Gene 80530.m00070 (T.vaginalis)

80530.m00070

Species: T.vaginalis
Alias: 80530.m00070, TvagK0576
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
80530.m00070.AA Protein None 356 None Fasta, JSON
80530.m00070.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of 80530.m00070.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 80530.m00070.AA MAPK 19-310 44 4.6e-154 518.11 In-house 1-328 (328) Show / Hide 
Range on Protein: 19-310
Range on HMM: 1-328/328
Sequence Identity: 44% (146 aa)

YKFVKTLGRGAYGVVFAAIEKA------TGKEVAVKHVDRVFESPLDAKRCLREVKILSQL-NHENITNLVDISCL------PDYENFKGLAIVMDLMDT
|. .| .| ||||||..|| |       .|| ||.| . |.|..|...|| .||.|.|  . .|||| .| ||         .. |.|. . |||.||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DMCQIINSGQPLLVEHHRYFIYQLLRG--LKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLARISEPDEPQE------------FLSEYVATRWYRAP
|..|||.|.|||  .| .||.||.|||  |||.||||..||||||||.|.|..|||||.||||||. .|.. ..            ...|||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVLLN--YDTYGAPMDMWSVGCITAELVL-RHPLFRGTSTRNQLELITQILGSPTDKDLEGCT-NQKAYRFMQQL---PPQTKVPWEELFQGKT--YNPE
|..||  .. |   .|||||||| ||..  |.|||.|... .|..||...||.|.. ...  . ...|. . |.|   |...|.|||..| .     ||.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

EIDFIDRLLKWNPNERMTVEEALEHPFV
 ||.....| ..|..| ||||||.||..
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 80530.m00070.AA ERK 19-310 45 6.30000000001e-148 497.74 In-house 1-307 (307) Show / Hide 
Range on Protein: 19-310
Range on HMM: 1-307/307
Sequence Identity: 45% (141 aa)

YKFVKTLGRGAYGVVFAAIEKA-----TGKEVAVKHVDRVFESPLDAKRCLREVKILSQLN-HENITNLVDISCLPDYE-NFKGLAIVMDLMDTDMCQII
|...| .|.||||||..|| |      ||. ||.| . ..|. |...|| ||| |.|  .. ||||..| ||  .|..  ..... .| .||.||. |||
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDI-MMPNSPEQYNDIYCVEELMETDLHQII

NSGQPLLVEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLARISEPDEPQ------EFLSEYVATRWYRAPEVLLNYDTYGAPMD
|| |.|  .|  ||.||.|.||||.||||..||||||||.|.||.|||||.||||||. ...         .|..||||||||||||..|..  |  .||
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

MWSVGCITAELVLRHPLFRGTSTRNQLELITQILGSP-TDKDLEGCTNQKAYRFMQQLPP--QTKVPWEELFQGKT--YNPEEIDFIDRLLKWNPNERMT
.||.||| ||.. | |||.| ....|...|.||.|.| .. ||.  ....|. .  .||   ....|||..|  ..   ||. || ....| ..|..| |
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIF--PNANCNPQAIDLLEKMLVFDPDKRIT

VEEALEHPFV
|||.||||. 
VEECLEHPYF
Kinase 80530.m00070.AA CMGC 19-310 25 6.6e-127 419.4 In-house 1-513 (513) Show / Hide 
Range on Protein: 19-310
Range on HMM: 1-513/513
Sequence Identity: 25% (131 aa)

YKFVKTLGRGAYGVVFAAIE--------------KATGKEVAVKHVDRVFESPLDAK----------RCLREVKILSQLN-----------------HEN
|. .| .|.|.||||. ..               . |...||.| . ..|  . .||          |.|||.||| .||                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ITNLVDISCLPDYEN-------------FKGLAIVMDLMDTDMCQIINSGQP--------LLVEHH-------------RYFI------YQLLRGLK--Y
| .| || . .. ..             |. | .|...||.| .|.| . |.         | | |             .||.      ||.|||||  |
IVKLYDI-FYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSAN--ILHRDLKPSNLLLNSDCDL--------------------KIADFGLARISEPD-------------------EPQEFLSEYVATRWYRAPEVL
.||..  |.||||||.|.|.|..|.|                    ||.||||||. .|                    .|......||.||||||||.|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNY---------DTYGAPMDMWSVGCITAELVLR--------HPLFR-----------GTSTRNQLELITQILGSPT---------------DKDLEGCT
|..         . |. |.|||||||| ||....        .|||            |.|. .||..| ..||.||               ...  ...
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

N---------------------QKAYRFMQQ---LPPQTKVPWEELFQGKT---------------------------------YNPEEIDFIDRLLKWN
.                      .|... |.   .|.. . ||..|| ..                                   .|. ||.....|...
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PNERMTVEEALEHPFV
|..|.|.|.||.||. 
PDKRITAEQALQHPYF
Kinase 80530.m00070.AA ERK5 19-310 43 1.1e-109 370.69 In-house 1-295 (295) Show / Hide 
Range on Protein: 19-310
Range on HMM: 1-295/295
Sequence Identity: 43% (130 aa)

YKFVKTLGRGAYGVVFAAIEKATGKEVAVKHVDRVFESPLDAKRCLREVKILSQLNHENITNLVDI-SCLPDYENFKGLAIVMDLMDTDMCQIINSGQPL
|| . ..| |||||| .|... .|..||.| .   |.    ||| .||.|||    |.||  . ||      |  .|   .|.|||. |. ||| | ||.
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

LVEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLAR-ISE--PDEPQEFLSEYVATRWYRAPEVLLNYDTYGAPMDMWSVGCITA
 .|| |||.||.||||||.|||...|||||||||| |  |.||| |||.|| ..   ||. | |. ||||||||||||...  . |   .|.||||||  
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELVLRHPLFRGTSTRNQLELITQILGSPTDKDLEGCTNQKAYRFMQQ-LPPQTKVPWEELFQGKTYNPEEIDFIDRLLKWNPNERMTVEEALEHPFV
|.. |. .| |    .||.|| ..|| |  . ..    .. | ..|. .|... ..||... .    .  .| . |.|.. | ||.|| .|| |||.
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKA--DRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 80530.m00070.AA ERK1 19-310 48 7.89999999999e-108 364.54 In-house 1-289 (289) Show / Hide 
Range on Protein: 19-310
Range on HMM: 1-289/289
Sequence Identity: 48% (141 aa)

YKFVKTLGRGAYGVVFAAIEKATGKEVAVKHVDRVFESPLDAKRCLREVKILSQLNHENITNLVDISCLPDYENFKGLAIVMDLMDTDMCQIINSGQPLL
|  .. .| ||||.| .|... ... ||.| .   ||     .| |||.|||   .|||| |. ||   .  |... . || .||.||. ... . |.| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

VEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLARISEPDEPQE-FLSEYVATRWYRAPEVLLNYDTYGAPMDMWSVGCITAELV
 .|  ||.||.||||||.||||.|||||||||||||  ||||| |||||||..|.     || ||||||||||||..||   |   .|.|||||| ||..
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

LRHPLFRGTSTRNQLELITQILGSPTDKDLEGCTNQKAYRFMQQLPPQTKVPWEELFQGKTYNPEEIDFIDRLLKWNPNERMTVEEALEHPFV
   |.| |     || .|  .||||  .||.   |.||  ..| || ..||||..|| .    .  .|..|..| .||..|.|||||| ||..
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKA--DSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 80530.m00070.AA ERK7 19-310 41 2.3e-107 362.97 In-house 1-292 (292) Show / Hide 
Range on Protein: 19-310
Range on HMM: 1-292/292
Sequence Identity: 41% (123 aa)

YKFVKTLGRGAYGVVFAAIEKATGKEVAVKHVDRVFESPLDAKRCLREVKILSQLN-HENITNLVDISCLPDYENFKGLAIVMDLMDTDMCQIINSGQPL
|.  | ||.||||.|  |. | |.. ||.| .   |  . || |  ||. .| ... |.||  |...      .| . . .| . |.||.  .|  |. |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRA---DNDRDIYLVFEFMETDLHAVIRKGNIL

LVEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLAR-ISEPD---EPQEFLSEYVATRWYRAPEVLLNYDTYGAPMDMWSVGCIT
   | .| .||||| .||.||.|..||||||||.||.|.| .|..|||||| |.. .   | .  | ||||||||||||.||   .|    ||||.||| 
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AELVLRHPLFRGTSTRNQLELITQILGSPTDKDLEGCTNQKAYRFMQQLPPQTKVPWEELFQGKTYNPEEIDFIDRLLKWNPNERMTVEEALEHPFV
.|..   |.| |||| ||.|.| .... || .|.|    . |   ..|.. | . . .....     .. || . |||  ||..|.|.|.||.||.|
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP--QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 80530.m00070.AA p38 19-310 38 7.69999999999e-107 361.24 In-house 1-289 (289) Show / Hide 
Range on Protein: 19-310
Range on HMM: 1-289/289
Sequence Identity: 38% (115 aa)

YKFVKTLGRGAYGVVFAAIEKATGKE---VAVKHVDRVFESPLDAKRCLREVKILSQLNHENITNLVDISCL--PDYENFKGLAIVMDLMDTDMCQIINS
|.... .| |||| | .|. . ||.    ||.|   | |.|...|||  ||.. |  ..|||.  | |.      . ..|.   .|. .|..|  .|. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

GQPLLVEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLARISEPDEPQEFLSEYVATRWYRAPEVLLNYDTYGAPMDMWSVGCIT
 . |  .| .. .||.|||||| |||.| ||||||||. .| ||.|.| ||||||     .  . . .|||||||||||..||   |    |.|||||| 
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-----HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AELVLRHPLFRGTSTRNQLELITQILGSPTDKDLEGCTNQKAYRFMQQLPPQTKVPWEELFQGKTYNPEEIDFIDRLLKWNPNERMTVEEALEHPFV
|||. . .||.|.   .||. |....|.|..  ...  ...|  ..| .|. ..   ...|.|  .|| .|| ....|.  |  |.|.|||..||. 
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMG--ANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 80530.m00070.AA S_TKc 19-310 28 1.2e-96 328.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-310
Range on HMM: 1-231/231
Sequence Identity: 28% (88 aa)

YKFVKTLGRGAYGVVFAAIEKATGKEVAVKHVDRVFESPLDAKRCLREVKILSQLNHENITNLVDISCLPDYENFKGLAIVMDLMDT---DMCQIINSGQ
|......|.||.|.|. ...| ||..||.| ..         .. .||..||.. .|.|| .| |.         . | .||...|.   |. ..| . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

P------LLVEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLARISEPDEPQEFLSEYVATRWYRAPEVLLNYDTYGA-PMDMWS
.      .   | |...||....|.|.|| .|.||||||.|.||..   .||.||||||.          . .. |.||.|||||     ||  . |.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCITAELVLRHPLFRGTSTRNQLELITQILGSPTDKDLEGCTNQKAYRFMQQLPPQTKVPWEELFQGKTYNPEEIDFIDRLLKWNPNERMTVEEALE--
.||| .|.. . |.|.      |.... ...|                                        || .|||...|...|..|.|. |||.  
CGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----HPFV
     ||..
WDIKCHPWF
Kinase 80530.m00070.AA nmo 20-310 41 1e-92 285.39 In-house 2-292 (292) Show / Hide 
Range on Protein: 20-310
Range on HMM: 2-292/292
Sequence Identity: 41% (122 aa)

KFVKTLGRGAYGVVFAAIEKATGKEVAVKHVDRVFESPLDAKRCLREVKILSQLNHENITNLVDISCLPDYENFKGLAIVMDLMDTDMCQIINSGQPLLV
.  . .| ||.|||..  .   || ||.| .  || . . .||  ||.|.|.  .|.|.  . ||   |. . |. . .| .||  |. .|| | |.|  
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

EHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLARISEPDEPQEFLSEYVATRWYRAPEVLLNYDTYGAPMDMWSVGCITAELVLR
.| . |.||.||||||||||||||||.|| |||.||.| ||| ||||||. |.|. ..   | | | .|||||.|.    | . .|.|||||| |||. |
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQE-VVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

HPLFRGTSTRNQLELITQILGSPTDKDL-EGCTNQKAYRF-MQQLPPQTKVPWEELFQGKTYNPEEIDFIDRLLKWNPNERMTVEEALEHPFV
. ||   |  .||..||..|| |.  |.   |   ||    | . ||...| . .|      . | .. . |.| ..|. |. ...||.||..
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLY-TLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 80530.m00070.AA Pkinase 19-310 29 2.7e-91 314.42 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-310
Range on HMM: 1-293/293
Sequence Identity: 29% (94 aa)

YKFVKTLGRGAYGVVFAAIEKATGKEVAVKHVDRVFESPLDAKRCLR--EVKILSQLNHENITNLVDISCLPDYENFKGLAIVMDLMDT-----DMCQII
|......|.|..|.|. ...| |||.|||| .... |..   .. .|  |..|.  |||.||  | |.         . . .||....      | . .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

N--SGQPL--LVEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDL----KIADFGLARISEPDEPQEFLSEYVATRWYRAPEVLLNYDTYGAP
   .. ..    .. . ..||.||||.|.|| .|.||||||.|.|.......    ||.|||||.  .   ... .. .. |.||.||||.. .  || .
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

MDMWSVGCITAELVLRHPLFRGT----STRNQLELITQILGSPTDKD-LEGCTNQKAYRFMQQLPPQTKVPWEELFQGKTYN--PEEIDFIDRLLKWNPN
 ||||.||| .|.....|.|.|     . ..|...| .|.| |.. |  . |..   . |..   .       . .. . .|  .| .|||...|...|.
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------F-HWTF-HNWSEECKDFIKWCLCKDPK

ERMTVEEALEHPFV
.| | |..|.||..
KRPTAEQILQHPWF
Kinase 80530.m00070.AA CDK 64-310 35 1.8e-87 279.91 In-house 56-284 (284) Show / Hide 
Range on Protein: 64-310
Range on HMM: 56-284/284
Sequence Identity: 35% (95 aa)

LREVKILSQLNHENITNLVDISCLP--DYENFKG-----LAIVMDLMDTDMCQIINSGQPLLVEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSD
.||...| .| |.|| .| |.      |..| |.     | .|.. ||.|  ...           . ...|||||| |.|| .|.||||||.|.|.|..
IREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNN

CD-----LKIADFGLARISE-----PDEPQEFLSEYVATRWYRAPEVLLNYDTYG--APMDMWSVGCITAELVL---RHPLFRGTSTRNQLELITQILGS
       ||||||||||.       . ||.  ..  | |.||||||.||   .|.   | |||||||| ||...   | ||| |.|  .||..| .|.|.
GEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGT

PTDKDLEGCTNQKAYRFMQQLPPQTKVPWEELFQGKTYNPEEIDFIDRLLKWNPNERMTVEEALEHPFV
||...  |.|    |                            |.....|  .|. |.. |.||.||. 
PTEDNWPGVTKLPDY----------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 80530.m00070.AA MAPK-Unclassified 19-168 49 1.8e-72 247.07 In-house 1-157 (575) Show / Hide 
Range on Protein: 19-168
Range on HMM: 1-157/575
Sequence Identity: 49% (78 aa)

YKFVKTLGRGAYGVVFAAIEKAT-GKEVAVKHVDRVFESPLDAKRCLREVKILSQLNHENITNLVDISCLPDYEN--FKGLAIVMDLMDT---DMCQIIN
|   | .| ||||.|  |..| . .. || | | ..|. . |.|| |||. ||  |||.|| .. ||    . .|  |. . ||||.| |   |. ||| 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SGQ-PLLVEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLAR
| | ..  .| .||.||.||||||||||.|.||||||||||.| || ..|.|||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase 80530.m00070.AA MAPK-Unclassified 179-310 30 2.6e-44 153.51 In-house 405-575 (575) Show / Hide 
Range on Protein: 179-310
Range on HMM: 405-575/575
Sequence Identity: 30% (52 aa)

LSEYVATRWYRAPEVLLNYDTYGAPMDMWSVGCITAELVLR-----------HPLFRGTS--------------------TRNQLELITQILGSPTDKDL
...||.|||||||| .|    |..  |.||.||| ||....            ||| |..                       |. .|   ||.|   |.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

EGCTNQKAYRFMQQLPPQTKVPWEELFQGKTY--------NPEEIDFIDRLLKWNPNERMTVEEALEHPFV
   |. .|  . | . . | |.. .|.  |..        |.|.|||.. .|  ||. | | ..|||||..
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 80530.m00070.AA TyrKc 19-313 20 1.6e-12 -20.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-313
Range on HMM: 1-280/280
Sequence Identity: 20% (69 aa)

YKFVKTLGRGAYGVVFAAIEKATGKEVAVKHVDRVFESPLDAKRCLREVKILSQL--NHENITNLVDISCLPDYENF---KGLAIVMDLMDT-DMCQIIN
 .. |.||.||.|.|. .. |    .|||| .          .  .|| .|...|  .|.|| .|. .   .    |   . | ||| .|.  |  . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

SGQP-LLVEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLARISEPD-------EPQEF----LSEY-VATRWYRAPEVLLNYDT
. .| | ...  .| .|  .|  |||| |. ||||   | |....   ||.||||.|  . |       .         . . .  ||. |||.. || .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YGAPMDMWSVGC--------------------ITAELVLRHPLFRGTSTRNQL--ELITQILGSPTDKDLEGCTNQKAYRFMQQLPPQTKVPWEELFQGK
.    | || |                     .... |...   ..   . .   . .                                      |   
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS-------------------------------------F--V

TYNPEEIDFIDRLLKWNPNERMTVEEALEHPFVVKL
.  .|  . . .  . .|..| | .|      . ..
CCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase 80530.m00070.AA Pkinase_Tyr 19-82 33 1.7e-09 32.76 Pfam 1-70 (270) Show / Hide 
Range on Protein: 19-82
Range on HMM: 1-70/270
Sequence Identity: 33% (24 aa)

YKFVKTLGRGAYGVVFAAIEK----ATGKEVAVKHVDRVFESPLD--AKRCLREVKILSQL-NHENITNLV
 .| |.||.||.|.|. .. |     |. .|||| . .   .. .   .  .||.||..|| .|.|| .|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase 80530.m00070.AA CDK 19-50 37 2.2e-08 22.76 In-house 1-37 (284) Show / Hide 
Range on Protein: 19-50
Range on HMM: 1-37/284
Sequence Identity: 37% (14 aa)

YKFVKTLGRGAYGVVFAAIEKATG-----KEVAVKHV
|. .. .|.|.||||. |. | ||     . || | .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKI
Kinase 80530.m00070.AA Pkinase_Tyr 112-174 38 2e-06 22.31 Pfam 103-165 (270) Show / Hide 
Range on Protein: 112-174
Range on HMM: 103-165/270
Sequence Identity: 38% (24 aa)

NSGQPLLVEHHRYFIYQLLRGLKYLHSANILHRDLKPSNLLLNSDCDLKIADFGLARISEPDE
...||| ...   . .|  .|. ||.| |. ||||   | |....   ||.||||||  ..|.
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD