Gene 88728.m00082 (T.vaginalis)
88728.m00082
Species: T.vaginalis
Alias: 88728.m00082, TvagK0542
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
88728.m00082.AA | Protein | None | 328 | None | Fasta, JSON |
88728.m00082.kin_dom | Protein Kinase Domain | None | 249 | None | Fasta, JSON |
Protein domains of 88728.m00082.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 88728.m00082.AA | CAMKL | 15-200 | 37 | 3.7e-72 | 229.54 | In-house | 1-225 (297) | Show / Hide |
Range on Protein: 15-200 Range on HMM: 1-225/297 Sequence Identity: 37% (84 aa) YSLMKVIGTGGFAEVYLAINTKT-KEKVAIKIIK-RKITEDSFLIQY-----------IENELRMITRFD---HPNIVKVQDIIYTPEE------ILIIM | . |..|.|.|..| ||....| .||||||||. .||..| . . |. | . ... ||||.| ..|.||| | ..| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM EYLPNGD--LQSFVDTK----TRTGQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKM--HPKIIDFGFCRE---K----SALLNTCCGTQPLM || ..|. |. ... . | . |. . |....||.|..||.|||||| ||..||.. |||||||. . . .|.|.||. | | EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM APEIVMG--KTYDGLKADIWSYGVT ||||. | | ||| |.|||| ||. APEIFQGNNKPYDGPKVDIWSCGVI |
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S_TKc | 88728.m00082.AA | S_TKc | 15-263 | 27 | 1e-69 | 238.85 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 15-263 Range on HMM: 1-231/231 Sequence Identity: 27% (74 aa) YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQYIENELRMITRFDHPNIVKVQDIIYTPEEILIIMEYLPN--GDLQSFVDTKTR--- | ....|| |.|..||.....||...||||||| . |..|... . .|||||| |.... ... ..|||... ||| .. . . | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---TGQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKMHPKIIDFGFCREKSALLNTCCGTQPLMAPEIVMGKTYDGLKADIWSYGVTIHIMAM . ... .|.....|.|..|| |||.||.||..|| | ||.|||..|. .|.||| ||||.. |.. |.|.|| |... .|. RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC LALPFEFQGYSQFIHDVKNNSIKMCIKATGVIGWLVKNSLAYNAEERASCDDLLN---------YI ||. . . .. .. .. .... | .. |.| .. ..|. .. GYPPFP--QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 88728.m00082.AA | CAMK | 20-204 | 21 | 7.3e-68 | 217.51 | In-house | 1-327 (425) | Show / Hide |
Range on Protein: 20-204 Range on HMM: 1-327/425 Sequence Identity: 21% (69 aa) VIGTGGFAEVYLAINTKTK------------EKVAIKIIKRK-ITED------------------------SFLIQYIENELRMITR-------FDHPNI ..|.|.|..|.|.|...|. .|||||||..| .... . . ...|... . ||||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKVQDIIYT-------------------PEEILIIM---EYLPNG----DLQSFVDTK---------------TRTGQTDQIRIATEILEGINYLHKRGI .| ... . .... ..| || ..| || ... . | . |. |.....|.|...| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI AHRDIKPANIMFDEKM-----------------HPKIIDFGFCREKSA--------------------------LLNTCCGTQPLMA-PEIVMG------ .|||.|| ||..|... ||||||| ... ...|.||| . || ||.. | VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM -------KTYDGLKADIWSYGVTIHIM |.|.| |.|.|| || || QNATDEEKPYYGPKCDMWSCGVILYIM |
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Pkinase | 88728.m00082.AA | Pkinase | 15-205 | 32 | 8e-67 | 233.11 | Pfam | 1-206 (293) | Show / Hide |
Range on Protein: 15-205 Range on HMM: 1-206/293 Sequence Identity: 32% (67 aa) YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQYIE-NELRMITRFDHPNIVKVQDIIYTPEEILIIMEYLPNG----DLQSFVD--TK | . ..|| |.|..||.... .| ..||.||||.. ........ . .|... |..|||||. |. ... .| ..|||...| || ... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH TRT--GQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKMHP----KIIDFGFC----REKSALLNTCCGTQPLMAPEIVMGKTYDGLKADIWSY .. . ......||.|..|.|..|| |||.||.||..|...|. ||.|||.. .. ..| ||| . ||||...| .|.| |.|.||. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVTIHIMA |.....|. GCILYEML |
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Kinase | 88728.m00082.AA | MARK | 15-199 | 41 | 2.4e-66 | 215.9 | In-house | 1-194 (262) | Show / Hide |
Range on Protein: 15-199 Range on HMM: 1-194/262 Sequence Identity: 41% (81 aa) YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQYIENELRMITRFDHPNIVKVQDIIY--TPEE-ILIIMEYLPNGDLQSFVDTK--TR | . |.||.|..|.|.||....|..||||||.... | .. .. |.. . |||||.| ..| |.. | .|||| ..|.| ... . | YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR TGQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKM--HPKIIDFGFCREK--SALLNTCCGTQPLMAPEIVMGKTYDGLKADIWSYGV . || . |....||.|...|.|||||| ||. ||.. |||||||... .|||.||| | |||||. .| ||| |.|||| || LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGV |
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Kinase | 88728.m00082.AA | Ciliate-E2 | 15-229 | 24 | 2.7e-55 | 188.27 | In-house | 1-306 (365) | Show / Hide |
Range on Protein: 15-229 Range on HMM: 1-306/365 Sequence Identity: 24% (79 aa) YSLMKVIGTGGFAEVYLAINTKTKEK-----------------------VAIKIIKRKITEDSFLIQYIE----------NELRMITRFDHPNIVKVQDI | . |.||.|.|. ||.. . |.... .|.||.| . | . ...| ||... . .||||.| . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IY--TPEEILIIMEYLPNGDLQSFV---DTKTRTGQT-------DQIR-IATEILE---------------GINYLHKRG-IAHRDIKPANIMFDEKMHP . . . | ..|||. |||... ..| .. .|. | ..||. ...|||... | |||||| ||.| . FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KIIDFGFCREKS----------------------------------ALLNTCCGTQPLMAPEIVMGKTYDG--------LKADIWSYGVTIHIMAMLALP ||||||.... . . ||.||| . |||||..|| ||. |.|||| ||....| . .| KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FEFQGYSQFIHDVKNNSIK | . |.. |. F--------QQQIKQCKID |
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Kinase | 88728.m00082.AA | ULK | 15-218 | 29 | 3.7e-55 | 189.55 | In-house | 1-262 (329) | Show / Hide |
Range on Protein: 15-218 Range on HMM: 1-262/329 Sequence Identity: 29% (78 aa) YSLMKVIGTGGFAEVYLAINTKTK----EKVAIKIIKRK-ITEDS------FLIQYIENELRMITRFD--------HPNIVKVQDIIYTPEE--ILIIME |.| ...| | |. || ..| ||| ||||.|.| .. . ... ...| ..|| . . . . |||||| |. .|. . | |||| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME YLPNGDLQSFVDTKTRTGQTD----------QIRIATEILEGINYLHKRGIAHRDIKPANIMFDEK------------MHPKIIDFGFCREKS------A | . |||... .. . . . | . ||.| .|||..| ||||||.||. ... .. || ||||.. . . YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ LLNTCC------GTQPLMAPEIVM----GKTYDGLKADIWSYGVTIHIMAMLALPFEFQGYSQ .. || || |||.|.. .| |. |.|||| |. .. | ||. . ... MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FND |
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Kinase | 88728.m00082.AA | ULK | 15-218 | 28 | 6.7e-55 | 188.71 | In-house | 1-258 (324) | Show / Hide |
Range on Protein: 15-218 Range on HMM: 1-258/324 Sequence Identity: 28% (75 aa) YSLMKVIGTGGFA-EVYLAINTKT---KEKVAIKIIKRK-ITEDSFL------IQYIENELRMITRFD---HPN--IVKVQDIIYTPEE--ILIIMEYLP |.| ...| | |. || ..| || ...||.|.| .| . ... . .| ..|| . . .. ||| ||| |. .|. . | ||||| . YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN NGDLQSFVDTKTRTGQTD----------QIRIATEILEGINYLHKRGIAHRDIKPANIMFDEK------------MHPKIIDFGFCREKS------ALLN |||... .. . . | . |..| .|||..| ||||||.||. .. . || ||||.. .. GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ TCC------GTQPLMAPEIVM----GKTYDGLKADIWSYGVTIHIMAMLALPFEFQGYSQ ||. || |||.|.. .| |. |.|||| |. .. | ||. . ... TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FND |
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Kinase | 88728.m00082.AA | Ciliate-E2-Unclassified | 15-229 | 25 | 2.6e-53 | 183.27 | In-house | 1-304 (352) | Show / Hide |
Range on Protein: 15-229 Range on HMM: 1-304/352 Sequence Identity: 25% (76 aa) YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQY----IENELRMITRF----------------DHPNIVKVQDIIY--TPEEILIIM | . |.||.|||..||.... |.|.. |.|..| .. .. .|.. . ....| . .||....| .. . . . | |.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM EYLPNGDLQSFVD-------------TKTRTGQ---TDQIR------IATEILEGINYLHKRG-IAHRDIKPANIMFDEKM---HPKIIDFGFCRE---- ||...|||. . ...... |.. .. .||.|..|||. . | |||||| ||.||... ..||||||.... EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN --------------KSALLNTCCGTQPLM----APEIVMGKTYDG---LKADIWSYGVTIHIMAMLALPFEFQGYSQ----------------FIHDVKN |. ...|.||| | |||. .|. ||. |.|||| || .. | . .||. . . | .. . |. NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ NSIK . |. KNIQ |
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Kinase | 88728.m00082.AA | TKL | 21-263 | 20 | 2.9e-51 | 176.62 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 21-263 Range on HMM: 1-364/364 Sequence Identity: 20% (77 aa) IGTGGFAEVYLAINTKTK--------EKVAIKIIKRK------------------------ITEDSFLIQYIENELRMITRFDHPNIVKVQDIIYTPEE- || |||.||| .. . . ||.|..|.. .| |.. . .|.|..|. |..|||||. . |. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------ILIIMEYLPNGDLQSFVDTKTRTGQTDQIRIATEILEGINYLHK--------RGIAHRDIKPANIMFDEKMH--------------PK . |.||| |.|.| ... .|.| .| |.|||| ..|.|||.|..||. ||... .| CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK IIDFGFCREKSA----------------------LLNTCCGTQPLMAPEIVMGKTYDG---------------LKADIWSYGVTIHIMAMLALPFEFQGY | |||..|..| ..|.||| ||||. .|.... |.|..|.|. . .. .|.. ..| ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY S---------QFIHDVKNNSIKMCIK------------ATG--VIGWLVKNSLAYNAEERASCDDLLNYI . ... | ... . |. . . | . ....|.| |....| .. MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 88728.m00082.AA | STE | 15-201 | 28 | 2.7e-49 | 170.06 | In-house | 1-258 (359) | Show / Hide |
Range on Protein: 15-201 Range on HMM: 1-258/359 Sequence Identity: 28% (75 aa) YSLMKVIGTGGFAEVYLAINT------KTKEK---------VAIKIIKRKITE--------------DSFLIQYIENELRMITRFD--HPNIVKVQDIIY . ....|| |.| .||.|.| ||.|. .|||... . . .. .| |..|... ... |||||| . . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF TP-------EEILIIMEYLPNGDLQSFVDTKTRTGQT-------------DQI-RIATEILEG-INYLHKRGIAHRDIKPANIMFDEKMHPKIIDFGFCR .|. |.|||...| | .....| .|.. .|| .|. .||.| .|||. .| |||||||||.. |..|||.| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG EKSA-------------------LLNTCCGTQPLMAPEIVMG------KTYDGLKADIWSYGVTI . ||..||. ||||.... | || |.|||| | || QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTI |
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Kinase | 88728.m00082.AA | QIK | 15-211 | 35 | 8.3e-49 | 168.47 | In-house | 1-218 (272) | Show / Hide |
Range on Protein: 15-211 Range on HMM: 1-218/272 Sequence Identity: 35% (77 aa) YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQYIENELRMITRFDHPNIVKVQDIIYTPEEILIIMEYLPNGDLQSFVDTKTR----- | . . || | || | || . ||.||||||| . . . |. .. | . . .||.|.| ... | . . |..|| .||.. . . | YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQK-CYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM ---------------TGQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKMHPKIIDFGFC--REKSALLNTCCGTQPLMAPEIVMGKTYDGLKA . |. ..|. .. |.|||.|.|||.| ||..|. | ||.|||| .. .||.|.||. | |||. || ||| |. VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKV DIWSYGVTIHIMAMLALPF |||| || .. |||| DIWSMGVVLYVLVCGALPF |
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Kinase | 88728.m00082.AA | Pkinase_Tyr | 15-139 | 27 | 7.4e-21 | 71.27 | Pfam | 1-137 (270) | Show / Hide |
Range on Protein: 15-139 Range on HMM: 1-137/270 Sequence Identity: 27% (38 aa) YSLMKVIGTGGFAEVYLAINT----KTKEKVAIKIIKRKITEDSFLIQYIENELRMITRF-DHPNIVKVQDIIY-TPEE--ILIIMEYLPNGDLQSFVDT ...|..| | | |||... . .|| .||.|..| . ... ... .|... . . .|||||. ... | |.|.||| |.||| .. . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK ----KTRTGQTDQIRIATEILEGINYLHKRGIAHRDI | . | . ....| .| .||. ... |||. HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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Kinase | 88728.m00082.AA | TyrKc | 15-263 | 22 | 5.5e-20 | 73.63 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 15-263 Range on HMM: 1-280/280 Sequence Identity: 22% (65 aa) YSLMKVIGTGGFAEVYLAINTKTKEKVAIKIIKRKITEDSFLIQYIENELRMITRF--DHPNIVKVQDIIYTP-------EEILIIMEYLPNGDLQSFV- .| |..| | | |||... . ..||.| .| .. . .|.|. ... .|||||. .. .. | ..|.||| |.|||... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR DTKTRTGQTDQIRIATEILEGINYLHKRGIAHRDIKPANIMFDEKMHPKIIDFGFCREKSAL--------LNTC----CGTQPL----MAPEIVMGKTYD ... . | . ... | .| .|||.... |||. |.. .|. . || ||| .|. . .| .| |||| . ... KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT GLKADIWSYGVTIH-IMAMLALPFEF-----QGYSQFIHDVKNNSIKMCIKA---------TGVIGWLVKNSLAYNAEERASCDDLLNYI | |.||.||.. |. . | . .. |..||. .. . . . . | ....|.| . .. .. -TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 88728.m00082.AA | Pkinase_Tyr | 177-201 | 40 | 0.86329 | 3.3 | Pfam | 181-204 (270) | Show / Hide |
Range on Protein: 177-201 Range on HMM: 181-204/270 Sequence Identity: 40% (10 aa) MAPEIVMGKTYDGLKADIWSYGVTI |||| . . . | |.||.||.. MAPECINYGKFT-TKSDVWSFGVLM |