Gene 84685.m00003 (T.vaginalis)

84685.m00003

Species: T.vaginalis
Alias: 84685.m00003, TvagK0585
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK5

Sequence

Name Sequence Type Origin Length Description Download
84685.m00003.AA Protein None 299 None Fasta, JSON
84685.m00003.kin_dom Protein Kinase Domain None 280 None Fasta, JSON

Protein domain

Protein domains of 84685.m00003.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84685.m00003.AA CMGC 5-284 21 6.30000000001e-104 342.47 In-house 1-513 (513) Show / Hide 
Range on Protein: 5-284
Range on HMM: 1-513/513
Sequence Identity: 21% (113 aa)

YNIVGQIHRGSSGIVYKATD--------------SKTNETVALKVVK---MDQ------EEDGVTVSSMREVNALRNMS-----------------HPNI
| |...| .|. |.|||..|               .||| ||.| .|   ..       |.||.  .. ||.  |....                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

ITLREVTTENE-----------------QLLIVYEFMDKDLRDFLTKSRK--------PLDNSL------------LQSYS------YQLLSGIN--YIH
..|... . ..                 .| .| |.||.|| ... . ..        ||.                ....      ||.| |..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SIG--FIHQQIEPSNILINRQGLL--------------------KISGFGKSRTYHHP---------------------MTRNILAIPVIWYMAPELLIE
| .  .||  . |.||||| .. |                    ||  || .| ||..                     .  .   .   || |||.|. 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

T---------DYYGLGIDVWSAGCIIAEMVRG--------NVLFPGDSP-----------VDQIVHICKALGTPS---------------KEDWPEFQS-
          ..|. .||.||.|||.|||..|          ||||.|            .||. .|.| ||||.               .|.||.. . 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

-----------------ALSDD----------ITLPQAENFASYFQN-----------------------------------INPDLLDLLQKLLTMNPS
                  .|..             ..  .. . | .                                   ..|...|||.|.|...|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRITANEALQHPYF
||||| .|||||||
KRITAEQALQHPYF
Kinase 84685.m00003.AA CDK 5-284 34 4.2e-99 317.72 In-house 1-284 (284) Show / Hide 
Range on Protein: 5-284
Range on HMM: 1-284/284
Sequence Identity: 34% (108 aa)

YNIVGQIHRGSSGIVYKATDSKTN-----ETVALKVVKMDQ-----EEDGVTVSSMREVNALRNMSHPNIITLREVTTEN-----------EQLLIVYEF
| .. .| .|. |.|||| | .|.     . |||| ..|..     |..|.  .. ||.. |... ||||..|..| . .             | .| |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MDKDLRDFLTKSRKPLDNSLLQSYSYQLLSGINYIHSIGFIHQQIEPSNILINRQGL-----LKISGFGKSRTYHHPMT----RNILAIPVI--WYMAPE
|| ||  ..            ..| .|||.|..|.|| ...|  . |.|||||..|      |||  || .| .. |      .. .   |.  || |||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLIETDYYG--LGIDVWSAGCIIAEMVR---GNVLFPGDSPVDQIVHICKALGTPSKEDWPEFQSALSDDITLPQAENFASYFQNINPDLLDLLQKLLTM
||  .  |.   .||.||.|||.|||..   .  ||||||  ||. .|.. .|||. ..||.. . | |                      |||.|.|..
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGV-TKLPDY---------------------DLLNKMLCY

NPSKRITANEALQHPYF
.|.|||.| .|||||||
DPKKRISAEQALQHPYF
Kinase 84685.m00003.AA CDC2 5-284 35 1.3e-91 281.82 In-house 1-301 (301) Show / Hide 
Range on Protein: 5-284
Range on HMM: 1-301/301
Sequence Identity: 35% (108 aa)

YNIVGQIHRGSSGIVYKATDSKTNETVALKVVKMDQEEDG--VTVSSMREVNALRNMS-HPNIITLREVTTENEQLLIVYEFMDKDLRDFLT---KSRKP
|  .  |  |. |.|||. | .||. |||| .. .||..|  |  ...||   | ..  ||||..|..|  .   | .| |..| ||. ..    ...|.
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LDNSLLQSYSYQLLSGINYIHSIGFIHQQIEPSNILINRQGLLKISGFGKSRTYHHPMTRNIL---AIPVIWYMAPELLIETDYYGLGIDVWSAGCIIAE
.. .|..|| ||.|.|... |. . .|  . |.||||...| .||. || .|.   |. |...    .   || |||.|    .| ...|.|| |||.||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPI-RTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAE

M---VRGNVLFPGDSPVDQIVHICKALGTPSKEDWPEFQSALSDDITLPQ--AENFASYFQN---------INPDLLDLLQKLLTMNPSKRITANEALQH
|   |    ||.|||  ||.  | . ||||. ..||.  .      | |.  . .. ... |         ..|. .|||...|  .|.|||.| |||||
MFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

PYF
|||
PYF
Kinase 84685.m00003.AA CDK7 5-284 34 2.3e-89 238.09 In-house 1-288 (288) Show / Hide 
Range on Protein: 5-284
Range on HMM: 1-288/288
Sequence Identity: 34% (100 aa)

YNIVGQIHRGSSGIVYKATDSKTNETVALKVVK----MDQEEDGVTVSSMREVNALRNMSHPNIITLREVTTENEQLLIVYEFMDKDLRDFLTKSRKPLD
|... .|  |  . ||||.| .|.. || | .|     .. .||.  . .||.  |. |.|.|.| |. .      .  |..||| ||      .   | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

NSLLQSYSYQLLSGINYIHSIGFIHQQIEPSNILINRQGLLKISGFGKSRTYHHPMTRNILAIPVIWYMAPELLIETDYYGLGIDVWSAGCIIAEMVRGN
 .   .|  ..| |. | |     |  . | | |.|  | |||  ||  | |  |       .  .|| |||||     || |.|.|| |||.||    .
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

VLFPGDSPVDQIVHICKALGTPSKEDWPEFQSALSDDITL-PQAE----NFASYFQNINPDLLDLLQKLLTMNPSKRITANEALQHPYF
  .|||| .||.. |...||||. |.||.  ... | |.. .. .     .  .|     |||||.....||||.||.|. ..|..|||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNM-CCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 84685.m00003.AA CDK5 5-284 35 1.5e-83 263.83 In-house 1-287 (287) Show / Hide 
Range on Protein: 5-284
Range on HMM: 1-287/287
Sequence Identity: 35% (102 aa)

YNIVGQIHRGSSGIVYKATDSKTNETVALKVVKMDQEEDGVTVSSMREVNALRNMSHPNIITLREVTTENEQLLIVYEFMDKDLRDFLTKSRKPLDNSLL
|. .  |  |  |.|||| . .| | |||| |..|.|  ||  . .||.  |. . |.||. |  |   .  | .|.||.|.||. .. .    .|  . 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

QSYSYQLLSGINYIHSIGFIHQQIEPSNILINRQGLLKISGFGKSRTYHHPMTRNILAIPVIWYMAPELLIETDYYGLGIDVWSAGCIIAEMV-RGNVLF
.|. |||| |. . |.    |    | | |||..| ||   ||  | .  |       .   || .|  |.    |   ||.||.|||.|||.  |  ||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGDSPVDQIVHICKALGTPSKEDWP------EFQSALSDDITLPQAENFASYFQNINPDLLDLLQKLLTMNPSKRITANEALQHPYF
|| .  ||   | | .|||. . ||      ...    .    |  . ...  .. .  ..|||||.| .|| .||.|..||.||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 84685.m00003.AA Pkinase 5-284 30 7.4e-78 269.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 5-284
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

YNIVGQIHRGSSGIVYKATDSKTNETVALKVVKMDQEEDGVTVSSMR--EVNALRNMSHPNIITLREVTTENEQLLIVYEFMDK-----DLRDFLT-KSR
| |...| .||.| |||... .|...||.|..| . |.... ..  |  |.  .....||||..|... ...  . .| |....     || |... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KPL--DNSLLQSYSYQLLSGINYIHSIGFIHQQIEPSNILINRQGLL----KISGFGKSR---TYHHPMTRNILAIPVIWYMAPELLIETDYYGLGIDVW
...  .   ...| ||.|.|..|.|| |.||  . |.||||...| .    ||. || ..   . . . .  .     .||||||.. .  |||  .|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG--TPWYMAPEVIRGGQYYGPKVDMW

SAGCIIAEMVRGNVLFPGD----SPVDQIVHICKALGTPSKEDWPEFQS-ALSDDITLPQAENFASYFQNINPDLLDLLQKLLTMNPSKRITANEALQHP
|.|||..||. |. .|||.    . .||.. ||. .|.| ..|||.  |  ..  ..  . .  .. | |......|.. ..|...|.||.|| ..||||
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase 84685.m00003.AA PITSLRE 5-284 34 8.2e-75 254.85 In-house 1-295 (295) Show / Hide 
Range on Protein: 5-284
Range on HMM: 1-295/295
Sequence Identity: 34% (101 aa)

YNIVGQIHRGSSGIVYKATDSKTNETVALKVVKMD--QEEDGVTVSSMREVN-ALRNMSHPNIITLREVT--TENEQLLIVYEFMDKDLRDFLTKSR---
. .. .|| |  |.||.| | .|.| |||| .||.  .| .|  . |.||.|  |. . ||||....|.   .      .| |... ||.. . . .   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

KPLDNSLLQSYSYQLLSGINYIHSIGFIHQQIEPSNILINRQGLLKISGFGKSRTYHHPMTRNILAIPVIWYMAPELLIETDYYGLGIDVWSAGCIIAEM
.|   .   .   |||.|. . |.   .|     ||.|.. .| |||  ||  | |  |.    . .   || ||||| ... |   .|.|| ||| ||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

VRGNVLFPGDSPVDQIVHICKALGTPSKEDWPEFQS-----ALSDDITLPQAENFASYFQ---NINPDLLDLLQKLLTMNPSKRITANEALQHPYF
. . .||.|.| .|||  | |..|||.   || ...     .. ..   |   |  . |.    |.   .|||...|| || .|||| .||.||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYP-YNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 84685.m00003.AA MAPK 5-284 33 9.4e-75 254.65 In-house 1-328 (328) Show / Hide 
Range on Protein: 5-284
Range on HMM: 1-328/328
Sequence Identity: 33% (111 aa)

YNIVGQIHRGSSGIVYKATDSK------TNETVALKVVK-MDQEEDGVTVSSMREVNALRNM-SHPNIITLREVTTEN-----------EQLLIVYEFMD
|.|. .|  |. |.| .|.| .      ....||.| .    | .        ||.  || .  |.||| |... |             ... || |.|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK-RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELME

KDLRDFLTKSRKPLDNSLLQSYSYQLLSG--INYIHSIGFIHQQIEPSNILINRQGLLKISGFGKSR----TYHHP-------------MTRNILAIPVI
 ||.  .   . ||..   |.  ||.| |  . |||| . ||  . |||||.|  ..|||  || .|    .|||.             || ..      
TDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVAT---R

WYMAPELLIE--TDYYGLGIDVWSAGCIIAEMVR-GNVLFPGDSPVDQIVHICKALGTPSKEDWPEFQ-S-ALSDDIT-L-----PQAENFASYFQN---
|| |||..    .. |  ..|.||.||| |||.. . .||||....||. .| . |||||.|..   . | .  . |  |     ... .... | |   
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

-INPDLLDLLQKLLTMNPSKRITANEALQHPYF
  ||. .|||.|.|...|.||||. ||||||||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 84685.m00003.AA S_TKc 5-284 28 6.2e-72 246.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 5-284
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

YNIVGQIHRGSSGIVYKATDSKTNETVALKVVKMDQEEDGVTVSSMREVNALRNMSHPNIITLREVTTENEQLLIVYEFMDK---DLRDFLTKSRKP---
| |. .| .|. | |||... ||.. ||.|..|          . .||.. |..  ||||..| .|  . . | .| |..|    ||.|.. | ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDNSLLQSYSYQLLSGINYIHSIGFIHQQIEPSNILINRQGLLKISGFGKSRTYHHPMTRNILAIPVIWYMAPELLIETDYYGL-GIDVWSAGCIIAE
  ..    ..| ||......|.|| |.||  . |.|||...   .||. || .| .          .   ||||||.|     ||   .|.|| |||..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MVRGNVLFPGDSPVDQIVHICKALGTPSKEDWPEFQSALSDDITLPQAENFASYFQNINPDLLDLLQKLLTMNPSKRITANEALQ-------HPYF
|. |  .||    .... ....                                     |...|...|.|...|.||.|| ||||       ||.|
MLCGYPPFP---QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 84685.m00003.AA GSK 170-284 32 5.7e-48 144.25 In-house 186-328 (328) Show / Hide 
Range on Protein: 170-284
Range on HMM: 186-328/328
Sequence Identity: 32% (47 aa)

APELLIETDYYGLGIDVWSAGCIIAEMVRGNVLFPGDSPVDQIVHICKALGTPSKEDWPEFQSAL--SDDI-----TLPQ--------------------
||||..   .|.  |||||.||..|||. | .|||||| |||.| |.|.||||.||. ...       ..      ..                      
APELIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKY

-AENFASYFQNINPDLLDLLQKLLTMNPSKRITANEALQHPYF
 . ..  .......|..||. |.|...|.||... ||..||.|
RTVYMFKWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 84685.m00003.AA RCK 167-284 43 8.2e-45 139.94 In-house 178-298 (298) Show / Hide 
Range on Protein: 167-284
Range on HMM: 178-298/298
Sequence Identity: 43% (53 aa)

WYMAPELLIETDYYGLGIDVWSAGCIIAEMVRGNVLFPGDSPVDQIVHICKALGTPSKEDWPEFQ-SALSDDITLPQ--AENFASYFQNINPDLLDLLQK
|| |||.|    ||   .|.|. |||..|    . |||| | .|||  ||| .|||.|.|||...  | .  ...||  . .  ... |...|...|..|
WYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEK

LLTMNPSKRITANEALQHPYF
.|. .|.|||||..|||||||
MLQWDPQKRITAQQALQHPYF
Kinase 84685.m00003.AA CDKL 167-284 35 1.1e-35 119.54 In-house 164-286 (286) Show / Hide 
Range on Protein: 167-284
Range on HMM: 164-286/286
Sequence Identity: 35% (44 aa)

WYMAPELLIETDYYGLGIDVWSAGCIIAEMVRGNVLFPGDSPVDQIVHICKALGTPSKEDWPEFQSA-LSDDITLPQAENFASY---FQNIN-PDLLDLL
|| |||||.    ||  .|.|..||..|||..|. |.||.| .||  || | ||.   .    | .  .  ....|. |.. .    ..|.. . .||..
WYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFM

QKLLTMNPSKRITANEALQHPYF
.|.| |.|..|.|. ....||||
KKCLHMDPDERMTCEQLMHHPYF
Kinase 84685.m00003.AA CDKL 5-147 32 3.4e-31 103.91 In-house 1-144 (286) Show / Hide 
Range on Protein: 5-147
Range on HMM: 1-144/286
Sequence Identity: 32% (47 aa)

YNIVGQIHRGSSGIVYKATDSKTNETVALKVVKMDQEEDGVTVSSMREVNALRNMSHPNIITLREVTTENEQLLIVYEFMDKDLRDFLTKSRKPLDNSLL
| . | .  || | |.|  .  |.. || |  |  ...  |    |||.  |... |.||  |.||   .  | .| |..|. . . | .  . .| ...
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

QSYSYQLLSGINYIHSIGFIHQQIEPSNILIN-RQGLLKISGFG
..| .|.|..||. |.   ||. | | ||||. ..| .|. .||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFG
Kinase 84685.m00003.AA RCK 5-150 33 7.8e-31 94.85 In-house 1-162 (298) Show / Hide 
Range on Protein: 5-150
Range on HMM: 1-162/298
Sequence Identity: 33% (54 aa)

YNIVGQIHRGSSGIVYKATDSKTNETVALKVVKMDQEEDGVTVSSMREVNALRNMS-HPNIITLREVTTENE--QLLIVYEFMDKDLRDFLTK---SRKP
|.|. |. .|. | | || . .|.| || |  |    ..   . . ||. .|| .. ||||| |.||  .|.  || .| |.||..|  ..     .||.
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

LDNSL--LQSYSYQLLSGINYIHSIGFIHQQIEPSNILINR---------QGLLKISGFGKSR
|  .   . .. ||.| |....|. || |  . | ||...          |...||  || .|
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCR
Kinase 84685.m00003.AA GSK 5-147 28 1.7e-28 83.63 In-house 1-162 (328) Show / Hide 
Range on Protein: 5-147
Range on HMM: 1-162/328
Sequence Identity: 28% (48 aa)

YNIVGQIHRGSSGIVYKATDS----KTNET----VALKVVKMDQEEDGVTVSSMREVNALRNM---SHPNIITL-----REVTTENE---QLL-IVYEFM
| .  .| .|| | ||.|...     |.|.    || | |  |..         ||.  ....    ||||..|     .  ... |    .. .| |.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYK-----CNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYM

DKDLRDFLT---KSRKPLDNSLLQSYSYQLLSGINYIHSIGFIHQQIEPSNILIN-RQGLLKISGFG
 ..| ...    |....... ..  |.||.. |..|.||.|  |  | |.|||.. . | |||. ||
PQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFG
Kinase 84685.m00003.AA Pkinase_Tyr 13-125 31 4.3e-15 51.73 Pfam 9-134 (270) Show / Hide 
Range on Protein: 13-125
Range on HMM: 9-134/270
Sequence Identity: 31% (41 aa)

RGSSGIVYKATDS----KTNETVALKVVKMDQEEDGVTVSS------MREVNALRNM-SHPNIITLREVTT-ENEQ--LLIVYEFMDK-DLRDFLTKS--
.|. | |||.|      .|. .|| |..|      | . .       |||.. .... .||||. |  | | . |.  ..|| |.| . ||.|.| |   
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRE

-RKPLDNSLLQSYSYQLLSGINYIHSIGFIH
 ..||. . | ....|  .| .| .|...||
DKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
Kinase 84685.m00003.AA TyrKc 5-284 24 2.8e-14 8.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 5-284
Range on HMM: 1-280/280
Sequence Identity: 24% (77 aa)

YNIVGQIHRGSSGIVYKATDSKTNETVALKVVKMDQEEDGVTVSSMREVNALRNM--SHPNIITLREVTTEN-------EQLLIVYEFMDK-DLRDFLTK
     .. .|  |.|||.| .   ..|| |..| |          ||| . ...   .||||. |  | |.        |.|.|| |.|.. ||.|.| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SRKPLDNSLLQSYSYQLLSGINYIHSIGFIHQQIEPSNILINRQGLLKISGFGKSRTYHHP--------MTRN----ILA--IPVIWYMAPELLIETDYY
.|. | .. | |...|  .| .|.|| ..||  .   |.|.....  ||| || ||  ..         . |          .|. | |||| .  .  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW-MAPECI-NYGKF

GLGIDVWSAGCIIAEMV-RGNVLFPGD----SPVDQIVHICKALGTPSKEDWPEFQSALSDDITLPQAENFASYFQNINPDLLDLLQKLLTMNPSKRITA
    |||| |  . |.  .|    ||.     . .....  |. . . . . ..    .|              |    ... .. ..    .|..| | 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS--------------FVCCPDEMYQIMKQCWHEDPEDRPTF

NEALQHPYF
.|   | .|
SEI--HECF