Gene 90492.m00229 (T.vaginalis)

90492.m00229

Species: T.vaginalis
Alias: 90492.m00229, TvagK0483
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-D

Sequence

Name Sequence Type Origin Length Description Download
90492.m00229.AA Protein None 351 None Fasta, JSON
90492.m00229.kin_dom Protein Kinase Domain None 208 None Fasta, JSON

Protein domain

Protein domains of 90492.m00229.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 90492.m00229.AA CK1-Unclassified 24-252 48 6.1e-118 349.66 In-house 5-244 (244) Show / Hide 
Range on Protein: 24-252
Range on HMM: 5-244/244
Sequence Identity: 48% (116 aa)

KHLGGGSFGDVYEAEDIETQSVVALKFETGNAVQSQLPNEYKCYSALQGSP-------NIPKVYGLFDY--KKSTFLVMERMGASLESCFKRNGKRFSLK
. .| ||||..|.. ...|. .||.|.|  |. ..||. | | . .||.         .|||.|  .        ..||.  | |||. |.  ...||||
EKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRKFSLK

TILMIGDQLFRCIEYIHKSGILHRDIKPHNFLIG-LGENRRQIYAIDFGVSTRYIDP-KTKEHQIYSPNNGLIGTAHYVSVNTHLGESQSRRDDLESIAY
|.|||.||.   |||.|. ...|||||| |||.| || |. |.| |||| | ||||. ||..|  |  | .|.||| | |.|.|||  |||||||||..|
TVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGY

VLIRFLRGSLPWQKIKIKDPDERQEKISQMKLQTTPEQLC
||| ||.|||||| || .. .|..|||  ||..|..||||
VLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 90492.m00229.AA CK1 24-278 44 4.3e-115 388.66 In-house 5-271 (271) Show / Hide 
Range on Protein: 24-278
Range on HMM: 5-271/271
Sequence Identity: 44% (120 aa)

KHLGGGSFGDVYEAEDIETQSV---VALKFETGNAVQSQLPNEYKCYSALQG------SPNIPKVYGLFDY--KKSTFLVMERMGASLESCFKRNGKRFS
. .| |||||.|..... |. .   || |.|  .. ..||. |.| |  |||      ...||..|       ..  ..||.  | |||. |.  ...||
RKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNRKFS

LKTILMIGDQLFRCIEYIHKSGILHRDIKPHNFLIGL-GENRRQIYAIDFGVSTRYIDPKTKEHQIYSPNNGLIGTAHYVSVNTHLGESQSRRDDLESIA
|||.|||.||. . |||.|. ...|||||| |||.|. | .  |.| |||| . ||.|.||..|  |  | .|.||| | |.|||||  ||||||.||..
LKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLG

YVLIRFLRGSLPWQKIKIKDPDERQEKISQMKLQTTPEQLCFG-IPSEFRQIYEYIRRLRYDETPNYS
|||. ||||||||| .| .  ... |||. .|..|..|||| | .|.|| .  .|.|.|...|.|.| 
YVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 90492.m00229.AA CK1 20-280 31 2.2e-98 333.16 In-house 1-339 (339) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-339/339
Sequence Identity: 31% (106 aa)

WIARKHLGGGSFG-DVYEA-----EDIETQ-----SVVALKFET-GNAVQ-SQLPNEYKCYSALQG--------------------SPNIPKVYGLFDYK
|   |..|.|.|| ..|..     .|....       .|.| |   .. | .||  ||. | .|||                    .| .....  .  .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

KST-FLVMERMGASLESCFK--RN-GKRFSLKTILMIGDQLFRCIEYIHKSGILHRDIKPHNFLIGL-------------GENRRQIYAIDFGVST-RYI
.   ..||.. | .||...|  |. ...||.||.|||..|.   .||.|  |..|||||| ||..|.             ....||.| |||| .  .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------KTKEHQIYSP---NNGLIG-TAHYVSVNTHLGESQSRRDDLESIAYVLIRFLRGS--LPWQKIKIKDP-------DERQEKISQMKL
|.           ||..|  . .   . |..| || |.|.|.|||  |.|||||.| .|.|| .|.|.  ||||..| ..        .. .|.|. .|.
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

QTTPEQLCFG-----IPSEFRQIYEYIRRLRYDETPNYSWI
.|... || .     .|.|| .|..||| |.|...|.|  |
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 90492.m00229.AA CK1-D 21-280 45 2.5e-89 303.09 In-house 3-261 (261) Show / Hide 
Range on Protein: 21-280
Range on HMM: 3-261/261
Sequence Identity: 45% (119 aa)

IARKHLGGGSFGDVYEAEDIETQSVVALKFETGNAVQSQLPNEYKCYSALQGSPNIPKVYGLFDYKKSTFLVMERMGASLESCFKRNGKRFSLKTILMIG
|.|| .|.|||||.|  ..|.|   ||.| |.  .   ||  | | |  .||   ||..  .        .||. .| |||  |   ...|||||.||..
IGRK-IGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLA

DQLFRCIEYIHKSGILHRDIKPHNFLIGLGENRRQIYAIDFGVSTRYIDPKTKEHQIYSPNNGLIGTAHYVSVNTHLGESQSRRDDLESIAYVLIRFLRG
||... |||||    .|||||| |||.|||     .| ||||.. || |..|..|  |  |  | ||| | |.|||.|  |||||||||. |||. | ||
DQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRG

SLPWQKIKIKDPDERQEKISQMKLQTTPEQLCFGIPSEFRQIYEYIRRLRYDETPNYSWI
||||| .|     .. |.|.. |..|  ..|| | |||| |  .| |.|..|. |.|...
SLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 90492.m00229.AA CK1-A 24-280 43 2.1e-86 293.36 In-house 5-261 (261) Show / Hide 
Range on Protein: 24-280
Range on HMM: 5-261/261
Sequence Identity: 43% (112 aa)

KHLGGGSFGDVYEAEDIETQSVVALKFETGNAVQSQLPNEYKCYSALQGSPNIPKVYGLFDYKKSTFLVMERMGASLESCFKRNGKRFSLKTILMIGDQL
...| |||||.| .  |.  . ||.| |  .|   ||  | | |  ||| . ||..      |    .||. .| |||  |    .||..||.||. ||.
RKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQM

FRCIEYIHKSGILHRDIKPHNFLIGLGENRRQIYAIDFGVSTRYIDPKTKEHQIYSPNNGLIGTAHYVSVNTHLGESQSRRDDLESIAYVLIRFLRGSLP
   |||.|. . .|||||| |||.|.|    ... ||||.. .| |..|..|  |     |.||| | |.| |||  ||||||.||..||.. | ||.||
IMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLP

WQKIKIKDPDERQEKISQMKLQTTPEQLCFGIPSEFRQIYEYIRRLRYDETPNYSWI
|| .| .    . ||||  |. |. |||| | |.||  . .|.| ||..|.|.| ..
WQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 90492.m00229.AA CK1-G 24-280 41 6.5e-82 277.41 In-house 5-266 (266) Show / Hide 
Range on Protein: 24-280
Range on HMM: 5-266/266
Sequence Identity: 41% (110 aa)

KHLGGGSFGDVYEAEDIETQSVVALKFETGNAVQSQLPNEYKCYSALQGSP-NIPKVYGLFDYKKSTFLVMERMGASLESCFKRNGKRFSLKTILMIGDQ
|  | |.|| ..| . . .   || |||       ||  ||. |  | | | .||.||      |   .||. .| |||  |   . .||.||..|.  |
KKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQ

LFRCIEYIHKSGILHRDIKPHNFLIGLGENRRQ--IYAIDFGVSTRYIDPKTKEHQIYSPNNGLIGTAHYVSVNTHLGESQSRRDDLESIAYVLIRFLRG
. . .||.|.   . ||.|| |||||   |..|  |. ||||    ||||.|| |  |     | ||| | |.|||||  ||||||.|..  . . ||||
MIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRG

SLPWQKIKIKDPDERQEKISQMKLQTTPEQLCFG--IPSEFRQIYEYIRRLRYDETPNYSWI
|||||  |     || .|| . | .| .| || .  .| .| .  .|.||| ..|.| | ..
SLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 90492.m00229.AA TTBKL 20-284 29 4.8e-57 191.14 In-house 1-288 (288) Show / Hide 
Range on Protein: 20-284
Range on HMM: 1-288/288
Sequence Identity: 29% (87 aa)

WIARKHLGGGSFGDVYEAEDIET-QSVVALKFETGN-AV-QSQLPNEYKCYSALQ--GSPNIPKVYGLFDYKKSTFLVMERMGASLESCFKRNGKR--FS
| . | .|.| || ||...|... ... |.| |    .   | .  | .  ..||  ||| .||...   .|. .|.||.  | .|    |..  .  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTILMIGDQLFRCIEYIHKSGILHRDIKPHNFLIGLGEN----RRQIYAIDFGVSTRYIDPKT--------KEHQIYSPNN-----GLIGTAHYVSVNT
  |.. || |.. .. ..|  |..|||.|| |. .|. ..    .| .| |||| . .|...          .. ..  | |     .. ||  |.|.| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLGESQSRRDDLESIAYVLIRFLRGSLPWQKIKIKDPDERQEKISQMKLQTTPEQLCFG------IPSEFRQIYEYIRRLRYDETPNYSWIRQTL
|..  |.| ||| |  |..| .. | |||. .. |      ..| .||.... |.|. .      .||||  .....|.||| ..|.|. |.. .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDK------MEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 90492.m00229.AA TTBK 20-280 34 3.2e-48 166.53 In-house 1-257 (257) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-257/257
Sequence Identity: 34% (93 aa)

WIARKHLGGGSFGDVYEAEDIETQ-SVVALKFETGNAVQSQLPNEYKCYSALQGSPNIPKVYGLFDYKKSTFLVMERMGASLESCFKRNGKR--FSLKTI
|   |  ||| || .|||.|. ..   ||.| |  ..    |  |      ||| . . . .|     |  ..||.  | .| .   |.  |  ||| | 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNL-ADLRRKQPRGCFSLSTT

LMIGDQLFRCIEYIHKSGILHRDIKPHNFLIG-LGENRRQIYAIDFGVSTRYIDPKTKEHQIYSPNN--GLIGTAHYVSVNTHLGESQSRRDDLESIAYV
| .| |.   || ||  | ||||||| || .| . ...|..| .|||   .|.   . . .. .| .  |  ||. | |.| |.     |.||| |. |.
LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYT---NACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYM

LIRFLRGSLPWQKIKIKDPDERQEKISQMKLQTTPEQLCFGIPSEFRQIYEYIRRLRYDETPNYSWI
|. |. | ||| ||| |      ... .|| .     |   .|.||.|  . |. | | ..|.|  |
LVEFVQGQLPWRKIKDK------DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 90492.m00229.AA Worm6 20-280 28 1.6e-40 140.97 In-house 1-279 (279) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-279/279
Sequence Identity: 28% (79 aa)

WIARKHLGGGSFGDVYEAEDIETQS--VVALKFET--GNAVQSQLPNEYKCYSAL--QGSPNIPKVYGLFDY--KKS---TFLVMERMGASLES-CFKRN
|  .| .| |.||.||..|| .. .   .|.| |    |.  ..|. |.    |.  ..... .|   ..|.  ...    ..||.  | .|.   . |.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCK---IEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP

GKRFSLKTILMIGDQLFRCIEYIHKSGILHRDIKPHNFLIGL-----GENRRQIYAIDFGVST--RYIDPKTKEHQIYSPNNGLIGTAHYVSVNTHLGES
...||. | | |. |  . ||  |. | .|||.|| || ||       .....|| .||| .   .|.. ... ..   .. |  ||  | ... | |  
DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQE

QSRRDDLESIAYVLIRFLRGSLPWQKIKIKDPDE-RQEKISQMKLQTTPEQLCFGIPS-EFRQIYEYIRRLRYDETPNYSWI
|.|.||.||  |... ...| |||...| .| .| .....   .  .  ... ...|  ||. | .||  ..| ..|.|  |
QCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 90492.m00229.AA Pkinase 20-244 23 6e-30 106.98 Pfam 1-235 (293) Show / Hide 
Range on Protein: 20-244
Range on HMM: 1-235/293
Sequence Identity: 23% (59 aa)

WIARKHLGGGSFGDVYEAEDIETQSVVALKFETGNAVQSQLP------NEYKCYSALQGSPNIPKVYGLFDYKKSTFLVMERMGASLESCFKRN------
.   . .| |||| ||.. .. |. .||.|        |. .      .| .    | ..||| . |. | .|..  .||| ..  |. ..         
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW

-GKRF--SLKTILMIGDQLFRCIEYIHKSGILHRDIKPHNFLIG-LGENRRQIYAIDFGVSTRYIDPKTKEHQIYSPNNGLIGTAHYVSVNTHL-GESQS
 ...|  | ... ..  |..| .||.|. ||.|||.|| |.||   |..   .  .|||..  .       .  .| .... || .|..   .. |.  .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RRDDLESIAYVLIRFLRGSLPWQKI----KIKDPDERQEKISQMKL
.. |  |.  .|. .| | .|..      .  |.... ..| . .|
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPL
Kinase 90492.m00229.AA Ciliate-E2 20-192 20 2.4e-26 87.46 In-house 1-255 (365) Show / Hide 
Range on Protein: 20-192
Range on HMM: 1-255/365
Sequence Identity: 20% (54 aa)

WIARKHLGGGSFGDVYEAEDIETQSVVALKFETGNA--------------------VQSQLPNEYKCYSALQ------------------GSPNIPKVYG
 .  | .| |.||.||.......|  .|.|... .                      ..|. .  .  . ..                   .||| | | 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

LFD--YKKSTFLVMERMGA-SLES-----CFKRNGK-----RFSLKTILMIGDQLFR---------------CIEYIHKSG-ILHRDIKPHNFLIGLGEN
 |    ... .||||     .|..     . ||| .     .|..| |. |  |...               ..||.|. . |.|||||| | |.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

RRQIYAIDFGVSTRYIDPKT----KEHQIYSPNNG---------------------LIGTAHYVS
   |  |||| |..| |.      | ..   .. .                     ..||..|..
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMA
Kinase 90492.m00229.AA S_TKc 20-280 19 1.2e-21 79.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

WIARKHLGGGSFGDVYEAEDIETQSVVALKFETGNAVQSQLPNEYKCYSALQGSPNIPKVYGLFDYKKSTFLVMERMGA---SLESCFKRNGKR-----F
.   ...| |.|| || . ...|. .||.|         .. .| .. .   . ||| | |. |.  .. ..||| ..    .| .  |..|..     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLKTILMIGDQLFRCIEYIHKSGILHRDIKPHNFLIGLGENRRQIYAIDFGVSTRYIDPKTKEHQIYSPNNGLIGTAHYVSVNTHLGESQSR-RDDLESI
.  ..  .  |... .||.|. ||.|||.|| | |.       .|  .|||.....              . ..|| .|..       . .. . |  |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

AYVLIRFLRGSLPWQKIKIKDPDERQEKISQMKLQTTPEQLCFGIPSEFR------QIYEYIRRLRYDETPN-------YSWI
  .|. .| |  |..          .... .. .           ..|..        ..  .|.   |  .         |.
GCILYEMLCGYPPFP---------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 90492.m00229.AA TyrKc 20-222 17 0.000111 -146.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-222
Range on HMM: 1-280/280
Sequence Identity: 17% (49 aa)

WIARKHLGGGSFGDVYEAEDIETQSVVALKFETGNAVQSQLPNEYKCYSAL-QGSPNIPKVYGLFDYK-------KSTFLVMERMGA-SLESCFKRNGKR
    | || | || ||... .     || |    .| .  . .| .  . |    ||| . ||    .       .  ..||| |   .| .  ......
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FSLKTILMIGDQLFRCIEYIHKSGILHRDIKPHNFLIGLGENR--------RQIYAI-DFGVSTRYIDP----KTK-------------EHQIYS-----
...|. | .  |  .  ||.|. .. |||.   | |.| .           | ||     |.|. |...     .|              . ...     
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

----------------PNNGLI---GTAHYVSVNTHLGESQSRRDD--------LESIAYVLIR--------------FLRGSL
                |  | |    ..  |  .   |.   . ..          .  | ...               ..  .
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF