Gene GL50803_16558 (G.lamblia)
GL50803_16558
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_16558.AA | Protein | None | 2259 | None | Fasta, JSON |
| GL50803_16558.kin_dom | Protein Kinase Domain | None | 312 | None | Fasta, JSON |
Protein domains of GL50803_16558.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3Kc | GL50803_16558.AA | PI3Kc | 1993-2255 | 21 | 2e-41 | 144.89 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1993-2255
Range on HMM: 1-336/336
Sequence Identity: 21% (74 aa)
GGIFKAGDDVSQDQLTMVLISLFKQVFEPL------KMWLSPYIALPIGKDYGFIELLNKASSLDQIG--------------------------------
. |||.||| ||...| ...|.. . .... || .|.|.. |.||. . . .| ||
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
----------------------------ATSDNFLVGYISSITEASREEATGTPHASQKLSLTVAKRRFLLSYAGYSILSYLLSFKDRHNGNIMIN-EYC
||. .. . .| . .. .. |...| .|.|||.. .|.| .||||.|||. .
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN---------EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTG
NVIHIDFGFLLEIAPGGKFNT----ESAPFKLTKAFKTILG--GEESTSYTLFQHIFVRGLLLSKIFGKDISYLIEAMLKSNL-PAIKGS-GSITQFRQR
...|||||.... .|. . | .||.||. . .. | | .| . .|. . .|.... . | |.|.|..... | .... .| . |||
HCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQR
MFLE-DSFGSAAEQAVQ-----LINES-SKKGYGAYDKFQSWQNN
..|. | ||... | ||..| . . .|. |. |...
FRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | GL50803_16558.AA | PI3_PI4_kinase | 1990-2207 | 17 | 5.3e-24 | 90.44 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1990-2207
Range on HMM: 1-300/300
Sequence Identity: 17% (55 aa)
AVKGGIFKAGDDVS--QDQLTMVLI-----------------------SLFKQVF--EPLKMW----LSPYIALPIGKDYGFIELLNKASSLDQIGATS-
. . ||| ||| ||...| .| .|.. . . . . ||. .| |.. |.||... . ....| |
WY-PFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYM
-----DNFL----------------------------------VGYISSITEASREE--ATGTPHASQKLSLTVAKRRFLLSYAGYSILSYLLSFKDRHN
.| .|. .. . .. . .. |...| .|.||.....|.| ||||
VKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWE-----------ARDNFVRSCAGMCVVDYILGNGDRHN
GNIMI---NEYCNVIHIDFGFLLE-IAPGGKFNTESAPFKLTK------AFKTILGG----EESTSYTLFQHIFVRGLLLSKIFGKDISYLI-------E
.|||. . ...|||||. .. . . .. | ||..|. . .|| ..|. | .|... .. ... . . |. |
DNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGE
AMLKSNLPAIKG
.|....|| ..
CMVHDGLPMWRS
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| Kinase | GL50803_16558.AA | ATR | 2091-2197 | 22 | 7.8e-10 | 29.24 | In-house | 163-267 (267) | Show / Hide |
Range on Protein: 2091-2197 Range on HMM: 163-267/267 Sequence Identity: 22% (25 aa) AKRRFLLSYAGYSILSYLLSFKDRHNGNIMINEYC-NVIHIDFGFLLEIAPGGKFNT-ESAPFKLTKAFKTILGGEESTSYTLFQHIFVRGLLLSKIFGK .. .. ||| .... |.. ||| ||.|.. ..|.|. . . | .|. | ||.||. .| .| || . . . . . SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIF--NSGEQFEVPEIVPFRLTHNMVFGMG--PMKTYGLFRRACEVIMMCMRDHRD DISYLIEAM || .... DIMSVWDCF |
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| Kinase | GL50803_16558.AA | PIKK | 2091-2162 | 34 | 1.8e-07 | 23.63 | In-house | 185-257 (290) | Show / Hide |
Range on Protein: 2091-2162 Range on HMM: 185-257/290 Sequence Identity: 34% (25 aa) AKRRFLLSYAGYSILSYLLSFKDRHNGNIMINEYC-NVIHIDFGFLLEIAPGGKFNTESAPFKLTKAFKTILG .. ... ||| .. | | ||| ||||... ..|||||.. | | .. | || ||. . . .| RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMG |
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| Kinase | GL50803_16558.AA | FRAP | 2098-2155 | 40 | 6e-06 | 17.91 | In-house | 143-201 (251) | Show / Hide |
Range on Protein: 2098-2155 Range on HMM: 143-201/251 Sequence Identity: 40% (24 aa) SYAGYSILSYLLSFKDRHNGNIMINEYC-NVIHIDFGFLLEIAPGGKFNTESAPFKLTK | | |. |.| ||| |||.. | ..||||| |.| | ||.||. SLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTR |
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| Kinase | GL50803_16558.AA | ATM | 2098-2155 | 42 | 1.3e-05 | 13.48 | In-house | 143-200 (304) | Show / Hide |
Range on Protein: 2098-2155 Range on HMM: 143-200/304 Sequence Identity: 42% (26 aa) SYAGYSILSYLLSFKDRHNGNIMINEY-CNVIHIDFGFLLEIAPGGKF--NTESAPFKLTK | | || |.| ||| ||.||| ..||| | | || | ||.||. SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQ---GKILPTPETVPFRLTR |
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