Gene 91127.m00242 (T.vaginalis)

91127.m00242

Species: T.vaginalis
Alias: TvagK0600, 91127.m00242
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK7

Sequence

Name Sequence Type Origin Length Description Download
91127.m00242.AA Protein None 260 None Fasta, JSON
91127.m00242.kin_dom Protein Kinase Domain None 187 None Fasta, JSON

Protein domain

Protein domains of 91127.m00242.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 91127.m00242.AA ERK7 1-206 49 8.8e-104 351.08 In-house 83-292 (292) Show / Hide 
Range on Protein: 1-206
Range on HMM: 83-292/292
Sequence Identity: 49% (104 aa)

MDTDVHTVIR-AGILLDVHQRYIFWQLLCALKFIHSAGVIHRDLKPSNMLIKSDSTIKVCDFGLSRCINDMH----KDELLTDYIATRWYRAPEILFGSS
|.|| | ||| . || |.|..||..||| |.|..||. ||||||||||.|. |. ..||||||| | | .      ..  ||.|.||||||||||| || 
METDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSH

KYGPGIDMWAAGCILAELVGGRPLFPGASTMDQLERVISFTGMPNKEDIESMGCQMVETMLGNLTFSRPQLVLEERLSHADPNAIDLIKKLCSFNPNKRP
.| .|.|||  ||||.|.. |.|.||| |||.|.|...  .. | .||||..| ..  .|| ..  ....  |.. . .. ..||||.|.|  |||.|| 
RYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN-QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRL

SAEQCLAHPYL
.|||.|.||| 
TAEQALQHPYV
Kinase 91127.m00242.AA MAPK 1-206 37 2.7e-101 342.84 In-house 98-328 (328) Show / Hide 
Range on Protein: 1-206
Range on HMM: 98-328/328
Sequence Identity: 37% (86 aa)

MDTDVHTVIRAGI-LLDVHQRYIFWQLLCA--LKFIHSAGVIHRDLKPSNMLIKSDSTIKVCDFGLSRCINDMHKDEL------------LTDYIATRWY
|.|| | .|. .  | | | .|...|.|..  ||.||||.|||||||||| |. .. . |.|||||.|.| .  ...             .|.|.|||||
METDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWY

RAPEILFG--SSKYGPGIDMWAAGCILAELVG-GRPLFPGASTMDQLERVISFTGMPNKEDIESMG-CQMVETMLGNLT-FSRPQL-VLEERLS----HA
|||||...  . .|  ..|||..|||.||... ..||||| ...||........|.| .|.|. .. .... ... .|  . ...   .|. ..    .|
RAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNA

DPNAIDLIKKLCSFNPNKRPSAEQCLAHPYL
.| ||||..|.  |.|.|| ..|..|.|||.
NPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 91127.m00242.AA ERK 1-206 42 2.3e-87 296.57 In-house 91-307 (307) Show / Hide 
Range on Protein: 1-206
Range on HMM: 91-307/307
Sequence Identity: 42% (93 aa)

MDTDVHTVIRAG-ILLDVHQRYIFWQLLCALKFIHSAGVIHRDLKPSNMLIKSDSTIKVCDFGLSRCINDMHKD------ELLTDYIATRWYRAPEILFG
|.|| | .|.    | | |  |  .|.||.||.||||.|||||||||| |. |. . |.|||||.||..  . .      . .|.|.||||||||||.  
METDLHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLS

SSKYGPGIDMWAAGCILAELVGGRPLFPGASTMDQLERVISFTGMP-NKEDIESMGCQMVETMLGNLTF-SRPQLVLEERLSHAD--PNAIDLIKKLCSF
 .||   .|.|..|||.||..|..|||||.....|..|... .| |  .||..  . . .  .. || .  ||   .|.. . |.  | ||||..|.  |
WQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVF

NPNKRPSAEQCLAHPYL
.|.|| ..|.||.|||.
DPDKRITVEECLEHPYF
Kinase 91127.m00242.AA CMGC 1-206 22 6.6e-87 285.51 In-house 137-513 (513) Show / Hide 
Range on Protein: 1-206
Range on HMM: 137-513/513
Sequence Identity: 22% (85 aa)

MDTDVHTVIRAG----------ILLDVH------------QRYIF------WQLLCALK--FIHSAG--VIHRDLKPSNMLIKSD---------------
||.| . .|.             | . |             .|..      .|.|..||  ..||..  .|||||||.| || ..               
MDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWN

-----STIKVCDFGLSRCINDMHKD-------------------ELLTDYIATRWYRAPEILFGS---------SKYGPGIDMWAAGCILAELVGG----
      ..|.|||||.| ... ...                   . .|.|..||||||||||.|.          .|...||||..|||.||.. |    
PCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSL

----RPLFP-----------GASTMDQLERVISFTGMPN---------------KEDIESMGC-------------------------QMVETMLGNLTF
    .||||           |.|. |||.. .   |.|.               .|.. .| .                         . ..  .   ..
IFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWW

SRPQLVLEERLSH---------------------------------ADPNAIDLIKKLCSFNPNKRPSAEQCLAHPYL
 .. .   .  ..                                 .|| ||||.||.  ..|.||..|||.|.|||.
PPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 91127.m00242.AA p38 1-206 39 3.7e-69 235.5 In-house 90-289 (289) Show / Hide 
Range on Protein: 1-206
Range on HMM: 90-289/289
Sequence Identity: 39% (81 aa)

MDTDVHTVIRAGILLDVHQRYIFWQLLCALKFIHSAGVIHRDLKPSNMLIKSDSTIKVCDFGLSRCINDMHKDELLTDYIATRWYRAPEILFGSSKYGPG
|..| . ...   | | | ...  |.| .||.|||||.|||||||||. .  |. ... ||||.|     |.|. .|.|.||||||||||..   .|   
MGADLNNIMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-----HCDDEMTGYVATRWYRAPEIMLNWMHYTQT

IDMWAAGCILAELVGGRPLFPGASTMDQLERVISFTGMPNKEDIESMGCQMVETMLGNLTFSRPQLVLEERLSHADPNAIDLIKKLCSFNPNKRPSAEQC
.|.|  |||.|||. ||.||||   .|||.|... .| | .| .. .  .   . . ...  .|.  ... .. |.| ||||. |.    | || .||. 
VDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYP-QMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEA

LAHPYL
..|||.
MQHPYF
Kinase 91127.m00242.AA CDK 1-206 32 4.1e-69 220.23 In-house 100-284 (284) Show / Hide 
Range on Protein: 1-206
Range on HMM: 100-284/284
Sequence Identity: 32% (72 aa)

MDTDVHTVIRAGILLDVHQRYIFWQLLCALKFIHSAGVIHRDLKPSNMLIKSDST-----IKVCDFGLSRCINDMHK----DELLTDYIATRWYRAPEIL
||.|  ....         . ..|||| .| ..|| ...||||||.| || .. .     .|. ||||.|  . .|.       .|  . |.||||||.|
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

FGSSKYG--PGIDMWAAGCILAELVG---GRPLFPGASTMDQLERVISFTGMPNKEDIESMGCQMVETMLGNLTFSRPQLVLEERLSHADPNAIDLIKKL
.||..|.  ..||||..|||.||..    ..||||| |  |||.... . | |. ..  .. ... .                           ||. |.
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGV-TKLPDY--------------------------DLLNKM

CSFNPNKRPSAEQCLAHPYL
  ..|.|| ||||.| |||.
LCYDPKKRISAEQALQHPYF
Kinase 91127.m00242.AA ERK1 1-206 43 1.6e-64 220.66 In-house 84-289 (289) Show / Hide 
Range on Protein: 1-206
Range on HMM: 84-289/289
Sequence Identity: 43% (90 aa)

MDTDVHTVIRAGILLDVHQRYIFWQLLCALKFIHSAGVIHRDLKPSNMLIKSDSTIKVCDFGLSRCINDMHKDE--LLTDYIATRWYRAPEILFGSSKYG
|.||.  ....  |   |  |  .|.|  ||.|||| |.||||||||.|.     .|.||||| | | | ..|    ||.|.||||||||||.  |  | 
METDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT

PGIDMWAAGCILAELVGGRPLFPGASTMDQLERVISFTGMPNKEDIESMGCQMVETMLGNLTFSRPQLVLEERLSHADPNAIDLIKKLCSFNPNKRPSAE
  ||.|. ||||||..  ||.|||   .|||  ...  | | ..|.. .  .     |  | . .|.. ...   .||. |.||. |. .|||.||   |
KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPH-KPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVE

QCLAHPYL
. ||||||
EALAHPYL
Kinase 91127.m00242.AA Pkinase 1-206 30 1.8e-63 222.0 Pfam 82-293 (293) Show / Hide 
Range on Protein: 1-206
Range on HMM: 82-293/293
Sequence Identity: 30% (69 aa)

MDT-----DVHTVIR---AGIL--LDVHQRYIFWQLLCALKFIHSAGVIHRDLKPSNMLIKSDSTI----KVCDFGLSRCINDMHKDELLTDYIATRWYR
..      | ...|.    | .   . . . ...|.|..|...|| |.|||||||.| ||... .|    |.|||||.....   ... .|..  |.||.
CEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYM

APEILFGSSKYGPGIDMWAAGCILAELVGGRPLFPGA----STMDQLERVISFTGMPNKEDIESMGCQMVETMLGNLTFSRPQLVLEERLSHADPNAIDL
|||.. |...||| .|||..||||.|.. |||.|||.    . .||....    | |...|..   . . .. .   . .     ....   ......|.
APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDF

IKKLCSFNPNKRPSAEQCLAHPYL
||... ..|.|||.|||.| ||..
IKWCLCKDPKKRPTAEQILQHPWF
Kinase 91127.m00242.AA RCK 20-206 36 5.7e-62 195.31 In-house 108-298 (298) Show / Hide 
Range on Protein: 20-206
Range on HMM: 108-298/298
Sequence Identity: 36% (72 aa)

RYIFWQLLCALKFIHSAGVIHRDLKPSNMLIKS---------DSTIKVCDFGLSRCINDMHKDELLTDYIATRWYRAPEILFGSSKYGPGIDMWAAGCIL
. |. |.| .|...|. |  |||||| | ....         . .||..||||.|.| . .     |||. ||||||||.|  . .|   .|.|| ||| 
KNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPP---YTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIM

AELVGGRPLFPGASTMDQLERVISFTGMPNKEDIESMGCQMVETMLGNLTFSRPQLVLEERLSHADPNAIDLIKKLCSFNPNKRPSAEQCLAHPYL
.||   ||||||.| .||.   ..  | |||.| .  | . ...|  |. ..     |.. .... ...|.|..|..  .|.||..|.|.| ||| 
YELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPD-GYKLASQMNFNFPQCK-GMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 91127.m00242.AA CDKL 20-129 49 2.1e-52 177.48 In-house 101-209 (286) Show / Hide 
Range on Protein: 20-129
Range on HMM: 101-209/286
Sequence Identity: 49% (55 aa)

RYIFWQLLCALKFIHSAGVIHRDLKPSNMLIK-SDSTIKVCDFGLSRCINDMHKDELLTDYIATRWYRAPEILFGSSKYGPGIDMWAAGCILAELVGGRP
| . ||.| |..| |.  .|||| || | ||  .....| ||||. | ..   ..| .||| ||||||||| | |  .||. .|.||.||..||.. | |
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLA--KPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQP

LFPGASTMDQL
|.|| |  |||
LWPGQSDIDQL
Kinase 91127.m00242.AA MAPK-Unclassified 67-206 29 2.8e-35 123.53 In-house 396-575 (575) Show / Hide 
Range on Protein: 67-206
Range on HMM: 396-575/575
Sequence Identity: 29% (53 aa)

INDMHKDELLTDYIATRWYRAPEILFGSSKYGPGIDMWAAGCILAELVGG-----------RPLFPGAS--------------------TMDQLERVISF
||| |    .| |..|||||||||.. .. |.  .|.|..|||.||..             |||||| .                      ||.   .. 
INDCHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDY

TGMPNKEDIESMGCQMVETMLGNLTFSRPQLVLEERLSHAD---------PNAIDLIKKLCSFNPNKRPSAEQCLAHPYL
 |||..||.   .|  .   .  .    |  . .   . |          . .||...|.  |||.|| .|.| | ||| 
LGMPPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 91127.m00242.AA S_TKc 1-206 23 4.2e-32 113.88 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-206
Range on HMM: 19-231/231
Sequence Identity: 23% (64 aa)

MD--------------------------------------------------T---DVHTVIRAGI-------LLDVHQRYIFWQLLCALKFIHSAGVIH
 .                                                  .   |....|.          .   | |....|..|||...|| |.||
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIH

RDLKPSNMLIKSDSTIKVCDFGLSRCINDMHKDELLTDYIATRWYRAPEILFGSSKYGP-GIDMWAAGCILAELVGGRPLFPGASTMDQLERVISFTGMP
|||||.| |. .  .||.|||||.| .         | .. |.||.|||.|    .||.  .|.|. ||||.|.. |.|.||   .|... ..|      
RDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----

NKEDIESMGCQMVETMLGNLTFSRPQLVLEERLSHADPNAIDLIKKLCSFNPNKRPSAEQCLA-------HPYL
                                    .| |.|.|.|.. ..|.|||.| ..|.       ||..
------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 91127.m00242.AA MAPK-Unclassified 1-65 47 2.1e-23 81.11 In-house 88-157 (575) Show / Hide 
Range on Protein: 1-65
Range on HMM: 88-157/575
Sequence Identity: 47% (33 aa)

MDT---DVHTVIRAGI--LLDVHQRYIFWQLLCALKFIHSAGVIHRDLKPSNMLIKSDSTIKVCDFGLSR
| |   | | .|.  .  . . | .|.| |.|  || .|||..||||||||| ||  | ....||||.||
MQTSLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase 91127.m00242.AA CDKL 168-206 35 1.6e-09 28.72 In-house 247-286 (286) Show / Hide 
Range on Protein: 168-206
Range on HMM: 247-286/286
Sequence Identity: 35% (14 aa)

LEERLSHAD-PNAIDLIKKLCSFNPNKRPSAEQCLAHPYL
||.|.. .  . |.|..||.   .| .|...||.. ||| 
LEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 91127.m00242.AA TyrKc 2-206 15 5e-06 -124.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-206
Range on HMM: 1-280/280
Sequence Identity: 15% (48 aa)

DT----------------------------------------------------------------------------------DVHTVIRAGI--LLDV
 |                                                                                  | .  .|.    |   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

HQRYIFWQLLCALKFIHSAGVIHRDLKPSNMLIKSDSTIKVCDFGLSRCINDM--------HKDEL---LTDY-IATRWYRAPEILFGSSKYGPGIDMWA
.  .. ||  |   ..|| ..|||||   | |.... |.|..|||||| | |          ..      ... .  ||. ||| .   .|. .  | |.
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFTTKSDVWS

AGCILAELV-GGRPLFPG---ASTMDQLERVISFTGMPNKEDIESMGCQMVETMLGNLTFSRPQLVLEERLSHADPNAIDLIKKLCSFNPNKRPSAEQCL
 |  . |.   | .  ||      |   ..|| .    .  ..   ..   . |                  .. .   ...|. . ..|..||. ... 
FGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDY---P-MS---------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI-

AHPYL
 | ..
-HECF
Kinase 91127.m00242.AA Pkinase_Tyr 28-65 39 0.000174 15.82 Pfam 122-159 (270) Show / Hide 
Range on Protein: 28-65
Range on HMM: 122-159/270
Sequence Identity: 39% (15 aa)

CALKFIHSAGVIHRDLKPSNMLIKSDSTIKVCDFGLSR
... . .| . |||||   | |.... ..|.|||||.|
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR