Gene GL50803_11040 (G.lamblia)

GL50803_11040

Species: G.lamblia
Alias: GK087, GL50803_11040
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_11040.AA Protein None 321 None Fasta, JSON
GL50803_11040.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of GL50803_11040.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_11040.AA Pkinase 68-273 21 7.4e-28 99.59 Pfam 54-293 (293) Show / Hide 
Range on Protein: 68-273
Range on HMM: 54-293/293
Sequence Identity: 21% (54 aa)

LTELSHPNLIRYEGIYKSNNAIYMTMARYAC-----SLESTVRAYKRTNRSF--STAQVIDVAKQIGSALEYLHNSADAHNEDKRQEIVHGDVKLANILV
. .|.||| .|. ... ... ||| |    .     .| . ...  . ...|  |  .......|| ..|||.|.            |.| |.|..|||.
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM----------GIIHRDLKPENILI

NKEETK---FVLTDLGFG----DQNATTALMYC-----IAPEVLL-GDKLTPAADMWSLGIVLYELSSKLKTPFLLEA------KQPRTVYVAGWTPNLS
... .    . ..| |.       | . .  .|     .||||.. | . .|..||||.|..|||. ..  .||  ..       |   ..  ...|. .
DNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR-PPFP-GHCWHDNHDQMQMICRIMGPPLHF

AIKDV----------------------TIRSILEHILVLNPKERLTASMLMQV--L
 .                         . ..... .| ..||.|.||  ..|   .
DWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc GL50803_11040.AA S_TKc 20-280 20 5.6e-24 86.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

SRLGQELGQGLYGTVHSIDG---EQDKVVKEISTLDLSEHSVAALEKGIITLTELSHPNLIRYEGIYKSNNAIYMTMARYAC---SLESTVRAYKR--TN
 ......|.| .|.|.        .   .|.|.           ... |  | .  |||.... ... . . .|| |        .| .  . ..|  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

RSFSTAQVIDVAKQIGSALEYLHNSADAHNEDKRQEIVHGDVKLANILVNKEETKFVLTDLGFGDQNATTALMYC-----IAPEVLLGDKLTP-AADMWS
. |.  ..  ...|| .||||.|          .. |.| |.| .|||...      ..| |.  |       .|     .|||||   . .. ..|.||
FPFPE-HARFYMYQICCALEYCH----------SHGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGIVLYELSSKLKTPFLLEAKQPRTVYVAGWTPNLSAIKDVTIRSILEHILVLNPKERLTASMLMQ--VLKPQDEFS
.|..|||. .  ..||     . ..  . |         .   .......|. .|..|.||  ..|  ..  .... 
CGCILYEMLC-GYPPFP---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_11040.AA Ciliate-E2 20-271 15 1e-19 64.33 In-house 1-361 (365) Show / Hide 
Range on Protein: 20-271
Range on HMM: 1-361/365
Sequence Identity: 15% (63 aa)

SRLGQELGQGLYG----TVHSIDGE-------------------QDKVVKEISTLDLSEHSVAALEKGII--------------TLTELSHPNLIRYEGI
  . . .||| .|      .  ...                   ...  ... ..  ..      |. |.               | .|.|||.|..   
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YK--SNNAIYMTMARYAC-SLESTVR--AYKRTNR-----SFSTAQVIDVAKQIGS---------------ALEYLHNSADAHNEDKRQE-IVHGDVKLA
..  ..| ||. |  .   .|..  .    ||..      .|.  ..... ||| .               ||||||.          .  |.| | |. 
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS----------KNNIIHRDIKPE

NILVNKEETKFVLTDLGFGDQNATT----------------------------------------ALMYCIAPEVLLGDK---------LTPAADMWSLG
|||.        ..|.|.  .. .                                          ..|  |||.| | |          . ..|.||||
NILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGY-MAPEILNGKKYDNQQKQKGYDYKCDIWSLG

IVLYELSSKLKTPFLLEAKQPRTVYVAGWTPNLSAIKDVTIR----------------------------SILEH----ILVLNPKERLT-ASMLMQ
..|||. .. |.||                  .  ||.  |.                             ..      .|. .|..|.| .. ...
VILYEMLFG-KPPF------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase GL50803_11040.AA Ciliate-E2-Unclassified 20-221 17 2e-17 57.03 In-house 1-270 (352) Show / Hide 
Range on Protein: 20-221
Range on HMM: 1-270/352
Sequence Identity: 17% (50 aa)

SRLGQELGQGLYGTVHSIDGEQDK--------VVKEISTLDLSEHSVAALEKGIITLTELS-----------------HPNLIRYEGIYKSNNAIYMTMA
 .... .||| .|.|.    ...|         .. |    . ...   .   .... ...                 ||.....  .|  ..  .. . 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

RYAC---SLESTVRAYK-------------RTNRSFSTAQVI-----DVAKQIGSALEYLHNSADAHNEDKRQEIVHGDVKLANILVNKEET--KFVLTD
   |   .|.   . .|             .... |.  |..     . ..|| ..||||| . .         |.| | |. |||....    .  ..|
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN---------IIHRDIKPENILFDNNGKNYYIKIID

LGF---------------------GDQNATTA---LMYCI---APEVLLGDKLT----PAADMWSLGIVLYELSSKLKTPF
.|.                      .|...|    ..| .   ||||| | .       ..|.||||..|||.      ||
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY-YPF
Kinase GL50803_11040.AA TKL 26-273 16 4.8e-17 57.91 In-house 1-364 (364) Show / Hide 
Range on Protein: 26-273
Range on HMM: 1-364/364
Sequence Identity: 16% (61 aa)

LGQGLYGTVHSIDGE-----------QDKVVKEISTLDLSEHSV-------------------------AALEKGIITLTELSHPNLIRYEGIYKSNNA-
.|.| .|.|.                .| .|| ... . .|..                            .|. |  .  |.|||.... |. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------IYMTMARYA--CSLESTVRAYKRTNRSFSTAQVIDVAKQIGSALEYLHNSA-DAHNEDKRQEIVHGDVKLANILVNKEET---------
            ..    |.   ||....             | .. |..| ....|||..   ..       |.| | | .||||..  |         
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT---KPPIIHRDLKSKNILVDENWTNVSNYMYNP

----KFVLTDLG-------FGDQNATT--------------ALMYCI------APEVLLGD----------------KLTPAADMWSLGIVLYELSSKLK
    .  ..|.|        |..|.|               ..| ..      ||||| |.                . ....|..| ||||.|. .  .
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

TPF--LLEAKQP---------RTVYVAGWTPNLSAI----------KDV--TIRSILEHILVLNPKERLTASMLMQVL
 |.  . .  .            |.. |  | .  |          .|.   .......    .|..|.... ... |
-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_11040.AA CAMK 25-211 15 8.4e-16 46.71 In-house 1-325 (425) Show / Hide 
Range on Protein: 25-211
Range on HMM: 1-325/425
Sequence Identity: 15% (53 aa)

ELGQGLYGTVHSIDGEQDK---------------VVKEISTLDLS--------------------------EHSVAALEKGIITLTELS-------HPNL
.||.| .|.|.     ...                .| |..  |.                          ... . ... |  .  |.       |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRYEGIYKS-------------------NNAIYMTM--ARYACSL----ESTVRAYKRTN-------------RSFSTAQVIDVAKQIGSALEYLHNSAD
|.   .| .                   .. .|| |    |.       .   .  ....             . |. ...  . .|| ||..|.|.   
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS---

AHNEDKRQEIVHGDVKLANILVNKEE----------------TKFVLTDLGFG-----------------------------DQNATTAL--MYCIA-PE
       . ||| | |. |||... .                 .  ..| ||                              .|  .|     . .| ||
-------HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE

VLLG--------------DKLTPAADMWSLGIVLY
||.|              .  .|..||||.|..||
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase GL50803_11040.AA TK 20-213 12 2.2e-15 47.29 In-house 1-387 (486) Show / Hide 
Range on Protein: 20-213
Range on HMM: 1-387/486
Sequence Identity: 12% (50 aa)

SRLGQELGQGLYG---TVHSI----------------------------DGEQDKVVKEISTLDLSEHSVAAL--------------EKGIITLTE---L
 .||..||.| .|   .|.                              .|...  || .   | ..     .              |  .. .     .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHPNLIRYEG--------------IYKSNNAIYMTMARYAC---SLESTVRAYKRTNRS-----------------------------------------
 |||..|  |              . .    | | .. . .   || .  |. ... .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FSTAQVIDVAKQIGSALEYLHNS---ADAHNEDKRQEIVHGDVKLANILVNKEETK----------FVL
                               ....| .  . || ...||||              | .||.|.   |.||... ..            .
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF-------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKI

TDLGFG-------------DQNATTALMYC-----------------------------IAPEVLLGDK---------LTPAADMWSLGIVLYEL
.| |               |.. ...  |                               |||.|.. .          |.. |.||.|....|.
ADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase GL50803_11040.AA MAPKAPK 105-211 31 4.6e-11 33.38 In-house 92-197 (268) Show / Hide 
Range on Protein: 105-211
Range on HMM: 92-197/268
Sequence Identity: 31% (36 aa)

RAYKRTNRSFSTAQVIDVAKQIGSALEYLHNSADAHNEDKRQEIVHGDVKLANILVNKEETKFV--LTDLGFGDQNA-TTALM------YCIAPEVLLGD
|  .| .. |   ..  . |||..|....|          . .| | |.|. |.|   ..   |  ||| ||  .   ...||      | .|||||  .
RIQERGDQHFTEREAAQIMKQICQAVQHCH----------SMNIAHRDLKPENLLYKDTQPNCVLKLTDFGFAKETTRHNTLMTPCYTPYYVAPEVLGPE

KLTPAADMWSLGIVLY
|     ||||||...|
KYDKSCDMWSLGVIMY
Kinase GL50803_11040.AA TyrKc 20-273 17 5.1e-11 -44.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-273
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

SRLGQELGQGLYGTVHSIDGEQDKV-VKEISTLDLSEHSVAALEKGIITLTEL--SHPNLIRYEGIYKSN-------NAIYMTMARYAC--SLESTVRAY
 .||..|| | .|.|.       .| || .         .... . .  ...|  .|||..|  |.  .          ... |  |..  .| .  |..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME-YMPHGDLKDYLRKH

KRTNRSFSTAQVIDVAKQIGSALEYLHNSADAHNEDKRQEIVHGDVKLANILVNKEE----TKFVLTDLGFGD-----QNATTALMY---CI--------
...   ..... .. . || .  ||||             ..| |    |.||...     . | |.  .  |        .   .    .         
RPK---LCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEVLLGDKLTPAADMWSLGIVLYELSSKLKTPFL------LEAKQPRTVYVAGWTPNLSAI--------KDVTIRSILEHILVLNPKERLTASMLMQVL
|||..   | |.. | || |....|. .  ..|        ..... .    .|  .   .             . .| .     .|..| | | . . .
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_11040.AA CAMK-Unique 71-171 17 5.3e-11 32.35 In-house 73-216 (363) Show / Hide 
Range on Protein: 71-171
Range on HMM: 73-216/363
Sequence Identity: 17% (27 aa)

LSHPNLIRYEGI----YKSNN---------------AIYMTMARYACS-LESTVRA----------------YKRTNRSFST--AQVIDVAKQIGSALEY
..|||.|. ...    .   .               ..|. | .  .  | . . .                 || ...||   .... .  .. ||..|
VDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAY

LHNSADAHNEDKRQEIVHGDVKLANILVNKE---------------ETKFVLTD
.|.          | |||.| || ||.|...                .. .|.|
MHS----------QDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCD
Kinase GL50803_11040.AA AGC 125-213 20 7e-11 22.85 In-house 161-298 (395) Show / Hide 
Range on Protein: 125-213
Range on HMM: 161-298/395
Sequence Identity: 20% (31 aa)

QIGSALEYLHNSADAHNEDKRQEIVHGD-VKLANILVNKEETKFVLTDLGFGDQNAT-------------------------------------------
.| .||||||.          . |.| | .|. ||| ...     ||| |.  .. .                                           
CIVLALEYLHSH---------MGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQ

----------TALMYC-------IAPEVLLGDKLTPAADMWS--LGIVLYEL
          ..   |       .|||.|     ..|.| ||  ||...||.
EDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEM
Kinase GL50803_11040.AA UTK 20-173 18 6.1e-09 26.72 In-house 1-170 (296) Show / Hide 
Range on Protein: 20-173
Range on HMM: 1-170/296
Sequence Identity: 18% (34 aa)

SRLGQELGQGLYGTVHSIDGEQDK-----VVKEISTLDLSEHSVAALE---------KGIITLTELS-HPNLIRYEGIYKSNNAIYMTMARYA-CSLEST
 .||..|||| .|.||  . .|..     ... . ... .. .  . |         ...  .  .. |||..|  |.  .   ... .  ..  .| | 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

VRAYKRTNR----SFSTAQVIDVAKQIGSALEYLHNSADAHNEDKRQEIVHGDVKLANILVNKEE------TKFVLTDLG
.|  ..| .    ...  | .. | .| ....|||          .. .||.|.   |.||.. .      ..... |.|
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLH----------SCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFG
Kinase GL50803_11040.AA CMGC 188-213 38 1.7e-07 19.74 In-house 293-328 (513) Show / Hide 
Range on Protein: 188-213
Range on HMM: 293-328/513
Sequence Identity: 38% (14 aa)

APEVLLGDKL----------TPAADMWSLGIVLYEL
|||.|||.|           |.. ||||.| ...|.
APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEM
Kinase GL50803_11040.AA CMGC 65-174 13 1e-06 16.66 In-house 72-250 (513) Show / Hide 
Range on Protein: 65-174
Range on HMM: 72-250/513
Sequence Identity: 13% (25 aa)

IITLTELS-----------------HPNLIRYEGIYKSNN-----------------AIYMTMARYACSLESTVRAYK----------------------
|  | .|.                 |.|...   |....|                  .|. .    ..|    . ..                      
IKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRR

--RTNRSFSTAQVIDVAKQIGSALE--YLHNSADAHNEDKRQE--IVHGDVKLANILVNKEETKF-------------------VLTDLGF
  .. ..|.  ..   ..||  .|.  |.|          ..   |.| | | .|||.|.. . .                    . | |.
PPHNIKYFMI-HIR-YMYQILRGLKLKYCH----------SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGL
Kinase GL50803_11040.AA UTK 188-213 40 0.000124 11.77 In-house 207-233 (296) Show / Hide 
Range on Protein: 188-213
Range on HMM: 207-233/296
Sequence Identity: 40% (11 aa)

APEVLLGD-KLTPAADMWSLGIVLYEL
|||.|    . | . |.||.|.|..|.
APEALTHHTRFTTKSDVWSFGVVCWEI
Kinase GL50803_11040.AA CAMK-Unique 187-213 26 0.000663 8.55 In-house 242-286 (363) Show / Hide 
Range on Protein: 187-213
Range on HMM: 242-286/363
Sequence Identity: 26% (12 aa)

IAP--------------EVLL----GDKLTPAADMWSLGIVLYEL
.||              ||.     . .. ||.| |||| ..|..
MAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYM
Kinase GL50803_11040.AA Pkinase_Tyr 188-213 38 0.000869 13.45 Pfam 182-207 (270) Show / Hide 
Range on Protein: 188-213
Range on HMM: 182-207/270
Sequence Identity: 38% (10 aa)

APEVLLGDKLTPAADMWSLGIVLYEL
|||..   | | . | || |....|.
APECINYGKFTTKSDVWSFGVLMWEI
Kinase GL50803_11040.AA CMGC 252-271 35 0.015391 3.12 In-house 490-509 (513) Show / Hide 
Range on Protein: 252-271
Range on HMM: 490-509/513
Sequence Identity: 35% (7 aa)

LEHILVLNPKERLTASMLMQ
|. .|...|..|.||.  .|
LKKMLQYDPDKRITAEQALQ
Kinase GL50803_11040.AA CAMK 249-271 17 0.041852 1.77 In-house 399-421 (425) Show / Hide 
Range on Protein: 249-271
Range on HMM: 399-421/425
Sequence Identity: 17% (4 aa)

RSILEHILVLNPKERLTASMLMQ
.. . ..|. .|..|.|..  ..
KDLIRKMLQVDPEKRMTIEQCLN
Kinase GL50803_11040.AA Pkinase_Tyr 108-135 16 5.522701 0.57 Pfam 99-129 (270) Show / Hide 
Range on Protein: 108-135
Range on HMM: 99-129/270
Sequence Identity: 16% (5 aa)

KRT---NRSFSTAQVIDVAKQIGSALEYLHN
..    ...... . .. . || ...|||..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase GL50803_11040.AA Pkinase 20-34 33 5.955237 0.91 Pfam 1-15 (293) Show / Hide 
Range on Protein: 20-34
Range on HMM: 1-15/293
Sequence Identity: 33% (5 aa)

SRLGQELGQGLYGTV
 ..|. .|.| .|.|
YHIGRKIGSGSFGCV