIR----LENADEGIPATAIREIAILKEMKHKNVVDLLSVIHTEAKLTLVFEYLDMDLKKYIDSKQGKLT
|| |. .|||....|.|| |..|||||| |.|.     . |. ||  |||||| ||.||.| ||..|. ..     . |||...| ||   |  |.  ||
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPVRSYTHEVVTLWYRCPSVLLGCRKYGGALDIWSCGCIFYECVTGK
| ..|..| ..  || | |   .||||||| |||. . | ||.|||||||  | | | ||| ||| |||.|  | | | || . |.|| |||| |     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPAKTEKDELIKIFKTLGTPDKQSWPDVDTLPQWQKDFPVYPG---INVAELLPTLDEAGRDLFSKMMALDPSKRPSARDCLKHPYF
| .|   . | | .||.|||||  . ||..  ..   | |  .||   .   ..     .   || ..| ...|.|| ....|||.|||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIK-FKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase GL50803_16802.AA CMGC 8-289 26 1.9e-131 434.56 In-house 1-513 (513) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-513/513
Sequence Identity: 26% (137 aa)

YERIQGLGEGTYGVVFKAKD--------------KETGQIVALKRIRLENADE----------GIPATAIREIAILKEMK-----------------HKN
|| |. .||||||||.|..|              .||..|||.|.|...  .|          |.| .|.||| |||...                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVDLLSVIHTEA-----------------KLTLVFEYLDMDLKKYIDSKQG--------KLTPKE------------VKSFM------GQLMTGLT--YI
.| |. .....                  .| |||||.|.||..||...|.        .|.. .            .|.||       |. .||   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HNKR--VLHRDLKPQNLLVTSSGLL--------------------KLADFGLARGSGIP---------------------VRSYTHEVVTLWYRCPSVLL
| ..  ..||||||.|.|... . |                    |..||||||  ...                     .| |||.|||.||| | .||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GC---------RKYGGALDIWSCGCIFYECVTG--------KPLFPAKTE-----------KDELIKIFKTLGTPD---------------KQSWPDVDT
|.         ..|. . |.||.||||.| .||        ||||| ..|            | | ||||.||||.               .. ||..  
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LPQWQK--------------------------DFPVYPGINVAELLPT-----------------------------------LDEAGRDLFSKMMALDP
|| ..|                          .|| .|...  .| |                                    .|. ..|| .||. .||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SKRPSARDCLKHPYF
.||..| ..|.||||
DKRITAEQALQHPYF
Kinase GL50803_16802.AA PFTAIRE 8-289 47 7.79999999999e-125 421.03 In-house 1-287 (287) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-287/287
Sequence Identity: 47% (138 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENADEGIPATAIREIAILKEMKHKNVVDLLSVIHTEAKLTLVFEYLDMDLKKYIDSKQGKLTPKEV
||... ||||.|  |.|.. . ..|.|||| |||. ..|| | |||||   ||..|| |.| |  .|||.  ||.||||.. ||..|.|.  | . |. |
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQ-QEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

KSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPVRSYTHEVVTLWYRCPSVLLGCRKYGGALDIWSCGCIFYECVTGKPLFP
. |. ||. || |.| .|||||||||||||..  | ||||||||||   .| . | ||||||||| | ||||   |   ||.|  |||| | ..|.|.||
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFP

AK-TEKDELIKIFKTLGTPDKQSWPDVDTLPQWQKD-FP--VYPGINVAELLPTLD--EAGRDLFSKMMALDPSKRPSARDCLKHPYF
   .  | | ||||.||||  . || |  ||....  |.  .|   .  . .| ..    . || .||. . | .| || . ..||||
GMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase GL50803_16802.AA PCTAIRE 8-289 48 4.4e-123 415.19 In-house 1-291 (291) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-291/291
Sequence Identity: 48% (142 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENADEGIPATAIREIAILKEMKHKNVVDLLSVIHTEAKLTLVFEYLDMDLKKYIDSKQGKLTPKEV
| ..  ||||||  |.| . | |. .|||| ||||  .|| | |||||.  ||..|| |.| |  .|||.  |||||||.|||||.|.|     .  ..|
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNV

KSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPVRSYTHEVVTLWYRCPSVLLGCRKYGGALDIWSCGCIFYECVTGKPLFP
| |. ||. || | | ...|||||||||||.   | ||||||||||   .| . | ||||||||| | ||.|   |   .|.|  ||||||  ||.||||
KLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFP

AKT------EKDELIKIFKTLGTPDKQSWPDVDTLPQWQKD-FPVYPGINVAELLPTLD---EAGRDLFSKMMALDPSKRPSARDCLKHPYF
  |       ||.|  ||. ||||| ..||.| ... ...  || |.   .    | ||   . . || .... . . .| || . .|||||
GSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase GL50803_16802.AA PITSLRE 8-289 43 1.4e-112 380.28 In-house 1-295 (295) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-295/295
Sequence Identity: 43% (127 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLE--NADEGIPATAIREIA-ILKEMKHKNVVDLLSVI--HTEAKLTLVFEYLDMDLKKYIDSKQ---
.. .   .|||||||..||||.|. ||||||. .|     ||.| |..|||  ||....| |.| .. ..   .  |  .|.||.. |||  ..  .   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GKLTPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPVRSYTHEVVTLWYRCPSVLLGCRKYGGALDIWSCGCIFYEC
 . .| |.|..| ||  |  . | . ..|||||  ||| . .| ||..||||||  | |...||  ||||||| | .||||.||  ..|.|| |||| | 
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

VTGKPLFPAKTEKDELIKIFKTLGTPDKQSWPDVDTLPQWQK-D-FPVYPGINVAELLP---TLDEAGRDLFSKMMALDPSKRPSARDCLKHPYF
.|.||||. | | |.. .||| .|||  ..||..  || | .   || ||  |  .. |   .. . | ||  .|  ..| .| .| | ||||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase GL50803_16802.AA S_TKc 8-289 30 3e-100 340.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENADEGIPATAIREIAILKEMKHKNVVDLLSVIHTEAKLTLVFEYLDM---DLKKYIDSKQGK---
|| .. .|.|..|.|.|...|.||.|||.|.|.          ...|||.|||. .|.|.| |. |...  .| .|.||.|    ||..||......   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LTPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPVRSYTHEVVTLWYRCPSVLLGCRKYGG-ALDIWSCGCIFYE
  ... .....| |.  .| |.|.....||||||.|.|...   .|..||||||         |. ..|.||. | ||    .||. . |.||||||.||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

CVTGKPLFPAKTEKDELIKIFKTLGTPDKQSWPDVDTLPQWQKDFPVYPGINVAELLPTLDEAGRDLFSKMMALDPSKRPSARDCLK-------HPYF
...|.|.||      .. ..|| .|                                   .. ..|. .|..  ||.|||.| ..|.       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_16802.AA CDK4 8-289 43 2.7e-98 332.85 In-house 1-290 (290) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-290/290
Sequence Identity: 43% (128 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENADE--GIPATAIREIAILK---EMKHKNVVDLLSVIHT------EAKLTLVFEYLDMDLKKYID
|. .. .||| || |..| | .||..||||..|  . .|  |.|   ||||....    . | |.| |..| |.      | |.|.|||  | ||. |.|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SKQGK--LTPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPVRSYTHEVVTLWYRCPSVLLGCRKYGGALDIWSCGC
 |  .  . |. .|  | ||..|. . |  |. ||||||||.||||.| .|||||||||  .      |  ||||||| | |||    |    |.|| ||
-KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGC

IFYECVTGKPLFPAKTEKDELIKIFKTLGTPDKQSWP-DVDTLPQWQKDFPVYPGINVAELLPTLDEAGRDLFSKMMALDPSKRPSARDCLKHPYF
|| |    .|||. . ||| | |||.  |.|  . || ||  ||     || .   .. .. | ... | ||  ||   ...||.||. ||.||||
IFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDV-SLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase GL50803_16802.AA Pkinase 8-289 31 1.2e-95 328.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENADEGIPATAIR--EIAILKEMKHKNVVDLLSVIHTEAKLTLVFEYLDM-----DLKKYID-SKQ
|.... .|.|..|.|.|...| ||.|||.|.|........ . |..|  ||.|.|...|.|.| |. . ... .. .|.||...     ||. ||  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKL--TPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLL----KLADFGLARGS-GIPVRSYTHEVVTLWYRCPSVLLGCRKYGGALDIWSC
|..  ...|.|..| |.  || |.|.....||||||.|.|. . | .    |..|||||.     . . .|. ..|.||. | |..|...|| . |.|||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIFYECVTGKPLFPAK----TEKDELIKIFKTLGTPDKQSWPDVDTLPQWQKDFPVYPGINVAELLPTLDEAGRDLFSKMMALDPSKRPSARDCLKHPY
|||.|| ..|.|.|| .    .  |.. .|....|.| . .||  .. .    ... .  .   .. . ..|...|. ... ..||.|||.|...|.||.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase GL50803_16802.AA CRK7 8-240 39 7e-90 304.91 In-house 1-287 (343) Show / Hide 
Range on Protein: 8-240
Range on HMM: 1-287/343
Sequence Identity: 39% (112 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENA---DEGIPATAIREIAILKEMKHKNVVDLLSVIHT--------EAK--LTLVFEYLDMDLKKY
||.|.  |||||| | |||.|.||..||||..|..|     || | |||||| ||....|.|.| |  ..          . |    .|||| | ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

IDSKQGK-LTPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPV--RSYTHEVVTLWYRCPSVLLGCRKY--------
 .||  .   . ..|.|| ||. |. |.|.| .||||.|  |.|.  .| .|.|||||||        | ||  |.||||| |  |||  .|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------GGALDIWSCGCIFYECVTGKPLFPAKTEKDELIKIFKTLGTPDKQSWPDVDTLPQWQ
                              | . |.||||||. |  |.||.|... | . | ||.|  |.|  ..||.|. || |.
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWN
Kinase GL50803_16802.AA Pkinase_Tyr 8-153 31 1.1e-23 80.78 Pfam 1-159 (270) Show / Hide 
Range on Protein: 8-153
Range on HMM: 1-159/270
Sequence Identity: 31% (51 aa)

YERIQGLGEGTYGVVFKAKDK----ETGQIVALKRIRLENADEGI--PATAIREIAILKEM-KHKNVVDLLSVIH-TEAK--LTLVFEYLDM-DLKKYID
 . .. |||| .|.|.|.. |    .|.. || | .  |.|..     .  .||..|.|.. .|.|.| |. |.   .    . .|.||    ||..|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SK---QGKLTPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLAR
..   ...||.|.  ..  |   |. | ..|.  ||||   | |||...  | .||||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase GL50803_16802.AA TyrKc 8-289 22 6e-14 2.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

YERIQGLGEGTYGVVFKAKDKETGQIVALKRIRLENADEGIPATAIREIAILKEM--KHKNVVDLLSVIHTE-------AKLTLVFEYLDM-DLKKYIDS
 . .. |||| .|.|.|.. |   . || | .. .       .  .||. |...   .|.|.| |. |. ..         | .|.|| .  |||.|. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KQGKLTPKEVKSFMGQLMTGLTYIHNKRVLHRDLKPQNLLVTSSGLLKLADFGLARGSGIPVRSY-----THEVVTLWY--RCPSVL---------LGCR
...||..|.  ||. |   |  |.| |.. ||||   | ||.. .  | .||||.|     . ..      ... .      . ..|         .  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSR----DIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KYGGALDIWSCGCIFYECVT-GKPLFPA----KTEKDELIKIFKTLGTPDKQSW--PDVDTLPQWQKDFPVYPGINVAELLPTLDEAGRDLFSKMMALDP
|.  . |.|| |   .|  | |..  |     . . .|.|.  |. . ...     | .                      ..  ..  .. ..  . ||
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS-------------------F-VCCPDEMYQIMKQCWHEDP

SKRPSARDCLKHPYF
..||. ...  | .|
EDRPTFSEI--HECF
Kinase GL50803_16802.AA CRK7 264-289 53 4.2e-11 34.32 In-house 318-343 (343) Show / Hide 
Range on Protein: 264-289
Range on HMM: 318-343/343
Sequence Identity: 53% (14 aa)

DLFSKMMALDPSKRPSARDCLKHPYF
||. ||..|||.|| .| .|| |..|
DLLDKMLCLDPKKRFTAEECLQHDWF