Gene GL50803_14578 (G.lamblia)

GL50803_14578

Species: G.lamblia
Alias: GL50803_14578, GK054
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_14578.AA Protein None 545 None Fasta, JSON
GL50803_14578.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of GL50803_14578.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_14578.AA CMGC 19-230 15 3.2e-17 52.26 In-house 1-295 (513) Show / Hide 
Range on Protein: 19-230
Range on HMM: 1-295/513
Sequence Identity: 15% (51 aa)

WSPAGYLGAGAYGTIYKGID--------------KETGKPVALKAVGISGVFNHLVL-------------REVTLLAYLA---------QVTAGGQPFKN
    ...| |.||. ||..|              .||.. ||.| .     . .  .             ||. .| .|          .          
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRR----------

PAIDLISSFKLRLDDTTKDLPFAKHFENCSS--------------------------LICLVTPLYPHDCERFRTYNL----------------------
                  | |..|| .|. .                           ..||. . .||  ..   |                       
------------------DDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRR

----VSSFTLSQMVFFWHSVVTCLR--NLHRLG--IAHRDVKPSNILLDGNGSA--------------------FLADLGMAK-YCVYSSPSASANYAEP
    . .|.. .   . . . ..|    .|. .  | ||| ||.|||.. |.                       ..| |.|. | ..|.. .. ..   
PPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS-

EVLSADHY---------SPISTGTTCTLVYRAPE
                 .   |   .|. |||||
-------FKNVNKDDKPNRPYTHYVVTRWYRAPE
Kinase GL50803_14578.AA AGC 150-189 50 8.6e-17 38.49 In-house 162-203 (395) Show / Hide 
Range on Protein: 150-189
Range on HMM: 162-203/395
Sequence Identity: 50% (21 aa)

VVTCLRNLHR-LGIAHRD-VKPSNILLDGNGSAFLADLGMAK
.| .|  ||. .|| ||| .|| ||||| .|   |.| |..|
IVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCK
S_TKc GL50803_14578.AA S_TKc 19-444 13 1.3e-16 62.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-444
Range on HMM: 1-231/231
Sequence Identity: 13% (58 aa)

WSPAGYLGAGAYGTIYKGIDKETGKPVALKAVGISGVFNHLVLREVTLLAYLAQVTAGGQPFKNPAIDLISSFKLRLDDTTKDLPFAKHFENCSSLICLV
.     .| ||.|. ||...|.||. ||.| .         ..||. .|                       .  .| |.  |           . ...|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------------------HHPNIVKLYDVFQD-----------DHLYMV

TPLYPH---DCERFRTYNLV----SSFTLSQMVFFWHSVVTCLRNLHRLGIAHRDVKPSNILLDGNGSAFLADLGMAKYCVYSSPSASANYAEPEVLSAD
. . ..   |  ..   .      . |.  .  |. . ..  |  .|..|| |||.||.|||||      ..| |.|.                      
MEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------

HYSPISTGTTCTLVYRAPESTLRCYDFLSTNGSLFDRQESVTPTSLDA-LGDVYSLGLTLLESIISRVVFFLPLEHDNPRTNNNSSPSNPKPPRQDASQK
      |    |. |.|||                         . .    |..|.| .| | .  .  |                              
------TTFCGTPWYMAPEVL-----------------------GYGKCKCDWWSCGCILYEMLCGYPPFP-----------------------------

HNVYLFRMRMLFIQTYKKQIYDLFLSYCMVCGYTLSPNTTADAFRAKVNLHLHNLLEPNSDDHSGSLSPEIENILTEEGPDLIDFVSCCIKIRFGHETGR
.   .|.. .                                                                                          
QMQMMFKKIG------------------------------------------------------------------------------------------

ETELMEFARIVGNCLSLSLTERSTTAQLSS-------LKLF
     |.  .. .||    ..| |  ..            |
---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_14578.AA Ciliate-E2b 145-190 43 2.3e-15 43.28 In-house 106-151 (272) Show / Hide 
Range on Protein: 145-190
Range on HMM: 106-151/272
Sequence Identity: 43% (20 aa)

