Gene GL50803_15049 (G.lamblia)

GL50803_15049

Species: G.lamblia
Alias: GL50803_15049, GK182
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_15049.AA Protein None 685 None Fasta, JSON
GL50803_15049.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of GL50803_15049.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_15049.AA S_TKc 10-279 28 1.4e-74 255.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-279
Range on HMM: 1-231/231
Sequence Identity: 28% (79 aa)

YKRLEELGRGSFGKVYKVQHRRTGEFYALKLVAYHGMSTKLYDMQTSEIELLTSVHHPGIINYHEAYDDHENKEFGIIMDIFTK--GDLHSYINKKRV--
|. |...|.|.||||||..|..||. .|.| .          ..  .||..| . ||| |........|   ... ..|.      |||..|| |..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TKASVSEQSIWAILSQLAYALSYCHSKTRAQGIEFGVVIHRDIKPENILISDDGRVVFSDFGICRALEERKATGTIVGTVAYLAPEIASMKSYDE-KVDI
..   .|  .. .. |.. || ||||.          .||||.||||||...  ..  .|||..| |       |..||  |.|||.    .|.  |.|.
LRFPFPE-HARFYMYQICCALEYCHSHG---------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGCTIYELCTKTLLFRAKNISDLANKHKEFSSESLIIQHHGYSEQLETVLKAMLQVDPTVRISAAEICH-------IDRV
||.||..||...   .|.  ..  . .| .              |...   .. .||.||. |..| |. .          .
WSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_15049.AA NEK 10-279 31 3e-69 236.36 In-house 1-286 (286) Show / Hide 
Range on Protein: 10-279
Range on HMM: 1-286/286
Sequence Identity: 31% (92 aa)

YKRLEELGRGSFGKVYKVQHRRTGEF-----YALKLVAYHGMSTKLYDMQT-SEIELLTSVHHPGIINYHEAYDDHENKEFGIIMDIFT-KGDLHSY---
|......|.|||||||||.....|       |..| . . .|| |  ..   .|. .| . .|| |. |.... ...|  . |.|.    .|||.     
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

INKKRVTKASVSEQSIWAILSQLAYALSYCHSK--TRAQGIEFGVVIHRDIKPENILISDDGR----VVFSDFGICRALE-ERKATGT-IVGTVAYLAPE
|.|..  .   .|  || .. |.. || |.|..          . ..|||||| || ......    |   |||| . |. ....  |  |||  |..||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGP------QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPE

IASMKSYDEKVDIWSLGCTIYELCTK--TLLFRAK--NISDLANKHKEFSSESLIIQHHG-YSEQLETVLKAMLQVDPTVRISAAEICHIDRV
. . |.|..|.||||||| .||.||      |.|.  |.  |..| ..   .   |. |  ||..|  ..  |||.||. | |. .|     .
VCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG-PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_15049.AA Pkinase 10-275 25 9.8e-61 212.88 Pfam 1-289 (293) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-289/293
Sequence Identity: 25% (76 aa)

YKRLEELGRGSFGKVYKVQHRRTGEFYALKLVAYHGMSTKLYDMQTS--EIELLTSVHHPGIINYHEAYDDHENKEFGIIMDIFTKG----DLHSYIN-K
|.... .|.||||.||| .|. ||. .|.| . ... . .     .   ||... ...|| |. ..... |  ...  ..|.   .|    ||..||  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

KRVTKASVSEQSIWAILSQLAYALSYCHSKTRAQGIEFGVVIHRDIKPENILISDDGRV----VFSDFGICRA--LEERKATGTIVGTVAYLAPEIAS-M
.. .    ||. .  .. |.. .| ||||.          .||||.|||||||...| .      .|||...   .     . |..||  |.|||.    
RHGCFY-FSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG

KSYDEKVDIWSLGCTIYELCTKTLLFRAK------NISDLANKHKEFSSESLIIQHHGYS-----------------EQLETVLKAMLQVDPTVRISAAE
. |. |||.||.||..||.... ..|. .      .   . .. ..   .. . . .  |                 | .  ..| .|..||. |..|..
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

ICH
|..
ILQ
Kinase GL50803_15049.AA AGC 10-273 19 1.5e-59 151.6 In-house 1-389 (395) Show / Hide 
Range on Protein: 10-273
Range on HMM: 1-389/395
Sequence Identity: 19% (78 aa)

YKRLEELGRGSFGKVYKVQHR------RTGEFYALKLVAYHG--------MSTKLYDM--------QTSEIELLTSVH----------HPGIIN-YHEAY
.. |  .|.||||||| |...       ||..||.| .            |  . .            .| . |. ..          || |..  | ..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DDHENKEFGIIMDI---FTK-----GDLHSYINKKRV-TKASVSEQSIWAILSQ-------LAYALSYCHS-KTRAQGIEFGVVIHRD-IKPENILISDD
 | ...   ..|.    . .     |.. ... .. .  . . .|. .  ....       .. || | || .          .|||| .||||||. .|
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMG---------IIHRDYLKPENILLDED

GRVVFSDFGICRALE---------------------------------------------------ERKATGTIVG--TVAYLAPEIASMKSYDEKVDIW
| .  .||| |  .                                                    .|. | |..|  |  |.||||     |.  .|.|
GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWW

S--LGCTIYELCTKTLLFRAK-------------NISDLANKHKEFSSESLIIQH---------HGYSEQLETVLKAMLQVDPTVRIS----------AA
|  ||| .||. |    |...              . ..  ... |... . . .            |...   .| .|..||. |.           | 
SFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAE

EI
||
EI
Kinase GL50803_15049.AA Ciliate-E2 10-273 22 3.2e-55 188.01 In-house 1-359 (365) Show / Hide 
Range on Protein: 10-273
Range on HMM: 1-359/365
Sequence Identity: 22% (87 aa)

YKRLEELGRGSFGKVYKVQHRRTGEFY------------------ALKLVAYHGMSTKLYDMQTSEIELLT----------------SVHHPGIINYHEA
|| .. .|.|.||.|||........ .                  . |..|   |. .   .. .|| ..                 .. || ||...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YDDHENKEFGIIMDIFTKGDLHSYIN---KKRVTKAS----VSEQSIWAILSQLAY---------------ALSYCHSKTRAQGIEFGVVIHRDIKPENI
. .  .. . ..|. .  ||| .||.   |||  . .     .|. |  |  |...               || |.|||        . .||||||||||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK--------NNIIHRDIKPENI

LISDDGRVVFSDFGICR----------------ALEERK-----------------ATGTIVGTVAYLAPEIASMKS---------YDEKVDIWSLGCTI
|.     .  .|||...                 . . |                  . ||.||  |.|||| ..|.         ||.|.||||||...
LF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

YELCTKTLLFRAKNISDLANKHKEFSSESLIIQ-----------------------HHGYSEQLETVLKA----MLQVDPTVRIS-AAEI
||.... . |                 .  |.|                       ..  |..    .|     |||.||  ||. . .|
YEMLFGKPPF-----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase GL50803_15049.AA CAMK 15-273 18 1.4e-53 170.61 In-house 1-419 (425) Show / Hide 
Range on Protein: 15-273
Range on HMM: 1-419/425
Sequence Identity: 18% (81 aa)

ELGRGSFGKVYKVQHRRTG------------EFYALKLVAYHGMST------------------------KLYDMQ--TSEIELLTS-------VHHPGI
.|||||||||....|..|.            . .| | .    ..                         . .|..   .|||.. .       ..|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

INYHEAYDDHE-----------------NKEFGIIM---DIFTKG----DLHSYINKK-----------RVTKA-SVSEQSIWAILSQLAYALSYCHSKT
|. .|.|.|..                 .|.. ..|   .  . |    || .|| ..            | .   ..|.    .  |.. |. ||||. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH-

RAQGIEFGVVIHRDIKPENILISDD-----------------GRVVFSDFGICRALEE------------------------RKATGTIVGTVAYLA-PE
       . ..|||.||||||..|.                 . .  .|||  . ...                         .   | .|| .| | ||
-------N-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE

IASMKS--------------YDEKVDIWSLGCTIYELCTKTLLFRAK-------------NISDLANKHK----EFSSESL------------------I
. . |.              |..|.|.||.|.  | . . .. |...             |...|  | .    .| .. .                  .
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEF

IQHHGYSEQLETVLKAMLQVDPTVRISAAEI
 .|   |..    .. ||||||. |......
-HH-FVSQECKDLIRKMLQVDPEKRMTIEQC
Kinase GL50803_15049.AA Ciliate-E2-Unclassified 10-274 22 2.6e-49 169.17 In-house 1-347 (352) Show / Hide 
Range on Protein: 10-274
Range on HMM: 1-347/352
Sequence Identity: 22% (82 aa)

YKRLEELGRGSFGKVYKVQHRRTGEFYALKLVAYHGMSTKLYDMQ----------TSEIE-------------LLTSVHHPGIINYHEAYDDHENKEFGI
|| .. .|.|.||||||.||. ....||.|    . .  ... |.            ...             .| .  || |......  | .|  . |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IYI

IMDIFTKGDLHSYINKKRV-------------TKASVSEQSIW-----AILSQLAYALSYCHSKTRAQGIEFGVVIHRDIKPENILISDDG---RVVFSD
.|. .  |||. ||.|.               ..  ..|| .       .. |.  .|.|.|.|          .|||||||||||....|   ..  .|
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN--------IIHRDIKPENILFDNNGKNYYIKIID

FGICRALEE----------------RKATGTIVGTVAYL----APEIASMKSYD----EKVDIWSLGCTIYELCTKTLLFRAKNISD-------------
|||.. ...                .. . |..||  |.    |||.   . ||    .|.||||||. .||... .. | ..|  .             
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAY

---LANKHKEFSSESLIIQH----HGYSEQLETVLK----AMLQVDPTVRISAAEIC
   | .. |.   .     .    .. |.. .  ..     ||...|  ||.. .|.
RKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase GL50803_15049.AA STE 10-272 22 6.4e-49 168.85 In-house 1-350 (359) Show / Hide 
Range on Protein: 10-272
Range on HMM: 1-350/359
Sequence Identity: 22% (81 aa)

YKRLEELGRGSFGKVYKVQHRR---------------TGEFYALKLVAYHGMST---------------KLYDMQTSEIELLTSVH--HPGIINYHEAYD
....|..|.|.||.|||  ..                |||..| | . .   ..               .  .    ||...   .  || |..|. .| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DHENKEFGIIMDIFTKGDLHSYINKKRVTKAS----------VSEQSIWAILSQLAYA-LSYCHSKTRAQGIEFGVVIHRDIKPENILISDDGRV
     .... |  |.|     | | . |..|  .. .          ..|. | .|. |.  . |.| ||.          .||||||| |||.     |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---------IIHRDIKPANILL-----V

VFSDFGICRALEE-----------------RKATGTIVGTVAYLAPEIASM------KSYDEKVDIWSLGCTIYELCTKTLLF---RAK-NISDLANKHK
  .|||.|  |..                  . . |.|||  . |||. .       | ||.|.||||||||| |..|    .       ..   .....
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

EFS---------SESLIIQHH------------------GYSEQLETVLKAMLQVDPTVRISAAE
 ..          ..  ...|                   .|. .   ..  || ||  | .| .
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase GL50803_15049.AA NEK2 10-279 29 6.5e-47 155.95 In-house 1-319 (319) Show / Hide 
Range on Protein: 10-279
Range on HMM: 1-319/319
Sequence Identity: 29% (97 aa)

YKRLEELGRGSFGKVYKVQHRRTGEFYALKLVAYHGMSTKLYDMQTSEIELLTSVHHPGIINYHEAYDDHENKEFGIIMDIFTKGDLHSYINKKRVTKAS
|  |...|.||||...|| .  .|.  . |   |  |  |  .|  ||. .|    || |. |     | .|.   |.|     ||| . | | |  .  
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

VSEQSIWAILSQLAYALSYCHS--------------KTRAQGIEFGVVIHRDIKPENILISDDGR-----------------------------------
  |. || |. ||  ||  ||               | |  |   ....|||||| ||  . |.                                    
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGK--HTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDY

----VVFSDFGICRALE-ERKATGTIVGTVAYLAPEIASMKSYDEKVDIWSLGCTIYELCTKTLLFRAKNISDLANKHKEFSSESLIIQHHGYSEQLETV
    |   |||  | |. .     | |||  |  ||  .  .|.|| ||||.|| |||.|.    |.|.|   |. | |.   . .  |   ||. |  .
SQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQ---YSRHLNEI

LKAMLQVDPTVRISAAEICHIDRV
   |. ||.  | |  ||    ..
IHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_15049.AA Ciliate-E2a 10-228 28 1.4e-46 135.17 In-house 1-223 (275) Show / Hide 
Range on Protein: 10-228
Range on HMM: 1-223/275
Sequence Identity: 28% (69 aa)

YKRLEELGRGSFGKVYKVQHRRTGEFYALKLVAYHGMSTKLYDMQ--TSEIELLTSVHHPGIINYHEAYDDHENKEFGIIMDIFTKGDLHSYINKKR-VT
|| . ..| |.||.||..||..||. .| | .    |. . .. .  . || .. .. || ||  .| | |. |  . ..|. .  |.| ..|...   .
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENN--YYLVMEYCEGGELYDKIKQCKRFF

KASVSEQSIWAILSQLAY-ALSYCHSKTRAQGIEFGVVIHRDIKPENILIS---DDG----RVVFSDFGICRAL--EERKATGTIVGTVAYLAPEIASMK
.    .| |  |. || . .|.|.|..          ..|||.||||||.     ..     .. .|||  .     | |   ...||  |.|||.. .|
EE---IQEICDIMQQLLWQGLHYMHQRN---------IMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNK

S------YDEKVDIWSLGCTIYELCTKTLLFRAKNISD
       ||.|.|.||.|. .| |.. ...| .|. ..
EVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNE
Kinase GL50803_15049.AA ULK 10-279 25 7.5e-41 142.03 In-house 1-324 (324) Show / Hide 
Range on Protein: 10-279
Range on HMM: 1-324/324
Sequence Identity: 25% (85 aa)

YKRLEELGRGSFG-KVYKVQHRRT---GEFYALKLVAYHGMSTKLYD--------MQTSEIELLTSVH---HPG--IINYHEAYDDHENKEFGIIMDIFT
|   ..|| |||| ||||  . .|   ....| | .   .|. | ..        .. .||...   .   ||   |. ... . .  .. . |||.   
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGDLHSYINKKRV-----TKASVSEQSIWAILSQLAYALSYCHSKTRAQGIEFGVVIHRDIKPENILISDD------------GRVVFSDFGICRALEE-
 ||| .||.|..      .|   ||| .  .. |.. .. . |..          .|||||||.||||...            |..  .||| .. ... 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN---------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

---RKATGTIV------GTVAYLAPEIAS----MKSYD-EKVDIWSLGCTIYELCTKTLLFRAKNISDLANKHKEFSSE---------SLIIQHH-----
      . |.|      ||  | ||.| .     | |.  |.||||||| .||. .    |..  ..|. .....                ||.      
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKD

-GYSEQLETVLKAMLQVDPTVRISAAEICHIDRV
   |....  .. |||.|.. |||  || ..  .
PKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_15049.AA ULK 10-279 25 1.6e-40 139.22 In-house 1-329 (329) Show / Hide 
Range on Protein: 10-279
Range on HMM: 1-329/329
Sequence Identity: 25% (85 aa)

YKRLEELGRGSFGKVYKVQHRRT----GEFYALKLVAYHGMSTKLYD--------MQTSEIELLTSVH--------HPGIINYHEA-YDDHENKEFGIIM
|   ..|| ||||||||  . .|    .| .| | .    |. |...        . ..||...   .        || |. ...  ..... . . |||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-NNIYIIM

DIFTKGDLHSYINKKRV------TKASVSEQSIWAILSQLAYALSYCHSKTRAQGIEFGVVIHRDIKPENILISDD------------GRVVFSDFGICR
.    ||| .||.|..       .|   ||| .  .. |.. .. . |..          .|||||||.||||...            |..  .||| ..
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN---------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

ALEER----KATGTIV------GTVAYLAPEIAS----MKSYD-EKVDIWSLGCTIYELCTKTLLFRAKNISDLA------NKHKEFSSE----SLIIQH
 ...     . . | |      ||  | ||.| .     | |.  |.||||||| .||. .    |.|  ..|.       .. ... ..    .  .| 
HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQF

HG------YSEQLETVLKAMLQVDPTVRISAAEICHIDRV
         |....  .. |||.|.. |||  |. ..  .
PKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_15049.AA TyrKc 10-279 20 4.8e-14 4.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-279
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YKRLEELGRGSFGKVYKVQHRRTGEFYALKLVA-YHGMSTKLYDMQTSEIELLTSV--HHPGIIN-YHEAYDDHEN----KEFGIIMDIFTKGDLHSYIN
 . ...||.| ||.||| . .   .  | | .  ..        .  .|.......  ||| |.. |  . .. .|    .   |.|    .|||..|. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KKRVTKASVSEQSIWAILSQLAYALSYCHSKTRAQGIEFGVVIHRDIKPENILISDDGRVVFSDFGICRALEER---------KAT----GTI-VGTVAY
|.| .   .. .    .  | |   .| |||          .||||.   |.|......|  |||| .|....          . .    |.  .  .  
KHRPK---LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

LAPEIASMKSYDEKVDIWSLGCTIYELCTKTLLFRA------KNISDLANKHKEFSSESLIIQHHGY-------SEQLETVLKAMLQVDPTVRISAAEIC
.|||    . . .| |.|| | ...|..|             .. ... .. |.   . . . ...|       .. . .. |   . ||  | . .|| 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG--YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-

HIDRV
 ... 
-HECF
Kinase GL50803_15049.AA Pkinase_Tyr 93-216 27 4.6e-09 31.33 Pfam 91-209 (270) Show / Hide 
Range on Protein: 93-216
Range on HMM: 91-209/270
Sequence Identity: 27% (36 aa)

KGDLHSYINKKRVTKASVSEQSIWAILSQLAYALSYCHSKTRAQGIEFGVVIHRDIKPENILISDDGRVVFSDFGICRAL----EE-RKATGTIVGTVAY
.|||..|  |.|  | ... . .  .  | | ...| .||           ||||.   |.|..... |  .||| .|..    .  ||..|.    .  
HGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---------CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKW

LAPEIASMKSYDEKVDIWSLGCTIYELCT
.|||  . . . .| |.|| | ...|..|
MAPECINYGKFTTKSDVWSFGVLMWEIFT
Kinase GL50803_15049.AA Pkinase_Tyr 10-26 47 0.001173 13.01 Pfam 1-17 (270) Show / Hide 
Range on Protein: 10-26
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

YKRLEELGRGSFGKVYK
 . ...||.|.||.|||
ITFGKKLGEGAFGEVYK
Kinase GL50803_15049.AA Ciliate-E2a 256-273 44 0.007576 4.24 In-house 252-269 (275) Show / Hide 
Range on Protein: 256-273
Range on HMM: 252-269/275
Sequence Identity: 44% (8 aa)

LKAMLQVDPTVRISAAEI
.| ||..||  ||.|...
MKKMLEKDPKKRITAQQA
Ank GL50803_15049.AA Ank 395-415 33 0.178191 9.58 Pfam 1-21 (33) Show / Hide 
Range on Protein: 395-415
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

SGRSALMHAVIMDRIEAVKIL
 |...|. |......| || |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_15049.AA Ank 426-448 30 0.125427 10.13 Pfam 1-21 (33) Show / Hide 
Range on Protein: 426-448
Range on HMM: 1-21/33
Sequence Identity: 30% (7 aa)

SGRTALHYACAKKEPNKQMLLLL
 |.|.||.|| .   ..... .|
DGFTPLHLACRCG--HTEVVKML
Ank GL50803_15049.AA Ank 459-482 29 1.571546 6.17 Pfam 1-24 (33) Show / Hide 
Range on Protein: 459-482
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

IGRTSLMLLIKDGRKDVAQLLVNK
 |.| |.| .. |...|...|...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_15049.AA Ank 490-513 37 0.331 8.61 Pfam 1-24 (33) Show / Hide 
Range on Protein: 490-513
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

AGTTALILAIRYGQTDIAMQLVHK
 | |.| ||.|.|.|...  |. .
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_15049.AA Ank 521-541 28 0.035208 12.12 Pfam 1-21 (33) Show / Hide 
Range on Protein: 521-541
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

NGWSALMEAAQQGNVTVARAL
.|...|. |.. |.. |.. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_15049.AA Ank 552-574 30 0.036583 12.06 Pfam 1-23 (33) Show / Hide 
Range on Protein: 552-574
Range on HMM: 1-23/33
Sequence Identity: 30% (7 aa)

MEWTALMVAAAHGSDGVCKILMD
. .|.|..|. .|.  |.| |..
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_15049.AA Ank 583-606 33 0.03303 12.22 Pfam 1-24 (33) Show / Hide 
Range on Protein: 583-606
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

LGETALMKAARAGKSNCAQVLLRA
 |.|.|. |.| |  .... || .
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_15049.AA Ank 614-634 47 0.000406 19.11 Pfam 1-21 (33) Show / Hide 
Range on Protein: 614-634
Range on HMM: 1-21/33
Sequence Identity: 47% (10 aa)

DGKSALMCAAEAGHTECVRVL
|| ..|..|.. ||||.|. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_15049.AA Ank 645-665 52 0.010074 14.08 Pfam 1-21 (33) Show / Hide 
Range on Protein: 645-665
Range on HMM: 1-21/33
Sequence Identity: 52% (11 aa)

DGRTALKFALERGHTECVDLL
||.|.|  | ..||||.| .|
DGFTPLHLACRCGHTEVVKML