Gene 81132.m00056 (T.vaginalis)

81132.m00056

Species: T.vaginalis
Alias: TvagK0672, 81132.m00056
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
81132.m00056.AA Protein None 444 None Fasta, JSON
81132.m00056.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of 81132.m00056.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81132.m00056.AA NEK 4-257 42 1.7e-141 476.39 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-286/286
Sequence Identity: 42% (121 aa)

YVIIKELGSGSYGKVYLAKIKKSGEQ-----VALKEIEMSLLDEQAKSKAF-EEVQFLSSLQHPNIVAHRESFQDNG--KFYIAMEYVD-GGDLSDK---
| |||..|.||.||||... |. | .     ...|.| |. ..|. | .|  .||. |..|.|||||. ..||....  ...| ||| . ||||..|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ISNRKT---PFTEDEVLKIFIQICFALKYIHEK-----KVVHRDIKPQNVFLTHLGI----VKLGDFGVARALEGTQDMCKT-VIGTPYYLSPEVWSNQP
| ..|    .| |......|||.| ||||.|..     |..||||||||.|||  ..    ||.||||... |. |.|| .| ..|||||.||||..|.|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YSTKTDIWSLGCILYELCTL--NRPFNGR--SPQQLFAAIIRG-HYNKVSTK--YSAAIRKLIDSMLNPDANARPTAADILQLPFI
|. | |||||||.|||.|||  ..||..   .  .|.  |..| .|.... .  ||   ..|| .||..|   ||.. .||..|||
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 81132.m00056.AA NEK1 4-257 43 3.3e-127 428.92 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-276/276
Sequence Identity: 43% (121 aa)

YVIIKELGSGSYGKVYLAKIKKSGEQVALKEIEMSLLDEQAKSKAFEEVQFLSSLQHPNIVAHRESFQDNGK--FYIAMEYVDGGDLSDKISNR---KTP
|..|| .|.||.||..|.| | .| . ..|||  .   |. .... .||  |. . |||||. .|||. ||.   || ||| |||||  || ..     .
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FTEDEVLKIFIQICFALKYIHEKKVVHRDIKPQNVFLT--HLG---------------IVKLGDFGVARALEGTQDMCKTVIGTPYYLSPEVWSNQPYST
| ||. .  |.||| ||..|| .|. |||||.||.|||  . |               .|||||||.|| |  | .  .|.|||||||||| . |.||  
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KTDIWSLGCILYELCTLNRPFNGRSPQQLFAAIIRGHYNKVSTKYSAAIRKLIDSMLNPDANARPTAADILQLPFI
|.|||||||.||||||| .||.... ..|   |..|.| ...  ||  .. |. .|.. ..  || . .||. |||
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 81132.m00056.AA NEK8 4-257 34 5.6e-101 289.04 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-278/278
Sequence Identity: 34% (97 aa)

YVIIKELGSGSYGKVYLAKIKKSG--EQVALKEIEMSLLDEQAKSKAFEEVQFLSSLQHPNIVAHRESFQDNGKFYIAMEYVDGGDLSDKISNRKTPFTE
|  |  .| |. | . |   |  .   .| .|.| |. ..|     |  |.| || ||||||..  ..| ...   |.||| ||| | ..|. ..    |
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

DE------------------VLKIFIQICFALKYIHEKKVVHRDIKPQNVFLTHL-GIVKLGDFGVARALEGTQDMC--KTVIGTPYYLSPEVWSNQPYS
.|                  .|  |.|.| |. ..|.. ..|||.|.||.|.|   ..||.|||| .  .     |   |||.|||||.|||  . .|| 
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

TKTDIWSLGCILYELCTLNRPFNGRSPQQLFAAIIRG-HYNKVSTKYSAAIRKLIDSMLNPDANARPTAADILQLPFI
 | |.|.|||.|||.|.| | | .  .  |   |...  |. .| .||.  | |. . |  |.  ||.|. |.  | .
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 81132.m00056.AA S_TKc 4-257 35 5.9e-100 339.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

