Gene 85859.m00346 (T.vaginalis)
85859.m00346
Species: T.vaginalis
Alias: 85859.m00346, TvagK0623
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 85859.m00346.AA | Protein | None | 2272 | None | Fasta, JSON |
| 85859.m00346.kin_dom | Protein Kinase Domain | None | 248 | None | Fasta, JSON |
Protein domains of 85859.m00346.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 85859.m00346.AA | nmo | 345-373 | 41 | 0.00034 | 8.12 | In-house | 264-292 (292) | Show / Hide |
Range on Protein: 345-373 Range on HMM: 264-292/292 Sequence Identity: 41% (12 aa) EAFSLLSYFLQFDPDSFVPFDSSLAHKLV || ||. .| |||| . |||. . EAVHLLCRMLHFDPDKRISCKDALAHPYL |
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| Kinase | 85859.m00346.AA | PIKK | 1906-2175 | 37 | 1.7e-90 | 306.97 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1906-2175 Range on HMM: 1-290/290 Sequence Identity: 37% (110 aa) RIQYFIEQLMIYDTKQQPKSLVIKGEDGSMYQYLLKGHEDLRLDERVMQFFRLVNSILKKE--CVMKDLLLHTMSVIPISSTNGLVQWVPGTDTLRSVID ||. . . . . .|| || ..|.| || | ||.|||||||.|.||||.|.|.| .| |. | ..| . | |||| |. ||..||....||. .. RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK QYRK---IRKFDEKQD---------------EFKMLEQTMYISYDNMMPIQKLQIFNNFCRINPDTDIASFFWLKATDAEHWLKMIDTFATSNSINDAIG |... ||. .| |. | ..| . ..|. .|...|. .. | . . .||.|..|.| |. .. | | QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YVIGLGDRHPGNILIDKITGKVVHIDFGDCFEKAMNRPYLPEVVPFRLTRMMVKAMGLTGYNGIFKSSFSDILAILRENWRVLILVLAIF |..||||||| ||.||..||..||||||.|||.|| | || |||||||.|| ||| .| .|.| .. ... ..|.. |. |. | YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | 85859.m00346.AA | FRAP | 1936-2185 | 39 | 5.2e-72 | 245.54 | In-house | 2-251 (251) | Show / Hide |
Range on Protein: 1936-2185 Range on HMM: 2-251/251 Sequence Identity: 39% (100 aa) YQYLLKGHEDLRLDERVMQFFRLVNSILK--KECVMKDLLLHTMSVIPISSTNGLVQWVPGTDTLRSVIDQYRKIRKFDEKQDEFKMLEQTMYISYDNMM | .|||||||.| |||||| | |.| .|. | |.| . |.||.| ||. ||. |||. | .||| . . |...... | || . YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNI-EYNIMDR-MCNDYDHLP PIQKLQIFNNFCRINPDTDIASFFWLKATDAEHWLKMIDTFATSNSINDAIGYVIGLGDRHPGNILIDKITGKVVHIDFGDCFEKAMNRPYLPEVVPFRL ..| || |.. ||| | |. . | . .||..||||||| ||.... |||.|||||||||| || | .|| .|||| LMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL TRMMVKAMGLTGYNGIFKSSFSDILAILRENWRVLILVLAIFVHEPLIEVPD |||.| || .| .| .. .. ..||. .. || || ||. TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | 85859.m00346.AA | PI3_PI4_kinase | 1935-2185 | 26 | 5.8e-63 | 220.28 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1935-2185 Range on HMM: 1-300/300 Sequence Identity: 26% (80 aa) MYQYLLKGHEDLR--LDERVMQFF-----------------------RLVNSILKKECVMKD--LLLHTMSVIPISSTNGLVQWVPGTDTLRSVIDQYR- |....||..||| |.|.||.. ||.| ..||. . . ... ..|| .. .|...||| ..|.. ... |. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV KIR-KFDEKQDEFKMLEQTMYISYDNMMPIQKLQIFNNFCRINPDTDIASFFWLKATDA-EHWLKMIDTFATSNSINDAIGYVIGLGDRHPGNILI--DK |.. |...|.. ..|. ...... .||...|... .| .. .|| . .|| | |.. .|.|..| ..|..|.||||..||.. || KCKHKHFNKEHKMWMKMWPDWWHLM---RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDK ITGKVVHIDFGDCFE-KAMNRPYLPEVVPFRLTR------MMVKAM------GLTGYNGIFKSSFSDILAILRENWRVLILVL-------AIFVHEPLIE ||...|||||.||. .|... || ||||.|. .||.|| . .|. | |... .....||.. .... .| ...|| .|.. TTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPM VPD .. WRS |
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| Kinase | 85859.m00346.AA | PI3Kc | 1937-2251 | 23 | 2.3e-60 | 207.75 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1937-2251
Range on HMM: 1-336/336
Sequence Identity: 23% (81 aa)
QYLLKGHEDLRLDERVMQFFRLVNSILKKE--CVMKDLLLHTMSVIPISSTNGLVQWVPGTDTLRSVIDQYRKIRKFDEKQDEFKMLE------------
. ..|...||| |.|.||.|||.| |..|. | || . ....||... |...||| ..||... . |.| .|.. . .|.
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
-------QTMYISYDNMMPIQKLQIFNNFCRINPDTDIASFFWLKATDA-EHWLKMIDTFATSNSINDAIGYVIGLGDRHPGNILIDKITGKVVHIDFGD
. ..|..| ...|. | ... ... .|| . .|. | | ...|.|. | ..|. |.||||..||..|. ||...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
CFEKAMNRPYLP----EVVPFRLTRMMVKAMG----LTGYNGIFKSSFSDILAILRENWRVLILVLAIFVHEPL-IEVPDSPSVRRRKPAHKVMDTYMAG
.|.... .| . |.||||||..|| .|| .|| | |.. .. ..|.. ... .....|. |. .. . |. ...... .
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-----EKDIKYLRQRFRLD
GKRIGIPRSESMTDEIRSVVKS----KLTGTDMAKKKRQPLTVEQQTELL
. .|.. .. || . . . . . .. . .
H---------LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | 85859.m00346.AA | ATR | 1906-2175 | 31 | 2.2e-47 | 159.32 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 1906-2175 Range on HMM: 2-267/267 Sequence Identity: 31% (86 aa) RIQYFIEQLMIYDTKQQPKSLVIKGEDGSMYQYLLKGHEDLRLDERVMQFFRLVNSILKK--ECVMKDLLLHTMSVIPISSTNGLVQWVPGTDTLRSVID | | . . | . |.|| . .|| || .| . | ..||| | | |.| |.| ...| | .. . . | .|||. . ... || | |||...| YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD QYRKIRKFDEKQDEFKMLEQTMYISYDNMMPIQKLQIFNNFCRINPDTDIASFFWLKATDAEHWLKMIDTFATSNSINDAIGYVIGLGDRHPGNILIDKI . | .| .. .|. | | | . .|...| .| .| . |.. | . . | . .||.||||||| ||||||| KLWKEKK---QYMQFYQLRQCMDKKSREEW--EKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKI TGKVVHIDFGDCFEK--AMNRPYLPEVVPFRLTRMMVKAMGLTGYNGIFKSSFSDILAILRENWRVLILVLAIF .| .||.|. | . .. ||.||||||. || .|| . .|.|. .|. ..|.. .. |. | NGECVHVDYNCIFNSGEQFE---VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 85859.m00346.AA | ATM | 2084-2180 | 41 | 4.3e-23 | 70.3 | In-house | 150-245 (304) | Show / Hide |
Range on Protein: 2084-2180 Range on HMM: 150-245/304 Sequence Identity: 41% (40 aa) IGYVIGLGDRHPGNILIDKITGKVVHIDFGDCFEKAMNRPYLPEVVPFRLTRMMVKAMGLTGYNGIFKSSFSDILAILRENWRVLILVLAIFVHEPL .||..|||||| |||| .|||| | ||. | || ||||||| .| ||.|| |.|. . ..| |. . . . .|| VGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILP-TPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPL |
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| Kinase | 85859.m00346.AA | FATC | 2240-2272 | 54 | 7.8e-19 | 63.37 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2240-2272 Range on HMM: 1-33/33 Sequence Identity: 54% (18 aa) QPLTVEQQTELLINSATSAYNLSKMYSGWAPFW .||.|||| . ||..||. .||..||.||.|.| EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | 85859.m00346.AA | DNAPK | 1905-1999 | 34 | 1.6e-18 | 63.87 | In-house | 2-98 (301) | Show / Hide |
Range on Protein: 1905-1999 Range on HMM: 2-98/301 Sequence Identity: 34% (33 aa) IRIQYFIEQLMIYDTKQQPKSLVIKGEDGSMYQYLLKGHEDLRLDERVMQFFRLVNSILKK--ECVMKDLLLHTMSVIPISSTNGLVQWVPGTDTLR .|| | | . || ..|.| | .. || ||||.| |. | | | |. | ..| | | ..|| . ||. || | .|. VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLK |
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| Kinase | 85859.m00346.AA | SMG1 | 1914-1994 | 43 | 3.1e-18 | 56.86 | In-house | 1-83 (242) | Show / Hide |
Range on Protein: 1914-1994 Range on HMM: 1-83/242 Sequence Identity: 43% (36 aa) LMIYDTKQQPKSLVIKGEDGSMYQYLLKGHEDLRLDERVMQFFRLVNSILKKECVMKDLLLHT--MSVIPISSTNGLVQWVPG . | || .|| |. | || | || || ||| ||||.||| .|| . | || |. ||.||| | ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDG |
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| Kinase | 85859.m00346.AA | SMG1 | 2058-2124 | 44 | 6.9e-17 | 52.34 | In-house | 174-242 (242) | Show / Hide |
Range on Protein: 2058-2124 Range on HMM: 174-242/242 Sequence Identity: 44% (31 aa) WLKATDAEHWLKMIDTFATSNSINDAIGYVIGLGDRHPGNILIDKITGKVVHIDFGDCFEK--AMNRPY | | . | .. .| | . .||.||||||| |.||| || |||||. |||| ..| | WSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | 85859.m00346.AA | DNAPK | 2085-2185 | 28 | 7.1e-16 | 54.1 | In-house | 201-301 (301) | Show / Hide |
Range on Protein: 2085-2185 Range on HMM: 201-301/301 Sequence Identity: 28% (29 aa) GYVIGLGDRHPGNILIDKITGKVVHIDFGDCFEKAMNRPYLPEVVPFRLTRMMVKAMGLTGYNGIFKSSFSDILAILRENWRVLILVLAIFVHEPLIEVP ... | |||| | .. .| .. |||| | | || |||||| . | . |||.... . .| .|. .|. .|.. HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK D N |
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| Kinase | 85859.m00346.AA | ATM | 1937-1995 | 34 | 8.5e-07 | 17.32 | In-house | 1-61 (304) | Show / Hide |
Range on Protein: 1937-1995 Range on HMM: 1-61/304 Sequence Identity: 34% (21 aa) QYLLKGHEDLRLDERVMQFFRLVNSILKK--ECVMKDLLLHTMSVIPISSTNGLVQWVPGT | || .||| | . | | . | .|.. | . | . | |.|.| | . | || RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGT |
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