Gene 90149.m00289 (T.vaginalis)

90149.m00289

Species: T.vaginalis
Alias: TvagK0307, 90149.m00289
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
90149.m00289.AA Protein None 820 None Fasta, JSON
90149.m00289.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of 90149.m00289.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 90149.m00289.AA TKL 30-276 23 8.4e-77 261.46 In-house 1-364 (364) Show / Hide 
Range on Protein: 30-276
Range on HMM: 1-364/364
Sequence Identity: 23% (88 aa)

IGEGAFGKVYLGTHKA--------TGLECAIKELIAETLEDRDK-------------------------VEFIRETSVLAECNDMFLLPFLG------W-
||.|.||.|| |...         || . |.| .  .    ..|                          ....|. ..  ..   ...|.|      . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-TAEKP------YSIITQFAPNSSLFDALRKKGKAPELTGTMRT--IIMIGVARAMNALHQ--------KKVIHRDLKSLNVLLDSR-------------
   ..|      . |.....|. ||.. |            .     .....||.|| ||.        ...||||||| |.|.|.              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

-CYPWVCDFGLSLFENENA--------------------IKTKDIGTPHWMAPELFDSD----------------NYTNKVDVYAYGILLWELLTGSTPY
 . . .|||||| | ...                      . . .||| |||||... .                 |. |.|||..||.|||.||. .||
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

K--GKSSIQIA-------IAVCQHGERPPIP------------IGTPKPLISLIKSCWHQDPNKRPSFSKIVSVL
.  . ......       . ||..|.|||||              .|.....|.. ||..||.|||||..|.. |
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 90149.m00289.AA MLK 24-276 30 1.6e-73 250.55 In-house 1-291 (291) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-291/291
Sequence Identity: 30% (88 aa)

FTIGRSIGEGAFGKVYLGTHKATG---LECAIKELIA-------ETLEDRDKVEFIRETSVLAECN-DMFLLPFLGWTAEKPYS--IITQFAPNSSLFDA
... . ||.|.||||..|. ...     . |.|.  |       .  |..|. ...|. ..|   |      .|.|  .. |.   |........||.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LRKKGKAPE-----------LTGTMRTIIMIGVARAMNALHQKK---VIHRDLKSLNVLLDS------RCYPWVCDFGLSLFENEN-AIKTKDIGTPHWM
|. . . ..            .      ..  .||.|. ||...   .||||||| |.|.|            .||||.| . ... . ... .||. ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APELF---DSDNYTNKVDVYAYGILLWELLTGSTPYK-GKSSIQIAIAVCQHGERPPIPIGTPKPLISLIKSCWHQDPNKRPSFSKIVSVL
||| .    .. |. |.||. .|..|||.||. .||| . ....||. | ..|.|||||.. |... .|.| ||.|||.|||||. ||. |
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 90149.m00289.AA TKL-Unique 26-276 30 6.3e-61 208.72 In-house 1-290 (290) Show / Hide 
Range on Protein: 26-276
Range on HMM: 1-290/290
Sequence Identity: 30% (91 aa)

IGRSIGEGAFGKVYLGTHKATGLECAIKELIA-ETLEDRDKVEFIRETSVLAECN-DMFLLPFLGWTA----EKP-YSIITQFAPNSSLFDALR------
.. .||||..|.|| |...  | . ||| .   | .. . . ||..| ...   .   ... . |...      | ..|.. . | .|| | |       
FWNKIGEGGYGQVYKGKWR--GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KKGKAPELTGTMRTIIMIGVARAMNALHQKK--VIHRDLKSLNVLLDSR-----CYPWVCDFGLSLFENENAIKTKD----------IGTPHWMAPE
   .. .  .|.  .|  . | .|..|. || ..  .|||||||.|.|.|..         .|||||| | . .  .|.           .|.. |||||
NNNNNNC--KLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

LFDS--DNYTNKVDVYAYGILLWELLTGST------PYKGKSSIQIAIAVCQ--HGERPPIPIGTPKPLISLIKSCWHQDPNKRPSFSKIVSVL
.. .  . |..|.|||..|| |||..|.        ||.| ...|.. .| .   . |||||   || .  ||. |||.|| .||||. |.. |
VLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 90149.m00289.AA Dicty5 25-280 33 8.6e-59 200.98 In-house 2-260 (260) Show / Hide 
Range on Protein: 25-280
Range on HMM: 2-260/260
Sequence Identity: 33% (89 aa)

TIGRSIGEGAFGKVYLGTHKATGLECAIKELIAETLEDRDKVEFIRETSVLAECN--DMFLLPFLG-WTAEKPY-SIITQFAPNSSLFDALRKKGK--AP
 ..  |  || |.|| |  |  |   |||..  |     | .|| ||  ..         .  ..|  . .. |  ..| .  | |||..|. . |    
SFHDWIASGASGRVYNGIYK--GMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQ

ELTGTMRTIIMIGVARAMNALHQKKVIHRDLKSLNVLLDSRCYPWVCDFGLSLFENENAIKTKDIGTPHWMAPELFDSDNYTNKVDVYAYGILLWELLTG
 .    .  . |..|..|  || . .|||||||.|.|.  .    . ||| | |       | ..||. |||.||| .  |..|.|||..|| |||..| 
PIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTR

STPYKGKSSIQIAIAVCQHGERPPIPIGTPKPLISLIKSCWHQDPNKRPSFSKIVSVLMKKQ
 .||.   .. |.. | . |||| ||   |     |||.|| | | .|||| .|. .. .  
KEPYDNINNWNIPVMV-MKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 90149.m00289.AA S_TKc 24-283 26 2.4e-58 201.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-283
Range on HMM: 1-231/231
Sequence Identity: 26% (71 aa)

FTIGRSIGEGAFGKVYLGTHKATGLECAIKELIAETLEDRDKVEFIRETSVLAECNDMFLLPFLGWTAEKPYSIITQFAPN--SSLFDALRKKGKAPE--
..|.| ||.|||||||...|| || ..|||..            ..|| ..| . .  ..  ....  .. . ... ....   .||| ..|.|. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LTGTMRTIIMIGVARAMNALHQKKVIHRDLKSLNVLLDSRCYPWVCDFGLSLFENENAIKTKDIGTPHWMAPELFDSDNYTN-KVDVYAYGILLWELLT
 ..  .   .|  ...|.. .|....||||||  |.|||.     .|||||. .       |  .|||..||||..    |.  |.|... |..|.|.|.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GSTPYKGKSSIQIAIAVCQHGERPPIPIGTPKPLISLIKSCWHQDPNKRPSFSKIVS--VLMKKQVMF
| .|.     .|  . ..            .......|. |.. ||.|||.  ..    .. |.   |
GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 90149.m00289.AA TyrKc 24-276 28 1.4e-57 198.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-280/280
Sequence Identity: 28% (84 aa)

FTIGRSIGEGAFGKVYLGTHKATGLECAIKELIAETLEDRDKVEFIRETSVLAEC--NDMFLLPFLGWTAE--------KPYSIITQFAPNSSLFDALRK
 | |. .||||||.||.|| |   ...|.| | ...     . .|.|| ... .   .   .. ..|   .        .|. |.. ..|. .| | |||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KGKAPELTGTMRTIIMIGVARAMNALHQKKVIHRDLKSLNVLLDSRCYPWVCDFGLSLFENEN--------AIKTKD-IGTP-----HWMAPELFDSDNY
...   |.      ... .|. |. ||.|..|||||   |.|....    ..||||| .  .          ...|   |.       ||||| ..   .
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TNKVDVYAYGILLWELLT-GSTPYKG----KSSIQIAIAVCQHGERPPIPIG--------TPKPLISLIKSCWHQDPNKRPSFSKIVSVL
| | ||...|...||..| | .|| |    . | | .|.  ..|.|.|.|           |. . ...|.||| ||..||.|| |.. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 90149.m00289.AA Pkinase 24-276 24 8.7e-57 199.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-293/293
Sequence Identity: 24% (72 aa)

FTIGRSIGEGAFGKVYLGTHKATGLECAIKELIAETLEDRDKVEFIR--ETSVLAECNDMFLLPFLGWTA-EKPYSIITQFAPNS----SLFDALR--KK
..||| ||.|.||.||...|| || . |.|..  .. ..  ... .|  | ......|  . . ...|   .. . ... ....     .||| ..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKAPELTGTMRTIIMI--GVARAMNALHQKKVIHRDLKSLNVLLDSRCYP----WVCDFGLSLF--ENENAIKTKDIGTPHWMAPELFD-SDNYTNKVDV
|.   . .........   ..|... .|....||||||. |.|.|.....     .|||||. .  .  |   |   |||..||||.   .  |. |||.
GCF--Y-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YAYGILLWELLTGSTPYKGK---SSIQIAIAVCQHGERPPIPIGTP-----------------------KPLISLIKSCWHQDPNKRPSFSKIVSV--L
...|..|.|.|.| .|..|.    .    ... .   .||..   |                       ......||.|...||.|||..  |.    .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 90149.m00289.AA Pkinase_Tyr 24-276 31 1.8e-56 191.9 Pfam 1-270 (270) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-270/270
Sequence Identity: 31% (85 aa)

FTIGRSIGEGAFGKVYLGTHK----ATGLECAIKELIAETLEDRD--KVEFIRETSVLAEC-NDMFLLPFLGWTA--EKP--YSIITQFAPNSSLFDALR
 |.|. .||||||.||.|| |     |....|.| |  |.  ...  . .|.|| ... .  .   .. ..|     ..|  . |.. ..|. .| | ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KK-GKAPELTGTMRTIIMIGVARAMNALHQKKVIHRDLKSLNVLLDSRCYPWVCDFGLSLFE--NENA--IKTKDIGTPHWMAPELFDSDNYTNKVDVYA
|.    . ||  .   . . .|..|. |..|. |||||   |.|...     .|||||.      ..    ...      ||||| .    .| | ||..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGILLWELLT-GSTP-YKGKSSIQIAIAVCQHGERPPIPIGTPKPLISLIKSCWHQDPNKRPSFSKIVSVL
.|.|.||..| | .| |.| |  ..  .. ..|.| |.| ..|... .|.|.|||.||..||.|| |.. |
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 90149.m00289.AA HH498 24-276 31 3.5e-56 176.43 In-house 1-284 (284) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-284/284
Sequence Identity: 31% (89 aa)

FTIGRSIGEGAFGKVYLGTHKATGLECAIKELIAETLEDRDK-----V-EFIRETSVLAECNDMFLLPFLGWTAEKP--YSIITQFAPNSSLFDAL----
.   ..|| |.|||||.|.    .   |.|   |..     .     |  |.|| |..   |      |.. . . |    |.||.  | |||  |    
IEFHEKIGSGSFGKVYKGEWR--NKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIP

-----------RKKGKAPELTGTMRTIIMIGVARAMNALHQ---KKVIHRDLKSLNVLLDSRCYPWVCDFGLSLFENENAIK--TKDIGTPHWMAPELFD
             |     .    . .| . ||. || ||    . .||||| | |.|..      | ||| | | ..   .  || .| . ||||| | 
IGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFS

-SDNYTNKVDVYAYGILLWELLTGSTPYKGKSSIQIAIAVCQHGERPPIPIG----TPKPLISLIKSCWHQDPNKRPSFSKIVSVL
 .  |. ||||. |.. .||..|.  |.     .  |  .  |  |||||.      |.. ..||  |||. |. ||.|. || .|
QCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 90149.m00289.AA Dicty4 128-278 42 8.8e-56 184.59 In-house 117-277 (277) Show / Hide 
Range on Protein: 128-278
Range on HMM: 117-277/277
Sequence Identity: 42% (69 aa)

IMIGVARAMNALHQ--KKVIHRDLKSLNVLLDSRCYPWVCDFGLSL----FENENA-IKTKDIGTPHWMAPELFDSDNYTNKVDVYAYGILLWELLTGST
... .|| || ||     .||||||| | | |      |||||||      |. ..  .|  .||| |||||   .. |. |.||| .||.|||.||.  
MAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQE

PYK--GKSSIQIAIAVCQHGERPPIPIGTPKPLISLIKSCWHQDPNKRPSFSKIVSV--LMK
||   ...  |...|||....|||||  .|.....||. ||. ||..||||. |..   |  
PYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 90149.m00289.AA TK 24-276 16 4.3e-54 179.34 In-house 1-486 (486) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-486/486
Sequence Identity: 16% (79 aa)

FTIGRSIGEGAFG---KVYLGTHKATG-------------------------LECAIKELIAE-TLEDRDKVE--------------FIRETSVLAE--C
 |.|. .|||.||   .||.|. .  .                          ..|.| | .. . ..... .              . .| ... .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NDMFLLPFLG-WTAE------------KPYSIITQFAPNSS----LFDALRKKGKAPE------------------------------------------
.   .. ..|  | .            .|. |.. ..|. .    | | |||. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTGTMRTIIMIGVARAMNALHQK------KVIHRDLKSLNVLLDSRCY-----------PWVCDFGLS-
                               ||   .  ..  .|..|  ||.|      ...||||   |.|....               ..||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

---------LFENENAIKTKDIGTPH-------------------------WMAPELFD---------SDNYTNKVDVYAYGILLWELLT-GSTPYKGKS
         . ....  .... ||.                          ||||| ..            .| | ||...|.|.||..| | .|| |  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SI---------QIAIAVCQHG--------------ERPPIPIGTPK-------------PLISL-IKSCWHQDPNKRPSFSKIVSVL
|          |  .   . |               |.| | . |              ... . ...||| ||..||.|| ... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 90149.m00289.AA UTK 24-276 27 4.9e-49 165.88 In-house 1-296 (296) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-296/296
Sequence Identity: 27% (81 aa)

FTIGRSIGEGAFGKVYLGTHK-----ATGLECAIKELIAETLEDRDKV---EFIRETS---VLAECN-DMFLLPFLGW-TAEKPYSIITQFAPNSSLFDA
  .|| .|.|||| |.... .     .. . .|.|.. ..    ...    .|..|.    ... ..  . .| ..|  |.|.|  |.| ...|..| . 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRKKGKAPE-----LTGTMRTIIMIGVARAMNALHQKKVIHRDLKSLNVLLDSR-------CYPWVCDFG---LSLFEN-----------ENAIKT-KDI
||. ...|.     || . |.  .  .||.|. ||.....||||   |.|...            ..|||   .|   |           .   ..  |.
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

GTPHWMAPELFDSD-NYTNKVDVYAYGILLWELLT-GSTPYKGKSSIQIAIAVCQHG-ERPPIPIGTPKPLISLIKSCWHQDPNKRPSFSKIVSVL
 .  ||||| ...   .|.| ||...|...||..| |..||.| |  |.. .||  |  |.| | . | |.  | ..|||.|| .||.|  .|...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase 90149.m00289.AA DRK 128-278 39 1.1e-48 163.01 In-house 103-258 (258) Show / Hide 
Range on Protein: 128-278
Range on HMM: 103-258/258
Sequence Identity: 39% (62 aa)

IMIGVARAMNALHQKK--VIHRDLKSLNVLLDSRCYPWVCDFGLSL----FENENAIKTKDIGTPHWMAPELFDSDNYTNKVDVYAYGILLWELLTGSTP
.|. .|. |. ||     .||||||| | | |      | |||||      .   . .|  .||| | |||   .. || | ||| ..| |||..|   |
MMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTM-CGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDP

YKGKSSIQIAIAVCQHGERPPIPIGTPKPLISLIKSCWHQDPNKRPSFSKIVSVLMK
| |.   |. ..| .||.|||.|   | . | |.. ||  ||  |||.  ..  |  
YFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase 90149.m00289.AA LRRK 93-278 30 4.7e-48 165.98 In-house 128-351 (351) Show / Hide 
Range on Protein: 93-278
Range on HMM: 128-351/351
Sequence Identity: 30% (69 aa)

KPYSIITQFAPNSSLFDALRKKGKAP------ELTGTMRTIIMIGVARAMNALHQKK--VIHRDLKSLNVLLDSRCYPW------------VCDFGLSL-
.|. ... .||. .| . |..| . .      ... ...  |.. .|..|. || ..  .||||||| |.|| |   .             ..|||.|  
HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRM

-FENENAIKTKDIGTPHWMAPELFDSD---NYTNKVDVYAYGILLWELLTGS-TPYKGKS-------SIQIAIAVCQHGERPPIP--IGTPK-----PLI
 .   ...  .  |.| |||||    .   .|| |||.|..|..||||||..  |. . .        .||  .. . | ||.||  .  |       . 
FQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKI-IEGLRPTIPQHY-CPPCQPWHMYQ

SLIKSCWHQDPNKRPSFSKIVSVLMK
.||..||..||.|||.||.||..|  
DLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 90149.m00289.AA Dicty4 24-42 52 1.5e-05 14.67 In-house 1-19 (277) Show / Hide 
Range on Protein: 24-42
Range on HMM: 1-19/277
Sequence Identity: 52% (10 aa)

FTIGRSIGEGAFGKVYLGT
 .|.  ||.|.||.||.||
INIEQRIGKGSFGEVYKGT
Kinase 90149.m00289.AA LRRK 24-39 47 0.000133 12.18 In-house 1-17 (351) Show / Hide 
Range on Protein: 24-39
Range on HMM: 1-17/351
Sequence Identity: 47% (8 aa)

FTIGRSIGEGAFG-KVY
. |...||.|.|| .||
LKIEEQIGRGGFGTFVY
Kinase 90149.m00289.AA DRK 24-64 34 0.000543 9.45 In-house 1-39 (258) Show / Hide 
Range on Protein: 24-64
Range on HMM: 1-39/258
Sequence Identity: 34% (14 aa)

FTIGRSIGEGAFGKVYLGTHKATGLECAIKELIAETLEDRD
  ||  || | .| |..||    | . |.| | .   .| .
IKIGNRIGRGNYGEVFRGTWR--GTQVAVKMLFNHNINDEN