Gene 81864.m00329 (T.vaginalis)

81864.m00329

Species: T.vaginalis
Alias: TvagK0580, 81864.m00329
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK7

Sequence

Name Sequence Type Origin Length Description Download
81864.m00329.AA Protein None 372 None Fasta, JSON
81864.m00329.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of 81864.m00329.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81864.m00329.AA ERK7 18-305 52 1.3e-156 526.63 In-house 1-292 (292) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-292/292
Sequence Identity: 52% (154 aa)

YEIIQKIGKGAYGVVWRCINKQNGQVVALKKAFGAFGNLTDAQRTYREITFLRQLKDCPAIVKLLAVHKAENDQDIYMVFECLETDVHAVIR-ANILLDV
|||....||||||.||. . |. .||||||| | || | ||||||.|||.||..... | |..|. | .|.||.|||.||| .||| ||||| .||| |.
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

HHRFIFWQLLVALKYVHSAGVIHRDLKPSNLLINSDATIKLCDFGLARAIDEDG----QTEDLTDYVATRWYRAPEILFGSNSYTSSVDMWAAGCILAEL
| ..|..||| |.||.||. ||||||||||.|..|. ..|.||||||| | .      |. .||.||||||||||||| ||  ||  ||||  ||||.|.
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

VSGRPLFPGSSTMDQLERIVAYTGPLSEQQIESMVSNFTSTMLSNLSYSRPKFYLEEKLPDAPPDAIDLIKKLISLNPADRPTAAECLEHPYV
. |.|.|||.|||.|.|.|.  ..  ... ||.. |.. ..||...  ....  |.. .|....|||||.|.|. .||  | || ..|.||||
LRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN-QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 81864.m00329.AA MAPK 18-305 40 2.3e-135 455.99 In-house 1-328 (328) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-328/328
Sequence Identity: 40% (134 aa)

YEIIQKIGKGAYGVVWRCINKQ------NGQVVALKKAFGAFGNLTDAQRTYREITFLRQLKDCPAIVKLLAVHKAE-----ND----QDIYMVFECLET
|.|...||.||||||. .| |       .|. ||.|| . .| |.|...|||||| .|| ... . |.||| . ..|     |.    .|||.|.|  ||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DVHAVIR-ANILLDVHHRFIFWQLLVA--LKYVHSAGVIHRDLKPSNLLINSDATIKLCDFGLARAIDED------GQTE------DLTDYVATRWYRAP
| |..|.  ..| | | .....|.| .  ||| |||.||||||||||.|.|.. . |.||||||| || .       ...      ..|.||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EILFG--SNSYTSSVDMWAAGCILAELVS-GRPLFPGSSTMDQLERIVAYTGPLSEQQIESMV-SNFTSTMLSNL--SYSRPKFYLEEKLPD----APPD
||...  .. || .||||..|||.||... ..|||||....||...|....|  ||. |. .  |    .....|     .||  .|. .|.    | |.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AIDLIKKLISLNPADRPTAAECLEHPYV
||||..|.  ..| .| |..|.|.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 81864.m00329.AA CMGC 18-305 24 4.8e-126 416.51 In-house 1-513 (513) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-513/513
Sequence Identity: 24% (124 aa)

YEIIQKIGKGAYGVVWRCINKQNG--------------QVVALKKAFGAFGNLTDAQ----------RTYREITFLRQLK----------------DCPA
||||.|||.|.||||..|..|...              ..||.|| . .| . ..|.          |..||| .|..|.                . . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLLAVHKAEN---------------DQDIYMVFECLETDVHAVIRANI-----------------------------LLDVHHRFIFWQLLVALK--Y
||||. . . .|               ....|.|||....| . .|. |                              ..  | | ...|.| .||  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

VHSAG--VIHRDLKPSNLLINSD--------------------ATIKLCDFGLARAIDED-------------------GQTEDLTDYVATRWYRAPEIL
 ||..  .|||||||.|.|||..                     ..|.|||||||....                    . .. .|.||.||||||||||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGS---------NSYTSSVDMWAAGCILAELVSG--------RPLFP-----------GSSTMDQLERIVAYTGPLS---------------EQQIESMV
.|.         . ||...|||..|||.||.. |        .||||           |.|. |||..|.   |. .               |... .|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

SN-----------------FTSTMLSNLSYS---RPKFY---LEEKLPD-----------------------------------APPDAIDLIKKLISLN
..                 . |    |   |    |...   .... |.                                   ..|.||||.||.  ..
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PADRPTAAECLEHPYV
|..|.||...|.||| 
PDKRITAEQALQHPYF
Kinase 81864.m00329.AA ERK 18-305 42 3.2e-116 392.4 In-house 1-307 (307) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-307/307
Sequence Identity: 42% (132 aa)

YEIIQKIGKGAYGVVWRCINKQ-----NGQVVALKKAFGAFGNLTDAQRTYREITFLRQLKDCPAIVKLLAVHKAE---NDQDIYMVFECLETDVHAVIR
|.||..||.||||||  .|.|      .|| || || . || .. .. ||.||| .|| .|  . |..|. . . .   .  |||.|.|  ||| | .|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

AN-ILLDVHHRFIFWQLLVALKYVHSAGVIHRDLKPSNLLINSDATIKLCDFGLARAIDE------DGQTEDLTDYVATRWYRAPEILFGSNSYTSSVDM
    | | |  .  .|.| .|||.|||.||||||||||.|.||. . | ||||||| .|.       .. ...|.||||||||||||.   . ||...|.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WAAGCILAELVSGRPLFPGSSTMDQLERIVAYTG-PLSEQQIESMVSNFTSTMLSNLSY-SRPKFYLEEKLPDAP--PDAIDLIKKLISLNPADRPTAAE
|..|||.||.. ..||||| ....|..|| ...| | ||....   |  .  ...||..  ||.  .|.  |.|.  |.||||..|..  .| .| |..|
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

CLEHPYV
|||||| 
CLEHPYF
Kinase 81864.m00329.AA S_TKc 18-305 31 1.4e-99 338.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-231/231
Sequence Identity: 31% (96 aa)

YEIIQKIGKGAYGVVWRCINKQNGQVVALKKAFGAFGNLTDAQRTYREITFLRQLKDCPAIVKLLAVHKAENDQDIYMVFECLET---DVHAVIRANI--
|||..||||||.|.|..|..|  |..||.|.           ....|||  |..  ..| ||||. |      ...|||.|....   |.. .|. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LLDVHHRFIFWQLLVALKYVHSAGVIHRDLKPSNLLINSDATIKLCDFGLARAIDEDGQTEDLTDYVATRWYRAPEILFGSNSYTS-SVDMWAAG
     .   | ||...|.. ||.| || |.|||||||.|.|...  .||.||||||| .         | .. |.||.|||.|    .|.  ..|.|. |
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

CILAELVSGRPLFPGSSTMDQLERIVAYTGPLSEQQIESMVSNFTSTMLSNLSYSRPKFYLEEKLPDAPPDAIDLIKKLISLNPADRPTAAECLE-----
|||.|...|.|.||   .|... ...                                          .|.|.|.|.|.   .|..|||| |.|.     
CILYEMLCGYPPFP---QMQMMFKKIG-----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HPYV
  ||..
KCHPWF
Kinase 81864.m00329.AA CDK 18-305 33 4.1e-97 311.24 In-house 1-284 (284) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-284/284
Sequence Identity: 33% (107 aa)

YEIIQKIGKGAYGVVWRCINKQNG-----QVVALKKAFGAF-GNLTDA-----QRTYREITFLRQLKDCPAIVKLLAVHKAEN---------DQDIYMVF
||...||| |.|||| ....||.|     |.|||||      | . ..     . . |||. |..|  .| ||||. |   .|         .  .||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVF

ECLETDVHAVIRANILLDVHHRFIFWQLLVALKYVHSAGVIHRDLKPSNLLINSDAT-----IKLCDFGLARAIDE----DGQ-TEDLTDYVATRWYRAP
| ...|   ...         . ..|||| .| | || ...||||||.|.|||.. .     .|. |||||||       .   .  .|  | |.|||||
EYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAP

EILFGSNSYT--SSVDMWAAGCILAELVS---GRPLFPGSSTMDQLERIVAYTGPLSEQQIESMVSNFTSTMLSNLSYSRPKFYLEEKLPDAPPDAIDLI
|.|.||  |.   ..|||..|||.||..    ..|||||.|  |||..|    |  .|..  ....                               ||.
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLL

KKLISLNPADRPTAAECLEHPYV
 |.  ..|. | .| ..|.||| 
NKMLCYDPKKRISAEQALQHPYF
Kinase 81864.m00329.AA Pkinase 18-305 32 6.3e-93 319.83 Pfam 1-293 (293) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-293/293
Sequence Identity: 32% (101 aa)

YEIIQKIGKGAYGVVWRCINKQNGQVVALKKAFGAFGNLTDAQRTYR--EITFLRQLKDCPAIVKLLAVHKAENDQDIYMVFECLET-----DVHAVIR-
|.|..|||.|..|.|..|..| .|..||.|.      .    |.  |  ||  .. | ..| ||.|. .     ...||||.|..|      | ...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

--ANIL--LDVHHRFIFWQLLVALKYVHSAGVIHRDLKPSNLLINSDATI----KLCDFGLARAIDEDGQTEDLTDYVATRWYRAPEILFGSNSYTSSVD
   . .   . . .|...|.| .|.| || |.|||||||.|.||... .|    |.||||||. .|     . .|... |.||.|||.. |.. |...||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

MWAAGCILAELVSGRPLFPGS----STMDQLERIVAYTGPLSEQQIESM--VSNFTSTMLSNLSYSRPKFYLEEKLPDAPPDAIDLIKKLISLNPADRPT
||..||||.|...|||.|||.    . .||...|.   ||  . ...    .|.|. ..    .     | .... . ......|.||... ..|..|||
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPT

AAECLEHPYV
|...|.||..
AEQILQHPWF
Kinase 81864.m00329.AA p38 18-305 39 1.4e-87 297.22 In-house 1-289 (289) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-289/289
Sequence Identity: 39% (117 aa)

YEIIQKIGKGAYGVVWRCINKQNGQV---VALKKAFGAFGNLTDAQRTYREITFLRQLKDCPAIVKLLAVHKA-----ENDQDIYMVFECLETDVHAVIR
|. .| .|.|||| |   . .. ||    || || .  |    .| |||||.  |. ..    ...|| |        .. ||.||| .  ..| . ...
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMR-HENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMK

ANILLDVHHRFIFWQLLVALKYVHSAGVIHRDLKPSNLLINSDATIKLCDFGLARAIDEDGQTEDLTDYVATRWYRAPEILFGSNSYTSSVDMWAAGCIL
   | | | .|.  |.| .|||.||||.|||||||||. .| |  ..  ||||||. |     ...|.||||||||||||..    ||  ||.|  |||.
CQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCD-----DEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AELVSGRPLFPGSSTMDQLERIVAYTGPLSEQQIESMVSNFTSTMLSNLSYSRPKFYLEEKLPDAPPDAIDLIKKLISLNPADRPTAAECLEHPYV
|||..||.||||.  .|||.||.. .|  .|  .. . |    . . ...  .|.  ... .. | | ||||. |.  | |  | ||.| ..||| 
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYP-QMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 81864.m00329.AA CDKL 18-305 37 1.1e-85 290.93 In-house 1-286 (286) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-286/286
Sequence Identity: 37% (111 aa)

YEIIQKIGKGAYGVVWRCINKQNGQVVALKKAFGAFGNLTDAQRTYREITFLRQLKDCPAIVKLLAVHKAENDQDIYMVFECLETDVHAVIRANI--LLD
||.. |.| |.||||  | || .||.|| ||      .     .. ||| .|.|||  . || |. | .  .   ...|||  .  |  .   .   . .
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKH-ENIVNLIEVFRRKR--KLHLVFEYCDHTVLHELEEYPNGVDE

VHHRFIFWQLLVALKYVHSAGVIHRDLKPSNLLIN-SDATIKLCDFGLARAIDEDGQTEDLTDYVATRWYRAPEILFGSNSYTSSVDMWAAGCILAELVS
   | . ||.| |... |.  .|||| || |.||. .. ..||||||.|| . . ...| .||||||||||||| | |  .| ..||.||.||..||...
HVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLA-KPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMID

GRPLFPGSSTMDQLERIVAYTGPLSEQQIESMVSN--FTSTMLSNLSYSRPKFYLEEKLPDAP-PDAIDLIKKLISLNPADRPTAAECLEHPYV
| ||.||.|  ||| .|.   |||  ...|   .|  |    .   .   |   ||...|..  . |.|..||.  ..|..|.|......||| 
GQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEP---LEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 81864.m00329.AA ERK5 18-305 39 3.2e-84 286.1 In-house 1-295 (295) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-295/295
Sequence Identity: 39% (116 aa)

YEIIQKIGKGAYGVVWRCINKQNGQVVALKKAFGAFGNLTDAQRTYREITFLRQLK--DCPAIVKLLAVHKAEND-QDIYMVFECLETDVHAVIRANILL
|.|| ||| ||||||   ....||| ||.||   ||  .| |.||.||.  ||  .     ||  .|  ..   . .|.|.||. .| |.| .| .|  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

DVHH-RFIFWQLLVALKYVHSAGVIHRDLKPSNLLINSDATIKLCDFGLARAIDE---DGQTEDLTDYVATRWYRAPEILFGSNSYTSSVDMWAAGCILA
 . | |.  .|.|  |||.||| ||||||||||||.|    .|. |||.|| .     | .   .|.|||||||||||..| |. ||  .|.|. |||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELVSGRPLFPGSSTMDQLERIVAYTGPLSEQQIESMVSNFTSTMLSN-LSYSRPKFYLEEKLPDAPPDAIDLIKKLISLNPADRPTAAECLEHPYV
|... | .|||   ..||. |.   |  . . |... ..     .   ..  .||  .|.  | | . |.||. ...   |..| |... | ||..
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPK-DWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 81864.m00329.AA ERK1 18-305 41 1.5e-80 273.9 In-house 1-289 (289) Show / Hide 
Range on Protein: 18-305
Range on HMM: 1-289/289
Sequence Identity: 41% (122 aa)

YEIIQKIGKGAYGVVWRCINKQNGQVVALKKAFGAFGNLTDAQRTYREITFLRQLK--DCPAIVKLLAVHKAENDQDIYMVFECLETDVHAVIRANILLD
|  .| ||.||||.|   . . ..| ||.||    |   |  ||| |||. |   |      |  .. ..  |. .|.|.| . .|||.  ....  |  
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKK-ISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSN

VHHRFIFWQLLVALKYVHSAGVIHRDLKPSNLLINSDATIKLCDFGLARAID-EDGQTEDLTDYVATRWYRAPEILFGSNSYTSSVDMWAAGCILAELVS
 |  .  .|.|  |||.||| |.||||||||||.|    .|.|||||||  | |   |  ||.||||||||||||.  |  || |.|.|. ||||||..|
DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS

GRPLFPGSSTMDQLERIVAYTGPLSEQQIESMVSNFTSTMLSNLSYSRPKFYLEEKLPDAPPDAIDLIKKLISLNPADRPTAAECLEHPYV
 ||.|||   .|||  |..  |  |.. .. .. .     |  | . .||  ...  |.| . |.||. |... ||  | |  | | |||.
NRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPH-KPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 81864.m00329.AA MAPK-Unclassified 18-171 43 1.1e-50 174.72 In-house 1-163 (575) Show / Hide 
Range on Protein: 18-171
Range on HMM: 1-163/575
Sequence Identity: 43% (71 aa)

YEIIQKIGKGAYGVVWRCINKQN-GQVVALKKAFGAFGNLTDAQRTYREITFLRQLKDCPAIVKLLAVHKAENDQD-----IYMVFECLET---DVHAVI
|| .. || ||||.| | . |.| .| || ||  ..| | ||. |. |||  || |   | |...  .  .. ..      || | .  .|   | | .|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLN-HPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQII

RANI--LLDVHHRFIFWQLLVALKYVHSAGVIHRDLKPSNLLINSDATIKLCDFGLARAIDEDGQ
. |.  . . | . .| |.|  ||| |||..||||||||||||| | ... ||||..| | || |
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSI-EDNQ
Kinase 81864.m00329.AA MAPK-Unclassified 174-236 34 8.5e-25 86.26 In-house 404-497 (575) Show / Hide 
Range on Protein: 174-236
Range on HMM: 404-497/575
Sequence Identity: 34% (32 aa)

DLTDYVATRWYRAPEILFGSNSYTSSVDMWAAGCILAELVSG-----------RPLFPGSS--------------------TMDQLERIVAYTG
..| ||.|||||||||.. .  |.  ||.|..|||.||...            ||||||..                      ||.  |. | |
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLG
Kinase 81864.m00329.AA TyrKc 18-308 22 1.9e-15 26.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-308
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

YEIIQKIGKGAYGVVWRCINKQNGQVVALKKAF-GAFGNLTDAQRTYREITFLRQL-KDCPAIVKLLAVHKAE-----NDQDIYMVFE-CLETDVHAVIR
 . ..|.| ||.|.|.... |   . || |.   .|       .  .||.  ...| .. | ||.|..|   .      .. ...|.| .   | .  .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ANI--LLDVHHRFIFWQLLVALKYVHSAGVIHRDLKPSNLLINSDATIKLCDFGLARAIDED-------GQTED----LTDY-VATRWYRAPEILFGSNS
..   |   .   . ||      | || ..|||||   | |.... |.| .||||.|.|..|                 ... .  ||. ||| .   . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YTSSVDMWAAGCILAELVS-GRPLFPG-----SSTMDQLERIVAYTGPLSEQQIESMVSNFTSTMLSNLSYSRPKFYLEEKLPDAPPDAIDLIKKLISLN
.|.  | |. |  . |. . | .  ||      |  . .|.. .   .   . ..  .|                |      . .|..  ...|.    .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS----------------F------VCCPDEMYQIMKQCWHED

PADRPTAAECLEHPYVAQF
|.|||| .|.     . .|
PEDRPTFSEI-----HECF
Kinase 81864.m00329.AA MAPK-Unclassified 272-305 34 5.4e-07 20.75 In-house 533-575 (575) Show / Hide 
Range on Protein: 272-305
Range on HMM: 533-575/575
Sequence Identity: 34% (15 aa)

PDAP---------PDAIDLIKKLISLNPADRPTAAECLEHPYV
. ||         ...||...|.   ||  | || . |||||.
CKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 81864.m00329.AA Pkinase_Tyr 128-204 34 9.1e-07 23.55 Pfam 123-199 (270) Show / Hide 
Range on Protein: 128-204
Range on HMM: 123-199/270
Sequence Identity: 34% (28 aa)

ALKYVHSAGVIHRDLKPSNLLINSDATIKLCDFGLARAI--DEDG-QTEDLTDYVATRWYRAPE-ILFGSNSYTSSVDMWA
.. | .| . |||||   | |.... ..| |||||||.|  |.   .. . .. .  .|. ||| | .|   .|.  | |.
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWM-APECINYGK--FTTKSDVWS
Kinase 81864.m00329.AA Pkinase_Tyr 18-98 26 2e-05 19.02 Pfam 1-87 (270) Show / Hide 
Range on Protein: 18-98
Range on HMM: 1-87/270
Sequence Identity: 26% (23 aa)

YEIIQKIGKGAYGVVWRCINK----QNGQVVALKKAFGAFGNLTD--AQRTYREITFLRQLKDCPAIVKLLAVHKAENDQ-DIYMVFE
 ....|.|.||.|.|.... |    .... || |.         .   .   ||.  ..|| ..| ||.|..|   . ..  ||.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVME