Gene GL50803_13964 (G.lamblia)
GL50803_13964
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_13964.AA | Protein | None | 485 | None | Fasta, JSON |
| GL50803_13964.kin_dom | Protein Kinase Domain | None | 263 | None | Fasta, JSON |
Protein domains of GL50803_13964.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_13964.AA | S_TKc | 8-270 | 21 | 5.4e-16 | 57.63 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 8-270 Range on HMM: 1-231/231 Sequence Identity: 21% (58 aa) FCLGKPFKACSYSIIYEAADLRIQKSCLCKVYEYGRLSPHEAAVLHREVALIKRLRHPLLVHYLSVLHDRAGQRYFLFMEQVKQ--ETLSQYIRRRKALD . .... ... | . . . .. . .|. . ||... |. .|| .|... | .| ......|| . . .| .||..|. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG RGSHLPERSVWYILSQFIDLLSYLHDVGPNHDQALLYA-LTPESIFIDNLDIITVSFLSLSRKLMYYKCFPVHTAEYRAPELLRTGVATTKSDIWSLGCI ... .|| ..... | .. | |.|. | .. | || |..|. | .. |.|.| . | .|.|||.| | . |.|.||.||| LRFPFPE-HARFYMYQICCALEYCHSHG------IIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI IYELCT-FRPFCLALNPMDALQKLGKLQRKVQMPLYSTSLTSIINTFLELEPECRLAVDVLSV-------NGII .||... ||. ... ..|.| | .. ..|. |. .|| |. . . . LYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_13964.AA | AGC | 175-210 | 44 | 1.2e-12 | 27.56 | In-house | 268-300 (395) | Show / Hide |
Range on Protein: 175-210 Range on HMM: 268-300/395 Sequence Identity: 44% (17 aa) PVHTAEYRAPELLRTGVATTKSDIWS--LGCIIYELCT |. |.|| ||| | . |.|| |||..||. | PC-TPEYMAPEIL----YGKACDWWSFGLGCLMYEMLT |
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| Kinase | GL50803_13964.AA | Pkinase | 178-227 | 36 | 3.1e-12 | 44.34 | Pfam | 174-227 (293) | Show / Hide |
Range on Protein: 178-227 Range on HMM: 174-227/293 Sequence Identity: 36% (20 aa) TAEYRAPELLR-TGVATTKSDIWSLGCIIYELCTFRPFCLAL----NPMDALQKL | .|.|||..| ..|.|.||.|||.||... || . | .| .|.. TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMI |
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| Kinase | GL50803_13964.AA | PDK1 | 178-206 | 62 | 4.2e-12 | 32.86 | In-house | 202-230 (307) | Show / Hide |
Range on Protein: 178-206 Range on HMM: 202-230/307 Sequence Identity: 62% (18 aa) TAEYRAPELLRTGVATTKSDIWSLGCIIY |||| |||| . .|. .|||.|||||| TAEYVSPELLTDKECTPSCDIWALGCIIY |
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| Kinase | GL50803_13964.AA | RCK | 181-213 | 55 | 3e-11 | 31.65 | In-house | 179-212 (298) | Show / Hide |
Range on Protein: 181-213 Range on HMM: 179-212/298 Sequence Identity: 55% (19 aa) YRAPE-LLRTGVATTKSDIWSLGCIIYELCTFRP ||||| ||| . ... |||..|||.||| ..|| YRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRP |
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| Kinase | GL50803_13964.AA | TK-Unique | 183-211 | 46 | 3.1e-11 | 35.09 | In-house | 204-235 (294) | Show / Hide |
Range on Protein: 183-211 Range on HMM: 204-235/294 Sequence Identity: 46% (15 aa) APELLR--TGVA-TTKSDIWSLGCIIYELCTF ||| |. .|.. |||||.||.|....|..|. APESLKCYHGMYHTTKSDVWSFGVLMWEIFTL |
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| Kinase | GL50803_13964.AA | NEK | 193-213 | 56 | 5.5e-11 | 35.31 | In-house | 202-224 (286) | Show / Hide |
Range on Protein: 193-213 Range on HMM: 202-224/286 Sequence Identity: 56% (13 aa) TTKSDIWSLGCIIYELCTF--RP . |||||||||..||.||. .. NNKSDIWSLGCVLYEMCTLKPKH |
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| Kinase | GL50803_13964.AA | NEK-Unclassified | 176-269 | 30 | 1.6e-10 | 30.7 | In-house | 158-258 (258) | Show / Hide |
Range on Protein: 176-269 Range on HMM: 158-258/258 Sequence Identity: 30% (31 aa) VHTAEYRAPELLRTGVATTKSDIWSLGCIIYELCTFRPFCLALNPMDALQKLGKLQRKVQMPL------YSTSLTSIINTFLELEPECR-LAVDVLSVNG | | . .|| . .||.|||||||||.||. || . | . . | . .. | ||| | .| . |. ... | |..... VGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDY I | I |
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| Kinase | GL50803_13964.AA | NEK8 | 195-210 | 62 | 1.6e-10 | 26.12 | In-house | 202-217 (278) | Show / Hide |
Range on Protein: 195-210 Range on HMM: 202-217/278 Sequence Identity: 62% (10 aa) KSDIWSLGCIIYELCT |||.|.|||..||.|. KSDMWALGCVLYEMCC |
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| Kinase | GL50803_13964.AA | CDC2 | 181-214 | 44 | 1.4e-09 | 25.06 | In-house | 171-208 (301) | Show / Hide |
Range on Protein: 181-214 Range on HMM: 171-208/301 Sequence Identity: 44% (17 aa) YRAPE-LLRTGVATTKSDIWSLGCIIYEL---CTFRPF ||||| ||. .| |.||.|||..|. .|..|. YRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPL |
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| Kinase | GL50803_13964.AA | STE | 183-256 | 21 | 2.5e-09 | 29.24 | In-house | 230-343 (359) | Show / Hide |
Range on Protein: 183-256 Range on HMM: 230-343/359 Sequence Identity: 21% (25 aa) APELLRT------GVATTKSDIWSLGCIIYELCTFRPFCLALNPMDALQKLGKLQRKV-----------QMP-----------------------LYSTS ||| .. . .||.||||||| | |..| .| . ..|| |. . .... . | .| . APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE LTSIINTFLELEPE . || |. .|. FKDFINKCLQKDPN |
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| TyrKc | GL50803_13964.AA | TyrKc | 8-269 | 16 | 6.1e-09 | -78.05 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 8-269 Range on HMM: 1-280/280 Sequence Identity: 16% (51 aa) FCLGKPFKACSYSIIYEAADLRIQKSCLCKVYEYGRLSPHEAAVLHREVALIKRL--RHPLLVHYLSVLHDRAG-----QRYFLFMEQVKQETLSQYIRR ||| . . ..|.. . |. . . ..|| . ..| .|| .| . | . . . ... || .. | .|.|. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK RKALDRGSHLPERSVWYILSQFIDLLSYLHDVGPNHDQALLYALTPES----------IFIDNLDIITVSFLSLSRKLM----------YYKC------- .. |. . .. | . .|||. . ... .. .| |||.. ||. HRPK-----LCMKDLLSFCWQIACGMEYLHSK---------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK --FPVHTAEYRAPELLRTGVATTKSDIWSLGCIIYELCTF--RPFCLA----LNPMDALQKLGKLQRKVQMPL--------YSTSLTSIINTFLELEPEC .|. ||| ...|. |||||.|| | ..|..|. | ... ...... . | |.| .. . .|. . . .||. TMLPIR---WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED RLAVDVLSVNGI | . . . RPTFSEI-HECF |
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| Kinase | GL50803_13964.AA | ASK | 10-131 | 29 | 1e-06 | 17.8 | In-house | 2-112 (254) | Show / Hide |
Range on Protein: 10-131 Range on HMM: 2-112/254 Sequence Identity: 29% (36 aa) LGKPFKACSYSIIYEAADLRIQKSCLCKVYEYGRLSPHEAAVLHREVALIKRLRHPLLVHYLSVLHDRAGQRYFLFMEQVKQETLSQYIRRRKALDRGSH ||| .| |.| . |.. |. | | ... || |.|| |.||| .|.|| . .. .||||| ||. .| . . LGK----GTYGIVYAGRDMHTQVRIAIK--EIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGC--CSENGYFKIFMEQVPGGSLSALLRSKWGPMKDN- LPERSVWYILSQFIDLLSYLHD | .. . | .. |.|||. --ENTMNFYTKQILEGLKYLHE |
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| Kinase | GL50803_13964.AA | Pkinase_Tyr | 183-211 | 48 | 1.2e-05 | 19.74 | Pfam | 182-210 (270) | Show / Hide |
Range on Protein: 183-211 Range on HMM: 182-210/270 Sequence Identity: 48% (14 aa) APELLRTGVATTKSDIWSLGCIIYELCTF ||| ...|. |||||.|| | ..|..|. APECINYGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | GL50803_13964.AA | ASK | 178-270 | 27 | 2.4e-05 | 13.55 | In-house | 158-254 (254) | Show / Hide |
Range on Protein: 178-270 Range on HMM: 158-254/254 Sequence Identity: 27% (27 aa) TAEYRAPELLRTGVA--TTKSDIWSLGCIIYELCTFR-PFCLALNPMDALQKLGKLQRKVQMP-LYSTSLTSIINTFLELEPECRLAVDVLSVNGII | | |||.. |. ||||.|| . |. | . || .| |. | | . ..| | | | .|. | . . | .. . TLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL |
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| Kinase | GL50803_13964.AA | CDC2 | 54-130 | 21 | 0.00055 | 7.56 | In-house | 49-120 (301) | Show / Hide |
Range on Protein: 54-130 Range on HMM: 49-120/301 Sequence Identity: 21% (17 aa) REVALIKRLR-HPLLVHYLSVLHDRAGQRYFLFMEQVKQETLSQYIRRRKALDRGSHLPERSVWYILSQFIDLLSYLH || ..| |. || .| |.| .. ... |.. . | .| .. . . .|.|. | .. | .. ....| REISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMD-LKKYMDMSIPKN--KHMPPQLVKSYMYQILQGVHFCH |
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| Kinase | GL50803_13964.AA | Pkinase | 54-105 | 24 | 0.00914 | 10.86 | Pfam | 47-106 (293) | Show / Hide |
Range on Protein: 54-105 Range on HMM: 47-106/293 Sequence Identity: 24% (15 aa) R--EVALIKRLRHPLLVHYLSVLHDRAGQRYFLFMEQVKQE----TLSQYIR--RRKAL--D | |... |||.|| | .. . .| .... . || . |. ||. |.... . RLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS |
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| Kinase | GL50803_13964.AA | STE | 52-131 | 19 | 0.015513 | 4.92 | In-house | 75-170 (359) | Show / Hide |
Range on Protein: 52-131 Range on HMM: 75-170/359 Sequence Identity: 19% (19 aa) LHREVALIKRLR--HPLLVHYLSVLH-----DRAGQRYFLFMEQVKQETLSQYIRRR-KALDRGS-------HLPERSVWYILSQFIDL-LSYLHD . .|. . |... || |.|. . ... ...|| . .|.. |... . ... . ..|| . ||. | . |.|||. ILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS |
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| Kinase | GL50803_13964.AA | NEK | 238-270 | 27 | 0.08082 | 2.66 | In-house | 254-286 (286) | Show / Hide |
Range on Protein: 238-270 Range on HMM: 254-286/286 Sequence Identity: 27% (9 aa) LYSTSLTSIINTFLELEPECRLAVDVLSVNGII .||. | ..|. | .|| | .. . . .| MYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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