Gene 95238.m00103 (T.vaginalis)
95238.m00103
Species: T.vaginalis
Alias: 95238.m00103, TvagK0119
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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95238.m00103.AA | Protein | None | 358 | None | Fasta, JSON |
95238.m00103.kin_dom | Protein Kinase Domain | None | 211 | None | Fasta, JSON |
Protein domains of 95238.m00103.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 95238.m00103.AA | AGC | 4-196 | 23 | 2.1e-69 | 177.7 | In-house | 67-369 (395) | Show / Hide |
Range on Protein: 4-196 Range on HMM: 67-369/395 Sequence Identity: 23% (73 aa) VNQEIAILKQLD----------HPFLAP-LYEFFQTDED--YYIVLEYLP---------GG-TLHSLLS---HIGKIQEWRARHYFVQ-------LISAL | .| ||.... |||. |. ||... |.|.||.| || |.. | . |. | |||.|. . ...|| VWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLAL HYLHSEIHIIHCD-IKLENILIDEYDNIRVVDFGLSHLLSEYN-------------------------------------------------PDVTHGFG .||||. .||| | .|.||||.|| .|. .||||. . .. | |. | EYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFC ---TISYCSQEMLRRKNYTITTDFWS--AGVVLYAMITGHLPFKELS----------KEGLINSIL------NSEPEYD----------SSLSPDLVSLL | | . |.| |. . | || |...| |.||. || . .. . ..|. | ..... ...||....|. GPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLI NHLLAKN ..|| |. KKLLCKD |
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Kinase | 95238.m00103.AA | CAMKL | 1-212 | 31 | 8e-64 | 202.5 | In-house | 57-297 (297) | Show / Hide |
Range on Protein: 1-212 Range on HMM: 57-297/297 Sequence Identity: 31% (78 aa) MQKVNQEIAILKQLD---HPFLAPLYEFFQTDED------YYIVLEYLPGGT--LHSLL---SHIG-KIQEWRARHYFVQLISALHYLHSEIHIIHCDIK | .. .||.|.|.|. || ||| ..|.| .|.|.|| .|| |. . | . ...|. ||.|| |..||..|.|| |.| ||| M-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIK LENILIDEYD--NIRVVDFGLSHLLSE--YNPDV--THGFGTISYCSQEMLRR--KNYT-ITTDFWSAGVVLYAMITGHLPFK----------ELSKEGL .||||.|| . || ..|||.| . . .|. . |. .|.. |.. . | | .| ||.||.||||..|.|||. .. . PENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYW INSILNSEPEYDSSLSPDLVSLLNHLLAKNNVQRATHNAIVKSKWI .. .. .| ...| |. .|. ..| .| .|.| |.. .| KIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | 95238.m00103.AA | CAMK | 1-212 | 21 | 1.9e-61 | 196.45 | In-house | 75-425 (425) | Show / Hide |
Range on Protein: 1-212 Range on HMM: 75-425/425 Sequence Identity: 21% (75 aa) MQKVNQEIAILKQ-------LDHPFLAPLYEFFQT-------------------DEDYYIVL---EYLPGGTL-HSLLSHI------------------G ...| .||.|.|. |||| . |||.... |...|.|. || .|| | |...| | RKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERG KIQEWRARHYFVQLISALHYLHSEIHIIHCDIKLENILIDEYD-----------------NIRVVDFGLSHLLSE-----------------------YN ...|. ||.|| |..||.||.|| |.|.|.|.||||.|. . || ..|||.. . . .. RFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEG PDVTHGFGTISYCS-QEMLRRKN--------------YTITTDFWSAGVVLYAMITGHLPFKEL-------------SKEGLINSILNSEPEYDSS---- . . .|| .|.. |.|..| |. .| ||.||.||.| .|..|| . . . | |.. . ..... QKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSP --------------------LSPDLVSLLNHLLAKNNVQRATHNAIVKSKWI .|.. .|....| .. .|.| . . .|. ISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | 95238.m00103.AA | MARK | 1-212 | 35 | 1.7e-58 | 189.93 | In-house | 43-262 (262) | Show / Hide |
Range on Protein: 1-212 Range on HMM: 43-262/262 Sequence Identity: 35% (79 aa) MQKVNQEIAILKQLDHPFLAPLYEFFQ--TDED-YYIVLEYLPGGTLHSLLSHI--GKIQEWRARHYFVQLISALHYLHSEIHIIHCDIKLENILIDEYD |..| ||.|.|.|||| |.. .. | . |...|| .|| |.. . |...| ||..| |..||..|.|| ..|.|.|||.||||||| MKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHS-KNIVHRDIKPENILIDENG --NIRVVDFGLSHLLSEYNPDVTHGFGTISYCSQEMLRRKNYT-ITTDFWSAGVVLYAMITGHLPFKELS--KEGLINSILNSEPEYDSSLSPDLVSLLN || |||.| . . |. || .|.. |.. .| |. .| || |||||.|..|..||.. . . | ||. .... . .|... .|.. NHNIKIIDFGFSICIPPGQKLNTFC-GTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQ HLLAKNNVQRATHNAIVKSKWI || | .|.| |.| .|. RLLTVNPEERPTIEEIMKHPWM |
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Pkinase | 95238.m00103.AA | Pkinase | 1-212 | 27 | 4.1e-58 | 204.17 | Pfam | 43-293 (293) | Show / Hide |
Range on Protein: 1-212 Range on HMM: 43-293/293 Sequence Identity: 27% (70 aa) MQKVN-QEIAILKQLDHPFLAPLYEFFQTDEDYYIVLEYLPGG----TLHSLLS--HIGKI--QEWRARHYFVQLISALHYLHSEIHIIHCDIKLENILI ..... .||.|.| |.||. ||..|... ..|.|.||..|| |....| |.. .|| ...|. |....| |.|| |||.|.|.||||| QTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILI DEYDNI----RVVDFGLSHLL-SEYNPDVTHGFGTISYCSQEMLR-RKNYTITTDFWSAGVVLYAMITGHLPFKEL------SKEGLINSILNSEPEYDS |. ..| .. ||||. .. |. |. ||. |.. | .| .. |. | ||.|..|| |..|..||.. .. .|. |. ....|. DNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDW SLS---------------------PDLVSLLNHLLAKNNVQRATHNAIVKSKWI . . ... .... .|.|. .| | |....|. PWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 95238.m00103.AA | Ciliate-E2 | 1-212 | 23 | 1.9e-52 | 178.37 | In-house | 70-365 (365) | Show / Hide |
Range on Protein: 1-212 Range on HMM: 70-365/365 Sequence Identity: 23% (73 aa) MQKVN------QEIAILKQLDHPFLAPLYEFFQ--TDEDYYIVLEYLPGGTLHSLLSHI-----------GKIQEWRARHYFVQLIS------------- |...| .| ||.||.||.. .||.|| .|. .|.|.||. ||.| ... . ... | ..... |... MREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACI --ALHYLHSEIHIIHCDIKLENILIDEYDNIRVVDFGLSHLLSEYNP---------DVTHGF-----------------------GTISYCSQEMLRRKN ||.||||. .||| |||.||||. | ..||||| ... | . . || | . |.|..|. ILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKK ---------YTITTDFWSAGVVLYAMITGHLPFKELSKEGLINSILNSEPEYD------------------SSLSPDLVSLLNH----LLAKNNVQRAT- |. |.||.||.|| |..| .|| .. |.. . ... ..|.. |.. .| |. .| | YDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITG HNAIVKSKWI . | . .|. WEQILNHPWF |
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Kinase | 95238.m00103.AA | Ciliate-E2-Unclassified | 10-212 | 26 | 4.4e-49 | 168.39 | In-house | 74-352 (352) | Show / Hide |
Range on Protein: 10-212 Range on HMM: 74-352/352 Sequence Identity: 26% (74 aa) ILKQLDHPFLAPLYEFFQTDEDYYIVLEYLPGGTLHSLLSHIGK-----------------IQEWRAR-----HYFVQLISALHYLHSEIHIIHCDIKLE ||....|||. ... ||... |||.||..||.|. ... .| ..| |. .|| |....| |||.. .||| |||.| ILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPE NILIDEYD---NIRVVDFGLS-HLLSEYN-------------PDVTHGF-GTISYC----SQEMLRRKNYT----ITTDFWSAGVVLYAMITGHLPFKEL |||.|. .|.. |||.| .. . .| .. .. | ||..| . |.|...|| . |.|| ||.||.|..| .||. NILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN SKEG----------------LINSILNSEPEYDS--------SLSPDLVSLLN----HLLAKNNVQRATHNAIVKSKWI ..| |.. |.. ...... .|| ..| .| || .| | . | . |. NCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 95238.m00103.AA | RSK | 4-212 | 27 | 1.2e-48 | 167.91 | In-house | 47-278 (278) | Show / Hide |
Range on Protein: 4-212 Range on HMM: 47-278/278 Sequence Identity: 27% (64 aa) VNQEIAILKQLD-HPFLAPLYEFFQTDEDYYIVLEYLPGGTLHSLLSHIGK---IQEWRARHYFVQLISALHYLHSEIHIIHCDIKLENILIDE---YDN . .|. ||. |||. |.. |||.. |...||..|| | |.. . . | .|. |. ....|. .||. ||| |.|.|||| |. TMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQG-IIHRDLKPENILYDDESNEGH IRVVDFGLSHLLSEYNPDVTHGF-GTISYCSQEMLR---RKN-YTITTDFWSAGVVLYAMITGHLPFKE---LSKEGLINSILNSE--PEYD--SSLSPD |...|||.. ... . |. | .|| |. |||. ... .. | || ||..| | ||..||. ... ... |.. . .. . ..||.. IKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQE LVSLLNHLLAKNNVQRAT-----HNAIVKSKWI .|....| .. .| . . | ...|. AKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | 95238.m00103.AA | S_TKc | 1-212 | 29 | 1.9e-47 | 164.9 | SMART | 18-231 (231) | Show / Hide |
Range on Protein: 1-212 Range on HMM: 18-231/231 Sequence Identity: 29% (71 aa) MQKVN---------------QEIAILKQLDHPFLAPLYEFFQTDEDYYIVLEYLPG--GTLHSLLSHIGK------IQEWRARHYFVQLISALHYLHSEI .... .||.|||. .||.. ||..||. ...|.|.||..| |.|.... . |. . | .||.|. |...|| |.|| CRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH- HIIHCDIKLENILIDEYDNIRVVDFGLSHLLSEYNPDVTHGFGTISYCSQEMLRRKNYTI-TTDFWSAGVVLYAMITGHLPFKELSKEGLINSILNSEPE .|||.|.| ||||.|| .| . ||||. .| |. || |.. |.| |. | || |..|| |..| || . ... |. GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----- YDSSLSPDLVSLLNHLLAKNNVQRATHNAIVK-------SKWI ||.. ......| |. .| | . . |. -----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 95238.m00103.AA | ULK | 1-212 | 23 | 2.4e-44 | 152.71 | In-house | 54-329 (329) | Show / Hide |
Range on Protein: 1-212 Range on HMM: 54-329/329 Sequence Identity: 23% (65 aa) MQKVNQEIAILKQLD--------HPFLAPLYEFFQTDED--YYIVLEYLPGGTLHSLLSHIGK----------IQEWRARHYFVQLISALHYLHSEIHII .| ...|| |.|.|. || ||..|.|. . .||..|| .||.| .... .| . | |...| |..... .||.. || WQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH-NII HCDIKLENILIDEYDN------------IRVVDFGLSHLLSEY--NPDVTHGF-------GTISYCSQEMLR----RKNYT-ITTDFWSAGVVLYAMITG |.|||..||||.. . . . |||.. ... . .... . || | . . | .|.|. ..| || |...| |..| HRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG HLP----FKELS---KEGLINS-------ILNSEPE-----YDSSLSPDLVSLLNHLLAKNNVQRATHNAIVKSKWI | | .. .. ||| | . .. .| .||.. .|. .| .. .| . . . .|. KPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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Kinase | 95238.m00103.AA | ULK | 1-212 | 24 | 2e-43 | 150.62 | In-house | 54-324 (324) | Show / Hide |
Range on Protein: 1-212 Range on HMM: 54-324/324 Sequence Identity: 24% (67 aa) MQKVNQEIAILKQLD---HPF--LAPLYEFFQTDED--YYIVLEYLPGGTLHSLLSHIGK---------IQEWRARHYFVQLISALHYLHSEIHIIHCDI .|. ..|| |.|.|. ||. ||..|.|. . .||..|| .||.| ... .| . | |...| |..... .||.. |||.|| WQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH-NIIHRDI KLENILIDEYDN------------IRVVDFGLSHLLSEYNPDVTHG---F------GTISYCSQEMLR----RKNYT-ITTDFWSAGVVLYAMITGHLP- |..|||| . . . . |||.. . ..| . . || | . . | .|.|. . .| || |...| |..| | KPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPF ---FKELS--KEGLINS-------ILNSEPEYD-----SSLSPDLVSLLNHLLAKNNVQRATHNAIVKSKWI | .. .. ||| | | ... .||.. .|. .| .. .| . | . .|. FSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | 95238.m00103.AA | AMPK | 1-110 | 39 | 8.6e-33 | 94.72 | In-house | 43-152 (254) | Show / Hide |
Range on Protein: 1-110 Range on HMM: 43-152/254 Sequence Identity: 39% (44 aa) MQKVNQEIAILKQLDHPFLAPLYEFF-QTDEDYYIVLEYLPGGTLHSLLSHIGKIQEWRARHYFVQLISALHYLHSEIHIIHCDIKLENILIDEYDNIRV .... || ||| . || . ||| | .| ..|.|| .|| | . |..|| |. .| | ||.. |.| .. | | | |.||.|.|. || . VERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCH-RHMIVHRDLKPENLLLDHNKNIKI VDFGLSHLLSE |||||| . .. VDFGLSNMMKD |
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Kinase | 95238.m00103.AA | AMPK | 139-212 | 36 | 1.9e-19 | 54.45 | In-house | 181-254 (254) | Show / Hide |
Range on Protein: 139-212 Range on HMM: 181-254/254 Sequence Identity: 36% (27 aa) TDFWSAGVVLYAMITGHLPFKELSKEGLINSILNSEPEYDSSLSPDLVSLLNHLLAKNNVQRATHNAIVKSKWI .| || ||.||||. | ||| . . | |.| |.. . |||. .|..|.| .. ..|.| ..|....| VDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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Kinase | 95238.m00103.AA | TyrKc | 1-213 | 18 | 4.6e-10 | -59.91 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-213 Range on HMM: 1-280/280 Sequence Identity: 18% (52 aa) MQKVN---------------------------------QEIAILKQL--DHPFLAPLYEFFQTD-------EDYYIVLEYLPGGTLHSLL-SHIGKIQEW .. .|. |...| .|| . || .. | ..||.|| |.| |.. | .| .|.. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK RARHYFVQLISALHYLHSEIHIIHCDIKLENILIDEYDNIRVVDFGLSHLLSEY-----NPDVT------HGF--GTISYCSQEMLRRKNYTITTDFWSA .. .| . |||| ..|| |. |.|..| ... ||||| . .. . |. .| | .. | .. . .|. .| || DLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF GVVLYAMIT-GHLPFKE-----LSKEGLINSILNSEPEYDSSL---------SPDLVSLLNHLLAKNNVQRATHNAIVKSKWIL ||... . | | | . .| . .|. . . . .... .. . . .| | ..| . .. GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF |
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Kinase | 95238.m00103.AA | Pkinase_Tyr | 6-105 | 30 | 1.7e-07 | 25.99 | Pfam | 52-158 (270) | Show / Hide |
Range on Protein: 6-105 Range on HMM: 52-158/270 Sequence Identity: 30% (33 aa) QEIAILKQL-DHPFLAPLYEFFQ-TDED--YYIVLEYLPGGTLHSLLSH----IGKIQEWRARHYFVQLISALHYLHSEIHIIHCDIKLENILIDEYDNI .|..|.||| .|| . || .| .|||.|| |.| |.. | ... . .. .| ... ||.| ...|| |. |.|..| . REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES-KNCIHRDLAARNCLVTENNVV RVVDFGLS .. ||||. KICDFGLA |
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UBA_CAMKL | 95238.m00103.AA | UBA_CAMKL | 238-275 | 17 | 2.2e-05 | 17.67 | In-house | 1-41 (41) | Show / Hide |
Range on Protein: 238-275 Range on HMM: 1-41/41 Sequence Identity: 17% (7 aa) NQTVMKNLQSK--GFNTQTILHAINSKDF-SGISAPYFILA .. ........ ||. . | ..... .. |.| |..|. DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL |