Gene GL50803_13215 (G.lamblia)

GL50803_13215

Species: G.lamblia
Alias: GK214, GL50803_13215
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL3

Sequence

Name Sequence Type Origin Length Description Download
GL50803_13215.AA Protein None 635 None Fasta, JSON
GL50803_13215.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of GL50803_13215.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_13215.AA S_TKc 49-313 34 1.1e-76 262.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-313
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

YEQLAVLGNGAFGKVYKVRRQSDGVIMALKIIDLSALSSNAQEVLRNETELFSLLEHRNLVKCYETFQNAAAGEQYVAMELCER---SLKDLILECRRSQ
|| | ..| ||||||||.|  ..| |.|.|||.         | .|.| .. .   | |.||.|..||.   .. |. ||.|.    .|.|.| ...|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

KH--LPEKTIWLYAAQILQGVSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDSMIKICDFGISRPLGVVSKAVTLAGTYHYMAPEIIKGQKYTE-KVDV
..  .|| ... |..||.... |.||         . ||||||||.||||.    |||||||..| |       |. || .|||||..   .|.  |.|.
LRFPFPE-HARFYMYQICCALEYCHS---------HGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSIGCVVYELCTLKVPTFDTLFSSGQPSMEFISFTLPDMYSTELKKFIEWCLIIRQDDRLSVYELLS-------YPPI
||.||..||... . |   ...   .  .           | |.| ||. ||    ..|... |.|         | .
WSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_13215.AA NEK 49-261 36 9.3e-72 244.7 In-house 1-227 (286) Show / Hide 
Range on Protein: 49-261
Range on HMM: 1-227/286
Sequence Identity: 36% (84 aa)

YEQLAVLGNGAFGKVYKVRRQSDGVI-----MALKIIDLSALSSNAQEVLR-NETELFSLLEHRNLVKCYETFQNAAAGEQYVAMELCER--SLKDL---
|| . ..|.|.|||||||||.||| .      ..| |... .|.  .. .  ||  . . | | | || |. |.    .  .  || ||.   | ..   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ILECRRSQKHLPEKTIWLYAAQILQGVSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDSM----IKICDFGISRPLG-VVSKAVT-LAGTYHYMAPEII
| ... . |...|..|| . .|.. .. |.|.|  |     . |.|||.|| || || . .    .|| |||||. |.  ...| | . || .||.||..
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGP----QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVC

KGQKYTEKVDVWSIGCVVYELCTLKV-PTFD
....|..|.|.||.|||.||.||||  . |.
QNKPYNNKSDIWSLGCVLYEMCTLKPKHPFE
Kinase GL50803_13215.AA Pkinase 49-313 30 3.7e-70 244.19 Pfam 1-293 (293) Show / Hide 
Range on Protein: 49-313
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

YEQLAVLGNGAFGKVYKVRRQSDGVIMALKIIDLSALSSNAQEVLRN--ETELFSLLEHRNLVKCYETFQNAAAGEQYVAMELCER-----SLKDLILEC
|. . ..| |.||.||| .....| | |.|||...  .|. .. .|.  | ..   | | | |..|..|..   .. |. ||.||      .|.|.|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

RRSQKHL--PEKTIWLYAAQILQGVSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDSMI----KICDFGISRP--LGVVSKAVTLAGTYHYMAPEIIK-
 .... .  .|...  |. |||.|. |.||.          ||||||||.|||.  .  |    ||||||...   .   | . |..||..|||||.|. 
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

GQKYTEKVDVWSIGCVVYELCTLKVPTFDT-----------LFSSGQPSMEFISFTLPDMY----------------STELKKFIEWCLIIRQDDRLSVY
||.|. |||.||.||..||... . |  .            ..  ..|  .| .... ...                | |.|.||.|||     .|..  
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

ELLSYPPI
..|  | .
QILQHPWF
Kinase GL50803_13215.AA STE 49-313 25 6.9e-64 218.56 In-house 1-359 (359) Show / Hide 
Range on Protein: 49-313
Range on HMM: 1-359/359
Sequence Identity: 25% (94 aa)

YEQLAVLGNGAFGKVYKVRRQS---------------DGVIMALKIIDLSALSS---------------NAQEVLRNETELFSLLE--HRNLVKCYETFQ
.| . ..|.||||.||| ..                  |.||| |...|.  ..               . .. . .| .. . .   | | ||.| .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NA-----AAGEQYVAMELCE-RSLKDLILECRRSQKHLP----------EKTIWLYAAQILQG-VSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDSMI
.      . .| ...||...  || |.| ..   .| |.          |. |  .. |||.|  .||||         . |||||.||.||||     .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS---------HHIIHRDIKPANILL-----V

KICDFGISRPLG-----------------VVSKAVTLAGTYHYMAPEIIKG------QKYTEKVDVWSIGCVVYELCTLKVPTFDTLFSSGQPSMEFI--
|.||||..  |                   ..|  |..||  .||||.|..      ..|..|.|.||.||.. |..| |.| .|    .    . |   
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

--------------SFTLPD-------------------MYSTELKKFIEWCLIIRQDDRLSVYELLS--YPPI
              . .|||                    .| |.| ||. ||..  ..| .. .||.   | |
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_13215.AA Ciliate-E2 49-313 24 2.4e-51 174.49 In-house 1-365 (365) Show / Hide 
Range on Protein: 49-313
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

YEQLAVLGNGAFG-----KVYKVRRQS------------------DGVIMALKIIDLS--ALSSNAQEVLR---------NETELFSLLEHRNLVKCYET
|. . ..|.|.||     ||.||..|.                  .. | |.||.  .     .. . ..|         || .. ..| | |..|.||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQNAAAGEQYVAMELCER-SLKDLILECRRSQKHLPE-------KTIWLYAAQILQ---------------GVSYLHSRYKPNDTRLKC-IIHRDLKPDN
||.      |  ||.|.  .|.|.| ... ...| .|       | |  . .||||               .. ||||         |  |||||.||.|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS---------KNNIIHRDIKPEN

ILLTGDSMIKICDFGISRPLGVVSKAVT--------------------------------LAGTYHYMAPEIIKGQK---------YTEKVDVWSIGCVV
||.     |||.|||.|. .   ..  |                                ..||..||||||..|.|         |..|.|.||.|.. 
ILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

YELCTLKVPTFDTLFSSGQPSMEFIS-----FTLPDM----------------YSTELKKFIEW----CLIIRQDDRLS-VYELLSYPPI
||... | |            .. |      |  |..                 | | | .|      .|   .. |..   ..|  | .
YEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_13215.AA CAMK 54-250 21 4.7e-51 162.36 In-house 1-325 (425) Show / Hide 
Range on Protein: 54-250
Range on HMM: 1-325/425
Sequence Identity: 21% (72 aa)

VLGNGAFGKVYKVRRQSDG------------VIMALKIIDLSALS--------------------------SNAQEVLRNETELFSL-------LEHRNL
.|| |.||||..... ...            .  | |||| . |.                           . .. .|.| |. ..       | |.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKCYETFQN-------AAAG-----------EQYVAM---ELCER-----SLKDLILECRRSQ-----------KHLPEKTIWLYAAQILQGVSYLHSRY
.|.||....          .           . |  |   |.|.       | | | | ..             ....|.    |  ||...| |.||  
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS--

KPNDTRLKCIIHRDLKPDNILLTGDS-----------------MIKICDFGISRPLGVVS------------------------KAVTLAGTYHYMA-PE
       . |.||||||.||||. ..                  |||.||| .. .   .                        |  |  || .||| ||
-------HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE

IIKG--------------QKYTEKVDVWSIGCVVY
...|              . |..|.|.||.|.. |
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase GL50803_13215.AA ULK 49-313 26 7.5e-50 171.94 In-house 1-329 (329) Show / Hide 
Range on Protein: 49-313
Range on HMM: 1-329/329
Sequence Identity: 26% (89 aa)

YEQLAVLGNGAFGKVYKVR-RQSD---GVIMALKIIDLSALSSNAQEV--------LRNETELFSLLE--------HRNLVKCYETFQNAAAGEQYVAME
|.   .|| |.|||||| |  ...   ... | |.||.. .. . .|         |.|| ..   |         | | || |. |...     |  ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCER-SLKDLILECRR------SQKHLPEKTIWLYAAQILQGVSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDS------------MIKICDFGISRP
.|.   |...| . ..       .|.|.|. .  .  |||.|  .||.         . |||||.||.|||.. .              .||.||| .. 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK---------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

LGV----VSKAVTLA------GTYHYMAPEIIK----GQKYT-EKVDVWSIGCVVYELCTLKVP---TFDTLF-----SS-GQPS-----MEFISFTLPD
.         ..|        ||  ||||.|..    ...|.  |.|.||.||. ||. . |.|    | ...     .   .|.     .. . .  |.
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPK

M-----YSTELKKFIEWCLIIRQDDRLSVYELLSYPPI
       | |.| .|  .|.. ..|| |  ||.. | .
DGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_13215.AA STE20 49-313 29 1.1e-49 171.4 In-house 1-288 (288) Show / Hide 
Range on Protein: 49-313
Range on HMM: 1-288/288
Sequence Identity: 29% (88 aa)

YEQLAVLGNGAFGKVYKVRRQSDGVI----MALKIIDLSALSS--NAQEVLRNETELFSLLEHRNLVKCYETFQNAAA--GEQYVAMELCER-SLKDLIL
|| | ..|.|..|||||..  . | .     | |...|.  .   . .| . .|    . . | | || |....       | ...||.|.  || |.. 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

ECRRSQK-----HLPEKTIWLYAAQILQGVSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDSMIKICDFGISRPLGV-----VS-KAVTLAGTYHYMAP
.| . .|      . |. |     ..||| .||||         . |||||.| |||||| |  .|..||| .  |        . |  |. ||  .|||
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHS---------NHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAP

EIIKG-----QKYTEKVDVWSIGCVVYELCTLKVPTFD-----TLFSSGQPSMEFISFTL--PDMYSTELKKFIEWCLIIRQDDRLSVYELLSYPPI
|.|..     ..|..|.|.|| |    |. . ..| ||      .|   . ....  .    |. .|.|.. |.. || .  ..| .. .||. | |
EVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GL50803_13215.AA ULK 49-313 25 7.1e-49 168.7 In-house 1-324 (324) Show / Hide 
Range on Protein: 49-313
Range on HMM: 1-324/324
Sequence Identity: 25% (86 aa)

YEQLAVLGNGAFG-KVYKVR-RQSD--GVIMALKIIDLSALSSNAQE--------VLRNETELFSLLE---HRN--LVKCYETFQNAAAGEQYVAMELCE
|.   .|| |.|| |||| |  ...  ... | |.||.. .. . .|         |.|| ..   |    | |   || |. |...     |  ||.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

R-SLKDLILECRR-----SQKHLPEKTIWLYAAQILQGVSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDS------------MIKICDFGISRPLGVV
   |...| . ..      .| |.|. .  .  ||..|  .||.         . |||||.||.|||.. .              .||.||| .. .   
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK---------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

SKAVTLA----------GTYHYMAPEIIK----GQKYT-EKVDVWSIGCVVYELCTLKVP----TFDTL------------FSSGQPSMEFISFTLPD--
... ..           ||  ||||.|..    ...|.  |.|.||.||. ||. . |.|      |.                 |  ..   .  |.  
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQ---QIYIKNQPIQFPKPP

---MYSTELKKFIEWCLIIRQDDRLSVYELLSYPPI
     | |.| .|  .|.. ..|| |  |... | .
KDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_13215.AA NEK2 49-256 31 5.5e-48 159.6 In-house 1-261 (319) Show / Hide 
Range on Protein: 49-256
Range on HMM: 1-261/319
Sequence Identity: 31% (82 aa)

YEQLAVLGNGAFGKVYKVRRQSDGVIMALKIIDLSALSSNAQEVLRNETELFSLLEHRNLVKCYETFQNAAAGEQYVAMELCER-SLKDLILECRRSQKH
|| |...||| ||...|||| ||| |.. | |.   . .     | .|  . . | | | |. |    . ..   |. || ||.  |  .|  ||   . 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LPEKTIWLYAAQILQGVSYLHS------------RYKPNDTRLKCIIHRDLKPDNILLTGDSM-------------------------------------
..|. ||   .|..      |             | ||     . |.|||.|| || |  |                                       
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--IKICDFGISRPLG-VVSKAVTLAGTYHYMAPEIIKGQKYTEKVDVWSIGCVVYELCTLK
  .|  |||  | |    | | |  || .|| || ..|||| || |.||.||..||.|.|.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALH
Kinase GL50803_13215.AA Ciliate-E2-Unclassified 49-313 23 4.2e-47 161.43 In-house 1-352 (352) Show / Hide 
Range on Protein: 49-313
Range on HMM: 1-352/352
Sequence Identity: 23% (83 aa)

YEQLAVLGNGAFGKVYKVRRQSDGVI----MALKIIDLSALSSNAQ-EVLRNETELF----------------SLLEHRNLVKCYETFQNAAAGEQYVAM
|. . ..|.|.||||||... ... .    .. ||.. . .. . . | .....|..                .|| | .... .. ..       |  |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELCER-SLKDLILEC-------------RRSQKHLPEKTIW-----LYAAQILQGVSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDS---MIKICDFG
|.||  .|.. | ..             ....|...|. .       |.|||||| .|||.         . |||||.||.|||.. .     |||.|||
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHK--------NNIIHRDIKPENILFDNNGKNYYIKIIDFG

ISRPLGVV----------------SKAVTLAGTYHYM----APEIIKGQKYT----EKVDVWSIGCVVYELCTLKVPTFDTLFSS---------------
||. ..                   .. | .||. ||    |||...||.|     .|.|.|| |.. ||... . | .|.   .               
ISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRK

GQPSMEFIS----FTLP-----DMYSTELKKFIE----WCLIIRQDDRLSVYELLSYPPI
 . .  .      .  |     .  | | | ||.     .|  ... |..  ..|  | .
QLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_13215.AA STE7-Unclassified 50-313 27 3.7e-45 156.33 In-house 2-301 (301) Show / Hide 
Range on Protein: 50-313
Range on HMM: 2-301/301
Sequence Identity: 27% (85 aa)

EQLAVLGNGAFGKVYKVRRQS------DGVIMALKIIDLSALSSNAQEVLRNETELFSLLE-HRNLVKCYETFQNAAA-GEQYVAMELCE-RSLK---DL
|.| .||.|..|.|.|..         ||.|||.| | .    .. .  .  | .     . | ..|..|  . .     . . .||. . .||    |.
ERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKIDI

ILECRR----SQKHLPEKTIWLYAAQILQGVSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDSMIKICDFGISRPLGVVS-KAVTLAGTYHYMAPEIIK
  .         . .||...   | |...| .|||        ... |||||.|| |||.  .  .||||||..  |     .|.| .|.  ||.||.|.
YKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLH-------EKHH-IIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQ

GQ-----KYTEKVDVWSIGCVVYELCTLKVPT-----FDTLFSSGQP--------SMEFISFT---LPD-----MYSTELKKFIEWCLIIRQDDRLSVYE
||      |..|.|.|| | .  |. |.| |       ...  . ||        .. .. |.   |||      .| |.. ||. |... . .| .. .
GQMPHRPSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQ

LLS-YPPI
||   | |
LLNEHPWI
Kinase GL50803_13215.AA Pkinase_Tyr 49-255 28 3.8e-22 75.62 Pfam 1-210 (270) Show / Hide 
Range on Protein: 49-255
Range on HMM: 1-210/270
Sequence Identity: 28% (63 aa)

YEQLAVLGNGAFGKVYKVRRQ----SDGVIMALKIIDLSALSSNA---QEVLRNETELFSLL-EHRNLVKCYETFQNAAAG-EQYVAMELCER-SLKDLI
 . . .|| ||||.||| .      ....  | |..     .. .   .. .| | .. . |  | |.|..|          . |. ||...  .|.|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

LECRRSQKHLPEKTIWLYAAQILQGVSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDSMIKICDFGISRPL-----GVVSKAVTLAGTYHYMAPEIIKG
 . | ....|. |..  ...|| .| .||.|.          .|||||   |.|.| .  .|||||| .| .       . |.         |||| |. 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---------CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINY

QKYTEKVDVWSIGCVVYELCTL
 |.|.| |||| | . .|..|.
GKFTTKSDVWSFGVLMWEIFTY
Kinase GL50803_13215.AA TyrKc 49-316 23 1.1e-17 63.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 49-316
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

YEQLAVLGNGAFGKVYKVRRQSDGVIMALKIIDLSALSSNAQEVLRNETELFSLL--EHRNLVKCYETFQNA-----AAGEQYVAMELCER-SLKDLILE
 . . .||.||||.||| .     .  | | .  .|     .| ...| .. . |  .| |.|..|            ..  .. ||...  .||| . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CRRSQKHLPEKTIWLYAAQILQGVSYLHSRYKPNDTRLKCIIHRDLKPDNILLTGDSMIKICDFGISRPLGVV--------SKAV----TLA--GTYHYM
.|.    |. |.   .. || .| .||||.         ..|||||   |.|.. .  .||.||| || ..           . .           .  |
HRPK---LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEIIKGQKYTEKVDVWSIGCVVYELCTL------K-----VPTFDTLFSSGQPSMEFISFT-LPDM----YSTELKKFIEWCLIIRQDDRLSVYELLSY
||| |.  |.|.| |||| | . .|..|.            .. .. .    |  .  .    .| |     ..|. . ...|     .|| .  |.   
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---

PPIKAI
  .. .
--HECF
Kinase GL50803_13215.AA NEK 278-313 28 1.1e-07 23.6 In-house 249-286 (286) Show / Hide 
Range on Protein: 278-313
Range on HMM: 249-286/286
Sequence Identity: 28% (11 aa)

LPDM--YSTELKKFIEWCLIIRQDDRLSVYELLSYPPI
.|..  ||..|...|. .|    ..| |. ..|. | |
IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_13215.AA NEK2 277-313 29 0.000246 10.37 In-house 283-319 (319) Show / Hide 
Range on Protein: 277-313
Range on HMM: 283-319/319
Sequence Identity: 29% (11 aa)

TLPDMYSTELKKFIEWCLIIRQDDRLSVYELLSYPPI
..|  ||..| . |   . .    | |. |.| .| |
RIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Ank GL50803_13215.AA Ank 438-458 38 0.119182 10.21 Pfam 1-21 (33) Show / Hide 
Range on Protein: 438-458
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DGETALHMAVDKQARAYVELL
||.|.||.|. .     |..|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_13215.AA Ank 486-506 23 2.994588 5.16 Pfam 1-21 (33) Show / Hide 
Range on Protein: 486-506
Range on HMM: 1-21/33
Sequence Identity: 23% (5 aa)

YNVSAMMLAALYGMSDIVDVL
.  .. .||...|  ..|  |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_13215.AA Ank 517-538 40 0.026927 12.54 Pfam 1-22 (33) Show / Hide 
Range on Protein: 517-538
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

EGYTALMLAILAGSTTSATLLL
.|.|.|.||.. |.|  ...||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_13215.AA Ank 547-568 31 0.146196 9.89 Pfam 1-22 (33) Show / Hide 
Range on Protein: 547-568
Range on HMM: 1-22/33
Sequence Identity: 31% (7 aa)

RGETALLFAAKVGNKDLVDRLI
 |.|.|  |.. |... |  |.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_13215.AA Ank 578-599 50 0.000357 19.31 Pfam 1-22 (33) Show / Hide 
Range on Protein: 578-599
Range on HMM: 1-22/33
Sequence Identity: 50% (11 aa)

YGSTALMEACRAGNMSIVKQLL
.| |.|. ||| |....|| ||
DGFTPLHLACRCGHTEVVKMLL