Gene 93846.m00121 (T.vaginalis)

93846.m00121

Species: T.vaginalis
Alias: TvagK0635, 93846.m00121
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
93846.m00121.AA Protein None 2200 None Fasta, JSON
93846.m00121.kin_dom Protein Kinase Domain None 235 None Fasta, JSON

Protein domain

Protein domains of 93846.m00121.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT 93846.m00121.AA HEAT 482-497 43 44.395513 0.67 Pfam 11-26 (31) Show / Hide 
Range on Protein: 482-497
Range on HMM: 11-26/31
Sequence Identity: 43% (7 aa)

DKSKEVRLAALNQLSK
|.. |||.||.. |..
DPDWEVREAACWCLGQ
HEAT 93846.m00121.AA HEAT 501-530 30 7.9e-05 20.58 Pfam 2-31 (31) Show / Hide 
Range on Protein: 501-530
Range on HMM: 2-31/31
Sequence Identity: 30% (9 aa)

FPQITQLLSDPSYKVRAAAVERVAAMVETM
.| . ..|.||...||.||.. .....| .
LPHLLKCLNDPDWEVREAACWCLGQLCEHC
FAT 93846.m00121.AA FAT 1330-1445 21 5.7e-05 16.88 Pfam 52-201 (408) Show / Hide 
Range on Protein: 1330-1445
Range on HMM: 52-201/408
Sequence Identity: 21% (32 aa)

LFQAIYLV--ASTQYD--SAIKHISKCFELLTENREI-YSGADSNQASKNLVFAQHLTELSEVIEVK-KSG----------VQCVPSI---WQQRLHSF-
.|||| ..     |.|  .| ..|.|. .|| ..     .|  .| .   .|  | |.|| |.|. | . .           .   ..   |..||    
FFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCK

SNDSDSWTKLIEVRGLLIT--------------PQEHMDACLKLISVLRK
  . . |  .. .| . ..              |.| |.  .|  .. ||
QRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCRK
FAT 93846.m00121.AA FAT 1467-1620 15 2.1e-09 31.72 Pfam 232-408 (408) Show / Hide 
Range on Protein: 1467-1620
Range on HMM: 232-408/408
Sequence Identity: 15% (27 aa)

NIAIAYLKIMWTRGEKTQAISLIKSLND-IIQGNSSIEVPQRLQ------TVKDEILKSGVSTAFRA-RALRLQATWEYQV---YKAQTASSDSLTDIIK
.. .||||.|| .|.. .|.. ..       |..   .  . ..      .|.    .....|   | |.  .|. |  .     . .    ..  .|..
QWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMN-WNQEQKDEILQ

TFKSSLSLFSGDYR-AWSGWAYASSRALSHKP-----------DERQLYATDAITAFLKATQLRPS-ESLEFLCQLFS
 ..    .    |. ||  ||..  ....| .           .... ... |.. |...  |  . .|.. .  | .
CYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
HEAT 93846.m00121.AA HEAT 1650-1680 16 0.00422 14.6 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1650-1680
Range on HMM: 1-31/31
Sequence Identity: 16% (5 aa)

IVPQIVVHIAHKDEKVRCLVQEIICNFADDH
|.| .. .. ..|..||. . . ...... .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Kinase 93846.m00121.AA FRAP 1891-2140 45 2.6e-97 329.6 In-house 2-251 (251) Show / Hide 
Range on Protein: 1891-2140
Range on HMM: 2-251/251
Sequence Identity: 45% (113 aa)

WKFLLKGNEDLRLDQRIMQFFNLINSLLKSNRVTSKQGMSIAMYAVVPFAPNAGLISWVTGADTMQQLISDYRNMRDIPCGLENDIVNSISTNFNQLNAL
. ||||| ||.| | |.|| | ||| ||. |  | | ..||  |...|   |.||| ||   ||.. || |||.   |  . |  | ..   ....|  .
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPLM

QKVEVYQAVCKGSSDGELRETLWLKSPTPSAWVERSYQFTVSTALMSMAGYVIGLGDRHPSNIMIQRHTGRVIHIDFGDSFEVTRQRPLFPELVPFRLTR
.|||... . .     .|.  ||||||    | ||   .| | | ||||||..|||||||||||.|| ||...|||||| |||  .|  |||..||||||
NKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTR

MIISALDGGSVEGLFKRSCEDILYVMREQQSPLISQLEIFVHEPIFAGNS
|.. |..   .|| ..  || .. |.||.   ..  || ||  |.|    
MLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 93846.m00121.AA PIKK 1861-2130 33 1.8e-85 290.28 In-house 1-290 (290) Show / Hide 
Range on Protein: 1861-2130
Range on HMM: 1-290/290
Sequence Identity: 33% (98 aa)

KLYSVGETLTVFATQQHPRTVEMTDETGKTWKFLLKGNEDLRLDQRIMQFFNLINSLLKSNRVTSKQGMSIAMYAVVPFAPNAGLISWVTGADTMQQLIS
   .  . .|| |. | |.   .    ||   .|.|| ||||.|||.||.| |.| .|  .  ..|   .|  |.|.|  .. ||| ||....| . .. 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DYRNMRDIPCGLE--------------------NDIVNSISTNFNQLNALQKVEVYQAVCKGSSDGELRETLWLKSPTPSAWVERSYQFTVSTALMSMAG
...    |    |                      .. . . . . ..  .||||   ..  .    ... .|.|.|.| .| ||   .| |.|.|.|.|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YVIGLGDRHPSNIMIQRHTGRVIHIDFGDSFEVTRQRPLFPELVPFRLTRMIISALDGGSVEGLFKRSCEDILYVMREQQSPLISQLEIF
|..|||||||.||||.. || ..|||||..||.  ||  .||.|||||||... |.    |||.| |.||... .||... .|.. .| |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 93846.m00121.AA PI3Kc 1892-2183 21 2.1e-66 227.83 SMART 1-336 (336) Show / Hide 
Range on Protein: 1892-2183
Range on HMM: 1-336/336
Sequence Identity: 21% (71 aa)

KFLLKGNEDLRLDQRIMQFFNLINSLLKSNRVTSKQGMSIAMYAVVPFAPNAGLISWVTGADTMQQLISDYRNMRDIPCGLENDIVNSI-----------
 ...|...||| |.|.||.|.|.| ...... .... . .  |...|  |. |.| ||. ..|. |. . |. .. .|  .. ..               
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

----------STNFNQLNALQKVEVYQAVCKGSSDGELRETLWLKSPTPS-AWVERSYQFTVSTALMSMAGYVIGLGDRHPSNIMIQRHTGRVIHIDFGD
           .   ... .......  . .   .  |.. .| ..|.|. .|.|.  .|| |.| ..|..|. |.||||..|||. . || ..|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

SFEVTRQRPLFP----ELVPFRLTRMIISALDGG----SVEGLFKRSCEDILYVMREQQSPLISQLEIFVHEPI-FAGNSG----RAQHNTLSRV--ATK
 |.  . .|.|.    |.||||||.... .  ||     ..|.|.. |. .. .||...  ... .|..|. || .  ...    . .....       .
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

LSGTDF-------IDADEVGVFMHTNEQVSMLIKAA
.. . |       .. .... . ..  .. .... .
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 93846.m00121.AA PI3_PI4_kinase 1890-2140 23 1.2e-65 229.19 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1890-2140
Range on HMM: 1-300/300
Sequence Identity: 23% (73 aa)

TWKFLLKGNEDLR--LDQRIMQFF-----------------------NLINSLLKSNRVTSKQGMSIAMYAVVPFAPNAGLISWVTGADTMQQLISDYRN
. .|..||..|||   |.|.||..                       .|.| ..|..... .. |... | ..| .|. |.| ||  ..|...... |..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

MRDIPC----------------GLENDIVNSISTNFNQLNALQKVEVYQAVCKGSSDGELRETLWLKSPTP-SAWVERSYQFTVSTALMSMAGYVIGLGD
.. ..                  |.               ..|||||.  . .    . |.. .| ..|..  .| |.  .|. | | |....|..|.||
KCKHKHFNKEHKMWMKMWPDWWHLM---------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGD

RHPSNIMI--QRHTGRVIHIDFGDSFE-VTRQRPLFPELVPFRLTR------MIISAL------DGGSVEGLFKRSCEDILYVMREQQSPLISQL-----
||..|||.   . || ..|||||..|. .  ... .||.||||.|.      ....|.      |  . .|.|...|.... ..|...  ... |     
RHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVM

--EIFVHEPIFAGNS
  |..|| ...  .|
RGECMVHDGLPMWRS
Kinase 93846.m00121.AA ATR 2017-2130 36 5e-31 102.64 In-house 155-267 (267) Show / Hide 
Range on Protein: 2017-2130
Range on HMM: 155-267/267
Sequence Identity: 36% (42 aa)

PTPSAWVERSYQFTVSTALMSMAGYVIGLGDRHPSNIMIQRHTGRVIHIDFGDSFEVTRQRPLFPELVPFRLTRMIISALDGGSVEGLFKRSCEDILYVM
| |  |      .  |.| ..| ||.|||||||  ||.|.. .| ..|.|.   |   .|    ||.||||||. .. ..     .|||.| ||.|. .|
PDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCM

REQQSPLISQLEIF
|... ...| .. |
RDHRDDIMSVWDCF
Kinase 93846.m00121.AA ATM 2019-2136 42 7.4e-31 95.53 In-house 130-246 (304) Show / Hide 
Range on Protein: 2019-2136
Range on HMM: 130-246/304
Sequence Identity: 42% (50 aa)

PSAWVERSYQFTVSTALMSMAGYVIGLGDRHPSNIMIQRHTGRVIHIDFGDSFEVTRQRPLFPELVPFRLTRMIISALDGGSVEGLFKRSCEDILYVMRE
|  | |.   .| | |  |. ||..||||||  ||.|      ..||| |  ||  .  |  || ||||||| |.  .    ||| |.| ||  . ||| 
PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRN

QQSPLISQLEIFVHEPIF
 |  |.   |. . .|.|
SQETLLTIVEVLLYDPLF
Kinase 93846.m00121.AA SMG1 2012-2067 50 5.4e-16 49.32 In-house 173-228 (242) Show / Hide 
Range on Protein: 2012-2067
Range on HMM: 173-228/242
Sequence Identity: 50% (28 aa)

LWLKSPTPSAWVERSYQFTVSTALMSMAGYVIGLGDRHPSNIMIQRHTGRVIHIDF
||    ||  |      .  ||| ||| ||.|||||||  |..|   || |.|||.
LWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY
Kinase 93846.m00121.AA DNAPK 2028-2140 30 2.2e-15 52.28 In-house 189-301 (301) Show / Hide 
Range on Protein: 2028-2140
Range on HMM: 189-301/301
Sequence Identity: 30% (34 aa)

QFTVSTALMSMAGYVIGLGDRHPSNIMIQRHTGRVIHIDFGDSFEVTRQRPLFPELVPFRLTRMIISALDGGSVEGLFKRSCEDILYVMREQQSPLISQL
.|  . |.    ... | ||||  | |.   .| .| |||| ||    |    ||| ||||||  |  .    . |... .    .  .| .   |.   
HFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFC

EIFVHEPIFAGNS
..|. .| |    
DVFINDPSFDWKN
Kinase 93846.m00121.AA FATC 2168-2200 36 8.5e-14 47.22 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2168-2200
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

VFMHTNEQVSMLIKAASDSTRYIRHFIGWCPFW
. . ...||..||. |.|  .. ...|||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 93846.m00121.AA SMG1 1869-1952 34 1.1e-13 41.61 In-house 1-84 (242) Show / Hide 
Range on Protein: 1869-1952
Range on HMM: 1-84/242
Sequence Identity: 34% (29 aa)

LTVFATQQHPRTVEMTDETGKTWKFLLKGNEDLRLDQRIMQFFNLINSLLKSNRVTSKQGMSIAMYAVVPFAPNAGLISWVTGA
.|.  |.  |. .      || . .| || ||| || |||||  ..| .                |.| |    .||| || ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGA
Kinase 93846.m00121.AA ATM 1892-1951 40 1.7e-12 35.86 In-house 1-60 (304) Show / Hide 
Range on Protein: 1892-1951
Range on HMM: 1-60/304
Sequence Identity: 40% (24 aa)

KFLLKGNEDLRLDQRIMQFFNLINSLLKSNRVTSKQGMSIAMYAVVPFAPNAGLISWVTG
. | || .||| |  . | | . | ||. |  | |  . |  | ||| .  .| . | ||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG
Kinase 93846.m00121.AA ATR 1861-1959 24 2.4e-11 34.51 In-house 2-100 (267) Show / Hide 
Range on Protein: 1861-1959
Range on HMM: 2-100/267
Sequence Identity: 24% (24 aa)

KLYSVGETLTVFATQQHPRTVEMTDETGKTWKFLLKGNEDLRLDQRIMQFFNLINSLLKSNRVTSKQGMSIAMYAVVPFAPNAGLISWVTGADTMQQLI
 .    . . ..|. |.|. . .    || .  . |  .||| | | |.| .||| ...      .. . .. |||.|   ....| ||    |.. ..
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL
Kinase 93846.m00121.AA DNAPK 1861-1949 29 6.1e-11 35.86 In-house 3-91 (301) Show / Hide 
Range on Protein: 1861-1949
Range on HMM: 3-91/301
Sequence Identity: 29% (26 aa)

KLYSVGETLTVFATQQHPRTVEMTDETGKTWKFLLKGNEDLRLDQRIMQFFNLINSLLKSNRVTSKQGMSIAMYAVVPFAPNAGLISWV
..    |  || |    |. . .     .   |. || ||||.|||| | |   |  .      . . .    | ..|     ||| ||
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWV