Gene GL50803_137743 (G.lamblia)

GL50803_137743

Species: G.lamblia
Alias: GK106, GL50803_137743
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_137743.AA Protein None 464 None Fasta, JSON
GL50803_137743.kin_dom Protein Kinase Domain None 204 None Fasta, JSON

Protein domain

Protein domains of GL50803_137743.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_137743.AA TKL 60-214 16 1.3e-24 85.5 In-house 134-364 (364) Show / Hide 
Range on Protein: 60-214
Range on HMM: 134-364/364
Sequence Identity: 16% (39 aa)

ILSVMKQVAAALAYLHGLS---GANTRGLVHCDLRPANVLISADGE------Y-------FIIAGLELCKDALWS----------------------EST
... ....| ...|||      .  .....|.|| ..|.|.  ...      |         |. . |...  .|                       .|
RCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMT

IAGMAAYMAPEVLLHN----------------EPSPASDVWSLGVIVYEMATLRKPDF-LKGKEPA---------EVFVD-EWRPDLS------------
. |  ..||||||  .                | |...||.| |.. .|..| ..| . ..  ..          .. .|   || .             
QCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPC

GVTDGFIQNVLERIFVLEPERRPTASELHETL
  ..  . . ...    .|| ||...|. ..|
PDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_137743.AA TK 45-214 14 8e-19 59.02 In-house 150-486 (486) Show / Hide 
Range on Protein: 45-214
Range on HMM: 150-486/486
Sequence Identity: 14% (50 aa)

LAKHKRGRIP------------------------------------------------------------------------VPITMILSVMKQVAAALA
| |.......                                                                        ..    |  . |.|....
LRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGME

YLHGL--SGANTRGLVHCDLRPANVLISADGE----------YFIIAGLE--------LCKDAL------------------------WSESTIA--GMA
||| .  .     ..|| ||   |.|.. ..              ||           |..|                          |.. . .  |. 
YLHSKNCE-FI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGK

A---YMAPEVLLHNE---------PSPASDVWSLGVIVYEMATLRKPDFLK----------GKEPAEVFVDEWR------------------PDLSGVTD
    .||||.|....          ...|||||.|| ..|. |. .  .            | ...||.    |                  |   . .|
LPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPD

-------------GFIQNVLERIFVLEPERRPTASELHETL
              ... .. . . ..||.||| |.||| |
WMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase GL50803_137743.AA Ciliate-E2 60-161 22 5.8e-17 54.75 In-house 147-295 (365) Show / Hide 
Range on Protein: 60-161
Range on HMM: 147-295/365
Sequence Identity: 22% (36 aa)

ILSVMKQVAA---------------ALAYLHGLSGANTRG-LVHCDLRPANVLISADGEYFIIAGLELCKDA--------------LWSEST--------
|. .|||..                || |||       ..  .| |. | |.|.        |. . |.|..              .. .          
IKYIMKQILQGFKTKAEFYIACIILALEYLH------SKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPG

-------------IAGMAAYMAPEVLL---------HNEPSPASDVWSLGVIVYEMATLRKP
             |.|.. |||||.|          ... . ..|.|||||| ||| . . |
YMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
Kinase GL50803_137743.AA Ciliate-E2-Unclassified 45-161 23 1.8e-16 53.7 In-house 125-269 (352) Show / Hide 
Range on Protein: 45-161
Range on HMM: 125-269/352
Sequence Identity: 23% (36 aa)

LAKHKRGRIPVPITMIL-----SVMKQVAAALAYLHGLSGANTRG-LVHCDLRPANVLISADGE--YFIIAGLELCKDALWS------------------
| .... |  ..   ..       ..|.  .| |||        .  .| |. | |.|.. .|.  |  |... ..|    .                  
LFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH------HKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQM

ESTIAGMAAYM----APEVLLHNEPS----PASDVWSLGVIVYEMATLRKP
 .|..|   ||    |||||  ....     ..|.|||||| ||| . . |
MWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase GL50803_137743.AA AGC 66-157 22 3.4e-15 34.26 In-house 161-300 (395) Show / Hide 
Range on Protein: 66-157
Range on HMM: 161-300/395
Sequence Identity: 22% (34 aa)

QVAAALAYLHGLSGANT-RGLVHCD-LRPANVLISADGEYFIIAGLELCKDALWSE--------------------------------------------
... || |||        .| .| | | | |.|. .|  .  ..   |||    ..                                            
CIVLALEYLH------SHMGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDD

---------STIAG--MAAYMAPEVLLHNEPSPASDVWS--LGVIVYEMAT
         .|. |   . |||||.|     ..| | ||  ||.. ||| |
TTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLT
Kinase GL50803_137743.AA ULK 60-161 23 7.4e-14 44.84 In-house 132-255 (329) Show / Hide 
Range on Protein: 60-161
Range on HMM: 132-255/329
Sequence Identity: 23% (30 aa)

ILSVMKQVAAALAYLHGLSGANTRGLVHCDLRPANVLISADGEY-----------FIIAGLELCKDAL-W-----SESTIA------GMAAYMAPEVLL-
.....|| .... .||       .. .|.|. |.|.||. . ..           . ||   ..|    .      . |        |   ||||..|  
AIQFFKQILNGFKELH------KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQG

---HNEPSPA-SDVWSLGVIVYEMATLRKP
   . ... . .|.||||.| ||| . . |
QGEQKPYYDYKCDIWSLGCIFYEMLYGKPP
Kinase GL50803_137743.AA UTK 61-157 23 9.2e-14 43.47 In-house 121-235 (296) Show / Hide 
Range on Protein: 61-157
Range on HMM: 121-235/296
Sequence Identity: 23% (29 aa)

LSVMKQVAAALAYLHGLSGANTRGLVHCDLRPANVLISADG------EYFIIAGLE---LCKDAL------------WSESTIAGM--AAYMAPEVLLHN
|. . ..|....|||      ..|.||.||   |.|. ...      . . ||..    .....              . .. ...   . ||||.| |.
LCMAWDIARGMQYLH------SCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHH

-EPSPASDVWSLGVIVYEMAT
  .. .|||||.|| ..|. |
TRFTTKSDVWSFGVVCWEIWT
Kinase GL50803_137743.AA ULK 60-161 23 1.7e-13 44.29 In-house 128-251 (324) Show / Hide 
Range on Protein: 60-161
Range on HMM: 128-251/324
Sequence Identity: 23% (30 aa)

ILSVMKQVAAALAYLHGLSGANTRGLVHCDLRPANVLISADGEY-----------FIIAGLELCKDALW--SESTIA----------GMAAYMAPEVLL-
.....|| .... .||       .. .|.|. |.| ||. . ..           . ||   ..|       | ..           |   ||||..|  
AIQFFKQICNGFKELH------KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQG

---HNEPSPA-SDVWSLGVIVYEMATLRKP
   . ... . .|.||||.| ||| . . |
QGEQKPYYDYKCDIWSLGCIFYEMLYGKYP
Kinase GL50803_137743.AA CAMK 63-155 20 2.4e-13 38.63 In-house 184-327 (425) Show / Hide 
Range on Protein: 63-155
Range on HMM: 184-327/425
Sequence Identity: 20% (31 aa)

VMKQVAAALAYLHGLSGANTRGLVHCDLRPANVLISADGE---------------Y-FIIAGLELCKDALWSES--------------------------
...|.. |..|.| .      . ||.|| | |.|.. ...               .   |.   . .    .|.                          
YFRQICSAVHYCHSH------NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMK

TIAGMAAYMA-PEVLLH-------------NEP-SPASDVWSLGVIVYEM
|  |  .||| ||||.              ... .|..|.||.||| | |
TFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIM
S_TKc GL50803_137743.AA S_TKc 10-221 20 3e-13 17.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-221
Range on HMM: 1-231/231
Sequence Identity: 20% (54 aa)

FLT------------------------------------------SHPDVLRHHQVLTDEGFTYIVIDRHDS---TLERPLAKHKR--GRIPVPITMILS
.                                             || . . . |  | .. |.| .  |    .| . . |..|  .| | |  .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

VMKQVAAALAYLHGLSGANTRGLVHCDLRPANVLISADGEYFIIAGLELCKDALWSESTIAGMAAYMAPEVLLHNEPSP-ASDVWSLGVIVYEMATLRKP
.|.|.. ||.|.|       .| .|.|| |.|.|..       |.   |..      .|. |   |||||||     .. ..|.||.|.|.|||.. ..|
YMYQICCALEYCHS------HGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYP

DFLKGKEPAEVFVDEWRPDLSGVTDGFIQNVLERIFVLEPERRPTASELHE--TLTAADIPV
 |       ..  .  .      .. ...  ...... .||.|||| |. .   . ...  .
PFP----QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_137743.AA TK-Unique 125-158 43 2e-12 39.24 In-house 199-235 (294) Show / Hide 
Range on Protein: 125-158
Range on HMM: 199-235/294
Sequence Identity: 43% (16 aa)

MAAYMAPEVLL--HNEP-SPASDVWSLGVIVYEMATL
. ..||||.|.  |.   .. |||||.||. .|..||
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL
Kinase GL50803_137743.AA Pkinase 128-214 21 1.6e-11 41.81 Pfam 177-293 (293) Show / Hide 
Range on Protein: 128-214
Range on HMM: 177-293/293
Sequence Identity: 21% (25 aa)

YMAPEVLL-HNEPSPASDVWSLGVIVYEMATLRKPDFLKGK------EPAEVFVDEWRPDLSGVTD-----------------------GFIQNVLERIF
||||||.. ... .|..|.||.|.|.|||.. ..| |  |.      .. ....   .|.|.   .                          . ......
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

VLEPERRPTASELHET--L
 . |..|||| .. .   .
CKDPKKRPTAEQILQHPWF
TyrKc GL50803_137743.AA TyrKc 9-214 18 6.4e-09 -78.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-214
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

LFLT---------------------------------------------SHPDVLRHHQVLTDE-------GFTYIVID--RHDSTLERPLAKHKRGRIP
. |                                              .|| ..| . | |..       .  .||     | . ... | ||..    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY-LRKHRPK---

VPITMILSVMKQVAAALAYLHGLSGANTRGLVHCDLRPANVLISADGEYFIIAGLELCKDALWS-------ESTIA-----GM----AAYMAPEVLLHNE
..    || . |.|.  .|||        ...| ||   |.|.....    |.   |..|           .   .     |        ||||.. ...
LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

PSPASDVWSLGVIVYEMATLRKPDF-------LKGKEPAEVFVDEWRPDLSGV--------TDGFIQNVLERIFVLEPERRPTASELHETL
 ...||||| ||  .|. |. ..         .. .|  |   .  |..                . .. ..    .|| ||| ||.|| .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Pkinase GL50803_137743.AA Pkinase 11-102 22 2e-06 23.58 Pfam 57-146 (293) Show / Hide 
Range on Protein: 11-102
Range on HMM: 57-146/293
Sequence Identity: 22% (22 aa)

LTSHPDVLRHHQVLTDEGFTYIVIDRHDSTLERPLAKHK-----RGRIPV--PITMILSVMKQVAAALAYLHGLSGANTRGLVHCDLRPANVLISADGE
| .|| ..| . . .|..  |.| . .. .|.  ..  .     . . ..  .   . ..|.|.. .|.|.|        | .|.|| |.|.||. .|.
L-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM------GIIHRDLKPENILIDNNGH
Kinase GL50803_137743.AA Pkinase_Tyr 129-158 43 2e-06 22.72 Pfam 181-210 (270) Show / Hide 
Range on Protein: 129-158
Range on HMM: 181-210/270
Sequence Identity: 43% (13 aa)

MAPEVLLHNEPSPASDVWSLGVIVYEMATL
||||.. ... . .||||| ||  .|. |.
MAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase GL50803_137743.AA Pkinase_Tyr 200-214 66 0.014023 9.36 Pfam 256-270 (270) Show / Hide 
Range on Protein: 200-214
Range on HMM: 256-270/270
Sequence Identity: 66% (10 aa)

EPERRPTASELHETL
.||.||| ||.|| |
DPEDRPTFSEIHEQL
Kinase GL50803_137743.AA TK-Unique 61-102 28 0.036686 3.4 In-house 134-171 (294) Show / Hide 
Range on Protein: 61-102
Range on HMM: 134-171/294
Sequence Identity: 28% (12 aa)

LSVMKQVAAALAYLHGLSGANTRGLVHCDLRPANVLISADGE
.. ..|.| ...||...     .. || ||   |||.. |..
YHFAWQIACGMEYLASQ----RKKIVHRDLCARNVLLTEDKV
Kinase GL50803_137743.AA UTK 200-214 26 0.074075 2.14 In-house 282-296 (296) Show / Hide 
Range on Protein: 200-214
Range on HMM: 282-296/296
Sequence Identity: 26% (4 aa)

EPERRPTASELHETL
.|..||.. .| ...
DPQERPDFEDLVQQM
Kinase GL50803_137743.AA Pkinase_Tyr 48-101 21 0.159921 5.78 Pfam 99-148 (270) Show / Hide 
Range on Protein: 48-101
Range on HMM: 99-148/270
Sequence Identity: 21% (12 aa)

HKR--GRIPVPITMILSVMKQVAAALAYLHGLSGANTRGLVHCDLRPANVLISADG
.|.  .. |... ..|.   |.|....||.         ..| ||.  |.|.. ..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN------CIHRDLAARNCLVTENN
Ank GL50803_137743.AA Ank 334-356 34 0.042099 11.84 Pfam 1-23 (33) Show / Hide 
Range on Protein: 334-356
Range on HMM: 1-23/33
Sequence Identity: 34% (8 aa)

QGMTALMHAGQQGHVDPVELLVG
 |.|.|. | . ||.. |..|..
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_137743.AA Ank 306-333 32 1.774204 5.98 Pfam 6-33 (33) Show / Hide 
Range on Protein: 306-333
Range on HMM: 6-33/33
Sequence Identity: 32% (9 aa)

LMRAAHTNGMETVRMLLEERLGVGQRDA
|. |.. ...| |.|||.    |  .| 
LHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_137743.AA Ank 365-383 42 0.001832 16.75 Pfam 1-19 (33) Show / Hide 
Range on Protein: 365-383
Range on HMM: 1-19/33
Sequence Identity: 42% (8 aa)

SGWTALMHAVHNNHPEVAK
 |.|.|. |....|.||.|
DGFTPLHLACRCGHTEVVK
Ank GL50803_137743.AA Ank 396-416 33 0.024782 12.67 Pfam 1-21 (33) Show / Hide 
Range on Protein: 396-416
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

DSRTALMMAAEEEYAEIVSLL
| .|.|..|..  ..|.|..|
DGFTPLHLACRCGHTEVVKML