Gene 88045.m00019 (T.vaginalis)

88045.m00019

Species: T.vaginalis
Alias: TvagK0964, 88045.m00019
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
88045.m00019.AA Protein None 318 None Fasta, JSON
88045.m00019.kin_dom Protein Kinase Domain None 248 None Fasta, JSON

Protein domain

Protein domains of 88045.m00019.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88045.m00019.AA Ciliate-E2-Unclassified 27-257 17 3.5e-26 87.82 In-house 15-347 (352) Show / Hide 
Range on Protein: 27-257
Range on HMM: 15-347/352
Sequence Identity: 17% (59 aa)

VMKVINKNKTEF-----LCKAFNKTKLEQTNSYDNFVKRLTIIKQLN-----------------HPNIPRVISIQEFG--NYIFIFFEAIHFVTAQEYLC
| |...|.. ..     ..|. .. .. . |.  ...  ........                 ||.. .|  . .|   ..|.|  | .   . ..|..
VYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIK

SNGN-----------------MTPEEIL-----SILTQLLSVIKFTHNLG-LYHGFITLDNIMFDKDM---VPQLANFHLGANIN---------------
....                  | ....      .. |.|. ... |  .   |  |...||.||...    . .. | .  ...               
KRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQI

--QTAFESIS---EYVN-YTTPEELKGSSVDY---FATDIWRLGVCVYTLLTGSFPFSDTNRAK----------------LCQSIMKNEPDFKNIPP---
  |  . ...   .| . || || |.|   |    .. ||| |||. | .|.| .||.|.|. .                | | |......|.. |.   
WKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQI

--TIS--------GRIRLMLMKDPKERPSASQLL
  ..|          .. || |.|..|....|.|
PKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase 88045.m00019.AA CAMK 27-258 14 2.7e-21 64.71 In-house 10-421 (425) Show / Hide 
Range on Protein: 27-258
Range on HMM: 10-421/425
Sequence Identity: 14% (59 aa)

VMKVINK-NK------------TEFLCKAFNKTKLE-------------------------QTNSYDNFVKRLTIIKQ-------LNHPNIPRVISIQE-
| ..|.| ..            ... .|  .|.||                          . .. .|. . . | |.       |.|||| . . . | 
VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYED

-----------FGNY--------IFIFF---------EA----IHFVTAQEY----------LCSNGNMTPEEILSILTQLLSVIKFTHNLGLYHGFITL
           . ..        .....         |       .......          . ..| .| .|   .  |..| ... |...  |  . .
PHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKP

DNIMFDKDM-----------------VPQLANFHLGANINQTA-------------------------FESISEYVNYTT-PEELKGSS-----------
.||..|...                    .. | . . ...                           ..       |   || |.|..           
ENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEE

VDY--FATDIWRLGVCVYTLLTGSFPFSDT-------------NRAKLCQSIMKNEPDFKNIP-------------------------PTISGRIRLMLM
 .|  ...|.| .||  |..|.| .|| .              |  .|.. ||| . ||   .                         .     || || 
KPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQ

KDPKERPSASQLLS
.||..|....| |.
VDPEKRMTIEQCLN
Kinase 88045.m00019.AA Ciliate-E2 28-262 17 2.6e-19 62.94 In-house 29-365 (365) Show / Hide 
Range on Protein: 28-262
Range on HMM: 29-365/365
Sequence Identity: 17% (62 aa)

MKVINKNK------------TEFLCKAFNKTKLEQTNSYDNFVKRLT----------IIKQLNHPNIPRVISIQE--FGNYIFIFFEAIHFVTAQEYLCS
.|.|. .|             ..  | ..| ..||... ..  ...           | .||||||| . .   .    |.|.. .| .   . ..|. .
IKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKN

N-----------GNMTPEEILSILTQLLS---------------VIKFTHNLG-LYHGFITLDNIMFDKDMVPQLANFHLGANINQ--------------
|           ...| .||. | .|.|.                ... |. .   |  | ..||.|     . .. | |  ....              
NKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWY

---------------------------TAFESISEYVNYTTPEELKGSSVDYFATDIWRLGVCVYTLLTGSFPFSDTNRAKLCQSIMKNEPDFKNI----
                           |. .   | .|.   .  ...    .. ||| |||. | .|.| .||         | |.... || .     
MFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQK

-----------PPTISGR----IRL----MLMKDPKERPS-ASQLLSQNID
           .  .|      |.     || |||..|.. ..|.|   . 
DTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 88045.m00019.AA MELK 64-262 26 2.2e-17 55.69 In-house 51-254 (254) Show / Hide 
Range on Protein: 64-262
Range on HMM: 51-254/254
Sequence Identity: 26% (54 aa)

IKQLNHPNIPRVISIQEFGNYIFIFFEAIHFVTAQEYLCSNGNMTPEEILSILTQLLSVIKFTHNLGLYHGFITLDNIMFDKDMVPQLANFHLGA----N
.|.| | .| ..  . |  . ||. .|        .|. ..  .  ||   .. |..| | . |  |  |  .  .|..|| |.  .| .| | |    .
LKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGR

INQTAFESISEYVNYTTPEELKGSSVDYFATDIWRLGVCVYTLLTGSFPFSDTNRAKLCQSIMK---NEPDFKNIPPTISGRIRLMLMKDPKERPSASQL
...   .       |  || ..| .      |.| .|. .|.|. |  || | |   . . ||.   .||..  . |     .| ||  ||| | |  .|
KDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKW--LSPESKQLLRHMLQVDPKKRISMKNL

LSQNID
|  .  
LNHPWV
Kinase 88045.m00019.AA CAMK-Unique 26-230 14 1.2e-15 47.96 In-house 14-323 (363) Show / Hide 
Range on Protein: 26-230
Range on HMM: 14-323/363
Sequence Identity: 14% (46 aa)

MVMKVIN-KNKTEFLCKAFNKTKLEQTNSYDN-----------------FVKRLTIIKQLNHPNIPRVISI----QEFGN---------------YIFIF
.| .... ...... || ..| . .    . .                 . . . | | ..|||| ..  .     .  .               |..|.
HVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIV

FEAIHFVTAQEYLCS--------------------NGNMTP--EEILSILTQLLSVIKFTHNLGLYHGFITLDNIMFDKD-----------------MVP
 | .   . .... .                    .| ..    ....| ..|||.... |...  |. . |.|||. .                  .. 
MEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHI-

QLANFHLGANINQTAFES-ISEYV---NYTTP--------------EELKGSSVDYFAT---DIWRLGVCVYTLLTGSFPFSDTNRA--------KLCQS
 |..|.| . .|.   .. .....    |  |              | ....  |.      ||| |||  |..|.|. ||  .. .        .. ..
KLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFEC

IMKNEP-DFKN
|.| .. .|..
ICKGDYCNFDW
S_TKc 88045.m00019.AA S_TKc 1-266 17 1.8e-15 49.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-266
Range on HMM: 1-231/231
Sequence Identity: 17% (49 aa)

MQTLSFPETGERFQVTEVMQRS-NDIMVMKVINKNKTEFLCKAFNKTKLEQTNSYDNFVKRLTIIKQLNHPNIPRVISIQEFGNYIFIFFEAIHF--VTA
 . |     |   .|  .  .. . |. .|.|.                      ... . . | |. .|||| . . . .  .......| .     . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

QEYLCSNGN------MTPEEILSILTQLLSVIKFTHNLGLYHGFITLDNIMFDKDMVPQLANFHLGANINQTAFESISEYV---NYTTPEELKGSSVDYF
 .|....|       ... .. ... |... ... |..|  |  .  .||..|.  .  .. | | . .        . ..   .|  || |   . ...
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKC

ATDIWRLGVCVYTLLTGSFPFSDTNRAKLCQSIMKNEPDFKNIPPTISGRIRLMLMKDPKERPSASQLLS---QNIDHRIV
. |.| .|...| .|.|  ||.  . ... . |.         .|     || .| |||..||.| ..|        |  .
KCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 88045.m00019.AA PLK1 38-262 24 2.1e-15 46.87 In-house 27-253 (253) Show / Hide 
Range on Protein: 38-262
Range on HMM: 27-253/253
Sequence Identity: 24% (55 aa)

FLCKAFNKTKLEQTNSYDNFVKRLTIIKQLNHPNIPRVISIQEFGNYIFIFFEAIHFVTAQEYLCSNGNMTPEEILSILTQLLSVIKFTHNLGLYHGFIT
|  |   |. | . .  |   . ..| .||.|..| .. .  |  ....|  |  .     |     . .|  |    . |..  ... ||. . |  . 
FAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLK

LDNIMFDKDMVPQLANFHLGANINQT--AFESISEYVNYTTPEELKGSSVDYFATDIWRLGVCVYTLLTGSFPFSDTNRAKLCQSIMKNEPDF-KNIPPT
| |. .. ..  ..  | |  ....       .    ||  || |.      |  ||| .|  .|.|| |. ||         . | |||    ..| ..
LGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLN-KKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQP

ISGRIRLMLMKDPKERPSASQLLSQNID
 .  || || .||..|| ..|.|...  
AAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase 88045.m00019.AA AGC 188-253 24 1.1e-13 30.26 In-house 282-376 (395) Show / Hide 
Range on Protein: 188-253
Range on HMM: 282-376/395
Sequence Identity: 24% (23 aa)

FATDIWR--LGVCVYTLLTGSFPFSDTN----------RAKLCQSIM------KNEPDF-----------KNIPPTISGRIRLMLMKDPKERPSA
.| |.|   ||.. | .|||  ||.. |          .... |.||      .... |           ... |     |. .| |||..|. .
KACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGC
Kinase 88045.m00019.AA GIN4 63-213 24 1.2e-12 36.31 In-house 87-239 (293) Show / Hide 
Range on Protein: 63-213
Range on HMM: 87-239/293
Sequence Identity: 24% (38 aa)

IIKQLNHPNIPRVISIQEFGNYIFIFFEAIHFVTAQEYLCSNGNMTPEEILSILTQLLSVIKFTHNLGLYHGFITLDNIMFDKDMV-PQLANFHLGA-NI
|.| ..|||. |.  . |  | ...  | .      .|| . | .   | . .  |..  . . | ... |  .  .|.. |.     ..| | . | ..
IMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAALET

NQTAFESISEYVNYTTPEELKGSSVDYFATDIWRLGVCVYTLLTGSFPFSDTN
..   |       | .||   |   . || |.|  || .. ||||  || . .
DNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEED
Kinase 88045.m00019.AA QIK 63-266 24 7.7e-12 42.35 In-house 51-272 (272) Show / Hide 
Range on Protein: 63-266
Range on HMM: 51-272/272
Sequence Identity: 24% (57 aa)

IIKQLNHPNIPRVISIQEFGNYIFIFFEAIHFVTAQEYLCSNGN--------------------MTPEEILSILTQLLSVIKFTHNLGLYHGFITLDNIM
|.|.|.||.| .   . |  ....|  |        .|||..|                     |. .|   . .|..| ... |...  |  .   ||.
IMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENIL

FDKDMVPQLANFHLGANINQTA-FESISEYVNYTTPEELKGSSVDYFATDIWRLGVCVYTLLTGSFPFSDTNRAKLCQSIMKNEPDFKNIPPTISGR---
.|..|   .| | ..    | .  ..      |  || ..| . |    ||| .||  | | .|..||   .  .| |...  .  |. ||. .|     
LDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVL--SGKFR-IPFFMSQDCEH

-IRLMLMKDPKERPSASQLLSQNIDHRIV
 || ||  ||. | .  | .     ||  
LIRHMLVVDPEHRYTIMQIC----QHRWM
Kinase 88045.m00019.AA CAMKL 188-258 23 8e-12 33.86 In-house 215-293 (297) Show / Hide 
Range on Protein: 188-258
Range on HMM: 215-293/297
Sequence Identity: 23% (19 aa)

FATDIWRLGVCVYTLLTGSFPFSDTN---------RAKLCQSIMKNEP-DFKNIPPTISGRIRLMLMKDPKERPSASQLLS
...||| .||  |....| .|| | .         . .. . .   .|  .. ..      || ||...|..||.. |...
PKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN
Kinase 88045.m00019.AA Pkinase 177-259 23 6.5e-07 25.52 Pfam 180-290 (293) Show / Hide 
Range on Protein: 177-259
Range on HMM: 180-290/293
Sequence Identity: 23% (26 aa)

PEELKGSSVDYFATDIWRLGVCVYTLLTGSFPFSDT------NRAKLCQSIMKNEPDFK----------------------NIPPTISGRIRLMLMKDPK
|| ..|.. .  . |.| .|. .| .|.| .||..       .  .. . ||. ...|                       |....    |. .| ||||
PEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

ERPSASQLLSQ
.||.| |.|  
KRPTAEQILQH
TyrKc 88045.m00019.AA TyrKc 19-261 14 3e-05 -137.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-261
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)

MQRSNDI------MVMKVINKNKTEFLCKAFNKTKLEQTNSYDNFVKRLTIIKQL--NHPNIPRVISIQEFG-------NYIFIFFEAIHFVTAQEYLCS
 .    .       |.| . |  ..   |  .. .         | . . | ..|  .|||| | . .   .         ..| .|       ..|| .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NGN-MTPEEILSILTQLLSVIKFTHNLGLYHGFITLDNIMFDKDMVPQLANFHLGANINQT--------AFES----ISEY---VNYTTPEELKGSSVDY
...  .... ||. .|  .   . |  .. |  .   |.. ... .   . | |  .|              .     . .   .  . || .     ..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYG

---FATDIWRLGVCVYTLLT-GSFPFSD-----TNRAKLCQSIMKN--EPDFKN--------IPPTISGRIRLMLMKDPKERPSASQLLSQNI
   ...|.|  ||| . ..| |  | ..      . . . . ...    |  .|         |. .   ..   . ||..||. |..  . .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase 88045.m00019.AA CAMKL 63-147 24 0.000123 10.55 In-house 65-164 (297) Show / Hide 
Range on Protein: 63-147
Range on HMM: 65-164/297
Sequence Identity: 24% (24 aa)

IIKQLN---HPNIPRVISIQEFGNY------IFIFFEAIHFVT--AQEYLCSNGN----MTPEEILSILTQLLSVIKFTHNLGLYHGFITLDNIMFDKDM
| |.||   |||| .   . |  ..      |... | .       ..|....|.    |...|   . .|..| ... |..|  |  | ..||..|...
IMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENG
Kinase 88045.m00019.AA Pkinase 63-133 25 0.004524 11.94 Pfam 53-131 (293) Show / Hide 
Range on Protein: 63-133
Range on HMM: 53-131/293
Sequence Identity: 25% (20 aa)

IIKQLNHPNIPRVISIQEFGNYIFIFFEAIHFV----TAQEYLC--SNGNM--TPEEILSILTQLLSVIKFTHNLGLYH
| | |||||| | . . | ...| . .|            .|.   ..|..  ...|. ....|.|. ... |. |  |
IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH