96955.m00178

Species: T.vaginalis
Alias: 96955.m00178, TvagK0864
External Links:
Annotation:

Classification

Group: CMGC
Family: CK2

Sequence

Name Sequence Type Origin Length Description Download
96955.m00178.AA Protein None 315 None Fasta, JSON
96955.m00178.kin_dom Protein Kinase Domain None 276 None Fasta, JSON

Protein domain

Protein domains of 96955.m00178.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 96955.m00178.AA CK2 40-314 27 2.7e-49 144.88 In-house 2-288 (288) Show / Hide
Range on Protein: 40-314
Range on HMM: 2-288/288
Sequence Identity: 27% (80 aa)

NTSEFIGKGHYSSVYKSYLSNGTA-V--AVKNLVTYSKKYLGKEINTLKALQDVPNVLRFYGFIGNESY--PTIIYSYHPSS--KSGYNGNITLEDFRWW
.  . ||.| || |.. . .. .  .   .| |    ||    ||  |. |.  ||. ..|. .  ...  | ... |      .  |   .|  | |..
EVIRKIGRGKYSEVFEGINIKNNEKCKIVIKILKPVKKKKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQ-TLTDYDIRYY

LKTTLETLADIHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRKGVPMNPRVGCFHITAPELAINVSNYNCEVDVWSLGLSCLDIMIKLKDHWNSK
.   | .|   |  |..||| . .||. | |.||| ..| ||..||  |   | ||.  .  .||| .. . |   .|.||||     ...|     . .
MFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLAEFYHPGQDYNVRVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGH

NDYMMIENLIKAYGSASWNEFVGKY----NPIFKT--NRKISGSFYEFGMPGNNHLITPDTMDLVSKMLELDPAKRISAREALNHNFF
. |      .|  |     ... ||    .| |.   ...   ..  |   .|.|| .|. .|...|||  |...||.|.||..| .|
DNYDQLVKIVKVLGTEDLYKYLDKYGIHLDPQFHDIMQQHKKKPWERFIHQENKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF

S_TKc 96955.m00178.AA S_TKc 39-314 22 2.7e-35 124.5 SMART 1-231 (231) Show / Hide
Range on Protein: 39-314
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

QNTSEFIGKGHYSSVYKSYLSN-GTAVAVKNLVTYSKKYLGKEINTLKALQDVPNVLRFYGFIGNESYPTIIYSYHPS---------SKSGYNGN---IT
    . |||| ...||| .  . |  ||.| .     . . .||. ||   . ||. ..|... . ..  ..  | .           | |..|.   ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LEDFRWWLKTTLETLADIHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRKGVPMNPRVGCFHITAPELAINVSNYNC-EVDVWSLGLSCLDIMI-
  . | ... ... |. .|.||.|||||  .||| |     . | ||||. ..      .  .|  .  |||.      |.. ..|.||.|      .  
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCG

--KLKDHWNSKNDYMMIENLIKAYGSASWNEFVGKYNPIFKTNRKISGSFYEFGMPGNNHLITPDTMDLVSKMLELDPAKRISAREALN-------HNFF
           ...||....                                          .|.  |...|.|. ||.||..| |||.       | .|
YPPFP------QMQMMFKKIG-----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF





Pkinase 96955.m00178.AA Pkinase 39-314 22 2.5e-29 104.79 Pfam 1-293 (293) Show / Hide
Range on Protein: 39-314
Range on HMM: 1-293/293
Sequence Identity: 22% (68 aa)

QNTSEFIGKGHYSSVYKSYLSNGTA-VAVKNLVTYSKKYLGK-------EINTLKALQDVPNVLRFYGFIGNESYPTIIYSYHPSS----KSG------Y
  . . ||.| ...||| .  .    |||| .   ..|   .       ||  .| | . ||..|.|..  ..... ..  |..               .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NGNI--TLEDFRWWLKTTLETLADIHEHGVIHRDLRLANILTDFENRKL----AIVDFGLSDF--YRKGVPMNPRVGCFHITAPELAIN-VSNYNCEVDV
.|..  . .. . ... .|. |. .|..|.||||| ..||| | .|  .     | ||||. .  | ... |. ..|  .  |||. |.  . |  .||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKVDM

WSLGLSCLDIMIKLKDHWNS------KNDYMMIENLIKAYGSASWNEFVGKYNPIFKTNRKISGSFYEFGMPGNNHLITPDTMDLVSKMLELDPAKRISA
||.|. .   . .    ...        ..|. ... . . . ....  . | . |.. .        |    . |.....  |.....|..||.||..|
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

REALNHNFF
...|.| .|
EQILQHPWF

Kinase 96955.m00178.AA Ciliate-E2a 137-216 29 1e-18 51.75 In-house 111-204 (275) Show / Hide
Range on Protein: 137-216
Range on HMM: 111-204/275
Sequence Identity: 29% (28 aa)

L-ETLADIHEHGVIHRDLRLANILTD---FEN---RKLAIVDFGLSDFYRKGVP--MNPRVGCFHITAPELAINVS-----NYNCEVDVWSLGL
| . |. .|  ...||||.. ||| .   ...    .. |.||||..|. |  .  | ...|  .  |||.. |       .| . .|.||.|.
LWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGV

Kinase 96955.m00178.AA Ciliate-E2a 283-314 53 2.2e-16 44.77 In-house 244-275 (275) Show / Hide
Range on Protein: 283-314
Range on HMM: 244-275/275
Sequence Identity: 53% (17 aa)

ITPDTMDLVSKMLELDPAKRISAREALNHNFF
.. ...||..|||| || |||.| .|||| .|
CSKECKDLMKKMLEKDPKKRITAQQALNHPWF

Kinase 96955.m00178.AA CMGC 280-314 45 3.3e-15 45.53 In-house 479-513 (513) Show / Hide
Range on Protein: 280-314
Range on HMM: 479-513/513
Sequence Identity: 45% (16 aa)

NHLITPDTMDLVSKMLELDPAKRISAREALNHNFF
.....|.  ||..|||..||.|||.| .||.| .|
RKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase 96955.m00178.AA CDK-DD1 285-314 50 6.1e-15 41.98 In-house 350-379 (379) Show / Hide
Range on Protein: 285-314
Range on HMM: 350-379/379
Sequence Identity: 50% (15 aa)

PDTMDLVSKMLELDPAKRISAREALNHNFF
|...||...|| |.| |||...|||.| .|
PSFLDLIERMLTLCPKKRINTKEALQHPWF

Kinase 96955.m00178.AA CDC2 229-314 22 7e-15 41.66 In-house 249-301 (301) Show / Hide
Range on Protein: 229-314
Range on HMM: 249-301/301
Sequence Identity: 22% (20 aa)

WNSKNDYMMIENLIKAYGSASWNEFVGKYNPIFKTNRKISGSFYEFGMPGNNHL--ITPDTMDLVSKMLELDPAKRISAREALNHNFF
|. ..   ...| .|                                     ..  ..|. .|| ..|| .||.|||||.|||.| .|
WKPQDLSKICPNNQKK-----------------------------------KNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF

Kinase 96955.m00178.AA STE 136-219 25 1.2e-14 48.26 In-house 160-259 (359) Show / Hide
Range on Protein: 136-219
Range on HMM: 160-259/359
Sequence Identity: 25% (27 aa)

TLET-LADIHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRK-----------------GVPMNPRVGCFHITAPELAIN-----VSNYNCEVDVW
.|.  |. .|.|..||||.  ||||         ..|||..    .                 .   |  ||.    |||   .     .. |.. .|.|
ILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIW

SLGLSCL
|||. ..
SLGCTII

Kinase 96955.m00178.AA CAMK 143-215 20 1.2e-14 42.94 In-house 195-321 (425) Show / Hide
Range on Protein: 143-215
Range on HMM: 195-321/425
Sequence Identity: 20% (26 aa)

IHEHGVIHRDLRLANILTDFEN----------------RKLAIVDFGLSDFYRK------------------------GVPMNPRVGCFHITA-PELAIN
.|.|...|||| . ||| |  |                 .. |.|||.. ....                        | .|. ..|. .  | ||.   
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

-------------VSNYNCEVDVWSLG
                |. ..|.||.|
KGHCNMQNATDEEKPYYGPKCDMWSCG

Kinase 96955.m00178.AA Ciliate-E2 283-314 37 3e-12 38.34 In-house 329-365 (365) Show / Hide
Range on Protein: 283-314
Range on HMM: 329-365/365
Sequence Identity: 37% (14 aa)

ITPDTMDLVSK----MLELDPAKRIS-AREALNHNFF
......|| .|    ||. || |||. . ..||| .|
WSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 96955.m00178.AA p38 284-314 58 6.2e-12 36.79 In-house 259-289 (289) Show / Hide
Range on Protein: 284-314
Range on HMM: 259-289/289
Sequence Identity: 58% (18 aa)

TPDTMDLVSKMLELDPAKRISAREALNHNFF
.|   ||  ||||||| |||.| ||. | .|
NPQAIDLLEKMLELDPDKRITAEEAMQHPYF

Kinase 96955.m00178.AA CAMK 283-314 37 3.5e-11 31.54 In-house 394-425 (425) Show / Hide
Range on Protein: 283-314
Range on HMM: 394-425/425
Sequence Identity: 37% (12 aa)

ITPDTMDLVSKMLELDPAKRISAREALNHNFF
.... .||..|||. || ||... ..||| ..
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 96955.m00178.AA CMGC 39-215 15 1.8e-10 29.68 In-house 1-322 (513) Show / Hide
Range on Protein: 39-215
Range on HMM: 1-322/513
Sequence Identity: 15% (51 aa)

QNTSEFIGKGHYSSVYKSYL---------------SNGTAVAVKNLV--TYSKKYLG-------------KEINTLKALQ----------------DVPN
    . ||.|.|. ||| .                 ..  ||.| .      .                  ||  || |.                . .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VLRFYGFIGNES-------------------------YPTIIYSYHPSSKSGYNG-----------------------NITLEDFRWWLKTTLETLA--D
... | ..  .                           ..  | |  . .  |.|                       .... . | . .  |. |.   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHEHG--VIHRDLRLANILTDFENRK-------------------LAIVDFGLSDFYRKG----------------------VPMNPRVGCFHITAPELA
.| |.  .|||||  .||| . ...                    | | ||||. .| .                        |. ..|   .  |||. 
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

INVSNYN---------CEVDVWSLG
.. ..|.         ...|.||.|
LGWKHYTNHNYSMHYTTPIDMWSVG

Kinase 96955.m00178.AA Ciliate-E2 143-215 21 2.5e-10 31.67 In-house 176-283 (365) Show / Hide
Range on Protein: 143-215
Range on HMM: 176-283/365
Sequence Identity: 21% (25 aa)

IHEHG-VIHRDLRLANILTDFENRKLAIVDFGLSDFY-----------------RKGVPMNPRVGCF----------------HITAPELAINVSN----
.|. . .||||. . |||       . |.||||| .|                   .. ..   |..                .  |||   . ..    
LHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ

----YNCEVDVWSLG
    |. ..|.||||
KQKGYDYKCDIWSLG

Kinase 96955.m00178.AA Ciliate-E2-Unclassified 283-314 36 1.2e-09 29.69 In-house 317-352 (352) Show / Hide
Range on Protein: 283-314
Range on HMM: 317-352/352
Sequence Identity: 36% (13 aa)

ITPDTMDLVS----KMLELDPAKRISAREALNHNFF
. |   |...    |||. .| |||.. ..||| .|
WSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 96955.m00178.AA Ciliate-E2-Unclassified 40-215 17 3.3e-09 28.11 In-house 2-257 (352) Show / Hide
Range on Protein: 40-215
Range on HMM: 2-257/352
Sequence Identity: 17% (47 aa)

NTSEFIGKGHYSSVYKSYLSNGTAVA------VKNLVTYSKKYLG--------KEINTLK-------------ALQDVPNVLRFYGFIGN--ESYPTIIY
.  . ||.| ...||| . ..    .       |. .  .|...         ||.| .|              |.. |. .. . |     . .. |..
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

SY---------HPSSKS------------GYNGNITLEDFR-----WWLKTTLETLADIHEHG-VIHRDLRLANILTDFENR--KLAIVDFGLSDFYRK-
 |         . ..|.             ..  .| .  .      ...  |. |  .|. . .||||. . ||| | ...  .. | |||.| .| . 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

-----------------------GVPM--NPRVGCFHITAPELAINVSNYN---CEVDVWSLG
                       | |.  . .     .||||.  .  ...    ..|.||||
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q-----YTAPEVLQGQNYDHSKAYKCDIWSLG

Kinase 96955.m00178.AA TyrKc 39-314 17 1.7e-08 -85.15 SMART 1-280 (280) Show / Hide
Range on Protein: 39-314
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)

QNTSEFIGKGHYSSVYKSYLSNGTAVAVKNLVTYSKKYLGKEINTLKAL-QDVPNVLRFYGFIGNE-------SYPTIIYSYHPS-------SKSGYNGN
    . .| |..  |||  ..  . |||| |  .... . .|.. .. |  . ||..|.|| .  .         . |.  | |         |.. .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

ITLEDFRWWLKTTLETLADIHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRKG---------VPM----NPR-VGCFHITAPELAINVSNYNCEV
....|.  .     .  . .|....|||||   |.| . ..    | ||||| .   .           .    . . .     .||| .|| . .. . 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE-CINYGKFTTKS

DVWS----------------LG-----LSCLDIMIKLKDHWNSKNDYMMIENL---IKAYGSASWNEFVGKYNPIFKTNRKISGSFYEFGMPGNNHLITP
||||                 |     .|  ... ..|     . ..|..      .                               |         ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-----QGYRMPQPPNDYPMS------------------------------F------VCCPD

DTMDLVSKMLELDPAKRISAREALNHNFF
.  .. ..  . ||..| . .|   | .|
EMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 96955.m00178.AA STE 284-314 36 3e-07 21.8 In-house 327-359 (359) Show / Hide
Range on Protein: 284-314
Range on HMM: 327-359/359
Sequence Identity: 36% (12 aa)

TPDTMDLVSKMLELDPAKRISAREALN--HNFF
.|.  | ..| |. || || .| . |.  | |.
SPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase 96955.m00178.AA STE 39-98 21 7.6e-07 20.33 In-house 1-97 (359) Show / Hide
Range on Protein: 39-98
Range on HMM: 1-97/359
Sequence Identity: 21% (21 aa)

QNTSEFIGKGHYSSVYKSYLSN----------------GTAVAVK--NLVTYS------------------KKYLGKEINTLKALQD-VPNVLRFYG
.   |.|||| . .||| .  .                |. .|.|  || . .                  .. . |||...| ...  ||. ..||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG

Kinase 96955.m00178.AA CDK-DD1 137-215 33 1e-06 15.85 In-house 108-187 (379) Show / Hide
Range on Protein: 137-215
Range on HMM: 108-187/379
Sequence Identity: 33% (27 aa)

LETLADIHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRKG--VPMNPRVGCFHITAPELAINVSNYNCEVDVWSLG
|| . ..|  |. |||   || |    .  | | |||..  | |     .  .|      .||| .   .|  |.|.|| |
LEGINECHNQGIMHRDIKPANLLIN-NRGDLKITDFGFTTYYTKRSEKHFSHQVVSLWYRPPELLMGSCQYGPEIDMWSVG

Kinase 96955.m00178.AA p38 143-215 39 1e-06 18.44 In-house 122-191 (289) Show / Hide
Range on Protein: 143-215
Range on HMM: 122-191/289
Sequence Identity: 39% (29 aa)

IHEHGVIHRDLRLANILTDFENRKLAIVDFGLSDFYRKGVPMNPRVGCFHITAPELAINVSNYNCEVDVWSLG
||  |.|||||   ||    |.  | | ||||.    .   |   |.     |||   |   |.  ||.||.|
IHSAGIIHRDLKPSNIAVN-EDCELRILDFGLAR--HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVG

Kinase 96955.m00178.AA CAMK 44-100 14 3.3e-05 11.93 In-house 1-107 (425) Show / Hide
Range on Protein: 44-100
Range on HMM: 1-107/425
Sequence Identity: 14% (16 aa)

FIGKGHYSSVYKSYLS-NG------------TAVAVKNLV-------------------------------TYSKKYLGKEINTLKALQ------DVPNV
 .|.| .. |.. .   ..            . ||.| .                                 ...| . .||. .| ||      | ||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRFYGFI
...| ..
IKLYEVY

Kinase 96955.m00178.AA Ciliate-E2 39-109 12 4.4e-05 13.38 In-house 1-112 (365) Show / Hide
Range on Protein: 39-109
Range on HMM: 1-112/365
Sequence Identity: 12% (14 aa)

QNTSEFIGKGHYSSVYKS--YLSNG-------------------TA---VAVKNLVTYSKKYLGKEINTLKALQ---------------DVPNVLRFYGF
 .  . ||.| ..||||   .. .                    ..   .|.|..  . .... .||. .. ..               . ||....| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IG--NESYPTII
    ....  ..
FQEKDDNNIYLV

Kinase 96955.m00178.AA CDC2 144-175 45 0.000111 9.74 In-house 120-150 (301) Show / Hide
Range on Protein: 144-175
Range on HMM: 120-150/301
Sequence Identity: 45% (15 aa)

HEHGVIHRDLRLANILTDFENR-KLAIVDFGLS
| ....||||   ||| | . . |.|  ||||.
HQRRIMHRDLKPQNILIDKKGNIKIA--DFGLA

Kinase 96955.m00178.AA CDC2 195-215 42 0.001758 5.98 In-house 173-193 (301) Show / Hide
Range on Protein: 195-215
Range on HMM: 173-193/301
Sequence Identity: 42% (9 aa)

APELAINVSNYNCEVDVWSLG
|||.    . |...||.||.|
APEILLGCKRYSTPVDMWSIG

Kinase 96955.m00178.AA Ciliate-E2a 72-99 35 0.047269 1.86 In-house 41-67 (275) Show / Hide
Range on Protein: 72-99
Range on HMM: 41-67/275
Sequence Identity: 35% (10 aa)

YSKKYLGKEINTLKALQDVPNVLRFYGF
. |.|. .||| .. | | ||....|..
KGKEYFMNEINIMRQL-DHPNIIKLYEV