Gene 90528.m00075 (T.vaginalis)

90528.m00075

Species: T.vaginalis
Alias: TvagK0598, 90528.m00075
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
90528.m00075.AA Protein None 357 None Fasta, JSON
90528.m00075.kin_dom Protein Kinase Domain None 290 None Fasta, JSON

Protein domain

Protein domains of 90528.m00075.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 90528.m00075.AA MAPK 21-310 43 6.00000000001e-147 494.49 In-house 1-328 (328) Show / Hide 
Range on Protein: 21-310
Range on HMM: 1-328/328
Sequence Identity: 43% (142 aa)

YKVLNIIGRGSYGVVLLAIDNQ------TGKHVALKQLQRIFTTVTDAKRVLREIRILSSL-NNENITNITDVVTY------PDYSKFSTLIVVSDIMDT
|. |  || |.||||  |||.       .||.||.| ..| |...|..||..|||..|  . . ||| .. |. |       .. ..| .. .|.. |.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYKLLISNVDLSLDYRKYFAYQIIRG--LKYIHSANILHRDLKPSNILVNSNSELKITDFGLARVLDQEEGGEP------------LSEYVTTRWYRAP
||.... |.  || |  .|| |||.||  ||||||||..||||||||||||.| .||| ||||||..|.|.  .             ..|||.|||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EILLN--YGTYGPAIDIWSTGCILAEIIL-RRPLFPGNGTLHQLQLIQDFLGSPTEQDLELLR-NPKARQFMESL---PPKDPVDWHQIFTN----SPEE
||.||  .  |  |.|.|| |||.|| .  |.|||||. ...|..|| ..||.|.|.... .  ...||.. .||   |......|...| |       .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

EIDLISKMLTWDPRKRITVLDALEHPFL
 |||..|||..|| ||||| .||.||..
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 90528.m00075.AA ERK 21-310 45 3.4e-130 438.82 In-house 1-307 (307) Show / Hide 
Range on Protein: 21-310
Range on HMM: 1-307/307
Sequence Identity: 45% (139 aa)

YKVLNIIGRGSYGVVLLAIDNQ-----TGKHVALKQLQRIFTTVTDAKRVLREIRILSSLN-NENITNITDVVTYPDYS-KFSTLIVVSDIMDTDLYKLL
|. .. ||.|.||||  |||.      ||..|| |  ...| .  ..|| ||||..|  ..  |||... |..  |... ..  . .|.. |.||| .  
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIM-MPNSPEQYNDIYCVEELMETDLHQII

ISNVDLSLDYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSNSELKITDFGLARVLDQEEGGEP------LSEYVTTRWYRAPEILLNYGTYGPAID
 | . || |  .|| |||..|||||||||..||||||||||||||  ||| ||||||..| .    .      ..|||.|||||||||.|..  |  |.|
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

IWSTGCILAEIILRRPLFPGNGTLHQLQLIQDFLGSP-TEQDLELLRNPKARQFMESLPP--KDPVDWHQIFTNSP--EEEIDLISKMLTWDPRKRITVL
|||.|||.|| . |.|||||....||...| . .|.| .|.||.   ...|...  .||   ..|..|  || | .   . |||..|||..|| ||||| 
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

DALEHPFL
..||||..
ECLEHPYF
Kinase 90528.m00075.AA CMGC 21-310 25 1.2e-129 428.54 In-house 1-513 (513) Show / Hide 
Range on Protein: 21-310
Range on HMM: 1-513/513
Sequence Identity: 25% (134 aa)

YKVLNIIGRGSYGVVLLAID--------------NQTGKHVALKQLQRIFTTVTDAK----------RVLREIRILSSLN----------------NEN-
|.... ||.|.||||  ..|              ..|...||.| . . |   ..||          | ||||.||  ||                ..| 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ITNITDVVTYPD-------------YSKFSTLIVVSDIMDTDLYKLLISNV---------DLSLDY------------RKYFA------YQIIRGLK--Y
| .. |......               .|  |  | . ||.|||... .|           ||                |||       |||.||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAN--ILHRDLKPSNILVNSNSEL--------------------KITDFGLARVLDQEEG-------------------GEPLSEYVTTRWYRAPEIL
.||..  |.||||||.|||.|.| ||                    || |||||| ......                   ..|...|| ||||||||||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNY---------GTYGPAIDIWSTGCILAEIILR--------RPLFP-----------GNGTLHQLQLIQDFLGSP----------------TEQDLELL
|..         . |...||.|| |||.||....        .||||           |. ...||..| . ||.|                .|.. . .
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

R--------------------NPKARQFMES---LPPKDPVDWHQIFTNSP-----------------------------------EEEIDLISKMLTWD
                     ...||.. .|   .|.. | .|...| ..|                                   .. |||..|||..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PRKRITVLDALEHPFL
| ||||. .||.||..
PDKRITAEQALQHPYF
Kinase 90528.m00075.AA p38 21-310 44 6.9e-112 378.02 In-house 1-289 (289) Show / Hide 
Range on Protein: 21-310
Range on HMM: 1-289/289
Sequence Identity: 44% (130 aa)

YKVLNIIGRGSYGVVLLAIDNQTGKH---VALKQLQRIFTTVTDAKRVLREIRILSSLNNENITNITDVVTY--PDYSKFSTLIVVSDIMDTDLYKLLIS
|. |  .| |.|| |  |.| .||..   || | | | | .. .|||  ||.| |  .. ||.  . || |    . . |.   .|.  |..||.... .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

NVDLSLDYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSNSELKITDFGLARVLDQEEGGEPLSEYVTTRWYRAPEILLNYGTYGPAIDIWSTGCIL
   || |  ..  |||.|||||||||.| ||||||||| || ..||.| ||||||  |.|     . .|| |||||||||.|| . |  ..|||| |||.
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE-----MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AEIILRRPLFPGNGTLHQLQLIQDFLGSPTEQDLELLRNPKARQFMESLPPKDPVDWHQIFTNSPEEEIDLISKMLTWDPRKRITVLDALEHPFL
||.| .|.||||.  ..||| |   .|.|.|  .. . . .|| ...|.|.    | |..|..    .|||. |||  || ||||. .|..||..
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 90528.m00075.AA ERK1 21-310 50 4.1e-110 372.11 In-house 1-289 (289) Show / Hide 
Range on Protein: 21-310
Range on HMM: 1-289/289
Sequence Identity: 50% (146 aa)

YKVLNIIGRGSYGVVLLAIDNQTGKHVALKQLQRIFTTVTDAKRVLREIRILSSLNNENITNITDVVTYPDYSKFSTLIVVSDIMDTDLYKLLISNVDLS
|  |. || | ||.|  |.|. ....||.|..   |   |  .| ||||.||   . ||| || |..  .   ..  . .| ..|.||||||| .   ||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQ-HLS

LDYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSNSELKITDFGLARVLD-QEEGGEPLSEYVTTRWYRAPEILLNYGTYGPAIDIWSTGCILAEII
 |   || |||.||||||||||.|||||||||.|.|   .||| ||||||. | . .    | ||| |||||||||.||   |  .||||| ||||||..
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

LRRPLFPGNGTLHQLQLIQDFLGSPTEQDLELLRNPKARQFMESLPPKDPVDWHQIFTNSPEEEIDLISKMLTWDPRKRITVLDALEHPFL
  ||.|||   | || .|   |||| ..||. . | |||....||| |  | |...| .. .  .||. ||||. | ||||| .|| ||.|
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 90528.m00075.AA ERK5 21-310 43 1.6e-105 356.9 In-house 1-295 (295) Show / Hide 
Range on Protein: 21-310
Range on HMM: 1-295/295
Sequence Identity: 43% (130 aa)

YKVLNIIGRGSYGVVLLAIDNQTGKHVALKQLQRIFTTVTDAKRVLREIRILSSLNNENITNITDVV--TYPDYSKFSTLIVVSDIMDTDLYKLLISNVD
||..  || | ||||  |.  ..|..||.|..   |  || ||| .||..||     .||  | |..  . | || .    || |.|. || ... ||  
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVP-YSEMKDVYVVFDLMESDLHQIIHSNQP

LSLDYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSNSELKITDFGLARVLDQ---EEGGEPLSEYVTTRWYRAPEILLNYGTYGPAIDIWSTGCIL
..|.  .|| |||.|||||.|||...||||||||.||| | |||| |||.|| |     ..    . ||| ||||||||...    |  |||.|| |||.
FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIF

AEIILRRPLFPGNGTLHQLQLIQDFLGSPTEQDLELLRNPKARQFMES-LPPKDPVDWHQIFTNSPEEEIDLISKMLTWDPRKRITVLDALEHPFL
 |.| || .|||   .|||||| . || |  . ..     . . .. . .|.. |.|| ...       .||...|| ..| .||||  || ||||
GEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 90528.m00075.AA S_TKc 21-310 28 1.4e-97 331.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-310
Range on HMM: 1-231/231
Sequence Identity: 28% (89 aa)

YKVLNIIGRGSYGVVLLAIDNQTGKHVALKQLQRIFTTVTDAKRVLREIRILSSLNNENITNITDVVTYPDYSKFSTLIVVSDIMDT---DLYKLLISNV
|..|..||.|..|.| ..... ||..||.|..          ....|||.||.. . .|| .. ||         . | .| . .|.   ||.... .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

D------LSLDYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSNSELKITDFGLARVLDQEEGGEPLSEYVTTRWYRAPEILLNYGTYGP-AIDIWS
       ..    ....|||...|.|.|| .|.||||||.|||...  ..||.||||||.|         . .. |.||.|||.|     ||. ..|.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWS

TGCILAEIILRRPLFPGNGTLHQLQLIQDFLGSPTEQDLELLRNPKARQFMESLPPKDPVDWHQIFTNSPEEEIDLISKMLTWDPRKRITVLDALE----
 ||||.| . ..|.||      |.|.. . .|                                     ..| .|.|.|.|..||.||.|. .||.    
CGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPFL
   ||..
IKCHPWF
Kinase 90528.m00075.AA nmo 22-310 43 1.5e-96 297.46 In-house 2-292 (292) Show / Hide 
Range on Protein: 22-310
Range on HMM: 2-292/292
Sequence Identity: 43% (127 aa)

KVLNIIGRGSYGVVLLAIDNQTGKHVALKQLQRIFTTVTDAKRVLREIRILSSLNNENITNITDVVTYPDYSKFSTLIVVSDIMDTDLYKLLISNVDLSL
.    || | .|||    |   || ||||..  .|  .  .||| ||...|.. . .|.    |..  |. . |  . || ..|  || |...|   || 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSNSELKITDFGLARVLDQEEGGEPLSEYVTTRWYRAPEILLNYGTYGPAIDIWSTGCILAEIILR
|  | | |||.|||||.|||||||||.|| |.|||||  ||| ||||||| .|..  . . . | | .|||||||.    |  |.|||| ||| ||.. |
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKH-MTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

RPLFPGNGTLHQLQLIQDFLGSPTEQDLELLRNPKARQFMESLPPKDPVDWHQIFTNSP-----EEEIDLISKMLTWDPRKRITVLDALEHPFL
| ||   . ..|||.| | || |.  |.    .  |.. |   |.| | . ....| |       | ..|...|| .|| ||| . |||.||.|
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACE-GAKAHMLRMPHKPP-CLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 90528.m00075.AA ERK7 21-310 37 6.2e-94 318.37 In-house 1-292 (292) Show / Hide 
Range on Protein: 21-310
Range on HMM: 1-292/292
Sequence Identity: 37% (111 aa)

YKVLNIIGRGSYGVVLLAIDNQTGKHVALKQLQRIFTTVTDAKRVLREIRILSSLN-NENITNITDVVTYPDYSKFSTLIVVSDIMDTDLYKLLI-SNVD
|...  .|.| ||.|  |.| .|.. ||||     |   ||| |  ||| .|  ..  .||  . .|.     .    . .| . |.|||       |. 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR---ADNDRDIYLVFEFMETDLHAVIRKGNI-

LSLDYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSNSELKITDFGLARVLDQEE----GGEPLSEYVTTRWYRAPEILLNYGTYGPAIDIWSTGCI
|    ..|  ||..| .||.||.|..||||||||||..|.  .|. |||||| . | |        | ||| |||||||||||   .| ...| || |||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

LAEIILRRPLFPGNGTLHQLQLIQDFLGSPTEQDLELLRNPKARQFMESLPPKDPVDWHQIFTNSPEEEIDLISKMLTWDPRKRITVLDALEHPFL
|.|..  .|.|||. |..|. .| . .. ||..|.| .    | . .|... . .   .|........ |||. ..|   |.||.|. .||.||. 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 90528.m00075.AA Pkinase 21-310 32 1.2e-83 288.95 Pfam 1-293 (293) Show / Hide 
Range on Protein: 21-310
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

YKVLNIIGRGSYGVVLLAIDNQTGKHVALKQLQRIFTTVTDAKRVLR--EIRILSSLNNENITNITDVVTYPDYSKFSTLIVVSDIMDT-----DLYKLL
|... .||.||.|.| ....  ||| ||.|.. .  .     .. .|  ||.|. .|| .||  . |....      . . .| . ..      ||. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

I--SNVDL--SLDYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSNSEL----KITDFGLARVLDQEEGGEPLSEYVTTRWYRAPEILLNYGTYGPA
   ..  .  | .  | ..|||.|||.|.|| .|.||||||.|||...| ..    ||.|||||...| .  .. .. .. |.||.|||... .  |||.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDIWSTGCILAEIILRRPLFPGN----GTLHQLQLIQDFLGSPTEQDLELLRNPKARQFMESLPPKDPVDWHQIFTNSPEEEIDLISKMLTWDPRKRITV
.|.|| ||||.| ...||.|||     . . |.|.|.  .| |.. | . ....  .      . .   . |. |.| .|| .|.|...|..|| ||.| 
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTFHNWSEECKDFIKWCLCKDPKKRPTA

LDALEHPFL
 ..|.||..
EQILQHPWF
Kinase 90528.m00075.AA CDK 66-310 35 1.7e-82 263.73 In-house 56-284 (284) Show / Hide 
Range on Protein: 66-310
Range on HMM: 56-284/284
Sequence Identity: 35% (96 aa)

LREIRILSSLNNENITNITDVVTYP----DYSKF---STLIVVSDIMDTDLYKLLISNVDLSLDYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSN
.||| .|  | ..|| .. ||..      .  |.   ..|  | . ||.||.|..           | . .|..||| |.|| .|.||||||.|||.|.|
IREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNN

SE-----LKITDFGLARVLD-----QEEGGEPLSEYVTTRWYRAPEILLNYGTYG--PAIDIWSTGCILAEIIL---RRPLFPGNGTLHQLQLIQDFLGS
 |     |||.||||||        . |   ...  | |.||||||.||   .|.  ..||.|| |||.||...   |.|||||.  ..|| .| ...|.
GEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGT

PTEQDLE-LLRNPKARQFMESLPPKDPVDWHQIFTNSPEEEIDLISKMLTWDPRKRITVLDALEHPFL
|||..   .   |                             ||..|||. || |||.  .||.||..
PTEDNWPGVTKLPDY---------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 90528.m00075.AA MAPK-Unclassified 21-170 44 2.1e-64 220.31 In-house 1-157 (575) Show / Hide 
Range on Protein: 21-170
Range on HMM: 1-157/575
Sequence Identity: 44% (70 aa)

YKVLNIIGRGSYGVVLLAIDNQT-GKHVALKQLQRIFTTVTDAKRVLREIRILSSLNNENITNITDVVTYPDYSK--FSTLIVVSDIMDT---DLYKLLI
| .   || |.||.|  |.|... .. || | . .||...||.||||||||||  || .|| .|.|. .  . .   | .. .| | | |   ||.... 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SNV-DLSLDYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSNSELKITDFGLAR
||   ..  . .|| ||| |||||.|||.|.||||||||.|.| .  ..| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase 90528.m00075.AA MAPK-Unclassified 172-310 33 4e-53 182.8 In-house 396-575 (575) Show / Hide 
Range on Protein: 172-310
Range on HMM: 396-575/575
Sequence Identity: 33% (60 aa)

LDQEEGGEPLSEYVTTRWYRAPEILLNYGTYGPAIDIWSTGCILAEIILR-----------RPLFPGNG--------------------TLHQLQLIQDF
.. .. .  ...|| |||||||||.|  . |. ..|||| |||.|| ...           ||||||                         |...| | 
INDCHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDY

LGSPTEQDLELLRNPKARQFMESLPPKDPVDWH-QIFTNSP---------EEEIDLISKMLTWDPRKRITVLDALEHPFL
||.| |.|.   ....||.. .|. .| ||..   .| . |          |.||...|||  .|.||||  .|||||. 
LGMPPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 90528.m00075.AA TyrKc 21-310 22 2.4e-14 9.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-310
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

YKVLNIIGRGSYGVVLLAIDNQTGKHVALKQLQRIFTTVTDAKRVLREIRILSSL--NNENITNITDVVTYPDYSKF---STLIVVSDIMDT-DLYKLLI
 . . ..|.| .|.| ... .     || | |.         .  .||.||...|  ...|| ..  |.| .    |     | .|   |.  || . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

SNVD-LSLDYRKYFAYQIIRGLKYIHSANILHRDLKPSNILVNSNSELKITDFGLARVLDQE-------EGGEP----LSEY-VTTRWYRAPEILLNYGT
.. . |...   .|..|| .|  |.|| |. ||||   |.||..|   ||.||||.| .. .       .   .     . . .  ||. ||| . |||.
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YGPAIDIWSTGCILAEII-LRRPLFPG-----NGTLHQLQLIQDFLGSPTEQD----LELLRNPKARQFMESLPPKDPVDWHQIFTNSPEEEIDLISKML
. .. |.|| |  . ||  .  .  ||         . ......    |  ..                               |   |.|  .....  
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVCCPDEMYQIMKQCW

TWDPRKRITVLDALEHPFL
  || .| |  .   | ..
HEDPEDRPTFSEI--HECF
Kinase 90528.m00075.AA CDK 21-52 48 5.2e-12 34.56 In-house 1-37 (284) Show / Hide 
Range on Protein: 21-52
Range on HMM: 1-37/284
Sequence Identity: 48% (18 aa)

YKVLNIIGRGSYGVVLLAIDNQTG-----KHVALKQL
|. |. ||.|.||||  |.| |||     . ||||..
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKI
Kinase 90528.m00075.AA Pkinase_Tyr 127-176 44 2.4e-09 32.28 Pfam 116-165 (270) Show / Hide 
Range on Protein: 127-176
Range on HMM: 116-165/270
Sequence Identity: 44% (22 aa)

FAYQIIRGLKYIHSANILHRDLKPSNILVNSNSELKITDFGLARVLDQEE
...|| .|. | .| |. ||||   |.||..|   ||.|||||| .  ..
MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD
Kinase 90528.m00075.AA Pkinase_Tyr 21-80 22 1e-06 22.92 Pfam 1-66 (270) Show / Hide 
Range on Protein: 21-80
Range on HMM: 1-66/270
Sequence Identity: 22% (15 aa)

YKVLNIIGRGSYGVVLLAIDN----QTGKHVALKQLQRIFTTVTD--AKRVLREIRILSSL-NNENI
 . .  .|.|..|.| ... .    .|. .|| | | .  ..  .   .  .||..|...| ...||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNI