Gene 83363.m00084 (T.vaginalis)

83363.m00084

Species: T.vaginalis
Alias: 83363.m00084, TvagK0757
External Links:
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
83363.m00084.AA Protein None 331 None Fasta, JSON
83363.m00084.kin_dom Protein Kinase Domain None 275 None Fasta, JSON

Protein domain

Protein domains of 83363.m00084.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 83363.m00084.AA GSK 23-306 31 3.1e-110 337.96 In-house 1-328 (328) Show / Hide 
Range on Protein: 23-306
Range on HMM: 1-328/328
Sequence Identity: 31% (104 aa)

YTVMKKDFASGAFGSVAQCKTD----DQQIV-----AIKKVIWNKSIK-SQEYDILLSL---DHRNIVKV---YDHIVDSESNQSKVNEFIVMEYLNESL
|. ||. ...|.|| | | .      ... .     |||||  .|  | . |..|.  |   || |||.    ...  .....  .. . .||||... |
YEEMKV-IGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTL

FDYMIEFNQNQKRIPMLDIKLFAYQIFSALNYIHSKGIAHCDLKPENILLDRSSGIIKVADFGSAQYITQ--ASANNTYIVSRFYRAPELLIDAKQYDTA
 ..  ... |....|...|||..||.| .|.|.||.||.| |.||.|||.|...|. | .|||||...     ..|..||.||.||||||......|...
YQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQ

VDIWSTGCIIVEMLTGHTLFHSNNSDEQLKAILKVLGKPSFDDLHSIPHKKVVPQYRDQ------TTP------------------------IESIIPSN
.|.|| ||.. |||.|. ||  ..|  ||. | |.|| |. ....|.  .   |.....      ..|                        .  .... 
IDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSM--NPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTD

TPQDLKELLKSILVFNPKKRPTALECMNHKFF
 . |. .|....||..||||...||.. | ||
MQ-DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 83363.m00084.AA CMGC 23-306 20 1.6e-98 324.36 In-house 1-513 (513) Show / Hide 
Range on Protein: 23-306
Range on HMM: 1-513/513
Sequence Identity: 20% (106 aa)

YTVMKKDFASGAFGSVAQCKT---------------DDQQIVAIKKVIWNKSIKSQ----------------EYDILLSL-----------------DHR
|...||   .|..| | .|.                ....||||||.  ..  . |                |  ||  |                 .| 
YEIIKK-IGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

NIVKVYDHIVDSESNQS-----------KVNEFIVMEYLNESLFDYMIEFN------------------------QNQKRIPMLDIKLFAYQIFSALN--
|||| ||......|. .            .. ..|.||.  .|..|. . .                        .| | ... .|. ..|||. .|.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YIHSKG--IAHCDLKPENILLDRS-------------------SGIIKVADFGSAQYITQAS----------------------ANNTYIVSRFYRAPEL
|.||..  | |.||||||||..                     .|..|..|||.| .. . |                      .. .|.|.|.|||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

LIDAKQYD---------TAVDIWSTGCIIVEMLTG--------HTLFHSNNS-----------DEQLKAILKVLGKPS------------FDDLHSIPHK
|. .|.|.         |..|.|| |||. ||.||        ..||. ...            .||. | ||||.|.            .     .| .
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNM

KVVPQY-------------------------------RDQTTPIESIIPS----------------------------------NTPQDLKELLKSILVF
.  | |                               . .  |.....|                                   . .... .||| .|..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

NPKKRPTALECMNHKFF
.|.||.|| ....| .|
DPDKRITAEQALQHPYF
Kinase 83363.m00084.AA S_TKc 24-306 30 8.2e-87 295.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-306
Range on HMM: 1-231/231
Sequence Identity: 30% (91 aa)

TVMKKDFASGAFGSVAQCKTDD-QQIVAIKKVIWNKSIKSQEYDILLSLDHRNIVKVYDHIVDSESNQSKVNEFIVMEYLNE---SLFDYMIEFNQNQKR
  . .   .||||.| .|.  . ..|||||..        .| .|| . .| |||| ||...|        . ..||||..    .||||. . . . .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IPMLDIKLFAYQIFSALNYIHSKGIAHCDLKPENILLDRSSGIIKVADFGSAQYITQASANNTYIVSRFYRAPELLIDAKQYDT-AVDIWSTGCIIVE
  .|  ... ..|||..||.|.||.|| |.||||||||||.    ||..|||.|  .      .|......|.|||.|    .|.. ..|.|| |||. |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MLTGHTLFHSNNSDEQLKAILKVLGKPSFDDLHSIPHKKVVPQYRDQTTPIESIIPSNTPQDLKELLKSILVFNPKKRPTALECMN-------HKFF
||.| ..|.      |.....|..|                                  ....|.... .|...|.||||| |...       | .|
MLCGYPPFP------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 83363.m00084.AA Pkinase 32-306 30 5.2e-79 273.59 Pfam 9-293 (293) Show / Hide 
Range on Protein: 32-306
Range on HMM: 9-293/293
Sequence Identity: 30% (94 aa)

SGAFGSVAQCKTDDQQI-VAIKKVIWNKSIKSQ--------EYDILLSLDHRNIVKVYDHIVDSESNQSKVNEFIVMEYLNE-----SLFDYMIEFNQNQ
||.||.| .|.  . .. ||.|..   .  ...        |  |...|.| |||. ||   |      | .  .||||..      .||||.    ...
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST--WRH

KRI--PMLDIKLFAYQIFSALNYIHSKGIAHCDLKPENILLDRSSGII----KVADFGSA-QY-ITQASANNTYIVSRFYRAPELLIDAKQYDTAVDIWS
...  .. ..| ..|||...|.|.||.|| |.||||||||.| . | |    |..|||.| |. .   | ..|. ....|.|||.. ... |...||.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

TGCIIVEMLTGHTLFHSN----NSDEQLKAILKVLG---KPSFDDLHSIPHKKVVPQYRDQTTPIESIIPSNTPQDLKELLKSILVFNPKKRPTALECMN
 |||. |||.|...| .     | ..|.. | ...|   . ... ..||.  . ... .    . ..    |.....|...|..| ..||||||| ....
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HKFF
|..|
HPWF
Kinase 83363.m00084.AA CDK 23-306 27 1.3e-70 225.05 In-house 1-284 (284) Show / Hide 
Range on Protein: 23-306
Range on HMM: 1-284/284
Sequence Identity: 27% (88 aa)

YTVMKKDFASGAFGSVAQCKTDD------QQIVAIKKVIWNK--------SIKS---QEYDILLSLDHRNIVKVYDHIVDSESNQSKVNE------FIVM
|   .|    |..| |  ..  .      .||||.||..  .         . .    |  .|  | | ||||..| ......  .          ..|.
YEKLEKI-GEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVF

EYLNESLFDYMIEFNQNQKRIPMLDIKLFAYQIFSALNYIHSKGIAHCDLKPENILLDRSSGI-----IKVADFGSAQYITQ------ASANNT-YIVSR
||.   |  ||              || . .|. ..|.|.||..| | |||| |||...  |.     .|.|||| |            .   |  .| .
EYMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINN-NGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTL

FYRAPELLIDAKQYD--TAVDIWSTGCIIVEMLT---GHTLFHSNNSDEQLKAILKVLGKPSFDDLHSIPHKKVVPQYRDQTTPIESIIPSNTPQDLKEL
 |||||||  .|.|.  |..|.|| |||..||.|   .  ||. ..  .||. | ...| |. |.  .. .                           .|
WYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------DL

LKSILVFNPKKRPTALECMNHKFF
| . |...|||| .| ....|..|
LNKMLCYDPKKRISAEQALQHPYF
Kinase 83363.m00084.AA CAMK 32-306 20 3.2e-58 185.89 In-house 4-425 (425) Show / Hide 
Range on Protein: 32-306
Range on HMM: 4-425/425
Sequence Identity: 20% (89 aa)

SGAFGSVAQCKT-DDQ------------QIVAIKK--------------------------------VIWNKSIKSQEYDILLS-------LDHRNIVKV
.|.|| |  |.   ..            | ||||                                    ..    .|..|. .       |||.||.| 
RGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKL

YDHIVDSES--------NQSKV------NEFIVM---EYLNE-----SLFDYMIEFNQNQ-----------KRIPMLDIKLFAYQIFSALNYIHSKGIAH
|... |..         . ||.      . ..||   ||         |||| .|  ..            .|..  . . .  || ||..|.||..|.|
YEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVH

CDLKPENILLDRSS----------------GIIKVADFGSAQYITQASANN------------------------TYIVSRFYRA-PELLID--------
.|||||||||| ..                . ||..||| |..... . |.                        |.  .  | | ||.|          
RDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQN

-----AKQYDTAVDIWSTGCIIVEMLTGHTLFHSNNSDEQLKAI------------LKVLGKPSFDDLH------------------SIPHKKVVPQYRD
      . |. ..|.|| |.|   ||.|.  | . . .|... .                || .|.. .                  .            
ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-DEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDE------------

QTTPIESIIPSNTPQDLKELLKSILVFNPKKRPTALECMNHKFF
       . ...  |. | |....|. .|.||.|. .|.||...
-------F-HHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 83363.m00084.AA DYRK 96-306 29 4.6e-55 189.24 In-house 77-320 (320) Show / Hide 
Range on Protein: 96-306
Range on HMM: 77-320/320
Sequence Identity: 29% (73 aa)

FIVMEYLNESLFDYMIEFNQNQKRIPMLDIKLFAYQIFSALNYIHSK-GIAHCDLKPENILLDR--SSGIIKVADFGSAQYITQASANNTYIVSRFYRAP
.|| | |  .|.... . ...   ...  .. ||.||. .| ..|..  | |||||||||.|    .   |||.||||. .. |     |||.|||||||
CIVFELLSMNLYEFLKNNHFQGF-FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ--RIYTYIQSRFYRAP

ELLIDAKQYDTAVDIWSTGCIIVEMLTGHTLFHSNNSDEQLKAILKVLGKPSFDDLHSI---------------------PHKKVVPQYRD---------
| ..  . |..|.|.|| |||..|..||. ||  .|  .||. |  |||.|. . ...                       ..|. ..|           
EVILGCP-YCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRG

-----QTTPIESIIPSNTPQDLKELLKSILVFNPKKRPTALECMNHKFF
      ...... .     ...| ..|  |...|.||.|. . ..|..|
QRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 83363.m00084.AA MAPK 125-306 32 5.4e-55 188.59 In-house 117-328 (328) Show / Hide 
Range on Protein: 125-306
Range on HMM: 117-328/328
Sequence Identity: 32% (70 aa)

IKLFAYQIFSA--LNYIHSKGIAHCDLKPENILLDRSSGIIKVADFGSAQYITQASANNT---------------YIVSRFYRAPELLID--AKQYDTAV
|. | |||  .  | |||| .. |.||||.|||.. . .  |..||| |  | . .  ..               |.. |.|||||..    .. |..||
IQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAV

DIWSTGCIIVEMLT-GHTLFHSNNSDEQLKAILKVLGKPSFDDLHSIP-H---KKVVPQY----RDQTTPIESIIPS---NTPQDLKELLKSILVFNPKK
|.|| |||  |||| ...||  ... .|.. |..|||.|| ...  |.     .... ..    . .  | |...|    |.  .   ||.  |||.|.|
DMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDK

RPTALECMNHKFF
| |. |...| .|
RITVEEALQHPYF
Kinase 83363.m00084.AA Ciliate-E2 32-306 21 8.5e-55 186.52 In-house 9-365 (365) Show / Hide 
Range on Protein: 32-306
Range on HMM: 9-365/365
Sequence Identity: 21% (88 aa)

SGAFGSVAQCKT------------------------DDQQIVAIKKVIWN-KSIKSQEYDIL----------------LSLDHRNIVKVYDHIVDSESNQ
.|.|||| .||                         ....|.|.| .. | . ...|| .|.                 .|.| ||.| |..  .    .
QGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQE----K

SKVNEFIVMEYLNE-SLFDYMIEFNQNQ-------KRIPMLDIKLFAYQIFS---------------ALNYIHSKG-IAHCDLKPENILLDRSSGIIKVA
.. | ..||||..  .||||........       |.. .  || . .||..               ||.|.|||. | | |.||||||.      ||..
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKII

DFGSAQYITQASANNTY--------------------------------IVSRFYRAPELLI--------DAKQYDTAVDIWSTGCIIVEMLTGHTLFHS
||| ...... . |.|.                                . .  | ||| |         . |.||...|||| |.|. |||.| . |  
DFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--

NNSDEQLKAILKVLGKPSFDDLHSIPHKKVVPQYRDQTTPIESII------------------------PSNTPQDLKELLKS----ILVFNPKKRPT-A
                                        .. |.                        . . .|. | |.|     .|. .|.||.| .
----------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGW

LECMNHKFF
 ...||..|
EQILNHPWF
Kinase 83363.m00084.AA STE 32-306 23 6e-48 165.62 In-house 9-359 (359) Show / Hide 
Range on Protein: 32-306
Range on HMM: 9-359/359
Sequence Identity: 23% (88 aa)

SGAFGSVAQC---------KTD-------DQQIVAIKKVI---------------------WNKSIKSQEYDILLSLD--HRNIVKVYDHIVDSESN-QS
.||||.| ..         ||.        ..|.|||..                       ..    .| .|.  ..  | |||| |.. ..   | ..
KGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKN

KVNEFIVMEYLN-ESLFDYMI-------EFNQNQ---KRIPMLDIKLFAYQIFSA-LNYIHSKGIAHCDLKPENILLDRSSGIIKVADFGSAQYITQASA
. . .|.|||..  || | .        ..|.|.   .|.|   |. ...||  . |.|.||..| | |.|| ||||      .| .||| .  .|. .|
DDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMA

-----------------NNTYIVSRFYRAPELLID-----AKQYDTAVDIWSTGCIIVEMLTGHTLFHSNNSDEQLKAILKV--------------LGKP
                 .|| . .  . ||| .        |.||| .|||| || |.||.||.  .|  .  . . .|..                . |
NIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPP

SFDD---------------LHSIPHKKVVPQYRDQTTPIESIIPSNTPQDLKELLKSILVFNPKKRPTALECMN--HKFF
.. |               .                      .|..  ...|. ..  |. .|.||||| . ..  |.|.
PLPDHLSQNEMISYGGSGTT----------------------YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 83363.m00084.AA RCK 23-248 32 1e-41 129.99 In-house 1-238 (298) Show / Hide 
Range on Protein: 23-248
Range on HMM: 1-238/298
Sequence Identity: 32% (79 aa)

YTVMKKDFASGAFGSVAQ-CKTDDQQIVAIKK-----VIWNKSIKSQEYDILLSLD-HRNIVKVYDHIVDSESNQSKVNEFIVMEYLNESLFDYMIEFNQ
|...|.    |..|.|   .......||||||       |.  ..  |   |  |  | ||.|... | |... |     ..|.||. . |. .| .| .
YQIIKQ-LGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQL----YFVFEYMDMNLYQMMKDFKE

NQKRIPMLD--IKLFAYQIFSALNYIHSKGIAHCDLKPENILLDRS--------SGIIKVADFGSAQYITQASANNTYIVSRFYRAPELLIDAKQYDTAV
 .|..|     ||   |||. .|...|..|. | |||||||..  |        ...||.||||..  |     .  |. .| |||||.|  . .|.. .
RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPM

DIWSTGCIIVEMLTGHTLFHSNNSDEQLKAILKVLGKPSFDDL
|||. |||..|  . . ||  ..   |.  |.||.| |. .|.
DIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDW
Kinase 83363.m00084.AA CAMKL 23-221 31 1.7e-41 130.11 In-house 1-233 (297) Show / Hide 
Range on Protein: 23-221
Range on HMM: 1-233/297
Sequence Identity: 31% (75 aa)

YTVMKKDFASGAFGSVAQCKT-DD-QQIVAIKKVI----WNKSIKSQ---------------EYDILLSLD---HRNIVKVYDHIVDSES-NQSKVNEFI
|.. |     |.|| |  ..     .. |||| .     ||. ....               |. |. .|.   | ||.| |..| ..|   ..    ..
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYL

VMEYLNES---LFDYMIEFNQNQKRIPMLDIKLFAYQIFSALNYIHSKGIAHCDLKPENILLDRSSG-IIKVADFGSAQYIT-Q----ASANNTYIVSRF
||||       |||| ..     .|.|  . . .  || ||.||.||.||.| |.|||||||| .    ||..||| . ... .        .|   |  
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YRAPELLID-AKQYD-TAVDIWSTGCIIVEMLTGH
| |||.. .  |.||  .||||| | |   |..|.
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGY
Kinase 83363.m00084.AA TyrKc 24-306 21 1e-14 15.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-306
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

TVMKKDFASGAFGSVAQCKTDDQQIVAIKKVIWNKSIKS--QEYDILLSL--DHRNIVKVYDHIVDSESNQSKV----NEFIVMEYL-NESLFDYMIEFN
 ...|   .|||| | ... .  . ||.|..  .. ..   .|  |. .|  .| |||. |  ..... |          .|||||  . .| ||  .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYIEPLMIVMEYMPHGDLKDYLRKHR

QNQKRIPMLDIKLFAYQIFSALNYIHSKGIAHCDLKPENILLDRSSGIIKVADFGSAQYITQA----SANNTYIV-----SR-----FYRAPELLIDAKQ
 .   ..| |   |..|| .  .|.|||.. | ||   |.|...   ..|..||| . .|.       .  .| .     ..        ||| . . . 
PK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGK

YDTAVDIWSTGCIIVEMLTGHTLFHSN-----NSDEQLKAILKVLGKPSFDDLH---SIPHKKVVPQYRDQTTPIESIIPSNTPQDLKELLKSILVFNPK
. |. |.|| |  . |..|     ...      |.... . .|  . .   . .   |                  .      |... .. |.   ..|.
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------F---VCCPDEMYQIMKQCWHEDPE

KRPTALECMNHKFF
.|||  |.  |..|
DRPTFSEI--HECF
Kinase 83363.m00084.AA RCK 258-306 34 1.1e-14 42.75 In-house 253-298 (298) Show / Hide 
Range on Protein: 258-306
Range on HMM: 253-298/298
Sequence Identity: 34% (17 aa)

PQYRDQTTPIESIIPSNTPQDLKELLKSILVFNPKKRPTALECMNHKFF
||.    .|....||.  .||. ||..  |  .|.||.|| .. .|..|
PQCK--GMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 83363.m00084.AA CAMKL 271-306 36 4e-12 34.85 In-house 263-297 (297) Show / Hide 
Range on Protein: 271-306
Range on HMM: 263-297/297
Sequence Identity: 36% (13 aa)

IPSNTPQDLKELLKSILVFNPKKRPTALECMNHKFF
|..  . |.. |....|. ||.||||. . |||...
IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 83363.m00084.AA Pkinase_Tyr 24-209 26 9.1e-09 30.31 Pfam 1-199 (270) Show / Hide 
Range on Protein: 24-209
Range on HMM: 1-199/270
Sequence Identity: 26% (55 aa)

TVMKKDFASGAFGSVAQCKTD-----DQQIVAIKKVIWNKSIKSQ--------EYDILLSL-DHRNIVKVYDHIV-DSESNQSKVNEFIVMEYLNE-SLF
 .. |   .||||.| ... .     ... ||.|..  ... ..|        |  |. .| .| |||. |  .. ..|.|    . .|||||    .| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGDLL

DYMIEFNQNQKRIPMLDIKLFAYQIFSALNYIHSKGIAHCDLKPENILLDRSSGIIKVADFGSAQYITQASANNTY-IVSR------FYRAPELLIDAKQ
||  .   ......| |.  ...|| ....| .||.. | ||   |.|... ....|..||| | .|       .|  ..       .  ||| . . | 
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGK-

YDTAVDIWS
. |. |.||
FTTKSDVWS
Kinase 83363.m00084.AA MAPK 32-54 34 0.055393 2.38 In-house 9-38 (328) Show / Hide 
Range on Protein: 32-54
Range on HMM: 9-38/328
Sequence Identity: 34% (11 aa)

SGAFGSVAQCKTDDQQ---------IVAIKKV
.||.| |  |. .|.          .|||||.
QGAYGVV--CSAIDKRTNQKTKCGKKVAIKKI
Kinase 83363.m00084.AA DYRK 23-52 32 0.056116 3.52 In-house 1-30 (320) Show / Hide 
Range on Protein: 23-52
Range on HMM: 1-30/320
Sequence Identity: 32% (10 aa)

YTVMKKDFASGAFGSVAQCKTDDQQ-IVAIK
|....    .| || |..|.    . .||||
YEILEY-IGKGSFGQVVKCWDHKTNEMVAIK
Kinase 83363.m00084.AA Pkinase_Tyr 271-306 30 6.958509 0.23 Pfam 237-270 (270) Show / Hide 
Range on Protein: 271-306
Range on HMM: 237-270/270
Sequence Identity: 30% (11 aa)

IPSNTPQDLKELLKSILVFNPKKRPTALECMNHKFF
.| |.|... .|.|.   ..|..|||  |.  | ..
CPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL