Gene 93205.m00037 (T.vaginalis)
93205.m00037
Species: T.vaginalis
Alias: TvagK0325, 93205.m00037
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 93205.m00037.AA | Protein | None | 1096 | None | Fasta, JSON |
| 93205.m00037.kin_dom | Protein Kinase Domain | None | 204 | None | Fasta, JSON |
Protein domains of 93205.m00037.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 93205.m00037.AA | TKL | 210-456 | 22 | 4.2e-59 | 202.66 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 210-456
Range on HMM: 1-364/364
Sequence Identity: 22% (82 aa)
ISTNPQIATYLGTQKNTS--------KPVLIQKLNFNERISVGL-----------------------FKKFKLQIE-VLSKCKHFALCKLIGITNSEP--
| | |. .... |.| . |.. .. . . |..|. . ..|...| .....|. ...|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------YYIITEYYPESQSLFSFLHEKASSITETNKLIIALGVAYGMAYLHSIG--------VIYRNLKSPNVFLDSDFA--------------
..|..||.| ||...|| .. .||..| ||.|||| . .|.|.|||.|...|...
CVCMHPVGPWGQLCIVMEYCPGG-SLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC
PHIFNFETSRFSDGSS--------------------RFTPKVGTLNWMAPEV-----YLSDF-----------YTKKSDVYSYGMLLYELLTQETPFKNK
. | | .||| ..|. . ...||..|||||| .... |..|.||||.|..|.|.|| ..|...
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY
TELQII---------NKVFSQKYRPNLP------------EDNNKSICDLISMCWDQDPDKRPSFPEIVSFF
. ..| .| . ..|| .| .| .|...|. .|||.||.||||| ||.. .
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 93205.m00037.AA | TKL-Unique | 227-456 | 28 | 3.5e-53 | 183.01 | In-house | 20-290 (290) | Show / Hide |
Range on Protein: 227-456 Range on HMM: 20-290/290 Sequence Identity: 28% (77 aa) SKPVLIQKLNFNERISVGLFKKFKLQIEVLSKCK-HFALCKLIGITN----SEP-YYIITEYYPESQSLFSFLH---------EKASSITETNKLIIALG ..|| | ....|| .| . ..|. .. ...| . | . ...|.. ..| ..|..||.|.. || . || .. . .. ... .|. GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGG-SLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAID VAYGMAYLHSIG--VIYRNLKSPNVFLDSD-----FAPHIFNFETSRFSDGSSRFTPK----------VGTLNWMAPEVYLS--DFYTKKSDVYSYGMLL .| || |||. . .| |.|||.|. .|.. . | |..|.|.. ... | . .|...|||||| . . |..||||||.|. | IAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL YELLTQET------PFKNKTELQIINKVFS--QKYRPNLPEDNNKSICDLISMCWDQDPDKRPSFPEIVSFF .|..| . |... . |.. .| . .||| .|.. .|.. ||| .||..||..|||| ||.. WEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | 93205.m00037.AA | Dicty5 | 276-460 | 36 | 7.1e-50 | 169.85 | In-house | 73-260 (260) | Show / Hide |
Range on Protein: 276-460 Range on HMM: 73-260/260 Sequence Identity: 36% (70 aa) Y-YIITEYYPESQSLFSFLHEKAS----SITETNKLIIALGVAYGMAYLHSIGVIYRNLKSPNVFLDSDFAPHIFNFETSRFSDGSSRFTPKVGTLNWMA | ...||| . |||. | .. | .| .|...| .| .|||...| | ||| |. . .. | | |||| | .| ||| .||| YPFHVTEYC-HNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMA PEVYLSDFYTKKSDVYSYGMLLYELLTQETPFKNKTELQIINKVFSQKYRPNLPEDNNKSICDLISMCWDQDPDKRPSFPEIVSFFEKGD .|.. . |. | ||||.| |.|..|. .|..| . | . | . || .| | .| || || | | .|||| ||. ||. CELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGE-RPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII |
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| Kinase | 93205.m00037.AA | MLK | 204-456 | 26 | 1.9e-49 | 169.72 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 204-456 Range on HMM: 1-291/291 Sequence Identity: 26% (77 aa) FEIGSQISTNPQIATYLGTQKNTS---KPVLIQKLNFNERISVGL----FKKFKLQIEVLSKCKHFA----LCKLIGITNSE-P-YYIITEYYPESQSLF ... | .. . ..|. .|. | | ... ... . ... ..|. .. |.. .| ... |. ... . ..|..|| ... ||. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGG-SLY SFLHEKAS-------------SITETNKLIIALGVAYGMAYLHSIG---VIYRNLKSPNVFLDS------DFAPHIFNFETSRFSDGS-SRFTPKVGTLN ..||.. | .. .. .|| .| ||.|||| .| | |||.|. .| . | | |||. . . . . ||. NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA WMAPEVY---LSDFYTKKSDVYSYGMLLYELLTQETPFK-NKTELQIINKVFSQKYRPNLPEDNNKSICDLISMCWDQDPDKRPSFPEIVSFF |||||| .. |..|.||.|.|..|.|.|| |.|.| ...|. .| . || .| . ..... |...||.||| ||||| .||... WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | 93205.m00037.AA | LRRK | 274-458 | 33 | 1.3e-45 | 157.9 | In-house | 128-351 (351) | Show / Hide |
Range on Protein: 274-458 Range on HMM: 128-351/351 Sequence Identity: 33% (76 aa) EPYYIITEYYPESQSLFSFLHEKASS--------ITETNKLIIALGVAYGMAYLHSIG--VIYRNLKSPNVFLDSDFAP------------HIFNFETSR .|. ...|| | | .|||.|... |. . || ||| .| ||.|||| .|.|.|||||..| | .. .| | .|| HPLCMVMEYAPHGD-LYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR --FSDGSSRFTPKVGTLNWMAPEVYLSD---FYTKKSDVYSYGMLLYELLTQE-TPFKNKT-------ELQIINKVFSQKYRPNLPED-NNK-----SIC ...... . .||. |||||. . || |.|.||.||.|.|||| . || . . . || .|. .. || .|.. .. . . MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGL-RPTIPQHYCPPCQPWHMYQ DLISMCWDQDPDKRPSFPEIVSFFEK ||| ||..||.|||.| .||.. . DLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | 93205.m00037.AA | Pkinase | 253-456 | 22 | 5.2e-41 | 146.1 | Pfam | 51-293 (293) | Show / Hide |
Range on Protein: 253-456
Range on HMM: 51-293/293
Sequence Identity: 22% (55 aa)
IEVLSKCKHFALCKLIGIT-NSEPYYIITEYYPES---QSLFSFLH-EKASSI--TETNKLIIALGVAYGMAYLHSIGVIYRNLKSPNVFLDSDFAP---
|... ...| ..|... .. .|...|| . ..||.... .. .. .| ... .. |..|.|| |.|.| ||. |...|.. .
IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDAC
-HIFNFETSRF--SDGSSRFTPKVGTLNWMAPEVYL-SDFYTKKSDVYSYGMLLYELLTQETPFKNK------TELQIINKVFSQKYRPNLPEDNN----
.| | ... .| .| .||...||||| . . |..|.|..|.| .|||.|. ..||... ...|.|... . ... . |....
VKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYF
---------------KSICDLISMCWDQDPDKRPSFPEIVSF--F
.. .|.|. |...|| |||....|. |
FFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | 93205.m00037.AA | Dicty4-Unclassified | 278-456 | 32 | 9.3e-40 | 133.82 | In-house | 79-263 (263) | Show / Hide |
Range on Protein: 278-456 Range on HMM: 79-263/263 Sequence Identity: 32% (61 aa) IITEYYPESQSLFSFLH----EKASSITETN--KLIIALGVAYGMAYLHSIGVIYRNLKSPNVFLDSDFAPHIFNFETSRFSDGSSRFTPKVGTLNWMAP |..| . . || | |. .| . .|. .| ||..||. .| | .|| |. .| .| | | || | | || | .| IVMEFMH-KGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESP EVYLSDFYTKKSDVYSYGMLLYELLTQETPFKNKT-ELQIINKVFSQKYRPNLPEDNNKSICDLISMCWDQDPDKRPSFPEIVSFF |. |. |||||||.|.||||.| . |. . . | . | || .|. . || || || |||.. .|. ECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | 93205.m00037.AA | HH498 | 305-456 | 33 | 8.3e-38 | 117.17 | In-house | 123-284 (284) | Show / Hide |
Range on Protein: 305-456 Range on HMM: 123-284/284 Sequence Identity: 33% (54 aa) KLIIALGVAYGMAYLHS---IGVIYRNLKSPNVFLDSDFAPHIFNFETSRF--SDGSSRFTPKVGTLNWMAPEVYL-SDFYTKKSDVYSYGMLLYELLTQ |..|.. || || |||. .| | | | |. .. | . | ||| . . | | | ||||||. . |..| ||.||.| ..|..| KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTR ETPFKNKTELQIINKVFSQKYRPNLPED----NNKSICDLISMCWDQDPDKRPSFPEIVSFF | || .. .. || .| ... || |||.. |. ||.| .|| EVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL |
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| Kinase | 93205.m00037.AA | TK | 266-456 | 14 | 1.5e-36 | 119.5 | In-house | 107-486 (486) | Show / Hide |
Range on Protein: 266-456
Range on HMM: 107-486/486
Sequence Identity: 14% (56 aa)
KLIG-ITNS------------EPYYIITEYYPESQ---SLFSFLHEKASS--------------------------------------------------
.|.| .| . ||..|..|| | || ..|...
RLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIK
-------------------------ITETNKLIIALGVAYGMAYLHSI------GVIYRNLKSPNVFLDSDFA-----------PHIFNFE--------T
.| .| ... .| ||.|||| ... |.| |. .... | |
DHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVL
SRFSDGSSRFTPKV-GTLN--------------------------WMAPEVYLSDF---------YTKKSDVYSYGMLLYELLT--QETPFKNKTE----
.| . .. . | .. . |||||. .. .| ||||.|.| |..|..| ||.. . .
ARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVW
-----LQIINKVFSQ-------------KYRPNLPEDNN--------------KSICDLISMCWDQDPDKRPSFPEIVSFF
...... . ..|. |.. . . ||. .||. ||..||.| ......
KDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | 93205.m00037.AA | TKL-ciliate1 | 247-456 | 29 | 1.5e-34 | 115.63 | In-house | 43-279 (279) | Show / Hide |
Range on Protein: 247-456
Range on HMM: 43-279/279
Sequence Identity: 29% (70 aa)
KKFKLQIEVLSKCK-HFALCKLIGITNS-EPYYIITEYYPESQSLFSFLHEKAS---SITETNKLIIALGVAYGMAYLHSIG--VIYRNLKSPNVFLDSD
|.| |. ..| | | | |.|| . .|||.|. . ..|. .| | | | . . . .| || |||. | |.||. | .| .
KEFQREIQQHIKIKQHINLQQLQGISFYDNNFYIIMEHCHKG-TMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEP
FAPHIFNF---ET---SRFSDGSSRFT----PKVGTLNWMAPEVYL-----SDFYTKKSDVYSYGMLLYELLTQETPFKNKTE-LQIINKVFSQKYRPNL
. . |.|| . | . .|. . .| |||||. .. | |.|.|| ..|.| .|||..| . |. . . ||||
YQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNL
-----PEDNNKSICDLISMCWDQDPDKRPSFPEIVSFF
. | .. .|. ||.|.| |||.| ||
GPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL
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| Kinase | 93205.m00037.AA | Dicty4 | 363-458 | 41 | 3.3e-33 | 108.23 | In-house | 178-277 (277) | Show / Hide |
Range on Protein: 363-458 Range on HMM: 178-277/277 Sequence Identity: 41% (41 aa) VGTLNWMAPEVYLSDFYTKKSDVYSYGMLLYELLTQETPFK--NKTELQIINKVFSQKYRPNLPEDNNKSICDLISMCWDQDPDKRPSFPEIVSF--FEK .|| |||||| .. |. |.||||.|..|.|.|| . |. . |... | . | || .| . .|. .|| ||| || .||||.||.. | CGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | 93205.m00037.AA | S_TKc | 204-456 | 24 | 2.8e-27 | 97.86 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 204-456 Range on HMM: 1-231/231 Sequence Identity: 24% (65 aa) FEIGSQISTNPQIATYLGTQKNTSKPVLIQKLNFNERISVGLFKKFKLQIEVLSKCKHFALCKLIGITNSEPYYIITEYYPES-QSLFSFLHEKASS--- .||. .| |... |.| . | | ... .... |..|.| .| ..||... .. .|...|| . . .||...... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --ITETNKLIIALGVAYGMAYLHSIGVIYRNLKSPNVFLDSDFAPHIFNFETSRFSDGSSRFTPKVGTLNWMAPEVYLSDFYTK-KSDVYSYGMLLYELL ..| .. .. ...|.|| |.|.| || |..||. | | .|. | .||...||||| |.| |.|..| | .|||.| FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML TQETPFKNKTELQIINKVFSQKYRPNLPEDNNKSICDLISMCWDQDPDKRPSFPEIVS---------FF . ..|| .. ....|. .. .|.|. |.. ||.|||. |. .| CGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 93205.m00037.AA | Pkinase_Tyr | 368-456 | 35 | 2.1e-23 | 79.9 | Pfam | 180-270 (270) | Show / Hide |
Range on Protein: 368-456 Range on HMM: 180-270/270 Sequence Identity: 35% (32 aa) WMAPEVYLSDFYTKKSDVYSYGMLLYELLTQE-TP-FKNKTELQIINKVFSQKYRPNLPEDNNKSICDLISMCWDQDPDKRPSFPEIVSFF |||||. .| ||||.|.| |..|..| .| ... . ....... . || ||. . | ||. .||..||..||.| ||.... WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | 93205.m00037.AA | TyrKc | 210-456 | 23 | 1.5e-17 | 61.09 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 210-456 Range on HMM: 1-280/280 Sequence Identity: 23% (68 aa) ISTNPQIAT------YLGTQKNTSKPVLIQKLNFNERISVGLFKKFKLQIEVLSKC--KHFALCKLIGITNS--------EPYYIITEYYPESQSLFSFL |. . .. |.|| | .| . .|. . . | .....| .| . .|.|. . ||..|..|| | .| ..| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYL HEKASSITETNKLIIALGVAYGMAYLHSIGVIYRNLKSPNVFLDSDFAPHIFNFETSRFSDGS-------SRFT------PK-VGTLNWMAPEVYLSDFY ... .. .| ... .| ||.|||| ..| | | |. ..... | | ||. . . . | . . |||||. . RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF TKKSDVYSYGMLLYELLTQ-ETPFKN-----KTELQIINKVFSQKYRPNLPED--------NNKSICDLISMCWDQDPDKRPSFPEIVSFF | ||||.|.| ...|..| ..| . .. ..|..| | ||. |.. . . .....||. ||..||.| ||...| TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV-KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 93205.m00037.AA | Pkinase_Tyr | 253-325 | 25 | 1.1e-08 | 30.03 | Pfam | 54-133 (270) | Show / Hide |
Range on Protein: 253-325 Range on HMM: 54-133/270 Sequence Identity: 25% (21 aa) IEVLSKC-KHFALCKLIGITN--SEP--YYIITEYYPESQSLFSFLHEK---ASSITETNKLIIALGVAYGMAYLHSIGVI ...... .| . .|.|. .|| .||..|| | .| ..|... ..| .| ... .| ||.||.|.. | AKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG-DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI |
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| Kinase | 93205.m00037.AA | Dicty4 | 308-333 | 42 | 0.092393 | 1.85 | In-house | 117-144 (277) | Show / Hide |
Range on Protein: 308-333 Range on HMM: 117-144/277 Sequence Identity: 42% (12 aa) IALGVAYGMAYLHS-I-GVIYRNLKSPN .|. .| ||..||. . .| | ||| | MAFDAARGMNWLHCCNPVIIHRDLKSHN |
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