Gene 87283.m00199 (T.vaginalis)

87283.m00199

Species: T.vaginalis
Alias: TvagK0624, 87283.m00199
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
87283.m00199.AA Protein None 2098 None Fasta, JSON
87283.m00199.kin_dom Protein Kinase Domain None 104 None Fasta, JSON

Protein domain

Protein domains of 87283.m00199.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 87283.m00199.AA PIKK 1752-2025 31 3.9e-82 279.17 In-house 1-290 (290) Show / Hide 
Range on Protein: 1752-2025
Range on HMM: 1-290/290
Sequence Identity: 31% (92 aa)

TVSKIRHVLKMIPSAKRPRKMRMLGSNGQSYKYLLKGREDLRLDQHIMQFFSLVNSILRMNKSTDGSFNIIMQYHVVPLTTASGLISWAAGGETLSSLIL
 .  .  ..  ... ..|.|. ..|..| .| ||.||.||||.|| .||.|.|.| .|. .. .   .  |  | |.|... .||| |  .  ||  .. 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIY-

WRRKICNRTE-ESEKKVFN-----------------EFLYKGRDIAIYMNNL-QKLELFRKLVNVAPDNEIDEALWLKSSGARQWLMQTTNFSRSLALMS
  .. | . . . |....                   ....  ..     .| .|.|.||....  | .   ...|.|.. . .|.  ..|. ||.|.|.
--KQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMC

VVGYIIGLGDRHPLNILFMKRNGNIVHIDLSDCFEKASLRRYVRETVPFRLTRMLVRALGAVGTHGLFKTTAEDVLGQLRRNSQTLLAFLDIF
.||||.||||||| ||.. . .| |||||. .|||.|  |  | |.|||||||..| |.|. |. |.|  . |.|.  .|..  ||..... |
MVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 87283.m00199.AA FRAP 1782-2035 39 1.3e-66 227.66 In-house 2-251 (251) Show / Hide 
Range on Protein: 1782-2035
Range on HMM: 2-251/251
Sequence Identity: 39% (100 aa)

YKYLLKGREDLRLDQHIMQFFSLVNSILRMNKSTDGSFNIIMQYHVVPLTTASGLISWAAGGETLSSLILWRRKICNRTEESEKKVFNEFLYKGRDIAIY
| .||||.||.| |  .|| | |.| .|. |  |      |  | ..|| . .||| |     ||  ||   ||  .  .  |   .| .. .  |    
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIE---YNIMDRMCNDYDH-

MNNLQKLELFRKLVNVAPDNEIDEALWLKSSGARQWLMQTTNFSRSLALMSVVGYIIGLGDRHPLNILFMKRNGNIVHIDLSDCFEKASLRRYVRETVPF
.  ..| |.||  .|    ...   |||||     |.   ||. |||| ||..|||.||||||| ||.  .  | |||||  |||| |  |    | .||
LPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPF

RLTRMLVRALGAVGTHGLFKTTAEDVLGQLRRNSQTLLAFLDIFVQEPVIDALW
||||||| |. | |  | .. | | |.  .| . . ..| |. ||  | .    
RLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 87283.m00199.AA PI3_PI4_kinase 1781-2037 22 6.1e-46 163.75 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1781-2037
Range on HMM: 1-300/300
Sequence Identity: 22% (71 aa)

SYKYLLKGREDLR--LDQHIMQFF-----------------------SLVNSILRMNKSTDGSFNI----IMQYHVVPLTTASGLISWAAGGETLSSLIL
 |....|| .|||   |...||..                       .|.| ...     ||  .     .  | ..|. . .|.| |    .|.. .. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWK----KDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPR

-WRRKICNRTEESEKKVF---------NEFLYKGRDIAIYMNNLQKLELFRKLVNVAPDNEIDEALWLKSSGA-RQWLMQTTNFSRSLALMSVVGYIIGL
 .. |..    ..|.|..         ..              .||.|.|..  .. | . . . .| ..  |   |.   .|| ||.| |.||.||.|.
TYMVKCKHKHFNKEHKMWMKMWPDWWHLM-------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGN

GDRHPLNILF--MKRNGNIVHIDLSDCFE-KASLRRYVRETVPFRLTR------MLVRAL------GAVGTHGLFKTTAEDVLGQLRRNSQTLLAFL---
||||. ||..  .| .|...|||  .||.  .. .  ..|.||||.|.      ..| |.      .  |  |.|... ....  |||..  ....|   
GDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKA

----DIFVQEPVIDALWYE
    ...|. ....  | .
VMRGECMVHDGLPM--WRS
Kinase 87283.m00199.AA PI3Kc 1783-2087 20 3.6e-42 147.33 SMART 1-336 (336) Show / Hide 
Range on Protein: 1783-2087
Range on HMM: 1-336/336
Sequence Identity: 20% (70 aa)

KYLLKGREDLRLDQHIMQFFSLVNSILRMNKSTDGSFNIIMQYHVVPLTTASGLISWAAGGETLSSLIL----WRRKICNRTEESEKKV-----------
  ..|...||| |...||.|.|.| |.. .| . .    . .|...|.   .|.| |    ||| ..      |.... .  .   .             
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

--FNEFLYKGRDIAIYMNNLQKLELFRKLVNVAPDNEIDEALWLKSSGAR-QWLMQTTNFSRSLALMSVVGYIIGLGDRHPLNILFMKRNGNIVHIDLSD
  ..... .. . .. |.....|..|.. ... ... . . .| .. ...  |    .|| ||.| ...|.|| |.||||. ||.. . .|...|||. .
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

CFEKASLRRYV-----RETVPFRLTRMLVRALG----AVGTHGLFKTTAEDVLGQLRRNSQTLLAFLDIFVQEPV-IDALWYEGSQDDKEGRGLKQAIRR
.|...  .. .     ||.||||||...| . |      |  |.|.|... ..  .|..| .... . ..|  |. ..  .      .|  . |.|..| 
IFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-----EKDIKYLRQRFRL

V--AEKLAGNDY------EMIMTI-PQHVQKLIEEATSEINL
    ...| .        ..|      .  ......    ..
DHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 87283.m00199.AA ATR 1914-2025 39 2.9e-33 110.37 In-house 157-267 (267) Show / Hide 
Range on Protein: 1914-2025
Range on HMM: 157-267/267
Sequence Identity: 39% (45 aa)

ARQWLMQTTNFSRSLALMSVVGYIIGLGDRHPLNILFMKRNGNIVHIDLSDCFEK-ASLRRYVRETVPFRLTRMLVRALGAVGTHGLFKTTAEDVLGQLR
..||     |. || | ...|||||||||||  |||. | || .||.|    | .   .   | |.||||||. .| ..|...|.|||.   |...  .|
PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE--VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMR

RNSQTLLAFLDIF
 . . .....| |
DHRDDIMSVWDCF
Kinase 87283.m00199.AA ATM 1917-2032 39 1.5e-24 75.03 In-house 133-247 (304) Show / Hide 
Range on Protein: 1917-2032
Range on HMM: 133-247/304
Sequence Identity: 39% (46 aa)

WLMQTTNFSRSLALMSVVGYIIGLGDRHPLNILFMKRNGNIVHIDLSDCFEKASLRRYVRETVPFRLTRMLVRALGAVGTHGLFKTTAEDVLGQLRRNSQ
|  .   . || |  |.||||.||||||  |||       .|||||   ||.  .     ||||||||| .|  .|  |  | |.   |  .  .|    
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILP-TPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

TLLAFLDIFVQEPVID
|||   .. . .|. |
TLLTIVEVLLYDPLFD
Kinase 87283.m00199.AA SMG1 1760-1842 43 5.2e-21 66.22 In-house 1-83 (242) Show / Hide 
Range on Protein: 1760-1842
Range on HMM: 1-83/242
Sequence Identity: 43% (36 aa)

LKMIPSAKRPRKMRMLGSNGQSYKYLLKGREDLRLDQHIMQFFSLVNSILRMNKSTDGSFNIIMQYHVVPLTTASGLISWAAG
. ..|   .|.|.  ||| |.|| || || ||| ||  |||| |.|| .       .        | | || | |||| |  |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDG
Kinase 87283.m00199.AA FATC 2066-2098 45 9.5e-18 59.89 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2066-2098
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

MIMTIPQHVQKLIEEATSEINLSRMYHGWAPYW
  ....|.|..||.|||.. ||..||.||.|.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 87283.m00199.AA SMG1 1894-1977 43 9.4e-17 51.88 In-house 160-242 (242) Show / Hide 
Range on Protein: 1894-1977
Range on HMM: 160-242/242
Sequence Identity: 43% (37 aa)

LVNVAPDNEIDEALWLKSSGARQWLMQTTNFSRSLALMSVVGYIIGLGDRHPLNILFMKRNGNIVHIDLSDCFEKA-SLRRYVRE
|.   | | .   ||        |   |  . || | ||.|||||||||||  |.|     | .||||   ||||  .|.  | |
LMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLN--VPE
Kinase 87283.m00199.AA DNAPK 1924-2037 29 1.2e-15 53.3 In-house 190-301 (301) Show / Hide 
Range on Protein: 1924-2037
Range on HMM: 190-301/301
Sequence Identity: 29% (34 aa)

FSRSLALMSVVGYIIGLGDRHPLNILFMKRNGNIVHIDLSDCFEKASLRRYVRETVPFRLTRMLVRALGAVGTHGLFKTTAEDVLGQLRRNSQTLLAFLD
| |. |.  . ..| | ||||  | .    || |. ||    |  | .   | |  ||||||  .  .  ..  |...      .  .|.    |. | |
FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCD

IFVQEPVIDALWYE
.|...| .|  |  
VFINDPSFD--WKN
Kinase 87283.m00199.AA ATR 1752-1855 27 4.8e-12 36.9 In-house 2-107 (267) Show / Hide 
Range on Protein: 1752-1855
Range on HMM: 2-107/267
Sequence Identity: 27% (29 aa)

TVSKIRHVLKMIPSAKRPRKMRMLGSNGQSYKYLLKGREDLRLDQHIMQFFSLVNSILRMNKSTDGSFNIIMQYHVVPLTTASGLISWAAGGETLSSLI-
 .. .  ..... | ..|.|. . ||.|. |  . | ..||| |   |.| .|.| ..|        |  .  | |.||   ...| |     || ... 
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

-LWRRK
 ||. |
KLWKEK
Kinase 87283.m00199.AA ATM 1783-1842 40 2.7e-11 31.94 In-house 1-60 (304) Show / Hide 
Range on Protein: 1783-1842
Range on HMM: 1-60/304
Sequence Identity: 40% (24 aa)

KYLLKGREDLRLDQHIMQFFSLVNSILRMNKSTDGSFNIIMQYHVVPLTTASGLISWAAG
. | |||.||| |  . | | . | .|  |  |      |  | ||||   || . |  |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG
Kinase 87283.m00199.AA DNAPK 1751-1839 26 7.6e-08 24.43 In-house 2-90 (301) Show / Hide 
Range on Protein: 1751-1839
Range on HMM: 2-90/301
Sequence Identity: 26% (24 aa)

ITVSKIRHVLKMIPSAKRPRKMRMLGSNGQSYKYLLKGREDLRLDQHIMQFFSLVNSILRMNKSTDGSFNIIMQYHVVPLTTASGLISW
. .        .. | .||... . |       .. || ||||.|| | | |   | |.               | ..|.|   ||| |
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEW