Gene 81869.m00200 (T.vaginalis)

81869.m00200

Species: T.vaginalis
Alias: TvagK0755, 81869.m00200
External Links:
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
81869.m00200.AA Protein None 382 None Fasta, JSON
81869.m00200.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of 81869.m00200.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81869.m00200.AA GSK 16-300 42 1.4e-145 447.95 In-house 1-328 (328) Show / Hide 
Range on Protein: 16-300
Range on HMM: 1-328/328
Sequence Identity: 42% (141 aa)

YTIEKVIGEGAFGTVYLIYSL----ETGER----VALKKICEDTRYK-SRELETLQTI---HHPNCLTLIHHFVSESQSTKM--LYLN-LVTEYVPENLA
|.. |||| |.||.||  |      ||.|     || ||.  |.||| .|||. .. .   .|||. .|. .| .   ..    .|.| || ||.|..|.
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

GVERQYLAVGQTLPTFLVKLISYQLLRVLAYLHAKKICHRDIKPLNILLHPSNCHLKLCDFGSAKFIKT--NEQSISYITSRPYRAPELILGASHYDGAI
 | |.|   .|..|. ..||..||..| ||||| ..|||||||| |||. |..  ||.||||||| ...  || .|||| || |||||||.|...|. .|
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DIWSAGCVIAEMLLGQPLFNGESNPEQLLAIIHILGSPTHSQLVAMNPQCAQFDLP-----SLPPLPWKS-------------------AFRA--SADPL
|.||.|||.||||.||||| |.|   ||  || .||.||  |. .|||.. .|. |      . | ||.                     |..  . .. 
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD

AVDLVSKLCVYNPQNRLRGYVALLHPFF
..||.||. ||.|..||... |..||||
WIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 81869.m00200.AA CMGC 16-300 21 8.9e-103 338.63 In-house 1-513 (513) Show / Hide 
Range on Protein: 16-300
Range on HMM: 1-513/513
Sequence Identity: 21% (112 aa)

YTIEKVIGEGAFGTVYLIYS--------------LETGERVALKKICEDTRYKS----------------RELETLQTI-----------------HHPN
|.| |.||||..|.||  .                ||.|.||.||| ..  |.                 ||.. |. .                 ||.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CLTLIHHFVSESQSTK-----------MLYLNLVTEYVPENLAGVERQYL--AVG----------------------QTLPTFLVKLISYQLLRVLA--Y
...|. .|...   ..           . .|.||.||.. .|... ...     |                      . ..  ... ..||.|| |.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHAKK--ICHRDIKPLNILLHPSN-------------------CHLKLCDFGSAKFIKTN----------------------EQSISYITSRPYRAPELI
.| ..  |.|||.|| |||. . .                    .||.||||.|... ..                      ..  .|. .| |||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGASHYD---------GAIDIWSAGCVIAEMLLG--------QPLFNGESN-----------PEQLLAIIHILGSPT---------------HSQLVAMN
||..||.          .||.||.||..|||..|        .||| |.|.            .||  |. .||.||                 .   |.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PQCAQFD---------------------------LPSLPPLPWKSAFRA----------------------------------SADPLAVDLVSKLCVYN
.    .                            .|  || |||. |                                     .||.|.||..|. .|.
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PQNRLRGYVALLHPFF
|..|.    || ||.|
PDKRITAEQALQHPYF
Kinase 81869.m00200.AA S_TKc 16-300 27 5e-83 283.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-300
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

YTIEKVIGEGAFGTVYLIYSLETGERVALKKICEDTRYKSRELETLQTIHHPNCLTLIHHFVSESQSTKMLYLNLVTEYVPE---NLAGVERQYLAVG--
|.| ..||.||||.||. .  .||..||.|.|    .   ||.. |.  ||||  .|. .|..        .| .|.||..    .|  . ...   |  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QTLPTFLVKLISYQLLRVLAYLHAKKICHRDIKPLNILLHPSNCHLKLCDFGSAKFIKTNEQSISYITSRPYRAPELILGASHYDG-AIDIWSAGCVIAE
. .|   .. . ||... |.|.| ..|.|||.|| ||||     |.|.||||.|...       ... .. |.|||..    .|.. ..|.|| ||...|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MLLGQPLFNGESNPEQLLAIIHILGSPTHSQLVAMNPQCAQFDLPSLPPLPWKSAFRASADPLAVDLVSKLCVYNPQNRLRGYVALL-------HPFF
|| |.|.|       |. ......|                                   .| | |...|.....|..|.    ||        ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81869.m00200.AA Pkinase 16-300 27 8.6e-72 249.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-300
Range on HMM: 1-293/293
Sequence Identity: 27% (87 aa)

YTIEKVIGEGAFGTVYLIYSLETGERVALKKICEDTRYKSR--------ELETLQTIHHPNCLTLIHHFVSESQSTKMLYLNLVTEYVPE-----NLAGV
|.|...||.|.||.||. .   ||..||.|.|. ... ..         |.. .. ..||| ..|.. | .   ....    .|.||..       |.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY---MVMEYCEGGLYVMDLF--

ERQYLA--VGQTL--PTFLVKLISYQLLRVLAYLHAKKICHRDIKPLNILLHPSNCHL----KLCDFGSAKF--IKTNEQSISYITSRPYRAPELILGAS
   |.    . ..  .   .| . ||.|| |.|.|...|.|||.|| |||.. .|.|.    |.||||.||.  .  |.   ..  ...|.|||.|.|..
--DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ

HYDGAIDIWSAGCVIAEMLLGQPLFNGE----SNPEQLLAIIHILGSPTHSQLVAMNPQCAQFDLPSLPPLPWKSAFRASADPLAVDLVSKLCVYNPQNR
.|. ..|.||.||...|||.|.|.| |.    .  .|.  |  |.| |.|..    ..    | ..  .  .  . |   ... . |...... ..|. |
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKR

LRGYVALLHPFF
.    .| ||.|
PTAEQILQHPWF
Kinase 81869.m00200.AA CDK 16-300 29 1.9e-68 218.04 In-house 1-284 (284) Show / Hide 
Range on Protein: 16-300
Range on HMM: 1-284/284
Sequence Identity: 29% (95 aa)

YTIEKVIGEGAFGTVYLIYSLETG-----ERVALKKIC--------EDTRYKS---RELETLQTIHHPNCLTLIHHFVSESQSTKM-----LYLNLVTEY
| . . ||||..|.||   ...||     . ||||||         |..   .   ||  .|. . |||  .|.  ..... ..         | .| ||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VPENLAGVERQYLAVGQTLPTFLVKLISYQLLRVLAYLHAKKICHRDIKPLNILLHPSNC----HLKLCDFGSAKFIKT------NEQSIS-YITSRPYR
..  |... .             .| . .|||| |.|.| ..| |||.|| |||.    .    .||. ||| |.          . .  .  .  . ||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELILGASHYD--GAIDIWSAGCVIAEMLL---GQPLFNGESNPEQLLAIIHILGSPTHSQLVAMNPQCAQFDLPSLPPLPWKSAFRASADPLAVDLVS
|||| ||..||.   .||.||.||..|||..   ..||| |.|  .||  |. |.|.||      . | . .. .                     || .
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPT----EDNWPGVTKLPDY--------------------DLLN

KLCVYNPQNRLRGYVALLHPFF
|. .|.|..|.    || ||.|
KMLCYDPKKRISAEQALQHPYF
Kinase 81869.m00200.AA CDC2 16-300 30 4.1e-60 183.21 In-house 1-301 (301) Show / Hide 
Range on Protein: 16-300
Range on HMM: 1-301/301
Sequence Identity: 30% (94 aa)

YTIEKVIGEGAFGTVYLIYSLETGERVALKKICEDTRYKS--------RELETLQTIH-HPNCLTLIHHFVSESQSTKMLYLNLVTEYVPENLAGVERQY
|.  . |||| .| ||    ..|.. ||||||  ..            ||. .|. .  |||  .|   ...     . ||  .|.||.  .|    ...
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----NKLY--MVFEYLDMDLKKYMDMS

LAVGQTLPTFLVKLISYQLLRVLAYLHAKKICHRDIKPLNILLHPSNCHLKLCDFGSAKFIKTNEQSIS---YITSRPYRAPELILGASHYDGAIDIWSA
.  .. .|  ||| . ||.|. ....|...| |||.|| |||.  ..  .|. ||| |. . ..   .     .  . |||||. ||...|. ..|.|| 
IPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSI

GCVIAEM---LLGQPLFNGESNPEQLLAIIHILGSPTHSQLVAMNPQCA--QFDLPSLPPLPWKSAFRA--------SADPLAVDLVSKLCVYNPQNRLR
||..|||       ||| |.|  .||  |  |||.|. . .  .  |.   . . | ..|   .. .           .|| ..|| ... .|.||.|. 
GCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVT-QLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

GYVALLHPFF
   || ||.|
AKEALQHPYF
Kinase 81869.m00200.AA ERK7 16-300 35 3.8e-57 193.86 In-house 1-292 (292) Show / Hide 
Range on Protein: 16-300
Range on HMM: 1-292/292
Sequence Identity: 35% (107 aa)

YTIEKVIGEGAFGTVYLIYSLETGERVALKKICE------DTRYKSRELETLQTIH-HPNCLTLIHHFVSESQSTKMLYLNLVTEYVPENLAGVERQYLA
| |.| .| ||.| |   |   |.. ||||||        |     ||   || .| ||| . ||  .  .    . .|  || |.    |  | |.   
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADND--RDIY--LVFEFMETDLHAVIRK---

VGQTLPTFLVKLISYQLLRVLAYLHAKKICHRDIKPLNILLHPSNCHLKLCDFGSAKFIKTNE-------QSISYITSRPYRAPELILGASHYDGAIDIW
 |. |    .. | ||||| . |.|  .. |||.|| ||||  |.|..|.|||| |  |   |           |.  | |||||  ||. .|  ..| |
-GNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLD-SECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMW

SAGCVIAEMLLGQPLFNGESNPEQLLAIIHILGSPTHSQLVAMNPQCAQFDLPSLPPLPWKS--AFRASADPLAVDLVSKLCVYNPQNRLRGYVALLHPF
| ||...||| |.|.| | |  .|.  |..... ||.  . |.....|   | ...  . |.  ..  .. . |.||. .| |.||..||    || ||.
SIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPY

F
 
V
Kinase 81869.m00200.AA ERK 123-300 38 4.1e-50 172.81 In-house 115-307 (307) Show / Hide 
Range on Protein: 123-300
Range on HMM: 115-307/307
Sequence Identity: 38% (75 aa)

YQLLRVLAYLHAKKICHRDIKPLNILLHPSNCHLKLCDFGSAKFIKTNEQSI---------SYITSRPYRAPELILGASHYDGAIDIWSAGCVIAEMLLG
||.|. | |.|  .. |||.|| |||.  ||| || |||| | .. .  |..          |...|.|||||..| .. |. |.||||.|| .|||| .
YQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGR

QPLFNGESNPEQLLAIIHILGSP-THSQLVAM-NPQCAQF--DLPS--LPPLPWKSAF-RASADPLAVDLVSKLCVYNPQNRLRGYVALLHPFF
.||| |..  .|. .|. |.|.| .  .|    ...  ..   ||    || ||.. | .|.. |.|.|| .|. | .|. |.    .| ||.|
KPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase 81869.m00200.AA MAPK 118-300 35 4.3e-50 171.35 In-house 117-328 (328) Show / Hide 
Range on Protein: 118-300
Range on HMM: 117-328/328
Sequence Identity: 35% (76 aa)

VKLISYQLLRV--LAYLHAKKICHRDIKPLNILLHPSNCHLKLCDFGSAKFIKTN-----EQSIS----------YITSRPYRAPELILG--ASHYDGAI
.. . ||.||   | |.|   . |||.|| |||.  .|| ||.|||| |  | ..     .|             |.. | |||||..|.  . ||. |.
IQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAV

DIWSAGCVIAEMLL-GQPLFNGESNPEQLLAIIHILGSPTHSQLVAMN-PQCA-----QFD-LPSLPPLPWKSAFRA---SADPLAVDLVSKLCVYNPQN
|.||.||  ||||  ..||| |..  .|.  |. .||.|.   .  .  .. |     ..  ||  |. ||.. |      |.|.|.||..|. | .|. 
DMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDK

RLRGYVALLHPFF
|.    || ||.|
RITVEEALQHPYF
Kinase 81869.m00200.AA RCK 88-300 30 5.2e-45 140.57 In-house 75-298 (298) Show / Hide 
Range on Protein: 88-300
Range on HMM: 75-298/298
Sequence Identity: 30% (69 aa)

LNLVTEYVPENLAGVERQYLAVGQT-LPTFL--VKLISYQLLRVLAYLHAKKICHRDIKPLNILLHPS--------NCHLKLCDFGSAKFIKTNEQSISY
| .| ||. .||    . .   ... || .   .| | ||.| .||..| . . |||.|| ||.. .|        . |.|..|||... |  .     |
LYFVFEYMDMNLYQMMKDFKE-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDY

ITSRPYRAPELILGASHYDGAIDIWSAGCVIAEMLLGQPLFNGESNPEQLLAIIHILGSPTHSQLVAMNPQCAQ--FDLPSLPPLPWKSAFRASADPLAV
...| |||||..| . .|.  .|||. ||...|    .|||.| |   |.  |. ..|.|..  .     .. |  |..|. .. | |. .   . . ..
VSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN-CSQDCI

DLVSKLCVYNPQNRLRGYVALLHPFF
.|. |.. ..|| |   . || ||.|
ELMEKMLQWDPQKRITAQQALQHPYF
Kinase 81869.m00200.AA DYRK 113-238 42 9.1e-38 131.79 In-house 100-225 (320) Show / Hide 
Range on Protein: 113-238
Range on HMM: 100-225/320
Sequence Identity: 42% (55 aa)

LPTFLVKLISYQLLRVLAYLHAK-KICHRDIKPLNILLHP--SNCHLKLCDFGSAKFIKTNEQSISYITSRPYRAPELILGASHYDGAIDIWSAGCVIAE
..  ||. . .|.|  | .|| . .| | |.|| ||.|    ... .|..||||. |..   .  .|| || ||||| |||   |. |||.|| ||..||
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ--RIYTYIQSRFYRAPEVILGCP-YCYAIDMWSLGCILAE

MLLGQPLFNGESNPEQLLAIIHILGSPTH
...| ||| ||.. .||  |. .|| |..
LFTGWPLFPGENEYDQLACIMEVLGMPPK
Kinase 81869.m00200.AA MAPK-Unclassified 16-162 29 7.7e-22 75.37 In-house 1-154 (575) Show / Hide 
Range on Protein: 16-162
Range on HMM: 1-154/575
Sequence Identity: 29% (47 aa)

YTIEKVIGEGAFGTVYLIYSLET-GERVALKKIC------EDTRYKSRELETLQTIHHPNCLTLIHHFVSESQST---KMLYLNLVTEYVPE---NLAGV
|. .|.|| ||.| |.      . .  || ||.        |..   ||.  |  . ||| . .   |  .. .    . .|  .|..| .    .|   
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIY--IVMDYMQTSLFDL---

ERQYLAVGQ-TLPTFLVKLISYQLLRVLAYLHAKKICHRDIKPLNILLHPSNCHLKLCDFG
  | .   | ..   ... . ||.|| |.|||.  | ||| || |.|.   .| .. ||||
-HQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLIN-QDCSVRICDFG
Kinase 81869.m00200.AA MAPK-Unclassified 176-236 30 1.3e-18 63.48 In-house 408-499 (575) Show / Hide 
Range on Protein: 176-236
Range on HMM: 408-499/575
Sequence Identity: 30% (28 aa)

YITSRPYRAPELILGASHYDGAIDIWSAGCVIAEMLLG-----------QPLFNGES--------------------NPEQLLAIIHILGSP
|.  |.|||||..|  . || ..||||.||. |||..            .||| |..                       |.  |.  ||.|
YVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMP
Kinase 81869.m00200.AA TyrKc 16-300 21 5.5e-12 -28.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-300
Range on HMM: 1-280/280
Sequence Identity: 21% (70 aa)

YTIEKVIGEGAFGTVYL-IYSLETGERVALKKICEDTRYKS--RELETLQTI--HHPNCLTLIHHFVSESQSTKM---LYLNLVTEYVPENLAGVERQYL
 | .|..||||||.||. ...    . || |.. ||.  .   ||.. .  .  |||| . |.   ....          | .|.||.|    |  ..||
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPH---GDLKDYL

AVGQT-LPTFLVKLISYQLLRVLAYLHAKKICHRDIKPLNILLHPSNCHLKLCDFGSAKFIKTN----EQSISYIT-----SR---PYR--APELILGAS
   .  |..     ...|  .  .||| |.. |||.   |.|..  . . | .||| ...|.      | .  | .     ..   |.|  ||| |   .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG

HYDGAIDIWSAGCVIAEML-LGQPLFNGE----SNPEQLLAII---HILGSPTH----SQLVAMNPQCAQFDLPSLPPLPWKSAFRASADPLAVDLVSKL
 .  . |.|| | .. |.. .||.   |.     ....... .   . .  | .    |                         |    | .   . .. 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQ-IMKQC

CVYNPQNRLRGYVALLHPFF
. ..| .| .      | .|
WHEDPEDRPTFSEI--HECF
Kinase 81869.m00200.AA RCK 16-46 48 6e-10 27.45 In-house 1-31 (298) Show / Hide 
Range on Protein: 16-46
Range on HMM: 1-31/298
Sequence Identity: 48% (15 aa)

YTIEKVIGEGAFGTVYLIYSLETGERVALKK
|.| | .|.|..|.| .  ..|||| || ||
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKK
Kinase 81869.m00200.AA MAPK-Unclassified 257-300 24 9.7e-08 23.51 In-house 523-575 (575) Show / Hide 
Range on Protein: 257-300
Range on HMM: 523-575/575
Sequence Identity: 24% (13 aa)

PPLPWKSAFRASAD---------PLAVDLVSKLCVYNPQNRLRGYVALLHPFF
.|....... . |          ... |.|.|. ..||. |     ||.||.|
TPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 81869.m00200.AA MAPK 16-47 42 1.1e-07 22.47 In-house 1-38 (328) Show / Hide 
Range on Protein: 16-47
Range on HMM: 1-38/328
Sequence Identity: 42% (16 aa)

YTIEKVIGEGAFGTVYL-IYSL-----ETGERVALKKI
|.| | ||.||.|.|   |  .     ..|..||.|||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKI
Kinase 81869.m00200.AA Pkinase_Tyr 16-68 32 1.1e-05 19.94 Pfam 1-65 (270) Show / Hide 
Range on Protein: 16-68
Range on HMM: 1-65/270
Sequence Identity: 32% (21 aa)

YTIEKVIGEGAFGTVYLIYSL----ETGERVALKKICEDTRYKS-------RELETLQTI-HHPN
 |. |..||||||.||. .      .|.  || |.. |..  .        ||.... .. ||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPN
Kinase 81869.m00200.AA DYRK 260-300 26 4.4e-05 15.26 In-house 281-320 (320) Show / Hide 
Range on Protein: 260-300
Range on HMM: 281-320/320
Sequence Identity: 26% (11 aa)

PWKSAFRASADPLAVDLVSKLCVYNPQNRLRGYVALLHPFF
.|.....   | . .|.. |. ...|..|.  . || ||.|
NWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 81869.m00200.AA DYRK 16-45 43 0.000113 13.71 In-house 1-30 (320) Show / Hide 
Range on Protein: 16-45
Range on HMM: 1-30/320
Sequence Identity: 43% (13 aa)

YTIEKVIGEGAFGTVYLIYSLETGERVALK
|.| ..|| | || |   .   |.| ||.|
YEILEYIGKGSFGQVVKCWDHKTNEMVAIK
Kinase 81869.m00200.AA ERK 16-47 48 0.000137 13.23 In-house 1-37 (307) Show / Hide 
Range on Protein: 16-47
Range on HMM: 1-37/307
Sequence Identity: 48% (18 aa)

YTIEKVIGEGAFGTVYL-IYSL----ETGERVALKKI
| | | ||.||.|.|   |. .    |||..|| |||
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKI
Kinase 81869.m00200.AA Pkinase_Tyr 129-162 41 2.561849 1.7 Pfam 124-156 (270) Show / Hide 
Range on Protein: 129-162
Range on HMM: 124-156/270
Sequence Identity: 41% (14 aa)

LAYLHAKKICHRDIKPLNILLHPSNCHLKLCDFG
..||..|.. |||.   |.|.. .| . | ||||
MEYLESKNCIHRDLAARNCLVTENN-VVKICDFG