Gene 94939.m00049 (T.vaginalis)

94939.m00049

Species: T.vaginalis
Alias: 94939.m00049, TvagK0638
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
94939.m00049.AA Protein None 2262 None Fasta, JSON
94939.m00049.kin_dom Protein Kinase Domain None 303 None Fasta, JSON

Protein domain

Protein domains of 94939.m00049.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94939.m00049.AA PIKK 1893-2161 36 1.2e-85 290.86 In-house 1-290 (290) Show / Hide 
Range on Protein: 1893-2161
Range on HMM: 1-290/290
Sequence Identity: 36% (105 aa)

RIEYFVGQFNVYMSKQQPKDVVVRGEDGNFYQYLVKGHEDLRLDERVMQFFHLVNSFIKKE--TSFGGQIISTMSVIPLSIQHGLVQWVRGTDTLRGIVE
||  .     |  .|| ||  . || || .| ||.|||||||.|.||||.| |.|    |.  ..     |.| ||||.| . ||..|| ...||..|  
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

NYRRLYE---TDPMIE----------------YTLLEQLSHQAYDYMLPIQKQQIIDKVCSLTPDTDIAQLFQLKAESSNVWLKQTRTFAMTAAITSIVG
...  ..    ..                   |. ..|  .. |.     .| ..  .... ||  . . .| .|. ..  |.  .  .. . |  ..||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YIIGLGDRHPSNLLIDRLTGKIVHIDFGDSFEKAAKRKFLPEVVPFRLTRMMVKAMGVAGVCGAFRTTFINLAQLLRDNRRVLVMVLSIF
||.|||||||.|..||..||.|||||||..||.| .|   || |||||||.|| |||. || | || . .  . ..|..|  |  |.  |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 94939.m00049.AA FRAP 1923-2171 40 1.6e-75 257.17 In-house 2-251 (251) Show / Hide 
Range on Protein: 1923-2171
Range on HMM: 2-251/251
Sequence Identity: 40% (102 aa)

YQYLVKGHEDLRLDERVMQFFHLVNSFIK--KETSFGGQIISTMSVIPLSIQHGLVQWVRGTDTLRGIVENYRRLYETDPMIEYTLLEQLSHQAYDYMLP
| .| |||||.| |||||| | |.|  ..   ||   .  |   |.||||.. ||. ||.  |||. .. .||. |.    ||| .... . . || .  
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDR-MCNDYDHLPL

IQKQQIIDKVCSLTPDTDIAQLFQLKAESSNVWLKQTRTFAMTAAITSIVGYIIGLGDRHPSNLLIDRLTGKIVHIDFGDSFEKAAKRKFLPEVVPFRLT
..|  |   .   |   |.. |  ||  .| .|.     .    |. |..|||.|||||||||....|.||||||||||| || | .|  .|| .|||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMMVKAMGVAGVCGAFRTTFINLAQLLRDNRRVLVMVLSIFVHEPLVDNED
||.| || ..|. | .| |     . .|...  .. ||  ||  ||     
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 94939.m00049.AA PI3_PI4_kinase 1922-2171 23 2.9e-57 201.33 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1922-2171
Range on HMM: 1-300/300
Sequence Identity: 23% (72 aa)

FYQYLVKGHEDLR--LDERVMQFF-----------------------HLVNSFIKKETSFGGQI----ISTMSVIPLSIQHGLVQWVRGTDTLRGIVENY
 |....||..|||   |.|.||..                        |.| . ||.   .       . . ..||.. ..|...||  ..|...|  .|
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDG--CDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTY

R-----------RLYETDPMIEYTLLEQLSHQAYDYMLPIQKQQIIDKVCSLTPDTDIAQLFQLKAESS-NVWLKQTRTFAMTAAITSIVGYIIGLGDRH
.           . ..... ...  |.            .||... ... ..||  .. |.|  . ..    |..  ..|.   |  ..|.||.|.||||
MVKCKHKHFNKEHKMWMKMWPDWWHLM-----------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRH

PSNLLI--DRLTGKIVHIDFGDSFE-KAAKRKFLPEVVPFRLTR------MMVKAM------GVAGVCGAFRTTFINLAQLLRDNRRVLVMVL-------
..|...  |. ||...|||||..|.  . |. . || ||||.|.      .||.||      .. | .| ||..   . ..|| . ......|       
NDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRG

SIFVHEPLVDNED
...|| .|..  .
ECMVHDGLPMWRS
Kinase 94939.m00049.AA PI3Kc 1924-2224 21 4.3e-51 176.97 SMART 1-336 (336) Show / Hide 
Range on Protein: 1924-2224
Range on HMM: 1-336/336
Sequence Identity: 21% (74 aa)

QYLVKGHEDLRLDERVMQFFHLVNSFIKKE-TSFGGQI-ISTMSVIPLSIQHGLVQWVRGTDTLRGIVENYRRLYE----------------------TD
. ..|...||| |.|.||.| |.|   .|.  ...    . ....||.. ..|...||  ..||. |  .|.                            
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMY-

PMIEYTLLEQLSHQAYDYMLPIQKQQIIDKVCSLTPDTDIAQLFQLKAESSN-VWLKQTRTFAMTAAITSIVGYIIGLGDRHPSNLLIDRLTGKIVHIDF
.||. . .... .  |. |  ..... .... . ... .... |. .  ..| .| .  ..|.   |  ..|.|| |.||||..|...|. ||...||||
MMIWHQQACHW-MMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDF

GDSFEKAAKRKFLP-----EVVPFRLTRMMVKAMG----VAGVCGAFRTTFINLAQLLRDNRRVLVMVLSIFVHEPL-VDNEDN-NDYKNNGETHVVDVV
|. |... ..|...     |.||||||..|| .||    ..|. | |||.     ...| .. ... .....|. |.  .   . .| |. ...  .|. 
GHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDH-

QQGSSIIDKGRLILA------DNASQQSSIEMRNRVNQKLSGM
    |  .  . . .      ...| .| .   . . ... ..
---LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 94939.m00049.AA ATR 2050-2161 37 1.8e-32 107.61 In-house 157-267 (267) Show / Hide 
Range on Protein: 2050-2161
Range on HMM: 157-267/267
Sequence Identity: 37% (42 aa)

SNVWLKQTRTFAMTAAITSIVGYIIGLGDRHPSNLLIDRLTGKIVHIDFGDSFEKAAKRKFLPEVVPFRLTRMMVKAMGVAGVCGAFRTTFINLAQLLRD
.  |      .  . |. ..|||||||||||  |.|||...| .||.|.   | .  . .  ||.||||||. || .||  .  | ||   .   ...||
PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRD

NRRVLVMVLSIF
.|  .. |.  |
HRDDIMSVWDCF
Kinase 94939.m00049.AA ATM 2052-2168 40 9.7e-27 82.14 In-house 132-247 (304) Show / Hide 
Range on Protein: 2052-2168
Range on HMM: 132-247/304
Sequence Identity: 40% (47 aa)

VWLKQTRTFAMTAAITSIVGYIIGLGDRHPSNLLIDRLTGKIVHIDFGDSFEKAAKRKFLPEVVPFRLTRMMVKAMGVAGVCGAFRTTFINLAQLLRDNR
.|  .   .    |  ||||||.||||||  |.||      .|||| |  ||.  |    || ||||||| .|  ||. || | ||         .|   
IWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQ-GKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ

RVLVMVLSIFVHEPLVD
  |. .  . . .|| |
ETLLTIVEVLLYDPLFD
Kinase 94939.m00049.AA DNAPK 2060-2171 32 1.3e-20 71.61 In-house 190-301 (301) Show / Hide 
Range on Protein: 2060-2171
Range on HMM: 190-301/301
Sequence Identity: 32% (36 aa)

FAMTAAITSIVGYIIGLGDRHPSNLLIDRLTGKIVHIDFGDSFEKAAKRKFLPEVVPFRLTRMMVKAMGVAGVCGAFRTTFINLAQLLRDNRRVLVMVLS
|. . |.  | ..| | ||||  | ..   .| |. |||| ||  |      ||  ||||||  .  |   .. | ..   |     .|  | .|.    
FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCD

IFVHEPLVDNED
.|. .|..|   
VFINDPSFDWKN
Kinase 94939.m00049.AA SMG1 2053-2113 52 1.2e-16 51.51 In-house 183-242 (242) Show / Hide 
Range on Protein: 2053-2113
Range on HMM: 183-242/242
Sequence Identity: 52% (32 aa)

WLKQTRTFAMTAAITSIVGYIIGLGDRHPSNLLIDRLTGKIVHIDFGDSFEKAAKRKFLPE
| . |  .|   |. |.|||||||||||  | |||  || .||||.   |||  | .  ||
WWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLN-VPE
Kinase 94939.m00049.AA SMG1 1901-1988 40 2.2e-15 47.3 In-house 1-90 (242) Show / Hide 
Range on Protein: 1901-1988
Range on HMM: 1-90/242
Sequence Identity: 40% (37 aa)

FNVYMSKQQPKDVVVRGEDGNFYQYLVKGHEDLRLDERVMQFFHLVNSFI----KKETSFGGQIISTMSVIPLSIQHGLVQWVRGTDTLRGI
  .   | .|| ..  | ||  | || || ||| ||||.|||  .||       ..||          || ||    ||.||| |   | |.
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPR--FHARHYSVTPLGTRSGLIQWVDGATPLFGL
Kinase 94939.m00049.AA ATR 1893-1990 36 4.2e-15 47.49 In-house 2-101 (267) Show / Hide 
Range on Protein: 1893-1990
Range on HMM: 2-101/267
Sequence Identity: 36% (36 aa)

RIEYFVGQFNVYMSKQQPKDVVVRGEDGNFYQYLVKGHEDLRLDERVMQFFHLVNSFIKK--ETSFGGQIISTMSVIPLSIQHGLVQWVRGTDTLRGIVE
 |  |    ..  | |.|| . ..| || ||  . | ..||| | | |.|  |.|   .|  |   .   . | .||||  | ... ||  | ||| |..
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD
Kinase 94939.m00049.AA DNAPK 1892-1991 31 1.3e-13 45.69 In-house 2-103 (301) Show / Hide 
Range on Protein: 1892-1991
Range on HMM: 2-103/301
Sequence Identity: 31% (32 aa)

IRIEYFVGQFNVYMSKQQPKDVVVRGEDGNFYQYLVKGHEDLRLDERVMQFFHLVNSFIKKETSFGGQI--ISTMSVIPLSIQHGLVQWVRGTDTLRGIV
.||  |     |  |   || ...|| |     ...|| ||||.| |. | |   |  .        .    .| ..||.    ||. ||  | .|. | 
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL

EN
 |
NN
Kinase 94939.m00049.AA ATM 1924-1982 37 1.8e-07 19.48 In-house 1-61 (304) Show / Hide 
Range on Protein: 1924-1982
Range on HMM: 1-61/304
Sequence Identity: 37% (23 aa)

QYLVKGHEDLRLDERVMQFFHLVNSFIKK--ETSFGGQIISTMSVIPLSIQHGLVQWVRGT
  |||| .||| |  . | | . |  ...  ||      | |  |.|||   | . |  ||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGT
FATC 94939.m00049.AA FATC 2230-2262 57 2.6e-19 64.88 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2230-2262
Range on HMM: 1-33/33
Sequence Identity: 57% (19 aa)

VPLTVEQQADMLISLATSRYQLAKMYSGWCPFW
.||.||||.|.||. ||. . |..||.||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW