Gene 96955.m00178 (T.vaginalis)
96955.m00178
Species: T.vaginalis
Alias: 96955.m00178, TvagK0864
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
96955.m00178.AA | Protein | None | 315 | None | Fasta, JSON |
96955.m00178.kin_dom | Protein Kinase Domain | None | 276 | None | Fasta, JSON |
Protein domains of 96955.m00178.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 96955.m00178.AA | CK2 | 40-314 | 27 | 2.7e-49 | 144.88 | In-house | 2-288 (288) | Show / Hide |
Range on Protein: 40-314 Range on HMM: 2-288/288 Sequence Identity: 27% (80 aa) NTSEFIGKGHYSSVYKSYLSNGTA-V--AVKNLVTYSKKYLGKEINTLKALQDVPNVLRFYGFIGNESY--PTIIYSYHPSS--KSGYNGNITLEDFRWW . . ||.| || |.. . .. . . .| | || || |. |. ||. ..|. . ... | ... | . | .| | |.. EVIRKIGRGKYSEVFEGINIKNNEKCKIVIKILKPVKKKKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQ-TLTDYDIRYY LKTTLETLADIHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRKGVPMNPRVGCFHITAPELAINVSNYNCEVDVWSLGLSCLDIMIKLKDHWNSK . | .| | |..||| . .||. | |.||| ..| ||..|| | | ||. . .||| .. . | .|.|||| ...| . . MFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLAEFYHPGQDYNVRVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGH NDYMMIENLIKAYGSASWNEFVGKY----NPIFKT--NRKISGSFYEFGMPGNNHLITPDTMDLVSKMLELDPAKRISAREALNHNFF . | .| | ... || .| |. ... .. | .|.|| .|. .|...||| |...||.|.||..| .| DNYDQLVKIVKVLGTEDLYKYLDKYGIHLDPQFHDIMQQHKKKPWERFIHQENKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF |
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S_TKc | 96955.m00178.AA | S_TKc | 39-314 | 22 | 2.7e-35 | 124.5 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 39-314 Range on HMM: 1-231/231 Sequence Identity: 22% (66 aa) QNTSEFIGKGHYSSVYKSYLSN-GTAVAVKNLVTYSKKYLGKEINTLKALQDVPNVLRFYGFIGNESYPTIIYSYHPS---------SKSGYNGN---IT . |||| ...||| . . | ||.| . . . .||. || . ||. ..|... . .. .. | . | |..|. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP LEDFRWWLKTTLETLADIHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRKGVPMNPRVGCFHITAPELAINVSNYNC-EVDVWSLGLSCLDIMI- . | ... ... |. .|.||.||||| .||| | . | ||||. .. . .| . |||. |.. ..|.||.| . E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCG --KLKDHWNSKNDYMMIENLIKAYGSASWNEFVGKYNPIFKTNRKISGSFYEFGMPGNNHLITPDTMDLVSKMLELDPAKRISAREALN-------HNFF ...||.... .|. |...|.|. ||.||..| |||. | .| YPPFP------QMQMMFKKIG-----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Pkinase | 96955.m00178.AA | Pkinase | 39-314 | 22 | 2.5e-29 | 104.79 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 39-314 Range on HMM: 1-293/293 Sequence Identity: 22% (68 aa) QNTSEFIGKGHYSSVYKSYLSNGTA-VAVKNLVTYSKKYLGK-------EINTLKALQDVPNVLRFYGFIGNESYPTIIYSYHPSS----KSG------Y . . ||.| ...||| . . |||| . ..| . || .| | . ||..|.|.. ..... .. |.. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR NGNI--TLEDFRWWLKTTLETLADIHEHGVIHRDLRLANILTDFENRKL----AIVDFGLSDF--YRKGVPMNPRVGCFHITAPELAIN-VSNYNCEVDV .|.. . .. . ... .|. |. .|..|.||||| ..||| | .| . | ||||. . | ... |. ..| . |||. |. . | .||. HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKVDM WSLGLSCLDIMIKLKDHWNS------KNDYMMIENLIKAYGSASWNEFVGKYNPIFKTNRKISGSFYEFGMPGNNHLITPDTMDLVSKMLELDPAKRISA ||.|. . . . ... ..|. ... . . . .... . | . |.. . | . |..... |.....|..||.||..| WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA REALNHNFF ...|.| .| EQILQHPWF |
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Kinase | 96955.m00178.AA | Ciliate-E2a | 137-216 | 29 | 1e-18 | 51.75 | In-house | 111-204 (275) | Show / Hide |
Range on Protein: 137-216 Range on HMM: 111-204/275 Sequence Identity: 29% (28 aa) L-ETLADIHEHGVIHRDLRLANILTD---FEN---RKLAIVDFGLSDFYRKGVP--MNPRVGCFHITAPELAINVS-----NYNCEVDVWSLGL | . |. .| ...||||.. ||| . ... .. |.||||..|. | . | ...| . |||.. | .| . .|.||.|. LWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGV |
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Kinase | 96955.m00178.AA | Ciliate-E2a | 283-314 | 53 | 2.2e-16 | 44.77 | In-house | 244-275 (275) | Show / Hide |
Range on Protein: 283-314 Range on HMM: 244-275/275 Sequence Identity: 53% (17 aa) ITPDTMDLVSKMLELDPAKRISAREALNHNFF .. ...||..|||| || |||.| .|||| .| CSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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Kinase | 96955.m00178.AA | CMGC | 280-314 | 45 | 3.3e-15 | 45.53 | In-house | 479-513 (513) | Show / Hide |
Range on Protein: 280-314 Range on HMM: 479-513/513 Sequence Identity: 45% (16 aa) NHLITPDTMDLVSKMLELDPAKRISAREALNHNFF .....|. ||..|||..||.|||.| .||.| .| RKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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Kinase | 96955.m00178.AA | CDK-DD1 | 285-314 | 50 | 6.1e-15 | 41.98 | In-house | 350-379 (379) | Show / Hide |
Range on Protein: 285-314 Range on HMM: 350-379/379 Sequence Identity: 50% (15 aa) PDTMDLVSKMLELDPAKRISAREALNHNFF |...||...|| |.| |||...|||.| .| PSFLDLIERMLTLCPKKRINTKEALQHPWF |
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Kinase | 96955.m00178.AA | CDC2 | 229-314 | 22 | 7e-15 | 41.66 | In-house | 249-301 (301) | Show / Hide |
Range on Protein: 229-314 Range on HMM: 249-301/301 Sequence Identity: 22% (20 aa) WNSKNDYMMIENLIKAYGSASWNEFVGKYNPIFKTNRKISGSFYEFGMPGNNHL--ITPDTMDLVSKMLELDPAKRISAREALNHNFF |. .. ...| .| .. ..|. .|| ..|| .||.|||||.|||.| .| WKPQDLSKICPNNQKK-----------------------------------KNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF |
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Kinase | 96955.m00178.AA | STE | 136-219 | 25 | 1.2e-14 | 48.26 | In-house | 160-259 (359) | Show / Hide |
Range on Protein: 136-219 Range on HMM: 160-259/359 Sequence Identity: 25% (27 aa) TLET-LADIHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRK-----------------GVPMNPRVGCFHITAPELAIN-----VSNYNCEVDVW .|. |. .|.|..||||. |||| ..|||.. . . | ||. ||| . .. |.. .|.| ILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIW SLGLSCL |||. .. SLGCTII |
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Kinase | 96955.m00178.AA | CAMK | 143-215 | 20 | 1.2e-14 | 42.94 | In-house | 195-321 (425) | Show / Hide |
Range on Protein: 143-215 Range on HMM: 195-321/425 Sequence Identity: 20% (26 aa) IHEHGVIHRDLRLANILTDFEN----------------RKLAIVDFGLSDFYRK------------------------GVPMNPRVGCFHITA-PELAIN .|.|...|||| . ||| | | .. |.|||.. .... | .|. ..|. . | ||. CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG -------------VSNYNCEVDVWSLG |. ..|.||.| KGHCNMQNATDEEKPYYGPKCDMWSCG |
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Kinase | 96955.m00178.AA | Ciliate-E2 | 283-314 | 37 | 3e-12 | 38.34 | In-house | 329-365 (365) | Show / Hide |
Range on Protein: 283-314 Range on HMM: 329-365/365 Sequence Identity: 37% (14 aa) ITPDTMDLVSK----MLELDPAKRIS-AREALNHNFF ......|| .| ||. || |||. . ..||| .| WSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 96955.m00178.AA | p38 | 284-314 | 58 | 6.2e-12 | 36.79 | In-house | 259-289 (289) | Show / Hide |
Range on Protein: 284-314 Range on HMM: 259-289/289 Sequence Identity: 58% (18 aa) TPDTMDLVSKMLELDPAKRISAREALNHNFF .| || ||||||| |||.| ||. | .| NPQAIDLLEKMLELDPDKRITAEEAMQHPYF |
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Kinase | 96955.m00178.AA | CAMK | 283-314 | 37 | 3.5e-11 | 31.54 | In-house | 394-425 (425) | Show / Hide |
Range on Protein: 283-314 Range on HMM: 394-425/425 Sequence Identity: 37% (12 aa) ITPDTMDLVSKMLELDPAKRISAREALNHNFF .... .||..|||. || ||... ..||| .. VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | 96955.m00178.AA | CMGC | 39-215 | 15 | 1.8e-10 | 29.68 | In-house | 1-322 (513) | Show / Hide |
Range on Protein: 39-215 Range on HMM: 1-322/513 Sequence Identity: 15% (51 aa) QNTSEFIGKGHYSSVYKSYL---------------SNGTAVAVKNLV--TYSKKYLG-------------KEINTLKALQ----------------DVPN . ||.|.|. ||| . .. ||.| . . || || |. . .| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VLRFYGFIGNES-------------------------YPTIIYSYHPSSKSGYNG-----------------------NITLEDFRWWLKTTLETLA--D ... | .. . .. | | . . |.| .... . | . . |. |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY IHEHG--VIHRDLRLANILTDFENRK-------------------LAIVDFGLSDFYRKG----------------------VPMNPRVGCFHITAPELA .| |. .||||| .||| . ... | | ||||. .| . |. ..| . |||. CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL INVSNYN---------CEVDVWSLG .. ..|. ...|.||.| LGWKHYTNHNYSMHYTTPIDMWSVG |
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Kinase | 96955.m00178.AA | Ciliate-E2 | 143-215 | 21 | 2.5e-10 | 31.67 | In-house | 176-283 (365) | Show / Hide |
Range on Protein: 143-215 Range on HMM: 176-283/365 Sequence Identity: 21% (25 aa) IHEHG-VIHRDLRLANILTDFENRKLAIVDFGLSDFY-----------------RKGVPMNPRVGCF----------------HITAPELAINVSN---- .|. . .||||. . ||| . |.||||| .| .. .. |.. . ||| . .. LHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ ----YNCEVDVWSLG |. ..|.|||| KQKGYDYKCDIWSLG |
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Kinase | 96955.m00178.AA | Ciliate-E2-Unclassified | 283-314 | 36 | 1.2e-09 | 29.69 | In-house | 317-352 (352) | Show / Hide |
Range on Protein: 283-314 Range on HMM: 317-352/352 Sequence Identity: 36% (13 aa) ITPDTMDLVS----KMLELDPAKRISAREALNHNFF . | |... |||. .| |||.. ..||| .| WSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 96955.m00178.AA | Ciliate-E2-Unclassified | 40-215 | 17 | 3.3e-09 | 28.11 | In-house | 2-257 (352) | Show / Hide |
Range on Protein: 40-215 Range on HMM: 2-257/352 Sequence Identity: 17% (47 aa) NTSEFIGKGHYSSVYKSYLSNGTAVA------VKNLVTYSKKYLG--------KEINTLK-------------ALQDVPNVLRFYGFIGN--ESYPTIIY . . ||.| ...||| . .. . |. . .|... ||.| .| |.. |. .. . | . .. |.. KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM SY---------HPSSKS------------GYNGNITLEDFR-----WWLKTTLETLADIHEHG-VIHRDLRLANILTDFENR--KLAIVDFGLSDFYRK- | . ..|. .. .| . . ... |. | .|. . .||||. . ||| | ... .. | |||.| .| . EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN -----------------------GVPM--NPRVGCFHITAPELAINVSNYN---CEVDVWSLG | |. . . .||||. . ... ..|.|||| NNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q-----YTAPEVLQGQNYDHSKAYKCDIWSLG |
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Kinase | 96955.m00178.AA | TyrKc | 39-314 | 17 | 1.7e-08 | -85.15 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 39-314 Range on HMM: 1-280/280 Sequence Identity: 17% (56 aa) QNTSEFIGKGHYSSVYKSYLSNGTAVAVKNLVTYSKKYLGKEINTLKAL-QDVPNVLRFYGFIGNE-------SYPTIIYSYHPS-------SKSGYNGN . .| |.. ||| .. . |||| | .... . .|.. .. | . ||..|.|| . . . |. | | |.. . ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-- ITLEDFRWWLKTTLETLADIHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRKG---------VPM----NPR-VGCFHITAPELAINVSNYNCEV ....|. . . . .|....||||| |.| . .. | ||||| . . . . . . .||| .|| . .. . LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE-CINYGKFTTKS DVWS----------------LG-----LSCLDIMIKLKDHWNSKNDYMMIENL---IKAYGSASWNEFVGKYNPIFKTNRKISGSFYEFGMPGNNHLITP |||| | .| ... ..| . ..|.. . | .. DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-----QGYRMPQPPNDYPMS------------------------------F------VCCPD DTMDLVSKMLELDPAKRISAREALNHNFF . .. .. . ||..| . .| | .| EMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | 96955.m00178.AA | STE | 284-314 | 36 | 3e-07 | 21.8 | In-house | 327-359 (359) | Show / Hide |
Range on Protein: 284-314 Range on HMM: 327-359/359 Sequence Identity: 36% (12 aa) TPDTMDLVSKMLELDPAKRISAREALN--HNFF .|. | ..| |. || || .| . |. | |. SPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 96955.m00178.AA | STE | 39-98 | 21 | 7.6e-07 | 20.33 | In-house | 1-97 (359) | Show / Hide |
Range on Protein: 39-98 Range on HMM: 1-97/359 Sequence Identity: 21% (21 aa) QNTSEFIGKGHYSSVYKSYLSN----------------GTAVAVK--NLVTYS------------------KKYLGKEINTLKALQD-VPNVLRFYG . |.|||| . .||| . . |. .|.| || . . .. . |||...| ... ||. ..|| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG |
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Kinase | 96955.m00178.AA | CDK-DD1 | 137-215 | 33 | 1e-06 | 15.85 | In-house | 108-187 (379) | Show / Hide |
Range on Protein: 137-215 Range on HMM: 108-187/379 Sequence Identity: 33% (27 aa) LETLADIHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRKG--VPMNPRVGCFHITAPELAINVSNYNCEVDVWSLG || . ..| |. ||| || | . | | |||.. | | . .| .||| . .| |.|.|| | LEGINECHNQGIMHRDIKPANLLIN-NRGDLKITDFGFTTYYTKRSEKHFSHQVVSLWYRPPELLMGSCQYGPEIDMWSVG |
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Kinase | 96955.m00178.AA | p38 | 143-215 | 39 | 1e-06 | 18.44 | In-house | 122-191 (289) | Show / Hide |
Range on Protein: 143-215 Range on HMM: 122-191/289 Sequence Identity: 39% (29 aa) IHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRKGVPMNPRVGCFHITAPELAINVSNYNCEVDVWSLG || |.||||| || |. | | ||||. . | |. ||| | |. ||.||.| IHSAGIIHRDLKPSNIAVN-EDCELRILDFGLAR--HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVG |
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Kinase | 96955.m00178.AA | CAMK | 44-100 | 14 | 3.3e-05 | 11.93 | In-house | 1-107 (425) | Show / Hide |
Range on Protein: 44-100 Range on HMM: 1-107/425 Sequence Identity: 14% (16 aa) FIGKGHYSSVYKSYLS-NG------------TAVAVKNLV-------------------------------TYSKKYLGKEINTLKALQ------DVPNV .|.| .. |.. . .. . ||.| . ...| . .||. .| || | ||. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI LRFYGFI ...| .. IKLYEVY |
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Kinase | 96955.m00178.AA | Ciliate-E2 | 39-109 | 12 | 4.4e-05 | 13.38 | In-house | 1-112 (365) | Show / Hide |
Range on Protein: 39-109 Range on HMM: 1-112/365 Sequence Identity: 12% (14 aa) QNTSEFIGKGHYSSVYKS--YLSNG-------------------TA---VAVKNLVTYSKKYLGKEINTLKALQ---------------DVPNVLRFYGF . . ||.| ..|||| .. . .. .|.|.. . .... .||. .. .. . ||....| . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IG--NESYPTII .... .. FQEKDDNNIYLV |
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Kinase | 96955.m00178.AA | CDC2 | 144-175 | 45 | 0.000111 | 9.74 | In-house | 120-150 (301) | Show / Hide |
Range on Protein: 144-175 Range on HMM: 120-150/301 Sequence Identity: 45% (15 aa) HEHGVIHRDLRLANILTDFENR-KLAIVDFGLS | ....|||| ||| | . . |.| ||||. HQRRIMHRDLKPQNILIDKKGNIKIA--DFGLA |
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Kinase | 96955.m00178.AA | CDC2 | 195-215 | 42 | 0.001758 | 5.98 | In-house | 173-193 (301) | Show / Hide |
Range on Protein: 195-215 Range on HMM: 173-193/301 Sequence Identity: 42% (9 aa) APELAINVSNYNCEVDVWSLG |||. . |...||.||.| APEILLGCKRYSTPVDMWSIG |
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Kinase | 96955.m00178.AA | Ciliate-E2a | 72-99 | 35 | 0.047269 | 1.86 | In-house | 41-67 (275) | Show / Hide |
Range on Protein: 72-99 Range on HMM: 41-67/275 Sequence Identity: 35% (10 aa) YSKKYLGKEINTLKALQDVPNVLRFYGF . |.|. .||| .. | | ||....|.. KGKEYFMNEINIMRQL-DHPNIIKLYEV |