88728.m00082

Species: T.vaginalis
Alias: 88728.m00082, TvagK0542
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
88728.m00082.AA Protein None 328 None Fasta, JSON
88728.m00082.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of 88728.m00082.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88728.m00082.AA CAMKL 15-200 37 3.7e-72 229.54 In-house 1-225 (297) Show / Hide
Range on Protein: 15-200
Range on HMM: 1-225/297
Sequence Identity: 37% (84 aa)

YSLMKVIGTGGFAEVYLAINTKT-KEKVAIKIIK-RKITEDSFLIQY-----------IENELRMITRFD---HPNIVKVQDIIYTPEE------ILIIM
| . |..|.|.|..| ||....| .||||||||. .||..| .  .            |. | .   ...   ||||.|  ..|.|||       | ..|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYLPNGD--LQSFVDTK----TRTGQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKM--HPKIIDFGFCRE---K----SALLNTCCGTQPLM
|| ..|.  |. ... .     |    .  |. . |....||.|..||.|||||| ||..||..    |||||||. .   .      .|.|.||. | |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEIVMG--KTYDGLKADIWSYGVT
||||. |  | ||| |.|||| ||.
APEIFQGNNKPYDGPKVDIWSCGVI

S_TKc 88728.m00082.AA S_TKc 15-263 27 1e-69 238.85 SMART 1-231 (231) Show / Hide
Range on Protein: 15-263
Range on HMM: 1-231/231
Sequence Identity: 27% (74 aa)

YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQYIENELRMITRFDHPNIVKVQDIIYTPEEILIIMEYLPN--GDLQSFVDTKTR---
| ....|| |.|..||.....||...|||||||          . |..|...  . .||||||  |.... ... ..|||...  ||| .. . . |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---TGQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKMHPKIIDFGFCREKSALLNTCCGTQPLMAPEIVMGKTYDGLKADIWSYGVTIHIMAM
       .  ... .|.....|.|..|| |||.||.||..||  | ||.|||..|.     .|.|||   ||||..    |.. |.|.|| |... .|. 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

LALPFEFQGYSQFIHDVKNNSIKMCIKATGVIGWLVKNSLAYNAEERASCDDLLN---------YI
   ||.   . . .. ..            ..  .... | .. |.| .. ..|.         ..
GYPPFP--QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 88728.m00082.AA CAMK 20-204 21 7.3e-68 217.51 In-house 1-327 (425) Show / Hide
Range on Protein: 20-204
Range on HMM: 1-327/425
Sequence Identity: 21% (69 aa)

VIGTGGFAEVYLAINTKTK------------EKVAIKIIKRK-ITED------------------------SFLIQYIENELRMITR-------FDHPNI
..|.|.|..|.|.|...|.            .|||||||..| ....                         .  . ...|...  .        |||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKVQDIIYT-------------------PEEILIIM---EYLPNG----DLQSFVDTK---------------TRTGQTDQIRIATEILEGINYLHKRGI
.|  ... .                   .... ..|   || ..|    || ...  .                |    .  |.   |.....|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHRDIKPANIMFDEKM-----------------HPKIIDFGFCREKSA--------------------------LLNTCCGTQPLMA-PEIVMG------
.|||.|| ||..|...                   ||||||| ...                            ...|.||| . || ||.. |      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------KTYDGLKADIWSYGVTIHIM
       |.|.| |.|.|| ||   ||
QNATDEEKPYYGPKCDMWSCGVILYIM

Pkinase 88728.m00082.AA Pkinase 15-205 32 8e-67 233.11 Pfam 1-206 (293) Show / Hide
Range on Protein: 15-205
Range on HMM: 1-206/293
Sequence Identity: 32% (67 aa)

YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQYIE-NELRMITRFDHPNIVKVQDIIYTPEEILIIMEYLPNG----DLQSFVD--TK
| . ..|| |.|..||.... .| ..||.||||.. ........ .  .|...  |..|||||.  |. ... .| ..|||...|    || ...    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TRT--GQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKMHP----KIIDFGFC----REKSALLNTCCGTQPLMAPEIVMGKTYDGLKADIWSY
..      . ......||.|..|.|..|| |||.||.||..|...|.    ||.|||..      ..  ..| ||| . ||||...| .|.| |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVTIHIMA
|.....|.
GCILYEML

Kinase 88728.m00082.AA MARK 15-199 41 2.4e-66 215.9 In-house 1-194 (262) Show / Hide
Range on Protein: 15-199
Range on HMM: 1-194/262
Sequence Identity: 41% (81 aa)

YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQYIENELRMITRFDHPNIVKVQDIIY--TPEE-ILIIMEYLPNGDLQSFVDTK--TR
| . |.||.|..|.|.||....|..||||||....   |   .. .. |..   . |||||.|  ..|   |..  | .|||| ..|.| ...  .   |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

TGQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKM--HPKIIDFGFCREK--SALLNTCCGTQPLMAPEIVMGKTYDGLKADIWSYGV
    .  || . |....||.|...|.|||||| ||. ||..    |||||||...     .|||.||| | |||||. .| ||| |.|||| ||
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGV

Kinase 88728.m00082.AA Ciliate-E2 15-229 24 2.7e-55 188.27 In-house 1-306 (365) Show / Hide
Range on Protein: 15-229
Range on HMM: 1-306/365
Sequence Identity: 24% (79 aa)

YSLMKVIGTGGFAEVYLAINTKTKEK-----------------------VAIKIIKRKITEDSFLIQYIE----------NELRMITRFDHPNIVKVQDI
| . |.||.|.|. ||.. . |....                       .|.||.| .  |  . ...|           ||...  . .||||.|  . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IY--TPEEILIIMEYLPNGDLQSFV---DTKTRTGQT-------DQIR-IATEILE---------------GINYLHKRG-IAHRDIKPANIMFDEKMHP
 .  . . | ..|||.  |||...    ..|    ..        .|. | ..||.               ...|||... | |||||| ||.|     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIIDFGFCREKS----------------------------------ALLNTCCGTQPLMAPEIVMGKTYDG--------LKADIWSYGVTIHIMAMLALP
||||||.... .                                   . ||.||| . |||||..|| ||.         |.|||| ||....| .  .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEFQGYSQFIHDVKNNSIK
|        .   |.. |.
F--------QQQIKQCKID

Kinase 88728.m00082.AA ULK 15-218 29 3.7e-55 189.55 In-house 1-262 (329) Show / Hide
Range on Protein: 15-218
Range on HMM: 1-262/329
Sequence Identity: 29% (78 aa)

YSLMKVIGTGGFAEVYLAINTKTK----EKVAIKIIKRK-ITEDS------FLIQYIENELRMITRFD--------HPNIVKVQDIIYTPEE--ILIIME
|.| ...| | |. || ..| |||    ||||.|.| .. . ...      ...| ..|| . . . .        ||||||  |. .|. .  | ||||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YLPNGDLQSFVDTKTRTGQTD----------QIRIATEILEGINYLHKRGIAHRDIKPANIMFDEK------------MHPKIIDFGFCREKS------A
| . |||...  .. . . .            | .   ||.|  .|||..| ||||||.||. ...            .. || ||||..  .      .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LLNTCC------GTQPLMAPEIVM----GKTYDGLKADIWSYGVTIHIMAMLALPFEFQGYSQ
.. ||       ||   |||.|..    .| |.  |.|||| |. .. |     ||. . ...
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FND

Kinase 88728.m00082.AA ULK 15-218 28 6.7e-55 188.71 In-house 1-258 (324) Show / Hide
Range on Protein: 15-218
Range on HMM: 1-258/324
Sequence Identity: 28% (75 aa)

YSLMKVIGTGGFA-EVYLAINTKT---KEKVAIKIIKRK-ITEDSFL------IQYIENELRMITRFD---HPN--IVKVQDIIYTPEE--ILIIMEYLP
|.| ...| | |.  || ..| ||   ...||.|.| .| . ... .      .| ..|| . .  ..   |||  |||  |. .|. .  | ||||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGDLQSFVDTKTRTGQTD----------QIRIATEILEGINYLHKRGIAHRDIKPANIMFDEK------------MHPKIIDFGFCREKS------ALLN
 |||...  .. . .              | .   |..|  .|||..| ||||||.||.  ..             . || ||||..          .. 
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TCC------GTQPLMAPEIVM----GKTYDGLKADIWSYGVTIHIMAMLALPFEFQGYSQ
||.      ||   |||.|..    .| |.  |.|||| |. .. |     ||. . ...
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FND

Kinase 88728.m00082.AA Ciliate-E2-Unclassified 15-229 25 2.6e-53 183.27 In-house 1-304 (352) Show / Hide
Range on Protein: 15-229
Range on HMM: 1-304/352
Sequence Identity: 25% (76 aa)

YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQY----IENELRMITRF----------------DHPNIVKVQDIIY--TPEEILIIM
| . |.||.|||..||.... |.|.. |.|..| ..  .. .|..    . ....|  .                 .||....| .. .  . . | |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYLPNGDLQSFVD-------------TKTRTGQ---TDQIR------IATEILEGINYLHKRG-IAHRDIKPANIMFDEKM---HPKIIDFGFCRE----
||...|||. .                ......     |..      .. .||.|..|||. . | |||||| ||.||...   ..||||||....    
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------KSALLNTCCGTQPLM----APEIVMGKTYDG---LKADIWSYGVTIHIMAMLALPFEFQGYSQ----------------FIHDVKN
              |. ...|.|||   |    |||. .|. ||.    |.|||| || .. | .  .||. . . |                .. . |.
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

NSIK
. |.
KNIQ

Kinase 88728.m00082.AA TKL 21-263 20 2.9e-51 176.62 In-house 1-364 (364) Show / Hide
Range on Protein: 21-263
Range on HMM: 1-364/364
Sequence Identity: 20% (77 aa)

IGTGGFAEVYLAINTKTK--------EKVAIKIIKRK------------------------ITEDSFLIQYIENELRMITRFDHPNIVKVQDIIYTPEE-
|| |||.||| ..   .         . ||.|..|..                         .| |.. . .|.|..|. |..|||||.   .   |.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------ILIIMEYLPNGDLQSFVDTKTRTGQTDQIRIATEILEGINYLHK--------RGIAHRDIKPANIMFDEKMH--------------PK
            . |.||| |.|.| ...           .|.| .|  |.||||         ..|.|||.|..||. ||...              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IIDFGFCREKSA----------------------LLNTCCGTQPLMAPEIVMGKTYDG---------------LKADIWSYGVTIHIMAMLALPFEFQGY
| |||..|..|                        ..|.|||   ||||. .|....                 |.|..|.|. .  ..   .|.. ..|
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

S---------QFIHDVKNNSIKMCIK------------ATG--VIGWLVKNSLAYNAEERASCDDLLNYI
.         ...  | ... .  |.             .    .  | .   ....|.| |....| ..
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 88728.m00082.AA STE 15-201 28 2.7e-49 170.06 In-house 1-258 (359) Show / Hide
Range on Protein: 15-201
Range on HMM: 1-258/359
Sequence Identity: 28% (75 aa)

YSLMKVIGTGGFAEVYLAINT------KTKEK---------VAIKIIKRKITE--------------DSFLIQYIENELRMITRFD--HPNIVKVQDIIY
. ....|| |.| .||.|.|       ||.|.         .|||... .  .              ..  .| |..|...  ...  ||||||  .  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TP-------EEILIIMEYLPNGDLQSFVDTKTRTGQT-------------DQI-RIATEILEG-INYLHKRGIAHRDIKPANIMFDEKMHPKIIDFGFCR
         .|. |.|||...| | .....|  .|..             .|| .|. .||.|  .|||. .| |||||||||..      |..|||.| 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

EKSA-------------------LLNTCCGTQPLMAPEIVMG------KTYDGLKADIWSYGVTI
  .                      ||..||.  ||||....      | ||  |.|||| | ||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTI

Kinase 88728.m00082.AA QIK 15-211 35 8.3e-49 168.47 In-house 1-218 (272) Show / Hide
Range on Protein: 15-211
Range on HMM: 1-218/272
Sequence Identity: 35% (77 aa)

YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQYIENELRMITRFDHPNIVKVQDIIYTPEEILIIMEYLPNGDLQSFVDTKTR-----
| . . || | || | || .  ||.||||||| .   . . |.  .. |   . . .||.|.|  ... | . . |..|| .||..   .  . |     
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQK-CYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

---------------TGQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKMHPKIIDFGFC--REKSALLNTCCGTQPLMAPEIVMGKTYDGLKA
                   .  |. ..|. .. |.|||.|.|||.|  ||..|. |  ||.||||    .. .||.|.||. |  |||.  || ||| |.
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKV

DIWSYGVTIHIMAMLALPF
|||| ||   ..   ||||
DIWSMGVVLYVLVCGALPF

Kinase 88728.m00082.AA Pkinase_Tyr 15-139 27 7.4e-21 71.27 Pfam 1-137 (270) Show / Hide
Range on Protein: 15-139
Range on HMM: 1-137/270
Sequence Identity: 27% (38 aa)

YSLMKVIGTGGFAEVYLAINT----KTKEKVAIKIIKRKITEDSFLIQYIENELRMITRF-DHPNIVKVQDIIY-TPEE--ILIIMEYLPNGDLQSFVDT
 ...|..| | | |||... .    .|| .||.|..| . ...  ...   .|... . . .|||||.   ...   |   |.|.||| |.||| ..  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----KTRTGQTDQIRIATEILEGINYLHKRGIAHRDI
    | .    | . ....| .| .||. ... |||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

Kinase 88728.m00082.AA TyrKc 15-263 22 5.5e-20 73.63 SMART 1-280 (280) Show / Hide
Range on Protein: 15-263
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQYIENELRMITRF--DHPNIVKVQDIIYTP-------EEILIIMEYLPNGDLQSFV-
 .| |..| | | |||... .   ..||.| .|         .. . .|.|. ...  .|||||.   .. ..       | ..|.||| |.|||...  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DTKTRTGQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKMHPKIIDFGFCREKSAL--------LNTC----CGTQPL----MAPEIVMGKTYD
... .    | . ... | .| .|||.... |||.   |.. .|. . || ||| .|.              .     .|  .|    ||||  . ... 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

GLKADIWSYGVTIH-IMAMLALPFEF-----QGYSQFIHDVKNNSIKMCIKA---------TGVIGWLVKNSLAYNAEERASCDDLLNYI
  | |.||.||..  |.   . | .         .. |..||.    .. .          .  .  . |   ....|.| .  ..  ..
-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 88728.m00082.AA Pkinase_Tyr 177-201 40 0.86329 3.3 Pfam 181-204 (270) Show / Hide
Range on Protein: 177-201
Range on HMM: 181-204/270
Sequence Identity: 40% (10 aa)

MAPEIVMGKTYDGLKADIWSYGVTI
||||  . . .   | |.||.||..
MAPECINYGKFT-TKSDVWSFGVLM