Gene 88273.m00284 (T.vaginalis)

88273.m00284

Species: T.vaginalis
Alias: TvagK0593, 88273.m00284
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
88273.m00284.AA Protein None 303 None Fasta, JSON
88273.m00284.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of 88273.m00284.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88273.m00284.AA CDC2 7-287 47 2.6e-142 440.44 In-house 1-301 (301) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-301/301
Sequence Identity: 47% (143 aa)

YIKQEKLGAGTYGMVFKAKDKTTGKIVAIKEMILDQEEEG--VSSTTMREISILKKMN-HPNIVSLVDTYVQGTQLTIVLEYLDMNIRDYMK--KPV--K
| | ||.| |||| |.|.||. |..|||.|   |.||.||  | ||..||||.||... |||||.| | ..|   | .| |||||. . ||.  .|   .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MDPKLVKSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGYLKICDFGLSRFFTIPIQQYT--ENIVTLWYRPPEILLHNPIYEISADIWSVGCVIAEI
|.| |||||..|.| |  ..|..|..|||.||.|.||. .| .|| ||||.| |.||| .||   ..||||||.|||||    | .. |.||.||..||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATKTPLFPGDSILDQIHRIFSVLGTPNEEMCKFFKDVKDELVIIPTYPPKDLSDVIKV---------NDLSLIDLISKLINIDPCKRLTAREALHHP
   .|| |||.|||  ||. .|| .||||||.     .. .|     | ..|.|||....          .|   |||..... .|| ||..|.||| ||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase 88273.m00284.AA CDK 7-287 39 8.8e-133 427.23 In-house 1-284 (284) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-284/284
Sequence Identity: 39% (125 aa)

YIKQEKLGAGTYGMVFKAKDKTTG-----KIVAIKEMILDQ-----EEEGVSSTTMREISILKKMNHPNIVSLVDTYVQG-----------TQLTIVLEY
| | ||.| |||| |.||.|| ||     .|||.|. ....     |.||...|. ||||.||.. |||||.| | ...            . |..| ||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDMNIRDYMKKPVKMDPKLVKSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGY-----LKICDFGLSRFFTI------PIQQYTENIVTLWYRPPEI
.|.    ||.         .|.| .||| | .|.| ....|||.|| |.|||..|      ||| ||||.| | |      |.. || ..||||||.||.
MDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPEL

LLHNPIYE--ISADIWSVGCVIAEIAT---KTPLFPGDSILDQIHRIFSVLGTPNEEMCKFFKDVKDELVIIPTYPPKDLSDVIKVNDLSLIDLISKLIN
||   .|    . |.|||||..||..|   . ||||||| .||...|| ..|||.|..   ...  |                         ||..|.  
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKMLC

IDPCKRLTAREALHHPYF
 ||.||..| .||.||||
YDPKKRISAEQALQHPYF
Kinase 88273.m00284.AA CMGC 7-287 24 1.4e-122 404.95 In-house 1-513 (513) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-513/513
Sequence Identity: 24% (127 aa)

YIKQEKLGAGTYGMVFKAKD--------------KTTGKIVAIKEMILDQ---------EEEGVSSTTMREISILKKMN-----------------HPNI
| . .|.| ||||.|.|..|              . |..||||| . ...         |..|..... |||.|||..|                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VSLVDTYVQGT-----------------QLTIVLEYLDMNIRDYMKK---------PVKMDPKL------------VKSYA------FQLLAGTY--YLH
|.| | ..                    .| .| ||.|..  .|.|.         |.....              .|..       .|.| |    |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

THR--VIHRDIKPDNLLINHDGYL--------------------KICDFGLSRFFTIP---------------------IQQYTENIVTLWYRPPEILLH
 |.  .||||.|| |.||||.. |                    |||||||.|.. ..                      ..||...||.|||.||||| 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

NPIYE---------ISADIWSVGCVIAEIATK--------TPLFPGDSI-----------LDQIHRIFSVLGTPN---------------EE--------
 . |           . |.|||||..||. |.         |||||.|            .||...|| |||||.               ||        
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

------------------MCKFFKDVKDELVIIPTYPPKDLSDVIKV-----------------------------------NDLSLIDLISKLINIDPC
                  ...| .  .      |..|||.......                                     |  .|||..|.  .|| 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRLTAREALHHPYF
||.|| .|| ||||
KRITAEQALQHPYF
Kinase 88273.m00284.AA CDK5 7-287 44 1.3e-119 379.8 In-house 1-287 (287) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-287/287
Sequence Identity: 44% (129 aa)

YIKQEKLGAGTYGMVFKAKDKTTGKIVAIKEMILDQEEEGVSSTTMREISILKKMNHPNIVSLVDTYVQGTQLTIVLEYLDMNIRDYMKK-PVKMDPKLV
| | ||.| ||||.|.||..|.|. |||.|.  ||.| ||| || .|||..|| . |.||| | |       ||.| |..|  .. || .  ..||....
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGYLKICDFGLSRFFTIPIQQYTENIVTLWYRPPEILLHNPIYEISADIWSVGCVIAEIA-TKTPLF
||. .||| |  . | |.| ||| || |||||  | ||  |||| | | ||.. |.  .|||||||| .|.    |  | |.||.||..||.| .  |||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGDSILDQIHRIFSVLGTPNEEM---CKFFKDVKDELVIIPTYPPKD-LSDVIKVNDLSLIDLISKLINIDPCKRLTAREALHHPYF
|| .  ||  ||| ..|||.|.         | | . .  | ||..  .. ...  |  . || .|.. ..| .|..| .|||||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 88273.m00284.AA CDK7 7-287 37 7.6e-114 304.63 In-house 1-288 (288) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-288/288
Sequence Identity: 37% (109 aa)

YIKQEKLGAGTYGMVFKAKDKTTGKIVAIKEMI----LDQEEEGVSSTTMREISILKKMNHPNIVSLVDTYVQGTQLTIVLEYLDMNIRDYMK-KPVKMD
| | ...|.|... |.|| |. ||.|||||.       .. . |.  | .||| ||. | |.|.. |.| . . . .  |....|       | | . . 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PKLVKSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGYLKICDFGLSRFFTIPIQQYTENIVTLWYRPPEILLHNPIYEISADIWSVGCVIAEIATKT
|  .|.|. ..| | .|.| . . |||.|| |||.| .| ||| |||| ||.  | . || ..|| ||| || |    .|  . |.|||||..||    .
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGDSILDQIHRIFSVLGTPNEE----MCKFFKDVKDELVIIPTYPP---KDLSDVIKVNDLSLIDLISKLINIDPCKRLTAREALHHPYF
| .|||| .||. |||. ||||.||    ||..      . ...  .|.     | ..       |.||....   .||||.|....| .|||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCM-----MDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 88273.m00284.AA Pkinase 7-287 31 1.2e-95 328.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

YIKQEKLGAGTYGMVFKAKDKTTGKIVAIKEMILDQEEEGVSSTTMR--EISILKKMNHPNIVSLVDTYVQGTQLTIVLEYLDM-----NIRDYMK--KP
| . .|.|.|..| |.|...| ||||||.|.. .. |....  |  |  ||.|.|..|||||| | |..  .. . .|.||...        ||..  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VKM--DPKLVKSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGYL----KICDFGLSRFF-TIPIQQYTENIVTLWYRPPEILLHNPIYEISADIWSV
 ..  ... .|.|. |.| | .|.| ...||||.||.|.||...|..    |||||||...| . . . .|   .|.||..||...... |  ..|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVIAEIATKTPLFPGD----SILDQIHRIFSVLGTPNEEMCKFFKDVKDELVIIPTYPPKDLSDVIKVNDLSLIDLISKLINIDPCKRLTAREALHHPY
||...| ... |.|||.    . .||...|. ..|.|... .    .. ..  . . . .. .. . .  . ...|.|..... || ||.||...|.||.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase 88273.m00284.AA S_TKc 7-287 31 1.2e-94 321.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-231/231
Sequence Identity: 31% (94 aa)

YIKQEKLGAGTYGMVFKAKDKTTGKIVAIKEMILDQEEEGVSSTTMREISILKKMNHPNIVSLVDTYVQGTQLTIVLEYLDM---NIRDYMKKPVK----
| . .|.| |..| |.|...| ||.|||||..           ...|||.|||| .||||| | |...  . | .|.||.|    . .||.||  .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MDPKLVKSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGYLKICDFGLSRFFTIPIQQYTENIVTLWYRPPEILLHNPIYEI-SADIWSVGCVIAE
  ...  ...|. |.. .  |.| |..||||.||.|.|...   .|||||||.|..       |  ..|.||..||.|     |   ..|.||.||...|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

IATKTPLFPGDSILDQIHRIFSVLGTPNEEMCKFFKDVKDELVIIPTYPPKDLSDVIKVNDLSLIDLISKLINIDPCKRLTAREALH-------HPYF
 ..  |.||      |....| ..|                                   . ...|.|.|. . || ||.|| |||.       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 88273.m00284.AA PCTAIRE 7-287 40 1.8e-87 296.88 In-house 1-291 (291) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-291/291
Sequence Identity: 40% (120 aa)

YIKQEKLGAGTYGMVFKAKDKTTGKIVAIKEMILDQEEEGVSSTTMREISILKKMNHPNIVSLVDTYVQGTQLTIVLEYLDMNIRDYMKKPVK-MDPKLV
||| .||| |||  |.| . | |. .|| ||  | . |||   |  ||.| || . | |||.| |   .  |||.| ||.||  . ||   .  |. . |
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRL-EHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNV

KSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGYLKICDFGLSRFFTIPIQQYTENIVTLWYRPPEILLHNPIYEISADIWSVGCVIAEIATKTPLFP
| . |||| |  | |  .. ||| || ||||| .| ||  |||| |   .| . | . .||||||||..|. . .|  . |.| |||. .|..|  ||||
KLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFP

GDS------ILDQIHRIFSVLGTPNEEM---CKFFKDVKDELVIIPTYPPKDLSDVIKVND---LSLIDLISKLINIDPCKRLTAREALHHPYF
|        . || | ||..|||| |.     | ... . ..   | |... |  .    |   .  .||...|    . .|. | .|..||||
GSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYN--FPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase 88273.m00284.AA PITSLRE 7-287 37 2.5e-86 293.1 In-house 1-295 (295) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-295/295
Sequence Identity: 37% (113 aa)

YIKQEKLGAGTYGMVFKAKDKTTGKIVAIKEMILD--QEEEGVSSTTMREIS-ILKKMNHPNIVSLVDTYVQGTQLT---IVLEYLDMNIRDYMKKPV--
. .  . . |||| |..|||| |. |||.| . ..  .| ||   | .|||. ||. ..|||||..    . |. ..   .|.||..  ... | .    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVM-GSNMDKIYMVMEYVEHDLKSLMENMKRR

--KMDPKLVKSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGYLKICDFGLSRFFTIPIQQYTENIVTLWYRPPEILLHNPIYEISADIWSVGCVIAE
  .  |  .|.   ||| |  ..| . ..||| |  |||..| | |||||||| | .  ||  || ..|||||| ||.||  ..|    |.|||||. ||
NQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAE

IATKTPLFPGDSILDQIHRIFSVLGTPNEEM---CKFFKDVKDELVI-IPTYPPKDLSDVIK----VNDLSLIDLISKLINIDPCKRLTAREALHHPYF
. |. |||.|.| .|||..||  .|||.|      . .. .|  ..  .| ||.  |   ..    ..|  . ||  ..   .| .|.|| .|| ||.|
FITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWK--MMNNFPHYPYNNLRKRFPAENHISDTGF-DLLNQMLTYNPKNRITASDALKHPWF
Kinase 88273.m00284.AA PFTAIRE 7-287 41 1.7e-81 277.06 In-house 1-287 (287) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-287/287
Sequence Identity: 41% (120 aa)

YIKQEKLGAGTYGMVFKAKDKTTGKIVAIKEMILDQEEEGVSSTTMREISILKKMNHPNIVSLVDTYVQGTQLTIVLEYLDMNIRDYMKK-PVKMDPKLV
| | |||| |.|  |.|.. . ....|| ||  | |.|||.  |  || | || . | ||| | |     . ||.| ||..     || | |  |.|. |
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRL-QQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

KSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGYLKICDFGLSRFFTIPIQQYTENIVTLWYRPPEILLHNPIYEISADIWSVGCVIAEIATKTPLFP
. . |||| |  | |  || |||.|| |||| | | ||  |||| |   .| . | . .|||||||| .||    |  . |.| |||.  |  .  |.||
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFP

GD-SILDQIHRIFSVLGTPNEEMCKFFKDVKD-ELVIIP--TYPPKDLSDVIKVND--LSLIDLISKLINIDPCKRLTAREALHHPYF
|   |.||  .|| |||||.|.           . . ..   | || |  ..   .      ||..|.  . | .|. | ||..||||
GMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase 88273.m00284.AA MAPK 7-287 33 2e-79 270.16 In-house 1-328 (328) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-328/328
Sequence Identity: 33% (111 aa)

YIKQEKLGAGTYGMVFKAKDKT------TGKIVAIKEM-ILDQEEEGVSSTTMREISILKKM-NHPNIVSLVDTYVQ------GT-----QLTIVLEYLD
|  ....| | ||.|..|.||       .||.|||| .    | .      | ||| .|. . .|.||..| | .        ..     .. || |. .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK-RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELME

MNIRDYMKKPVKMDPKLVKSYAFQLLAG--TYYLHTHRVIHRDIKPDNLLINHDGYLKICDFGLSRFFTI-PIQQY-------------TENIVTLWYRP
 . .  .| . ... . ...  .|.| |    |.|  .|||||.|| |.|.| .. ||||||||.| .     . .             ||...| ||| 
TDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PEILLH--NPIYEISADIWSVGCVIAEIAT-KTPLFPGDSILDQIHRIFSVLGTPNEEMCKFFK-DVKDELVII-----PTYPPKDLSDVIK-----VND
|||.|      |  . |.|||||  ||  |  .|||||.. .||. .|..||||| ||.... . . .   .|      | ||.|.......     .|.
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

LSLIDLISKLINIDPCKRLTAREALHHPYF
.  |||..|.  .|| ||.|. ||| ||||
Q-AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 88273.m00284.AA CDKL 7-222 39 7.2e-69 234.59 In-house 1-218 (286) Show / Hide 
Range on Protein: 7-222
Range on HMM: 1-218/286
Sequence Identity: 39% (87 aa)

YIKQEKLGAGTYGMVFKAKDKTTGKIVAIKEMILDQEEEGVSSTTMREISILKKMNHPNIVSLVDTYVQGTQLTIVLEYLDMNIRDYMKKPVK-MDPKLV
| |  |.| | ||.|.| ..| ||.|||||     .... |  ..|||| .|| . |.|||.|.    .   | .| || | .. .. .. ..  |...|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

KSYAFQLLAGTYYLHTHRVIHRDIKPDNLLIN-HDGYLKICDFGLSRFFTIPIQQYTENIVTLWYRPPEILLHNPIYEISADIWSVGCVIAEIATKTPLF
..| .|.| .  ..| | .||||||| |.||. ..| .|.||||. |  . |   ||.   | ||| || |.  . |  . |||..|||.|| ..  ||.
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGDSILDQIHRIFSVLGT
||.| .|| ..|  .||.
PGQSDIDQLYHIQKCLGP
Kinase 88273.m00284.AA Pkinase_Tyr 7-151 32 1.8e-22 76.76 Pfam 1-159 (270) Show / Hide 
Range on Protein: 7-151
Range on HMM: 1-159/270
Sequence Identity: 32% (52 aa)

YIKQEKLGAGTYGMVFKAKDK----TTGKIVAIKEM--ILDQEEEGVSSTTMREISILKKM-NHPNIVSLVDTYV-QGTQ--LTIVLEYLDM-NIRDYMK
 .. .|||.| .|.|.|.. |     |.  ||.| .    ..|.   .   |||..|.|.. .|||||.|.   . || .  . ||.||    . .|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----PVKMDPKLVKSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGYLKICDFGLSR
|    . . ..|   ....|  .|  ||. .. ||||.   | |.....  |||||||.|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 88273.m00284.AA TyrKc 7-287 23 1.1e-14 14.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 7-287
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

YIKQEKLGAGTYGMVFKAKDKTTGKIVAIKEMILDQEEEGVSSTTMREISILKKM--NHPNIVSLVDTYVQG-------TQLTIVLEYLDM-NIRDYMKK
  . .||| | .| |.|.. |     ||.| .  |          |||..|..|   .||||| |.   .|.        .| ||.|| .  . .|| .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

PVK-MDPKLVKSYAFQLLAGTYYLHTHRVIHRDIKPDNLLINHDGYLKICDFGLSRFFTIP------IQQYTE-----NI--VTLWYRPPEILLHNPIYE
. .   .|   |...|  .|  ||| ...||||.   | |.....  ||.||||||. .         . |.          . .   .|| . .. .. 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG-KFT

ISADIWSVGCVIAEIATKTPLFPGDSIL--DQIHRIFSVLGTPNEEMCKFF----KDVKDELVIIPTYPPKDLSDVIKVNDLSLIDLISKLINIDPCKRL
.  |.|| | .. || |     . . |.      ...  . . .  ..                         . |.   .  . .....  . || .| 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------F-VCCPDE--MYQIMKQCWHEDPEDRP

TAREALHHPYF
| .|   | .|
TFSEI--HECF
Kinase 88273.m00284.AA CDKL 260-287 39 5.2e-09 26.96 In-house 259-286 (286) Show / Hide 
Range on Protein: 260-287
Range on HMM: 259-286/286
Sequence Identity: 39% (11 aa)

LIDLISKLINIDPCKRLTAREALHHPYF
..|.. |.  .|| .|.|. ...|||||
ALDFMKKCLHMDPDERMTCEQLMHHPYF