Gene GL50803_112553 (G.lamblia)
GL50803_112553
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_112553.AA | Protein | None | 376 | None | Fasta, JSON |
| GL50803_112553.kin_dom | Protein Kinase Domain | None | 254 | None | Fasta, JSON |
Protein domains of GL50803_112553.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Pkinase | GL50803_112553.AA | Pkinase | 49-278 | 22 | 1.5e-27 | 98.49 | Pfam | 28-293 (293) | Show / Hide |
Range on Protein: 49-278
Range on HMM: 28-293/293
Sequence Identity: 22% (62 aa)
AVQEILIDGLDKDDVDTIKL--ELATLPELSHPGVLKHHQVVEDEGLIYVVTDRHDSTLEHLLAEHK-----QRKIPI--PIATILSVMKQLAAALAYLH
|| .| .. ... | . |.. . .|.|| ... . ..||.. ||.|.. .. .|. ... . .|. .. . .. ..|.|.. .|.|.|
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCH
SVNGANTRGLVHCDLRPANVLISADGER---FVIADFGLCRNT-LWSGS--TLIGIMAYVAPEVLL-HNEASPASDVWSLEVIVYELTTLKRPDFLKGK-
| | .|.|| |.|.||. .|. . |.||||.. . ..| |. | |.||||.. ... .|..|.||. .|.||. . .|| | |.
SM------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFP-GHC
-----DPKDVFIDGWRPDLSGVTD-----------------------GFIKSVLERIFVLEPEERLTARELHET--L
|.. .. .|.|. . |....... . |..|.||... . .
WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | GL50803_112553.AA | TKL | 104-278 | 18 | 2.9e-27 | 95.22 | In-house | 124-364 (364) | Show / Hide |
Range on Protein: 104-278
Range on HMM: 124-364/364
Sequence Identity: 18% (47 aa)
TLEHLLAEHKQRKIPIPIATILSVMKQLAAALAYLHSVN---GANTRGLVHCDLRPANVLISADGE-------------RFVIADFGLCRNTLWSGS---
.|.|.| . ... ... | ...|||| | . .....|.|| ..|.|. ... . |.||||.|. .||.
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMND
----------------TLIGIM---AYVAPEVLLHN----------------EASPASDVWSLEVIVYELTTLKRPDF-LKGKDPK---------DVFID
|.. . .. ||||| . |.|...||.| .. .|. | .|| . .. ... . .|
TMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCD
-GWRPDLS------------GVTDGFIKSVLERIFVLEPEERLTARELHETL
| || . .. .|. ... .||.|... |. ..|
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| S_TKc | GL50803_112553.AA | S_TKc | 25-285 | 21 | 1.2e-23 | 85.78 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 25-285 Range on HMM: 1-231/231 Sequence Identity: 21% (59 aa) ERLGDVLNESTMVTVYSLKDFP---DLAVQEILIDGLDKDDVDTIKLELATLPELSHPGVLKHHQVVEDEGLIYVVTDRHDS---TLEHLLAEHKQRK-- ...... . .. .|| .. |. .| ..|. |.. | . || . | . | .| . .|.|.. | .| ... ... .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR IPIPIATILSVMKQLAAALAYLHSVNGANTRGLVHCDLRPANVLISADGERFVIADFGLCRNTLWSGSTLIGIMAYVAPEVLLHNEASP-ASDVWSLEVI |.| .. ..|.|.. ||.|.|| .| .|.|| |.|.|.. . |.||||.| .|..| |.||||| .. ..|.||. .| FPFPE-HARFYMYQICCALEYCHS------HGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI VYELTTLKRPDFLKGKDPKDVFIDGWRPDLSGVTDGFIKSVLERIFVLEPEERLTARELHE--TLTTADIPV .||. . . | .. .. . .. .. ...... .||.|.|| |. . . .. . LYEMLCGYPPFP-----QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_112553.AA | Ciliate-E2 | 49-225 | 19 | 7.2e-20 | 64.87 | In-house | 46-295 (365) | Show / Hide |
Range on Protein: 49-225
Range on HMM: 46-295/365
Sequence Identity: 19% (50 aa)
AVQEILIDGLDKDDVDTIKLELATLP----------------ELSHPGVLKHHQVVE--DEGLIYVVTDRHDS-TLEHLLA--EHKQRKI-----PIPIA
..... . . |... || |. . .|.|| ..| . . . |. || |.. . .|.... .|. .. .. .
KIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEK
TILSVMKQLAA---------------ALAYLHSVNGANTRG-LVHCDLRPANVLISADGERFVIADFGLCR--------------NTLWSGST-------
|. .|||.. || |||| .. .| |. | |.|. |.||||.. . ..
EIKYIMKQILQGFKTKAEFYIACIILALEYLHS------KNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTP
--------------LIGIMAYVAPEVLL---------HNEASPASDVWSLEVIVYELTTLKRP
..| |.|||.| ... . ..|.||| || ||. . |.|
GYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
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| Kinase | GL50803_112553.AA | TK | 76-278 | 13 | 3.8e-17 | 53.29 | In-house | 100-486 (486) | Show / Hide |
Range on Protein: 76-278
Range on HMM: 100-486/486
Sequence Identity: 13% (54 aa)
LSHPGVLKHHQVVEDE------------GLIYVVTDRHD-ST----LEHLLAEHKQRKIP----------------------------------------
. || ... . |. .. . ...|. . | . | ... ....
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD
--------------------------------IPIATILSVMKQLAAALAYLHSVN--GANTRGLVHCDLRPANVLISADGER----------FVIADFG
.. .. | . |.|....|||| | . ..|| || |.|.. .. . |||||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF--IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
LCRNTLWSGSTLIGIMAY--------------------------------------------VAPEVLLHNE---------ASPASDVWSLEVIVYELTT
|.|.. ..| |||.|.... ...|||||. | ..|. |
LSRQGS-G------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
LKRPDFLKGKDPKDVFID---------------------------GWRPDLSGVTD-------------GFIKSVLERIFVLEPEERLTARELHETL
. . . | . || .| .| . .| .. .. . . ..||.| | ..||| |
YGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | GL50803_112553.AA | AGC | 130-219 | 22 | 1.5e-16 | 37.82 | In-house | 161-298 (395) | Show / Hide |
Range on Protein: 130-219
Range on HMM: 161-298/395
Sequence Identity: 22% (34 aa)
QLAAALAYLHSVNGANTRGLVHCD-LRPANVLISADGERFVIADFGLCRNTLWSG---------------------------------------------
... || |||| .| .| | | | |.|. .| ..||||| .|
CIVLALEYLHSH-----MGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDT
--------STLIG--IMAYVAPEVLLHNEASPASDVWS--LEVIVYEL
.|. | |.|||.| ..| | || | .. ||.
TRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEM
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| Kinase | GL50803_112553.AA | CAMK | 75-217 | 16 | 6.5e-16 | 47.07 | In-house | 94-325 (425) | Show / Hide |
Range on Protein: 75-217 Range on HMM: 94-325/425 Sequence Identity: 16% (40 aa) ELSHPGVLKHHQVVED-------------------EGLIYVVT---DRHDST------LEHLLAE-----------HKQRKIPIPIATILSVMKQLAAAL .|.|| ..| ..| || . .| |. . . .... . .. .. . ...|.. |. KLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAV AYLHSVNGANTRGLVHCDLRPANVLISADG----------------ERFVIADFGLCRNTLWSGS--------------------------TLIGIMAYV .|.|| .. ||.|| | |.|.. .. |.|||. . . . | | .|. HYCHS------HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM A-PEVLLH--------------NEASPASDVWSLEVIVY | ||||. .|..|.||. || | AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY |
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| Kinase | GL50803_112553.AA | ULK | 104-225 | 21 | 2.8e-14 | 46.31 | In-house | 106-255 (329) | Show / Hide |
Range on Protein: 104-225
Range on HMM: 106-255/329
Sequence Identity: 21% (34 aa)
TLEHLLAEHKQ------RKIPIPIATILSVMKQLAAALAYLHSVNGANTRGLVHCDLRPANVLISADGER-----------FVIADFGLCRN-TLW----
.||... ..| .| .. .....||..... .||. .. .|.|. |.|.||. . . . |||||... . .
DLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ
-SGSTLI------GIMAYVAPEVLL----HNEASPA-SDVWSLEVIVYELTTLKRP
| | | ||..| . . . . .|.||| .| ||. . | |
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPP
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| Kinase | GL50803_112553.AA | ULK | 104-225 | 21 | 3.2e-14 | 46.93 | In-house | 103-251 (324) | Show / Hide |
Range on Protein: 104-225 Range on HMM: 103-251/324 Sequence Identity: 21% (33 aa) TLEHLLAEHKQ-----RKIPIPIATILSVMKQLAAALAYLHSVNGANTRGLVHCDLRPANVLISADGER-----------FVIADFGLCRN-TLW-SGST .||... ..| .| .. .....||..... .||. .. .|.|. |.| ||. . . . |||||... . . DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ LI----------GIMAYVAPEVLL----HNEASPA-SDVWSLEVIVYELTTLKRP .. | | ||..| . . . . .|.||| .| ||. . | | MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYP |
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| Kinase | GL50803_112553.AA | CDC2 | 69-178 | 30 | 4.8e-14 | 39.03 | In-house | 50-152 (301) | Show / Hide |
Range on Protein: 69-178 Range on HMM: 50-152/301 Sequence Identity: 30% (34 aa) ELATLPELS-HPGVLKHHQVVEDEGLIYVVTDRHDSTLEHLLAEHKQRKIPIPIATILSVMKQLAAALAYLHSVNGANTRGLVHCDLRPANVLISADGER |. .| || || . | | |. .| |... | | .. . .. . ..| ... | |.|. .....|. |. .| || | | ||...|. EISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQ------RRIMHRDLKPQNILIDKKGN- FVIADFGLCRN |||||| |. IKIADFGLARA |
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| Kinase | GL50803_112553.AA | Ciliate-E2-Unclassified | 76-225 | 20 | 1e-13 | 43.99 | In-house | 78-269 (352) | Show / Hide |
Range on Protein: 76-225 Range on HMM: 78-269/352 Sequence Identity: 20% (41 aa) LSHPGVLKHHQVVEDEGLIYVVTDR-----HDSTLEH---------LLAEHKQRKIPIPIATIL-----SVMKQLAAALAYLHSVNGANTRGLVHCDLRP . || ..| . . .|. || |.. . ... .| ...... .. .. ..|. .| |||. |. .| |. | HPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN-----IIHRDIKP ANVLISADGE--RFVIADFGLCRNTLWS------------------GSTLIGIMAYV----APEVLLHNEAS----PASDVWSLEVIVYELTTLKRP |.|.. .|. . |.|||.... . .| .| | ||||| .. . ..|.||| || ||. . ..| ENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP |
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| Kinase | GL50803_112553.AA | CMGC | 65-177 | 17 | 1.2e-12 | 36.99 | In-house | 67-252 (513) | Show / Hide |
Range on Protein: 65-177
Range on HMM: 67-252/513
Sequence Identity: 17% (33 aa)
TIKLELATLPELS-----------------HPGVLKHHQVVEDEG-----------------LIYVVTDRHDSTLEHLLAEHKQ-----RKIPIPIAT--
.. |. | .|. |. ..| . .. ... .| |.. | .| ... .... |..| .
RALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HEN
----------ILSVM------KQLAAALA--YLHSVNGANTRG-LVHCDLRPANVLISADGERF-------------------VIADFGLCR
| . | .|. .|. |.|| . | .|.|| |.|.||. ..| . |.||||.|
KHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHW-----GNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLAR
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| TyrKc | GL50803_112553.AA | TyrKc | 25-278 | 18 | 6e-12 | -29.51 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 25-278
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)
ERLGDVL--------NESTMVTVYSLKDFPDLAVQEILIDGLDKDDVDTIKLELATLPEL--SHPGVLKHHQVVEDE-------GLIYVVTD--RHDSTL
.||..| . |. .. . | .| . . |. . .| .|| ... . |. .. . ...|. | . .
ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK
EHLLAEHKQRKIPIPIATILSVMKQLAAALAYLHSVNGANTRGLVHCDLRPANVLISADGERFVIADFGLCRNTLWS------GSTLI-----GIM----
..| . ... .. .. || . | |. .|||| ...| || |.|..... . |.||||.|. ... |
DYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP
-AYVAPEVLLHNEASPASDVWSLEVIVYELTTLKRPDFLKG----KDPKDVF---IDGWRPDLSGV--------TDGFIKSVLERIFVLEPEERLTAREL
|||.. ... ...||||| | .|. |. . .....|. .| |.. . .. .. .||.| | .|.
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI
HETL
|| .
HECF
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| Kinase | GL50803_112553.AA | Pkinase_Tyr | 113-211 | 27 | 2e-10 | 35.91 | Pfam | 99-199 (270) | Show / Hide |
Range on Protein: 113-211 Range on HMM: 99-199/270 Sequence Identity: 27% (30 aa) KQR---KIPIPIATILSVMKQLAAALAYLHSVNGANTRGLVHCDLRPANVLISADGERFVIADFGLCRNT-------LWSGSTLIGIMAYVAPEVLLHNE ... | |... ..|. | |....||.| | ..| ||. |.|.. .. |.||||.| .|.. . | |||.. ... RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN------CIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPI-KWMAPECINYGK ASPASDVWS . .||||| FTTKSDVWS |
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| Kinase | GL50803_112553.AA | APH | 131-170 | 27 | 0.000152 | 16.38 | Pfam | 160-197 (248) | Show / Hide |
Range on Protein: 131-170 Range on HMM: 160-197/248 Sequence Identity: 27% (12 aa) LAAALAYLHSVNGANTRGLVHCDLRPANVLIS--ADGERF--VI .|. .| .. ....|.|..| ||... .||.|. || WAWLEAHWP------PPCWCHGDFHPGNVMWDPRPDGGRVTGVI |
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| Kinase | GL50803_112553.AA | Pkinase_Tyr | 264-278 | 53 | 0.631449 | 3.76 | Pfam | 256-270 (270) | Show / Hide |
Range on Protein: 264-278 Range on HMM: 256-270/270 Sequence Identity: 53% (8 aa) EPEERLTARELHETL .||.| | .|.|| | DPEDRPTFSEIHEQL |
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