YVIIKELGSGSYGKVYLAKIKKSGEQVALKEIEMSLLDEQAKSKAFEEVQFLSSLQHPNIVAHRESFQDNGKFYIAMEYVDG--GDLSDKISNRKTP---
| |....|.|..||||... ||.|..||.|.|           ..  |.| |.. .|||||   ..||| ...|. |||.||  ||| | | .|...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FTEDEVLKIFIQICFALKYIHEKKVVHRDIKPQNVFLTHLGIVKLGDFGVARALEGTQDMCKTVIGTPYYLSPEVWSNQPYST-KTDIWSLGCILYEL
  |.| .. ... ||| ||.|.|.....|||.||.|..|..   .|..|||.|| |       .|..|||.|..|||    .|.. | |.||.||||||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CTLNRPFNGRSPQQLFAAIIRGHYNKVSTKYSAAIRKLIDSMLNPDANARPTAADILQ-------LPFI
..   ||    .|..|  |            |   . .|. .|. | . |||| ..||        |..
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81132.m00056.AA Pkinase 4-257 31 6.6e-94 323.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

YVIIKELGSGSYGKVYLAKIKKSGEQVALKEIEMSLLDEQAKSKAFE--EVQFLSSLQHPNIVAHRESFQDNGKFYIAMEYVDGG----DLSDKIS-NRK
|.|.. .||||.|.||... |..|..||.|.|. .  ... .  ..   |.| . .|.|||||  ...|.|... |. |||..||    ||.| ||  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TPF--TEDEVLKIFIQICFALKYIHEKKVVHRDIKPQNVFLTHLGIV----KLGDFGVARAL-EGTQDMCKTVIGTPYYLSPEVWS-NQPYSTKTDIWSL
..|  .|.|. ... ||. .|.|.|.....|||.||.|... . | .    |..|||.|. . .  .  ..|. |||.|..|||   .|.|..| |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYELCTLNRPFNGR------SPQQLFAAIIRGHYNKVSTKYS--------------------AAIRKLIDSMLNPDANARPTAADILQLPFI
||||||... . || |.      ...|... | .. .   . . .                     . ...|...|..| . ||||..||| |..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 81132.m00056.AA NEK4 4-257 42 1.1e-91 310.87 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-257/257
Sequence Identity: 42% (109 aa)

YVIIKELGSGSYGKVYLAKIKKSGEQVALKEIEMSLLDEQAKSKAFEEVQFLSSLQHPNIVAHRESFQ-DNG-KFYIAMEYVDGGDLSDKISNRKTPF-T
| ..|  | |||| |.| . .. . |  .| ...   . . .  |  |.| || |.|||||   ||.. .||   || | . .||||  |   .|  |  
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EDEVLKIFIQICFALKYIHEKKVVHRDIKPQNVFLTHLGIVKLGDFGVARALEGTQDMCKTVIGTPYYLSPEVWSNQPYSTKTDIWSLGCILYELCTLNR
|  |.  |.||  || |.|||...||| | ||.|||   |.|.||||..| |.   || ||.||||||.|||...|.||  | ||||||| .||. ||  
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFNGRSPQQLFAAIIRGHYNKVSTKYSAAIRKLIDSMLNPDANARPTAADILQLPFI
 |. .    |   || |.   .. .||  .  |.  ||.   . ||   ||.| |.|
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 81132.m00056.AA STE 4-257 24 5.3e-83 282.06 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-359/359
Sequence Identity: 24% (89 aa)

YVIIKELGSGSYGKVYLAKIK------KSGEQ---------VALKEIEMSLLD---------------EQAKSKAFEEVQFLSSLQ--HPNIVAHRESFQ
. .|...|.|..|.||.|. .      |.||.         .| |.....  .               .. . .  .|..... ..  |||||    .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DNG-------KFYIAMEYVDGGDLSDKIS-NRKTPFT------------EDEVLKIFIQICFA-LKYIHEKKVVHRDIKPQNVFLTHLGIVKLGDFGVAR
..|       . .|.|||.||| |.| |  . .....            |... .|  ||. . |.|.|.....||||||.|..|     ||| ||||. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ALEG---------------TQD-MCKTVIGTPYYLSPEVWSN------QPYSTKTDIWSLGCILYELCTLNRPF-NGRSPQQLFAAIIR-----------
 |.                |.. ...|..||| . .||| ..      ..|.|| ||||||| . |..| . |. ..  .. .|....            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GHYNKVST-------------------KYSAAIRKLIDSMLNPDANARPTAADILQ--LPFI
   |.  .  .                   |.|   .  |.  |. | | |||| . |.   |||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 81132.m00056.AA CAMK 9-257 21 8.6e-83 266.49 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-257
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

ELGSGSYGKVYLAKIKKSG------------EQVALKEIEMSLLD--------------------------EQAKSKAFEEVQFLSSLQ-------HPNI
.||.||.|||.|.. |...            ..|| | |. . |.                          .. . . . |.. ...||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAHRESFQDNG-------------------KFYIAM---EYVDGG----DLSDKISNR--------------KTPFTEDEVLKIFIQICFALKYIHEKKV
.   | ..|.                    ..|. |   ||..||    || |.|  .              .  |||.|. ..| ||| |..|.|....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKPQNVFLTHL-----------------GIVKLGDFGVARALEGTQ-----------------------DMCKTVIGTPYYLS-PEVWSN------
||||.|| |. |..                  . .|. ||| |. ... .                       ...||. |||.| . ||| .       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QPYSTKTDIWSLGCILYELCTLNRPFNGR-------------SPQQLFAAIIRGHYNKVSTK---------------YSAA--------IRK
        ..|. |.|.||.|.||| . .   ||.|              ....||  |..| |.  . .                |           . 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIDSMLNPDANARPTAADILQLPFI
|| .||..| . |.|....|. |..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 81132.m00056.AA Ciliate-E2-Unclassified 4-257 27 4.8e-78 265.6 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-352/352
Sequence Identity: 27% (97 aa)

YVIIKELGSGSYGKVYLAKIKKSGEQV------------ALKEIEMSLLDEQAKSKAFEEVQ-------------FLSSLQHPNIVAHRESFQDNGKFYI
| ||| .|.|..||||... || . |.            . | |. .  ..  . |. .. .              |....||.||   . |||  ..||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

AMEYVDGGDLSDKISNRKT----------------PFTEDEVL-----KIFIQICFALKYIHEKK-VVHRDIKPQNVFLTHLG---IVKLGDFGVARALE
 |||..||||.. |..||.                 ||| ...     ..| ||. .|.|.|.|. ..||||||.|....  |    .|. ||| .. ..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

GT---------------QDMCKTVIGTPYYL----SPEVWSNQPYS----TKTDIWSLGCILYELCTLNRPFNGRSPQQ----------------LFAAI
                 |.|..|..|||.|.    .|||  .| |.     | ||||||.||||... ..||....  |                |.  |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

IRGHYN-----------KVSTKYSAAIRKLIDSMLNPDANARPTAADILQLPFI
. . ..           ..| ..   |..|. .||. . | |.|. .||. |..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 81132.m00056.AA Ciliate-E2 4-257 24 6e-78 265.27 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

YVIIKELGSGSYGKVYLAKIKKSGE------------------QVALKEIEMSLLDEQAKSKAFEEVQFL----------------SSLQHPNIVAHRES
| .|| .|.|..|.||..| .| ..                  .|. |...|  . .. .   . | . .                ..|.||||.   |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DNGKFYIAMEYVDGGDLSDKISNRKT----------PFTEDEVLKIFIQICF---------------ALKYIHEKK-VVHRDIKPQNVFLTHLGIV
||  |. ..|. |||..|||| | | |.|.          .||| |...|. ||.                ||.|.|.|. ..||||||.|...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGVAR----------------------ALEGTQD---------MCKTVIGTPYYLSPEVWSNQP---------YSTKTDIWSLGCILYELCTLNRP
|. ||| ..                        ..|.          | .|..|||.|..||. ....         |..| ||||||.||||... ..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FNGRSPQQLFAAIIRGHYNKVST-----------------KYSAAIRKLIDS----MLNPDANARPT-AADILQLPFI
|        .  |. . ..  .                  | |     ||      ||. | . |.| . .||. |..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 81132.m00056.AA ULK 4-257 28 4.1e-75 255.86 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-324/324
Sequence Identity: 28% (92 aa)

YVIIKELGSGSYG-KVYLA--KIKK-SGEQVALKEIEMSLLDEQAKS--------KAFEEVQFLSSLQ---HPN--IVAHRESFQDN--GKFYIAMEYVD
|.....||.||.| ||| .  |... ....|| | |... . .. .         .   |.| .  |    |||  ||   . |..     .|| ||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLSDKISNRKT--------PFTEDEVLKIFIQICFALKYIHEKKVVHRDIKPQNVFLTHL------------GIVKLGDFGVARALEGT---QDMCKT
||||.. | ..|.         ..|.|....|.||| ..|..|.....||||||||  ...             |..|..||| |. ..     |.||.|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

VI------GTPYYLSPEVWS----NQPYS-TKTDIWSLGCILYELCTLNRPFNGRSPQQLF-------------AAIIRG---HYNKVS--TKYSAAIRK
        |||.| .|....    ..||.  |.||||||||.||. .   ||... .....               .|.     ..|..   | |  .. 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIDSMLNPDANARPTAADILQLPFI
||  ||  | . | .  .|.. |..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 81132.m00056.AA ULK 4-257 26 3.4e-74 252.81 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-329/329
Sequence Identity: 26% (89 aa)

YVIIKELGSGSYGKVYLAK-IKKS---GEQVALKEIEMSLLDEQAK-------SKAFE-EVQFLSSL--------QHPNIVAHRESFQDN--GKFYIAME
|.....||.||.|||| .. .|.    .|.|| | |. . .... .        . .. |.. .  |        .|||||   . |..     .|| ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YVDGGDLSDKISNRKT---------PFTEDEVLKIFIQICFALKYIHEKKVVHRDIKPQNVFLTHL------------GIVKLGDFGVARALEGT---QD
| .||||.. |...|.          ..|.|....|.||. ..|..|.....||||||||. ..              |..|..||| |. ..     |.
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

MCKTVI------GTPYYLSPEVWS----NQPYS-TKTDIWSLGCILYELCTLNRPFNGRSPQQLFAAIIRGHYNK-------------------VSTKYS
| .|        |||.| .|....    ..||.  |.||||||||.||. .   ||..  .....  ||.  .|.                    . . |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

AAIRKLIDSMLNPDANARPTAADILQLPFI
  .. ||  ||  | . | .  .... |..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 81132.m00056.AA Pkinase_Tyr 4-218 26 8.6e-38 128.61 Pfam 1-233 (270) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-233/270
Sequence Identity: 26% (63 aa)

YVIIKELGSGSYGKVYLAKIK----KSGEQVALKEIEMSLLDEQA--KSKAFEEVQFLSSL-QHPNIVAHRESFQ-DNGK--FYIAMEYVDGGDLSDKIS
 ...|.||.|..|.||... |    . . .|| | .     ....  . . ..|.. ...| .|||||        . .    || |||. .||| |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

NR---KTPFTEDEVLKIFIQICFALKYIHEKKVVHRDIKPQNVFLTHLGIVKLGDFGVARALEGTQDM-CKTV---IGTPYYLSPEVWSNQPYSTKTDIW
..   | |.|  . |.. .||. .. | ..|. .|||.   |. .|. ..|| .||| ||... .     |.    .  . . .||....  ..||.|.|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGKFTTKSDVW

SLGCILYELCTLN-RP-FNGRSPQQLFAAI-IRGH
| |  ..|..|.   | . | |.......|  .|.
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGY
Kinase 81132.m00056.AA TyrKc 4-255 22 4.4e-35 123.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

YVIIKELGSGSYGKVYLAKIKKSGEQVALKEIEMSLLDEQAKSKAFEEVQFLSSL--QHPNIVAHRESFQDN-------GKFYIAMEYVDGGDLSDKISN
 . .|.||.| .|.||... |   .||| | .  .      .    .| . ...|  .|||||.      .        .  .| |||...||| | . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RKTPFTEDEVLKIFIQICFALKYIHEKKVVHRDIKPQNVFLTHLGIVKLGDFGVARALEGT-------QDMCKTV-IGTP-----YYLSPEVWSNQPYST
..  .. .. |.. .||.    |.|.|...|||.   |. ... ..|| .||| .|...         .   |.   |.        ..||..    ..|
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KTDIWSLGCILYELCTL-NRPFNG-----RSPQQLFAAIIRGHYNKVSTK--------YSAAIRKLIDSMLNPDANARPTAADILQLP
|.|.|| |  ..|..|.   |  |      |.|.... . .|.. .             .... ... .  . |.. ||| ..| .. 
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF