Gene 88026.m00191 (T.vaginalis)

88026.m00191

Species: T.vaginalis
Alias: TvagK0683, 88026.m00191
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
88026.m00191.AA Protein None 402 None Fasta, JSON
88026.m00191.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of 88026.m00191.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88026.m00191.AA NEK 6-260 36 4e-114 385.46 In-house 1-286 (286) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-286/286
Sequence Identity: 36% (103 aa)

FVEQKVLGKGTYGCVYKAKRLSDGQS-----YAVKVINLGNLNHREIEDSV-NEIRLMASFSSPFIIRFYEAFCDNR--RLCIVTEYSR-LGDLAHL---
. ..|..|.| .|.|||..| |||.      |. | ||.||.. .| .... ||.|. ..  .| |...|..| ..   .|||| ||    |||. .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IERRKKKRRPFHEDDIWRYLLQMLEGLKVLHNC-----GVVHRDIKSANILLSAPDL----IKIADLGVSTVLHTT-QLART-QIGTPLYLAPEVWKRRP
|...|.|. .| |. ||... ||. .|| .|.       ..|||||..|| |.. .     .|| |.|.| || .| ..|.| |.||| |..|||.. .|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDSKCDMWSLGVLLYEMMTF--TYPFTAR--TTQELAQRCCLG-KFT-IPHG--YSAELVSIVRRLLQVNPLMRPSVDDLLNTQCI
|..|.|.||||..||||.|.    || |      .|. . . | ..  ||    || .| ......||..| .|||....|.. .|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 88026.m00191.AA S_TKc 6-260 31 6.4e-92 312.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-231/231
Sequence Identity: 31% (83 aa)

FVEQKVLGKGTYGCVYKAKRLSDGQSYAVKVINLGNLNHREIEDSVNEIRLMASFSSPFIIRFYEAFCDNRRLCIVTEYSRL--GDLAHLIERRKK--KR
.   ...|||..|.|||..  ..|. .|.|.|.         |.  .||... .   |.|...|..| |  .|..|.||     ||| ..|..|..  .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

RPFHEDDIWRYLLQMLEGLKVLHNCGVVHRDIKSANILLSAPDLIKIADLGVSTVLHTTQLARTQIGTPLYLAPEVWKRRPYDS-KCDMWSLGVLLYEMM
.||.| ....|. |....|. .|. |..|||.| .||||.    |||.| |....|      .|..||| |.||||    .|.  |||.||.|..||||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TFTYPFTARTTQELAQRCCLGKFTIPHGYSAELVSIVRRLLQVNPLMRPSVDDLLN-------TQCI
.   ||   . |.. ....          | |. ...|..||..|  ||.. ..|.        . .
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 88026.m00191.AA NEK1 6-260 36 9.2e-82 277.94 In-house 1-276 (276) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-276/276
Sequence Identity: 36% (102 aa)

FVEQKVLGKGTYGCVYKAKRLSDGQSYAVKVINLGNLNHREIEDSVNEIRLMASFSSPFIIRFYEAFCDNRR--LCIVTEYSRLGDLAHLIERRKKKRRP
....|..|.|..| ....|. .||| |. | ||. .    |.|.|.||  . |    | |....|.|  | .  | || ||   |||.  |.|.| |  .
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FHEDDIWRYLLQMLEGLKVLHNCGVVHRDIKSANILLS--APD---------------LIKIADLGVSTVL-HTTQLARTQIGTPLYLAPEVWKRRPYDS
| || |  .  |.  .|.  |   . |||||| || |.    .               |.|..| |.. .| ||. .|.| |||| || || .  .||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KCDMWSLGVLLYEMMTFTYPFTARTTQELAQRCCLGKFT-IPHGYSAELVSIVRRLLQVNPLMRPSVDDLLNTQCI
| |.||||. ||| .| . || |.  . |  . | | .. ||  || || | |  ....||  |||| ..|    |
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 88026.m00191.AA Pkinase 6-260 26 1e-79 275.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

FVEQKVLGKGTYGCVYKAKRLSDGQSYAVKVINLGNLNHREIEDSVN--EIRLMASFSSPFIIRFYEAFCDNRRLCIVTEYSRLG----DLAHLIERRKK
..  ...|.|..|||||... ..|. .|||.|.. . .. . .  ..  ||..|.....|.|.|.|..| |......|.|| . |    ||...|..  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KRRPF--HEDDIWRYLLQMLEGLKVLHNCGVVHRDIKSANILLSAPDLI----KIADLGVSTV--LHTTQLARTQIGTPLYLAPEVWK-RRPYDSKCDMW
....|   |... .|..|.|.||. .|..|..|||.|..|||..  . |    ||.| |.. .  .   . . |  ||| |.|||| . ...|..|.|||
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGVLLYEMMTFTYPFTAR------TTQELAQRCCLGKFTIPHGYS---------------------AELVSIVRRLLQVNPLMRPSVDDLLNTQCI
|.|..||||..   ||  .      . ... .|   ...  .  ..                      |. ......|...|  ||. ...|.   .
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 88026.m00191.AA CAMK 11-260 20 1.9e-72 232.52 In-house 1-425 (425) Show / Hide 
Range on Protein: 11-260
Range on HMM: 1-425/425
Sequence Identity: 20% (85 aa)

VLGKGTYGCVYKAKRLSDG------------QSYAVKVINLGNLN--------------------------HREIEDSVNEIRLMAS-------FSSPFI
.||.|..| |..... ...            | .|.|.|.   |                            .  .   .||..| .        . | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRFYEAFCD-------------------NRRLCIVT---EYSRLG----DLAHLIERRKKKR-----------RPFHEDDIWRYLLQMLEGLKVLHNCGV
|..||.. |                   ......|.   ||   |    ||   | ......           . |.|..  ||  |...... .|....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKSANILLSAPD-----------------LIKIADLGVSTVLHT------------------------TQLARTQIGTPLYLA-PEVWKR------
||||.|  ||||.  .                  |||.| | ....                          .|. .|. ||| | | ||| ..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------RPYDSKCDMWSLGVLLYEMMTFTYPFTAR-------------TTQELAQRCCLGKFT-IPHG-----------------------YSAELVS
        ..|. ||||||.||.|| | . ..|| .              . .|| .. . ||.. .|.                         |.|  .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

IVRRLLQVNPLMRPSVDDLLNTQCI
 .|..|||.|  |..... || . .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 88026.m00191.AA Ciliate-E2 6-260 23 2.2e-69 236.82 In-house 1-365 (365) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

FVEQKVLGKGTYGCVYKAKRLSDG-----------------------QSYAVKVINLGNLNHREIEDSVN-EIR----------LMASFSSPFIIRFYEA
.  .|..|.|..|.|||.|. ...                       . ||.|...  .... . |.... ||.          .. . ..|.||..||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FC--DNRRLCIVTEYSRLGDLAHLIERRKKKR-------RPFHEDDIWRYLLQMLE---------------GLKVLHNCG-VVHRDIKSANILLSAPDLI
|   |.  . .|.||   ||| ..|. .||||        .| |  | ..  | |.               .|. ||. . ..|||||  |||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADLGVSTVLHTT--------------------------------QLARTQIGTPLYLAPEVWKRRP---------YDSKCDMWSLGVLLYEMMTFTYP
||.|.| |. ...                                 ....|..||| |.|||. .. .         || |||.|||||.||||..  .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FTARTTQELAQRCCLGKFTIP------------------HGYSAELVSIVRR----LLQVNPLMRPS-VDDLLNTQCI
|         |  . .|. .|                  .  | |   . ..    .||..|  |..  ...|| . .
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 88026.m00191.AA CAMKL 6-260 28 8.9e-68 215.32 In-house 1-297 (297) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-297/297
Sequence Identity: 28% (84 aa)

FVEQKVLGKGTYGCVYKAKR-LSDGQSYAVKVINLGNLNHREIEDSV-------------NEIRLMASFS---SPFIIRFYEAFCDNRR------LCIVT
.   |.||||..| |  |.  .  |. .|.|.|.   .. ... ..               ||..| ...    | ||..|| . . .       ...|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYSRLGD--LAHLIERRKKKRRPFHEDDIWRYLLQMLEGLKVLHNCGVVHRDIKSANILLSAPD--LIKIADLGVSTVLHT-----TQLARTQIGTPLYL
||   |.  | . |......|....|..  ||  |...... .|..|.||||||  ||||.  .   |||.| | |.          |. .|. |.| | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVWKR--RPYD-SKCDMWSLGVLLYEMMTFTYPFTART---------TQELAQRCCLGKFTIPHGYSAELVSIVRRLLQVNPLMRPSVDDLLNTQCI
|||. ..  .|||  | |.||.||.|| |.. ..|| . |         . .. ..|. ....|.   | .. .. |..|||||  ||......|    
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 88026.m00191.AA STE 6-260 23 3.1e-65 223.05 In-house 1-359 (359) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-359/359
Sequence Identity: 23% (87 aa)

FVEQKVLGKGTYGCVYKAKRL------SDGQS---------YAVKVINLGNLN---------------HREIEDSVNEIRLMASFS--SPFIIRFYEAFC
.  ....|||..| ||||..       . |.          .|.|..|| | |               | |...  .||..|  ..  .|.|...| .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DNR-------RLCIVTEYSRLGDLAHLIERRKKKRRPFH----------EDDIWRYLLQMLEG-LKVLHNCGVVHRDIKSANILLSAPDLIKIADLGVST
..         |.|. ||   | |  .|...... .|..          |. | ... | |.| |. ||. ...|||||.|||||     .|..| ||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLHT---------------TQL--ARTQIGTPLYLAPEVWKR------RPYDSKCDMWSLGVLLYEMMTFTYPFTA-RTT---QELA--QRCCL------
 |                 |.     | .||| . |||| ..       .|| |||.|||| .. || |  .|.     .    . .  ....       
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GKFTIPH-------------------GYSAELVSIVRRLLQVNPLMRPSVDDLLN--TQCI
    .  ..|.                    .| |.   ... || .|  ||....||.     |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 88026.m00191.AA ULK 6-260 25 4.2e-65 222.6 In-house 1-324 (324) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-324/324
Sequence Identity: 25% (84 aa)

FVEQKVLGKGTYG-CVYKAKRLSD---GQSYAVKVINLGNLNHREIEDS--------VNEIRLMASFS---SPF--IIRFYEAFCDN--RRLCIVTEYSR
..  ..||||..|  |||..   .   .| .|.|.|.. ..|  . |.          |||..|  .    .|.  |...|. | .     ..|..||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

LGDLAHLIERRKK-----KRRPFHEDDIWRYLLQMLEGLKVLHNCGVVHRDIKSANILLSAPD------------LIKIADLGVSTVLHT----TQLART
 ||| ..|...||     . . . |. .  .. | ..|.| ||. ...||||| .|||.. ..             .|||| | . ..       |.  |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QI------GTPLYLAPEVWKRR----PYD-SKCDMWSLGVLLYEMMTFTYP---FTARTTQ----ELAQR-------CCLGKFTIP-----HGYSAELVS
.       ||||| ||......    ||. .|||.||||...||| .  ||     .....    .| .         .  .. .|        | |. .
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

IVRRLLQVNPLMRPSVDDLLNTQCI
. ||.||...  | | ....|  ..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 88026.m00191.AA ULK 6-260 26 2e-62 213.7 In-house 1-329 (329) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-329/329
Sequence Identity: 26% (87 aa)

FVEQKVLGKGTYGCVYKAKRLSD----GQSYAVKVINLGNLNHREIEDS--------VNEIRLMASFS----SPF----IIRFYEAFCDN--RRLCIVTE
..  ..||||..| |||..   .    .. .|.|.| .  .|  . |.          |||..|        ...    |...|. | .     . |..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YSRLGDLAHLIERRKK------KRRPFHEDDIWRYLLQMLEGLKVLHNCGVVHRDIKSANILLSAPD------------LIKIADLGVSTVLHTT----Q
|   ||| ..|...||      . . . |. .  .. | |.|.| ||  ...||||| .|||.. ..             .|||| | . ..       |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LARTQI------GTPLYLAPEVWKRR----PYD-SKCDMWSLGVLLYEMMTFTYPFTAR-TTQELAQRCCLGKFTIPHG------------------YSA
.. |.       ||||| ||......    ||. .|||.||||...||| .  .|| |  ..| | .   | . . |..                   | 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

ELVSIVRRLLQVNPLMRPSVDDLLNTQCI
|. .. ||.||...  | | ..|.|  ..
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 88026.m00191.AA Ciliate-E2-Unclassified 6-260 24 3.2e-59 203.07 In-house 1-352 (352) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

FVEQKVLGKGTYGCVYKAKRLSDG-----------QSYAVKVINLGNLNHREIEDSVNEIR-------------LMASFSSPFIIRFYEAFCDNRRLCIV
.  .|..|.| .|.|||... ...           |.|..| |.  . ..  ... .|..              .. .. .|||......| |   ..||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TEYSRLGDLAHLIE-------------RRKKKRRPFHEDDIW-----RYLLQMLEGLKVLHNCG-VVHRDIKSANILLSAPD---LIKIADLGVSTVLHT
.|| . |||   |.             ...|.|. | |  .      .|. | |.||. ||  . ..|||||  |||..       |||.|.| |  . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------------TQLARTQIGTPLYL----APEVWKRRPYD----SKCDMWSLGVLLYEMMTFTYPFTARTTQE----------------LAQRCC
                 |.. |..||| |.    |||| ..  ||     |||.|||||.||||.. .||| ...  .                | | ..
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

LGKFTIPH--------GYSAELVSIVR----RLLQVNPLMRPSVDDLLNTQCI
 ... .|.        . | |   ...    ..|..||  |.. ...|| . .
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 88026.m00191.AA NEK2 10-260 28 2.3e-55 184.86 In-house 5-319 (319) Show / Hide 
Range on Protein: 10-260
Range on HMM: 5-319/319
Sequence Identity: 28% (90 aa)

KVLGKGTYGCVYKAKRLSDGQSYAVKVINLGNLNHREIEDSVNEIRLMASFSSPFIIRFYEAFCD--NRRLCIVTEYSRLGDLAHLIERRKKKRRPFHED
...|.| .| ..| .| |||   . | |. |...  |    |.|. .      |.|.|.|    |  | .| || ||   |||. .| . .| |. . | 
YTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEE

DIWRYLLQMLEGLKVLHN------------------CG---VVHRDIKSANILLSAPDL---------------------------------------IK
 ||| ..|..  |.. ||                   |   . ||||| ||| |.. .                                        .|
FIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVK

IADLGVSTVLH-TTQLARTQIGTPLYLAPEVWKRRPYDSKCDMWSLGVLLYEMMTFTYPFTARTTQELAQRCCLGKF-TIPHGYSAELVSIVRRLLQVNP
  | |   .|   |. | | .||| |  ||. ....|. | | ||.| |.||| .   ||.|.  ..|.     |.| .||  || .|  |. . . |..
LGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDH

LMRPSVDDLLNTQCI
  |||.. .|    |
YHRPSIEEILQHPQI
Kinase 88026.m00191.AA Pkinase_Tyr 6-202 26 3.7e-27 92.62 Pfam 1-210 (270) Show / Hide 
Range on Protein: 6-202
Range on HMM: 1-210/270
Sequence Identity: 26% (56 aa)

FVEQKVLGKGTYGCVYKAKRL----SDGQSYAVKVINLGNLNHRE--IEDSVNEIRLMASF-SSPFIIRFYEAFC-DNRR--LCIVTEYSRLGDLAHLIE
 .  |.||.| .| |||..      ....  |||..   .  |..  .||  .|...| .. . | |.|.| .   . .   ..||.||  .||| .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RRKKKRRPFHEDDIWRYLLQMLEGLKVLHNCGVVHRDIKSANILLSAPDLIKIADLGVSTVLHTTQLA-RTQIGTPL---YLAPEVWKRRPYDSKCDMWS
...  ..|.   |.  . .|  .|.  |.. . .|||.   |.|.. .  .||.| | .  .. .    |.. |..|    .|||... . . .| | ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGVLLYEMMTF
 |||..|..|.
FGVLMWEIFTY
Kinase 88026.m00191.AA TyrKc 6-260 23 9e-18 64.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-260
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FVEQKVLGKGTYGCVYKAKRLSDGQSYAVKVINLGNLNHREIEDSVNEIRLMASF--SSPFIIRFYEAFCDN-------RRLCIVTEYSRLGDLAHLIER
 .  |.|| | .| |||..     .  |||... .      .||  .|.|.| ..  . | |.|.| .  .          |.||.||  .||| . . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RKKKRRPFHEDDIWRYLLQMLEGLKVLHNCGVVHRDIKSANILLSAPDLIKIADLGVSTVLHTT-------QLARTQ--IGTP--L---YLAPEVWKRRP
...|   .  .|   . .|  .|   ||  ...|||.   |.|....  .||.| | |  ..         .  |..   |.   |    .|||... . 
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDSKCDMWSLGVLLYEMMTFTYPFTA------RTTQELAQRCCLG-KFTIPHG--------YSAELVSIVRRLLQVNPLMRPSVDDLLNTQCI
. .| | || ||...|..|.  .          . ||. ..   |    .|.          ..|. .| ..  . .| .||.  ..   .|.
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF