Gene GL50803_111938 (G.lamblia)

GL50803_111938

Species: G.lamblia
Alias: GL50803_111938, GK100
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_111938.AA Protein None 376 None Fasta, JSON
GL50803_111938.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of GL50803_111938.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GL50803_111938.AA Pkinase 28-286 23 5e-40 142.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 28-286
Range on HMM: 1-293/293
Sequence Identity: 23% (73 aa)

KLLDGVLGRGVTGVVYALRGYPS---LAVKEILLDGLGKGNVDAIRL--ELATLPDLSHPGILKYHQVVEDEGFIYIVMNRHDKTLEQVFIDC----KRR
  . ...|.|  |.||  .   .    |||.| ...  ..   . |.  |.. .  |.|| |.... ..||.. ||.||  ....|. |.  .     .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

KTPV--SPELVLSVLRQLAAALAYLHGVSGVGADGRPYQGLVHRDLRPASILVSADDEHF----IIADFGLC----KDALRCGSTIAGTAVYMAPEMLL-
....  |.. . ....|.. .|.|.|             | .|||| |. ||.. .. |      |.||||.        .  .|..||  ||||| .. 
HGCFYFSEWECKFYMYQILRGLEYCHSM-----------GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

HNEASPASDVWSLGVIIYELVTLKRPDFLGG------KEPAEVFVDGWRPDLSGVTDG----------------------FIKSVLERIFVLDPVKRPTA
... .|..|.||.|.|.||... .|| | |        . . .. ....|  .                             |....... .|| |||||
GQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

RELHKT--F
... .   |
EQILQHPWF
S_TKc GL50803_111938.AA S_TKc 28-287 25 2.3e-38 134.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-287
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

KLLDGVLGRGVTGVVYALRGYP---SLAVKEILLDGLGKGNVDAIRLELATLPDLSHPGILKYHQVVEDEGFIYIVMNRHDK---TLEQVFIDCKRRKTP
  .  ..|.|  |.||  |        |.|.|          . || |.. |    || | |.. | .| ...|.||   |    .| ..  ...|....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VSPELVLSVLRQLAAALAYLHGVSGVGADGRPYQGLVHRDLRPASILVSADDEHFIIADFGLCKDALRCGSTIAGTAVYMAPEMLLHNEASP-ASDVW
   ..  . ....|.. ||.|.|            .| .|||| |. ||..    |  |.||||..      .|. ||  |||||.|     .. ..|.|
FPFPE-HARFYMYQICCALEYCH-----------SHGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWW

SLGVIIYELVTLKRPDFLGGKEPAEVFVDGWRPDLSGVTDGFIKSVLERIFVLDPVKRPTARELHK--------TFA
|.|.|.||... . |      .....|           .. ..   ...... || ||||| |. .         . 
SCGCILYEMLCGYPPFP----QMQMMFKKIG-------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_111938.AA TKL 79-286 18 3e-27 95.18 In-house 82-364 (364) Show / Hide 
Range on Protein: 79-286
Range on HMM: 82-364/364
Sequence Identity: 18% (54 aa)

LSHPGILKYHQVVEDEGF-------------IYIVMNRHDK-TLEQVFIDCKRRKTPVSPELVLSVLRQLAAALAYLHGVS---GVGADGRPYQGLVHRD
|.|| |...  .. ....             ..|||  ... .|. ...          ... ..  .. | ...|||      .         ...|||
LRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT------KPPIIHRD

LRPASILVSADDEH-------------FIIADFGLCKDA-----LRCGST-----------------IAGTAVYMAPEMLLHN----------------E
| .. |||  . ..               |.||||...        ...|                 . ||  .||||.|  .                |
LKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFE

ASPASDVWSLGVIIYELVTLKRPDF-LGGKEPA---------EVFVD-GWRPDLS------------GVTDGFIKSVLERIFVLDPVKRPTARELHKTF
.|...||.| |....|..| .|| . ..  ..          .. .| | || .               ..  .|. ...    || |||.. |. |..
YSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_111938.AA Ciliate-E2 72-233 23 1.3e-26 88.41 In-house 82-295 (365) Show / Hide 
Range on Protein: 72-233
Range on HMM: 82-295/365
Sequence Identity: 23% (54 aa)

ELATLPDLSHPGILKYHQVVE--DEGFIYIVMNRHDK-TLEQVFIDCKRRKTPVSP-------ELVLSVLRQLAA---------------ALAYLHGVSG
|.  |  |.|| |.|.. . .  |.  ||.||   .  .|..  ...|  ..   .       . .. . .|..                || |||    
EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH----

VGADGRPYQG-LVHRDLRPASILVSADDEHFIIADFGLCKDAL----------RCG------------------------STIAGTAVYMAPEMLL----
        ..  .|||. |  ||.        |.||||.|..           .|.                         ||.||. |||||.|     
-------SKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKY

-----HNEASPASDVWSLGVIIYELVTLKRP
     ... . ..|.||||||.||... |.|
DNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
Kinase GL50803_111938.AA CAMK 33-229 17 4.8e-26 80.3 In-house 1-329 (425) Show / Hide 
Range on Protein: 33-229
Range on HMM: 1-329/425
Sequence Identity: 17% (59 aa)

VLGRGVTGVVYALRGYPS---------------LAVKEILLDGLG--------------------------KGNVDAIRLELATLPDLS-------HPGI
.||||  |.|.  .   .                |.| |  . |                             . . .| |.. .  |.       || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKYHQVVEDEGF-------------------IYIVM---NRHDKT-L--E-QVFIDCKRR------------KTPVSPELVLSVLRQLAAALAYLHGVSG
.| ..| ||. .                   .|.||      .   |  .   .|  ...            .  .. . .  . ||.. |..|.|    
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS---

VGADGRPYQGLVHRDLRPASILVSADD----------------EHFIIADFGLCKDALR--------------------------CGSTIAGTAVYMA-P
        .. ||||| |  ||.. ..                    |.|||. .   .                            .|  ||  ||| |
--------HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP

EMLLH--------------NEASPASDVWSLGVIIYELVT
|.|.                  .|..|.||.||| | ...
EVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLC
Kinase GL50803_111938.AA AGC 155-229 26 1.8e-25 61.45 In-house 172-300 (395) Show / Hide 
Range on Protein: 155-229
Range on HMM: 172-300/395
Sequence Identity: 26% (35 aa)

Q-GLVHRD-LRPASILVSADDEHFIIADFGLCKDALRCG-----------------------------------------------------STIAG--T
. | .||| | |  ||  .|  |  ..||||||   . |                                                     .|. |  |
HMGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCT

AVYMAPEMLLHNEASPASDVWS--LGVIIYELVT
. |||||.|     ..| | ||  ||...||..|
PEYMAPEIL----YGKACDWWSFGLGCLMYEMLT
Kinase GL50803_111938.AA Ciliate-E2-Unclassified 78-233 23 7.5e-25 83.14 In-house 77-269 (352) Show / Hide 
Range on Protein: 78-233
Range on HMM: 77-269/352
Sequence Identity: 23% (48 aa)

DLSHPGILKYHQVVEDEGFIYIVMNR-HDKTLEQVFIDCK-------------RRKTPVSPELVL-----SVLRQLAAALAYLHGVSGVGADGRPYQG-L
.. || |.|.. . .|.  |||||    ...|.|   ..|             ...  .. . ..       ..|.  .| |||           ...  
NHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH-----------HKNNI

VHRDLRPASILVSADDE--HFIIADFGLCKDALRC------------------GSTIAGTAVYM----APEMLLHNEAS----PASDVWSLGVIIYELVT
.|||. |  ||.. . .  .  |.|||..|    .                   .|..||  ||    |||.|  .. .     ..|.||||||.||...
IHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF

LKRP
 ..|
GYYP
Kinase GL50803_111938.AA TK 79-286 15 2.5e-24 77.79 In-house 100-486 (486) Show / Hide 
Range on Protein: 79-286
Range on HMM: 100-486/486
Sequence Identity: 15% (60 aa)

LSHPGILKYHQVVEDE------------GFIYIVMNRHDKT-----LEQVFIDCKRRKTP----------------------------------------
. || |.. . |. ..            . ..|||   ..      | .   .|......                                        
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------VSPELVLSVLRQLAAALAYLHGV--SGVGADGRPYQGLVHRDLRPASILVSADDE----------HFI
                                ....  |   .|.|....|||    .         |..|||||    .||. ..           .  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-F------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

IADFG--------LCKDALR----CGSTIAGTAV-------------------------YMAPEMLLHNE---------ASPASDVWSLGVIIYELVTLK
|||||        |..|  .    . ..  ||..                         .|||| |....          ...|||||.|| ..|..|. 
IADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYG

RPDFLGG------------KEPAEVFVDG---------------WRPDLSGVTD-------------GFIKSVLERIFVLDPVKRPTARELHKTF
.  . ||            .|  |  ..|                .|   . .|              ..  .. . . .|| .||| ..||. .
QEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase GL50803_111938.AA ULK 123-233 24 1.6e-20 69.55 In-house 124-251 (324) Show / Hide 
Range on Protein: 123-233
Range on HMM: 124-251/324
Sequence Identity: 24% (34 aa)

SPELVLSVLRQLAAALAYLHGVSGVGADGRPYQGLVHRDLRPASILVSADDEH-----------FIIADFGLCKDAL------RCGSTIA------GTAV
| . ......|..... .||            .. .|||. |. ||.. ....           . |||||..|             |.       ||  
SEQEAIQFFKQICNGFKELH-----------KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPL

YMAPEMLL----HNEASPA-SDVWSLGVIIYELVTLKRP
||||. |     . . . . .|.||||.|.||... | |
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYP
Kinase GL50803_111938.AA ULK 123-233 24 9.1e-20 65.75 In-house 128-255 (329) Show / Hide 
Range on Protein: 123-233
Range on HMM: 128-255/329
Sequence Identity: 24% (34 aa)

SPELVLSVLRQLAAALAYLHGVSGVGADGRPYQGLVHRDLRPASILVSADDEH-----------FIIADFGLCKDALRC------GSTIA------GTAV
| . ......|..... .||            .. .|||. |. ||.. ....           . |||||..|             |        ||  
SEQEAIQFFKQILNGFKELH-----------KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPL

YMAPEMLL----HNEASPA-SDVWSLGVIIYELVTLKRP
||||. |     . . . . .|.||||.|.||... | |
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPP
Kinase GL50803_111938.AA RSK 130-229 33 1e-17 61.62 In-house 109-207 (278) Show / Hide 
Range on Protein: 130-229
Range on HMM: 109-207/278
Sequence Identity: 33% (37 aa)

VLRQLAAALAYLHGVSGVGADGRPYQGLVHRDLRPASILVSA--DDEHFIIADFGLCKD-ALRCGS---TIAGTAVYMAPEMLL---HNE-ASPASDVWS
...... |. .||            || .|||| |  ||     ...|  . |||.||   .. ..   |  .|. |||||||    ...  . | |.||
YMAEIVLAVEHLHQ-----------QGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWS

LGVIIYELVT
|||..||. |
LGVLMYEMLT
Kinase GL50803_111938.AA STE 155-233 26 4.8e-17 56.84 In-house 171-267 (359) Show / Hide 
Range on Protein: 155-233
Range on HMM: 171-267/359
Sequence Identity: 26% (28 aa)

QGLVHRDLRPASILVSADDEHFIIADFGLCKDALR-------------------CGSTIAGTAVYMAPEMLLH------NEASPASDVWSLGVIIYELVT
.. .|||. || ||.        ..|||.|.                          |..||  .||||...       .. .  .|.||||  | |..|
HHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT

LKRP
 | |
GKPP
Kinase GL50803_111938.AA TyrKc 28-286 21 2.8e-14 8.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 28-286
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

KLLDGVLGRGVTGVVYALRGYPSL--AVKEILLDGLGKGNVDAIRLELATLPDL--SHPGILKYHQVVEDE-------GFIYIVM-------------NR
  |. .||.|  |.||  . .  .  ||| .  |      . ... |.  .  |  .|| |.. . |. ..       . ..|||             ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

HDKTLEQVFIDCKRRKTPVSPELVLSVLRQLAAALAYLHGVSGVGADGRPYQGLVHRDLRPASILVSADDEHFIIADFGLCKDALRC------GSTIA--
..|               ....  ||   | |.  .|||             ...||||    .||...  .  |.||||..|          ....   
RPK---------------LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKK

----GTAV----YMAPEMLLHNEASPASDVWSLGVIIYELVTLKRPDFLGG----KEPAEVF---VDGWRPDLSGV--------TDGFIKSVLERIFVLD
    | ..     |||| . ... ...||||| || ..|. |.  .   |     ....||.    .| |..                . .. ..    |
EHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED

PVKRPTARELHKTF
| .||| .|.|. |
PEDRPTFSEIHECF
Kinase GL50803_111938.AA STE 28-101 16 6e-10 31.45 In-house 1-116 (359) Show / Hide 
Range on Protein: 28-101
Range on HMM: 1-116/359
Sequence Identity: 16% (19 aa)

KLLDGVLGRGVTG-VVYALRGYPS-----------------LAVKEILLDGLGK---------------GNVDAIRLELATLPDLS--HPGILKYHQVVE
  . ...|.| .| |..|..  ..                  |.|.. |.   .                ... |  |. .. ...  || | ||.   .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DEG-------FIYIVM
.||        ..|.|
KEGHNHKNDDELWICM
Kinase GL50803_111938.AA Pkinase_Tyr 201-230 43 9e-06 20.13 Pfam 181-210 (270) Show / Hide 
Range on Protein: 201-230
Range on HMM: 181-210/270
Sequence Identity: 43% (13 aa)

MAPEMLLHNEASPASDVWSLGVIIYELVTL
|||| . ... . .||||| || ..|..|.
MAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase GL50803_111938.AA Pkinase_Tyr 116-186 25 0.009454 9.94 Pfam 99-160 (270) Show / Hide 
Range on Protein: 116-186
Range on HMM: 99-160/270
Sequence Identity: 25% (19 aa)

KRR---KTPVSPELVLSVLRQLAAALAYLHGVSGVGADGRPYQGLVHRDLRPASILVSADDEHFIIADFGLCKD
...   | |....  |.  .| |....||.              ..||||.   .||. .  .  |.||||..|
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-----------CIHRDLAARNCLVTENN-VVKICDFGLARD
Kinase GL50803_111938.AA STE 265-287 38 0.042339 3.36 In-house 334-359 (359) Show / Hide 
Range on Protein: 265-287
Range on HMM: 334-359/359
Sequence Identity: 38% (10 aa)

LERIFVLDPVKRPTARELHK---TFA
... .. || ||||| .| |    | 
INKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_111938.AA Pkinase_Tyr 272-286 46 0.666744 3.68 Pfam 256-270 (270) Show / Hide 
Range on Protein: 272-286
Range on HMM: 256-270/270
Sequence Identity: 46% (7 aa)

DPVKRPTARELHKTF
|| .||| .|.|  .
DPEDRPTFSEIHEQL