Gene 81902.m00119 (T.vaginalis)

81902.m00119

Species: T.vaginalis
Alias: 81902.m00119, TvagK0676
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
81902.m00119.AA Protein None 240 None Fasta, JSON
81902.m00119.kin_dom Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of 81902.m00119.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase 81902.m00119.AA Pkinase 4-213 31 9.8e-66 229.49 Pfam 1-225 (293) Show / Hide 
Range on Protein: 4-213
Range on HMM: 1-225/293
Sequence Identity: 31% (72 aa)

YYKVRKLGQGGFGKVYLIKNSNGKQ-YALKQIDLSDLSYEMRQKTLS--EVVILSHLNNDFIVKHVSSWTEGNNLNIVMDYIDGG----NLRELIS-RQN
| ..||.|.|.||.||. .. .  . .|.|.|.... . ...|  .   |. |. .|| ..||.   ........ .||.| .||     | ..|| ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRL-IGLDRICYIARHIINALQYIHDHHIIHRDLKPDNILCSSSGNN---FYLSDFGLARPL-TNYSPYAVTQCGTRGYSAPEVLL-GYPYNEKADIYSF
|..    . .. ... |. .|.|.|.. ||||||||.|||... |..   . ..|||||. . .  .. . | |||..| ||||.. | .|  |.|..|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GLILYELCTLRPFYEGK----RGLDSQY
|.||||... || . |.    . .| ..
GCILYEMLCGRPPFPGHCWHDN-HDQMQ
S_TKc 81902.m00119.AA S_TKc 4-231 30 1.9e-61 211.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-231
Range on HMM: 1-231/231
Sequence Identity: 30% (78 aa)

YYKVRKLGQGGFGKVYLIKNSN-GKQYALKQIDLSDLSYEMRQKTLSEVVILSHLNNDFIVKHVSSWTEGNNLNIVMDYIDG--GNLRELISRQNGRL--
| ..||.|.|.|||||. .. . |...|.|.|.         .....|. ||.. . ..|||   .. . ..| .||.|.||  |.|...| .....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IGLDRICYIARHIINALQYIHDHHIIHRDLKPDNILCSSSGNNFYLSDFGLARPLTNYSPYAVTQCGTRGYSAPEVLLGYPYNE-KADIYSFGLILYE
  .   ....... |..||.|.|.|.||||||||.|||...   .  ..|||||| |        |.|||. | |||||   .|.  |.|..|.| ||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LCTLRPFYEGKRGL------DSQYALILPCCLQT--------QMLD-------HQSI
... .| ..    .      ...   ..  |||         . |        |. .
MLCGYPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 81902.m00119.AA NEK 4-206 36 5.9e-60 205.51 In-house 1-229 (286) Show / Hide 
Range on Protein: 4-206
Range on HMM: 1-229/286
Sequence Identity: 36% (83 aa)

YYKVRKLGQGGFGKVYLIKN-SNGKQ-----YALKQIDLSDLSYEMRQKTL-SEVVILSHLNNDFIVKHVSSWTEGN--NLNIVMDYID-GGNLREL---
| ...|.||| |||||...  |.||.     |..|.|... .| . .|... .|| ||..|... |||   |. | .   |.|||.| . ||.| ..   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ISRQN--GRLIGLDRICYIARHIINALQYIHDH-----HIIHRDLKPDNILCSSSGN---NFYLSDFGLARPLTNYSPYAVT-QCGTRGYSAPEVLLGYP
| .|   | ..  . |  .  ... ||.|.||.     .|.|||.|| ||  ....|   |  . |||... | . . .| | | ||  | .|||. . |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNEKADIYSFGLILYELCTL--RPFYEGK
||.|.|| |.| .|||.|||  ..  |..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAW
Kinase 81902.m00119.AA STE 4-203 26 9e-57 194.93 In-house 1-268 (359) Show / Hide 
Range on Protein: 4-203
Range on HMM: 1-268/359
Sequence Identity: 26% (74 aa)

YYKVRKLGQGGFGKVYLIKNSN----------------GKQYALKQIDLSDLS---------------YEMRQKTLSEVVILSHLN--NDFIVKHVSSWT
. ...|.|.|.||.||. .| .                |. .| ||..|.. .                | .|. | |. |....|   ..|||   .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------NNLNIVMDYIDGGNLRELISRQNGRLIG------------LDRICYIARHIINA-LQYIHDHHIIHRDLKPDNILCSSSGNNFYLSDFGLA
 .       ..|.|.| |.||| |...| .  |.. .             . |.||.| |. . |.|.|.|||||||.||.|||         |.|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

RPLTN----------------YSPYAVTQCGTRGYSAPEVLLG------YPYNEKADIYSFGLILYELCTLRPFY
  ||.                 .    | .||  . ||||...       .|..|.||.|.|. . |..| .| .
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase 81902.m00119.AA Ciliate-E2 4-201 24 2.8e-54 184.71 In-house 1-294 (365) Show / Hide 
Range on Protein: 4-201
Range on HMM: 1-294/365
Sequence Identity: 24% (74 aa)

YYKVRKLGQGGFGKVYLIKN------------------------SNGKQYALKQIDLSDLSYEMRQKTLS-----------EVVILSHLNNDFIVKHVSS
| ...|.|||.||.||. |.                         ..|.||.|..  ... . .. . .            |  ||..||...|.| . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WT--EGNNLNIVMDYIDGGNLRELIS-----RQNGRL----IGLDRICYIARHIIN---------------ALQYIHDHH-IIHRDLKPDNILCSSSGNN
.     ||. .||.|..||.|...|      |.. .     . .  |.|| ..|..               ||.|.|  . |||||.||.|||       
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FYLSDFGLAR------------PLTNYSPYAV--------------------TQCGTRGYSAPEVLL---------GYPYNEKADIYSFGLILYELCTLR
  ..||||..            .. .  ..                      |.||| || |||.|          . .|..|.||.|.| ||||... .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

P
|
P
Kinase 81902.m00119.AA CAMK 9-194 20 2.9e-53 169.61 In-house 1-325 (425) Show / Hide 
Range on Protein: 9-194
Range on HMM: 1-325/425
Sequence Identity: 20% (67 aa)

KLGQGGFGKVYLIKNS-NG------------KQYALKQIDLSDLS--------------------------YEMRQKTLSEVVILSH-------LNNDFI
.||.|.||||.| ..  ..            ...| | || . |.                           ..|.. ..|. |...       |.   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKHVSSWTEGNN-------------------LNIVM---DYIDGG----NLRELISRQNG-------------RLIGLDRICYIARHIINALQYIHDHHI
.|    .  ...                   . .||   .|..||     | . | .. .             . .  .  ... | |. |..|.|.|.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPDNILCSSSG----------------NNFYLSDFGLARPLTN-----------------------YSPYAVTQCGTRGYSA-PEVLLG------
.||||||.|||.....                ||  ..|||.|. ..                        . .   |.||| .| | ||||.|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------YPYNEKADIYSFGLILY
         .|..|.|. | | |||
QNATDEEKPYYGPKCDMWSCGVILY
Kinase 81902.m00119.AA Ciliate-E2-Unclassified 4-206 25 1.1e-52 181.0 In-house 1-273 (352) Show / Hide 
Range on Protein: 4-206
Range on HMM: 1-273/352
Sequence Identity: 25% (70 aa)

YYKVRKLGQGGFGKVYLIKNSNGKQY-----ALKQIDLSDLSY------------EMRQKTLSEVV--------ILSHLNNDFIVKHVSSWTEGNNLNIV
| .....|||||||||. .... |||     . |... .....            ....|  . .         ||..... |||| .   .  .|. ||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MDYIDGGNLRELISRQNG---------------RLIGLDRIC-----YIARHIINALQYIHDHH-IIHRDLKPDNILCSSSGN--NFYLSDFGLAR-PLT
|.|..||.|.. |. ...               . .    ..     .....|...|.|.|  . |||||.||.||| ...|.  .  ..|||... . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

N--------------YSPYAVTQCGTRGYS----APEVLLGYPYN----EKADIYSFGLILYELCTLRPFYEGK
|              ..  . |.||| .|     ||||| |  |.    .|.||.|.| ||||... .. ....
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN
Kinase 81902.m00119.AA CAMKL 4-194 30 9e-50 156.93 In-house 1-227 (297) Show / Hide 
Range on Protein: 4-194
Range on HMM: 1-227/297
Sequence Identity: 30% (70 aa)

YYKVRKLGQGGFGKVYLIKN-SN-GKQYALKQID--LSDLSYEMRQK-----------TLSEVVILSHLN---NDFIVKHVSSWTEGNN------LNIVM
|  .. ||.|.|||| | .. .. |...| | ||     .   |...              |. |...||      |.|    ..  ..      ...||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

DYIDGGN--LRELISRQNGRL--IGLDRICYIARHIINALQYIHDHHIIHRDLKPDNILCSSSGN-NFYLSDFGLA---RPL-TNYSPYAVTQCGTRGYS
 |..||.  | . | .. .|   .  .  . . | |. |..|.|.|.|.|||.||.||| ...|| |  ..|||..   ||   ..     |.||.  | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLLG--YPYN-EKADIYSFGLILY
|||...|   ||.  |.|| | | |||
APEIFQGNNKPYDGPKVDIWSCGVILY
Kinase 81902.m00119.AA TKL 10-204 23 8.6e-48 165.1 In-house 1-291 (364) Show / Hide 
Range on Protein: 10-204
Range on HMM: 1-291/364
Sequence Identity: 23% (70 aa)

LGQGGFGKVYLIKNSN---------GKQYALKQIDLSDLSYEMR-------------------------QKTLSEVVILSHLNNDFIVKHVSSWTEGNN-
.|.||||.||  |  .         ||  | |..   . . ...                         ..   |....| |. . ||. . . ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LNIVMDYIDGGNLRELISRQNGRLIGLDRICYIARHIINALQYIHDHH--------IIHRDLKPDNILCSSSGNN-------------
            | |||.|..||.|....         ....| .|. |  ...| | ..        |||||||..|||  . ..|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

FYLSDFGLARPLT-----NYSPYAVT--------------QCGTRGYSAPEVLL----------------GYPYNEKADIYSFGLILYELCTLR-PFYE
  ..||||.| ..     | . ...               |||| .. |||||                 |..|.||.|.||||..|.|..| . |.|.
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD
Kinase 81902.m00119.AA ULK 4-204 28 3.3e-47 163.17 In-house 1-254 (324) Show / Hide 
Range on Protein: 4-204
Range on HMM: 1-254/324
Sequence Identity: 28% (72 aa)

YYKVRKLGQGGFG-KVYLI--KNSN--GKQYALKQID---LSDLSYE-----MRQKTLSEVVILSHLN------NDFIVKHVS-SWTEG-NNLNIVMDYI
|.. ..||.| || |||    |..|  ....| |.||   ... ..|     | |.  .|. |.  |.      .  |||    ..|   ||. |.|.| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

DGGNLRELISRQ-------NGRLIGLDRICYIARHIINALQYIHDHHIIHRDLKPDNILCSSSGNN-----------FYLSDFGLARPLTNYS---PYAV
.||.|...| ..       ... .  . .  . ..|.|.....|.| |||||.||.||| .                . ..|||.|. . |..       
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TQC------GTRGYSAPEVLL----GYPYN-EKADIYSFGLILYELCTLR-PFYE
|..      ||  | ||..|     . ||.  |.||.|.| |.||. . . ||..
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFS
Kinase 81902.m00119.AA ULK 4-204 27 3.2e-45 155.84 In-house 1-258 (329) Show / Hide 
Range on Protein: 4-204
Range on HMM: 1-258/329
Sequence Identity: 27% (72 aa)

YYKVRKLGQGGFGKVYLI--KNSN---GKQYALKQID---LSDLSYE-----MRQKTLSEVVILSHLN----NDF----IVKHVS-SWTEG-NNLNIVMD
|.. ..||.| |||||    |...   ....| |.||   ..  ..|     | |   .|. |.  |.    . .    |||    ..|   ||. |.|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YIDGGNLRELISRQ--------NGRLIGLDRICYIARHIINALQYIHDHHIIHRDLKPDNILCSSSGNN-----------FYLSDFGLARPLTNY---SP
| .||.|...|...        ... .  . .  . ..|.|.....|.| |||||.||.||| .                . ..|||.|. ..|      
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

YAVTQC------GTRGYSAPEVLL----GYPYN-EKADIYSFGLILYELCTLR-PFYE
 ..|.       ||  | ||..|     . ||.  |.||.|.| |.||. . . |||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYA
Kinase 81902.m00119.AA RSK 7-196 29 2.7e-44 153.47 In-house 1-205 (278) Show / Hide 
Range on Protein: 7-196
Range on HMM: 1-205/278
Sequence Identity: 29% (61 aa)

VRKLGQGGFGKVYLIKNS----NGKQYALKQIDLSDLSYEMR--QKTLSEVVILSHLN-NDFIVKHVSSWTEGNNLNIVMDYIDGGNLRELISRQNGRL-
.. |||||.|||.| .      .|..|| |... . .    .    |. |. ||.. .   |||.   .  ..  | ..|.|. || | . .... ... 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKE-KHFG

-IGLDRICYIARHIINALQYIHDHHIIHRDLKPDNILCSS-SGN--NFYLSDFGLARP-LTNYSPYAVTQCGTRGYSAPEVLL---GYP-YNEKADIYSF
 .  |. |.... |. |....|...||||||||.|||  . | |     |.|||...    ...  . | |.|  | |||.|    .   ... .|..|.
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GLILYEL
| ..||.
GVLMYEM
Kinase 81902.m00119.AA TyrKc 4-231 20 2e-14 10.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-231
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YYKVRKLGQGGFGKVYLIKNSNGKQYALKQIDLSDLSYEMRQKTLSEVVILSHL--NNDFIVKHVSSWTEG-------NNLNIVMDYIDGGNLRELISRQ
  . .||| | ||.||. . .   | | | .  .      |.  ..|  |...|  ... ||. .   |..         | ||| | ..|.|.. . . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

NGRLIGLDRICYIARHIINALQYIHDHHIIHRDLKPDNILCSSSGNNFYLSDFGLARPLTNY------SPYAVTQC--GTRG-----YSAPEVLLGYPYN
 .. . ..  ....  | .  .|.|....|||||   |.| .. .     |||||.| ....      . | ...   |...       |||..  . ..
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKADIYSFGLILYELCTL-RPFYEG------------------------KR--------GLDSQYALILPCCLQ--------TQMLDHQSI
.| |..|||  ..|..|.  . |.|                        .           |  | ... |.          ..   |. .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 81902.m00119.AA Pkinase_Tyr 4-199 24 4.8e-14 48.2 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-199
Range on HMM: 1-210/270
Sequence Identity: 24% (52 aa)

YYKVRKLGQGGFGKVYLIKNS-----NGKQYALKQIDLSDLSYEM--RQKTLSEVVILSHL-NNDFIVKHVSSWT-EGNN--LNIVMDYIDGGNLRELIS
  . .|||.| ||.||. .       .. . | | .   . . |   |.. ..|. |...| ... ||. .   | .|    . ||| |  .|.|..   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RQ--NGRLIGLDRICYIARHIINALQYIHDHHIIHRDLKPDNILCSSSGNNFYLSDFGLARPLTNYSPYA-VTQCGTRG---YSAPEVLLGYPYNEKADI
..  ... . . ... ... | ....| .....|||||   |.| ....     .|||||| .     |  ... |..      |||..  . ...| |.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGLILYELCTL
.|||  ..|..|.
WSFGVLMWEIFTY