FFWHSVVTCLRNLHRLGIAHRDVKPSNILLDGNGSAFLADLGMAKY
|.  |.. ||. || ..| .||.||.||..| .|   |.|.| ||.
FYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKH
Kinase GL50803_14578.AA CAMK 157-215 19 1.8e-11 32.49 In-house 195-313 (425) Show / Hide 
Range on Protein: 157-215
Range on HMM: 195-313/425
Sequence Identity: 19% (23 aa)

LHRLGIAHRDVKPSNILLDGN-----------------GSAFLADLGMAKYC----------------------------VYSSPSASANYAE-PEVLSA
.| ..|.||| || ||||| |                 .   ..| |.|...                             .. .  .  |.  ||||. 
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

--------------DHYSP
              . |.|
KGHCNMQNATDEEKPYYGP
Kinase GL50803_14578.AA CDK-DD1 139-190 32 5.7e-11 29.48 In-house 96-147 (379) Show / Hide 
Range on Protein: 139-190
Range on HMM: 96-147/379
Sequence Identity: 32% (17 aa)

TLSQMVFFWHSVVTCLRNLHRLGIAHRDVKPSNILLDGNGSAFLADLGMAKY
.|..  .| |     .  .|  || |||.||.| |   .|. ...|.|.. |
SLPCIKCFFHQLLEGINECHNQGIMHRDIKPANLLINNRGDLKITDFGFTTY
Kinase GL50803_14578.AA CDK4 19-72 33 1.1e-10 32.64 In-house 1-59 (290) Show / Hide 
Range on Protein: 19-72
Range on HMM: 1-59/290
Sequence Identity: 33% (20 aa)

WSPAGYLGAGAYGTIYKGIDKETGKPVALKAVGISGVFN-----HLVLREVTLLAYLAQ
  ..  .| |||||.|.  | .||. |||| | |.   .       ..||....  |.|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQ
Kinase GL50803_14578.AA PDK1 156-178 60 1.8e-10 27.75 In-house 125-147 (307) Show / Hide 
Range on Protein: 156-178
Range on HMM: 125-147/307
Sequence Identity: 60% (14 aa)

NLHRLGIAHRDVKPSNILLDGNG
.||..||.|||.|| ||||| ..
HLHSNGIIHRDLKPENILLDKDM
Kinase GL50803_14578.AA Pkinase 136-215 31 2e-10 37.95 Pfam 104-191 (293) Show / Hide 
Range on Protein: 136-215
Range on HMM: 104-191/293
Sequence Identity: 31% (29 aa)

SSFTLSQMVFFWHSVVTCLRNLHRLGIAHRDVKPSNILLDGNGSA----FLADLGMAK---YCVYSSPS---ASANYAEPEVLS-ADHYSP
. |.  .  |..  ..  |  .|. || |||.||.|||.| ||       ..| | ||   |  .| ..    . .|. |||.  . .|.|
Y-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP
Kinase GL50803_14578.AA CDK 19-67 30 6.5e-10 27.73 In-house 1-62 (284) Show / Hide 
Range on Protein: 19-67
Range on HMM: 1-62/284
Sequence Identity: 30% (19 aa)

WSPAGYLGAGAYGTIYKGIDKETG-----KPVALKAVGISG--------VFNHLVLREVTLL
      .| |.||. ||..||.||     . |||| . .           |..  .||..||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLL
Kinase GL50803_14578.AA CDK 157-189 42 1.1e-09 26.94 In-house 124-161 (284) Show / Hide 
Range on Protein: 157-189
Range on HMM: 124-161/284
Sequence Identity: 42% (16 aa)

LHRLGIAHRDVKPSNILLDGNGS-----AFLADLGMAK
.|. .| ||| ||.|||.. ||.       .|| | |.
CHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLAR
Kinase GL50803_14578.AA CDC2 157-189 48 2e-09 24.55 In-house 119-151 (301) Show / Hide 
Range on Protein: 157-189
Range on HMM: 119-151/301
Sequence Identity: 48% (16 aa)

LHRLGIAHRDVKPSNILLDGNGSAFLADLGMAK
.|. .| ||| ||.|||.| .|.  .|| | |.
CHQRRIMHRDLKPQNILIDKKGNIKIADFGLAR
Kinase GL50803_14578.AA MAPK-Unclassified 157-189 45 2.8e-08 25.47 In-house 125-157 (575) Show / Hide 
Range on Protein: 157-189
Range on HMM: 125-157/575
Sequence Identity: 45% (15 aa)

LHRLGIAHRDVKPSNILLDGNGSAFLADLGMAK
||  .|.||| ||||.|.....|   .| ||..
LHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase GL50803_14578.AA MAPK-Unclassified 19-50 33 6.6e-08 24.11 In-house 1-33 (575) Show / Hide 
Range on Protein: 19-50
Range on HMM: 1-33/575
Sequence Identity: 33% (11 aa)

WSPAGYLGAGAYGTIYKGIDKET-GKPVALKAV
  . ...|.||||  .. .|| . ...|| | |
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKV
Kinase GL50803_14578.AA CAMK 24-67 15 7e-07 17.44 In-house 1-85 (425) Show / Hide 
Range on Protein: 24-67
Range on HMM: 1-85/425
Sequence Identity: 15% (13 aa)

YLGAGAYGTIYKGIDKETG------------KPVALKAVGISGVFN-----------------------------HLVLREVTLL
 || |..|. ...|.|.|.            . || | .  . . .                             . |.||. ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIM
Kinase GL50803_14578.AA CDC2 25-48 50 3e-06 14.57 In-house 7-30 (301) Show / Hide 
Range on Protein: 25-48
Range on HMM: 7-30/301
Sequence Identity: 50% (12 aa)

LGAGAYGTIYKGIDKETGKPVALK
.| | || .||..|..|.. ||||
IGEGTYGVVYKCKDMQTNQIVALK
Kinase GL50803_14578.AA CDK4 157-195 48 3e-06 17.37 In-house 126-162 (290) Show / Hide 
Range on Protein: 157-195
Range on HMM: 126-162/290
Sequence Identity: 48% (19 aa)

LHRLGIAHRDVKPSNILLDGNGSAFLADLGMAKYCVYSS
||   | ||| || |||.  .|   ||| | |.  .||.
LHSHRIIHRDLKPQNILVTSDGHVKLADFGLAR--IYSF
Kinase GL50803_14578.AA Pkinase 19-50 37 1.3e-05 20.95 Pfam 1-32 (293) Show / Hide 
Range on Protein: 19-50
Range on HMM: 1-32/293
Sequence Identity: 37% (12 aa)

WSPAGYLGAGAYGTIYKGIDKETGKPVALKAV
.   . .|.|..|. ||...| ||| ||.| .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKII
Kinase GL50803_14578.AA PDK1 19-48 32 2.5e-05 11.74 In-house 1-34 (307) Show / Hide 
Range on Protein: 19-48
Range on HMM: 1-34/307
Sequence Identity: 32% (11 aa)

WSPAGYLGAGAYGTIYKGIDKET----GKPVALK
 .   ..| |.|.| |....|||    .| .|.|
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIK
Kinase GL50803_14578.AA CDK-DD1 26-50 48 0.000206 8.86 In-house 8-32 (379) Show / Hide 
Range on Protein: 26-50
Range on HMM: 8-32/379
Sequence Identity: 48% (12 aa)

GAGAYGTIYKGIDKETGKPVALKAV
| | || ..|.| | |   |||| .
GQGIYGSVFKAIHKITHCMVALKNF
Kinase GL50803_14578.AA Ciliate-E2b 25-56 27 0.012991 3.95 In-house 7-39 (272) Show / Hide 
Range on Protein: 25-56
Range on HMM: 7-39/272
Sequence Identity: 27% (9 aa)

LGAGAYGTIYKGID-KETGKPVALKAVGISGVF
|| |..| .| .   |.| .  |.|.. .. ..
LGFGQFGSVYLVWNTKNTKQYYAMKCISKNQII