Gene TVAG_359220 (T.vaginalis)

TVAG_359220

Species: T.vaginalis
Alias: TVAG_359220, TvagK1067
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
TVAG_359220.AA Protein None 281 None Fasta, JSON
TVAG_359220.kin_dom Protein Kinase Domain None 230 None Fasta, JSON

Protein domain

Protein domains of TVAG_359220.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH TVAG_359220.AA PH 5-42 28 0.000615 16.85 Pfam 57-92 (92) Show / Hide 
Range on Protein: 5-42
Range on HMM: 57-92/92
Sequence Identity: 28% (11 aa)

DSCKFSIETEGSTEPLYFRAPSTESLLQWIHALRSCTY
. . | | | .  . .||.|.| |.. .|..|..|. .
RPHCFQIRT-DR-RTYYFQAESEEEMNDWMQAIQSACR
Kinase TVAG_359220.AA AGC 52-281 30 1e-141 369.01 In-house 1-363 (395) Show / Hide 
Range on Protein: 52-281
Range on HMM: 1-363/395
Sequence Identity: 30% (112 aa)

FKVLSVLGRGNYGKVMLAEKI------DSGELFAIKSVHKKR-LALAG--KVHTMLSE------------RNTLINAS----------NPFIVK-LFYAF
|..| |.|.| .|||.|..|       |.|...|.| . ||.   .    .|.  ..|            || | ...          .||||| |.|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QNATK--FYLVLEYVP---------GG-EMFNYMS---TNGAVPLEDARIYAAE-------IVTALHFLHQ-NDIIYRD-LKPENILLAQDGHIKLTDFG
|. ..   |.|.||.|         || |.| ..     .|  . | ||.||||       || ||..||. ..||.|| |||||||| .||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKDLSQSE---------------------------------------------------VTKTFCG--TNEYLAPEVISRVNYGPAVDWWT--LGILLY
..| . ...                                                    |.||||  | ||.|||..    ||.|.|||.  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLFQTTPFFHQNTS----------RMFTRIL------MDPVVFP----------KGADPDVCSLIT
|||.  .||...|.            || .|.      ...| ||          .  .|.  .||.
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIK
Kinase TVAG_359220.AA Akt 52-275 43 3.3e-113 363.24 In-house 1-231 (264) Show / Hide 
Range on Protein: 52-275
Range on HMM: 1-231/264
Sequence Identity: 43% (101 aa)

FKVLSVLGRGNYGKVMLAEKIDSGELF-AIKSVHKKRLALAGKVHTMLSERNTLINASNPFIVKLFYAFQNATKFYLVLEYVPGGEMFNYMSTNGAVPLE
| .| |||.| .|||.|..| |..... |.|.  |...   ..|   . ||| | .  .||||.| |.||...| |.|..|..||| |....  .  . .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DARIYAAEIVTALHFLHQNDIIYRD-LKPENILLAQDGHIKLTDFGFAK-D-LSQSEVTKTFCGTNEYLAPEVISRVNYGPAVDWWT-LGILLYEMLFQT
 || |.|||. |. .||...||||| |||||||. .||||.||||| .| . ... ..||||||| ||||||... . .. |||||. ||...|||..  
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFFHQNTSRMFTRILMDPVVFP--KGADPD
 ||..|.  .||  |.. || ||  .  .|.
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPE
Kinase TVAG_359220.AA SGK 52-281 40 1e-106 330.62 In-house 1-257 (283) Show / Hide 
Range on Protein: 52-281
Range on HMM: 1-257/283
Sequence Identity: 40% (103 aa)

FKVLSVLGRGNYGKVMLAEKIDS------------------GELFAIKSVHKKRLA-------LAGKVHTMLSER-NTLINASNPFIVKLFYAFQNATKF
|. |.|.| |..|||..... |                   . ..|.|   |.             ..   ..|| . | | . ||||.| ||||...| 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVLEYVPGGEMFNYMSTNGAVPLEDARIYAAEIVTALHFLHQNDIIYRDLKPENILLAQDGHIKLTDFGFAK-DLSQSEVTKTFCGTNEYLAPEVISRV
|.|..|| |||||...   .  |   ||.|||||| ||  ||  ||||||||||||||  .||..||||| .| .  ... |.||||| |||||||.   
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

NYGPAVDWWTLGILLYEMLFQTTPFFHQNTSRMFTRILMDPVVFPKGADPDVCSLIT
 .. .|||| ||..||||..   ||...|.. |.  |.  |  .|..  .| ..||.
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQ
Kinase TVAG_359220.AA AktR 52-270 43 3.8e-102 345.67 In-house 1-227 (268) Show / Hide 
Range on Protein: 52-270
Range on HMM: 1-227/268
Sequence Identity: 43% (98 aa)

FKVLSVLGRGNYGKVMLAEKI-DSGELFAIKSVHKKRLALAGKVHTMLSERNTLI-NASNPFIVKLFYAFQNATKFYLVLEYVPGGEMFNYMSTNGAVPL
|.|. .||.|..|||.|..|  |.....|.|...|| .    . | .. ||| ..  ...||||||.|.||. .| ....||.||||.|.. ....    
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EDARIYAAEIVTALHFLHQN-DIIYRDLKPENILLAQDGHIKLTDFGFAK---DLSQSEVTKTFCGTNEYLAPEVISR-VNYGPAVDWWTLGILLYEMLF
|.||.|.|.|. || .|||. .||||||||||||| .|||.|.|||| .|   . . .|....||||.||.|||.| . . .. .||||..||..|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

QTTPFFHQNTSRMFTRILMDP-VVFPK
  .||.|.|. .|| .|.  . . ||.
GCPPFYHKNQNQMFQKIKIKQQNKFPY
Kinase TVAG_359220.AA PKA 52-280 44 1.2e-92 314.08 In-house 1-235 (263) Show / Hide 
Range on Protein: 52-280
Range on HMM: 1-235/263
Sequence Identity: 44% (105 aa)

FKVLSVLGRGNYGKVMLAEKIDSGELFAIKSVHKKRLALAGKVHTMLSERNTLINASNPFIV-KLFYAFQNATKFYLVLEYVPGGEMFNYMSTNGAVPLE
|. . .||.| .|.|||. . .||. .|.|   | .      |.  ..|.| | | ..|||| |. . ||.... |.|.||||||||| |.  .|  .  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DARIYAA-EIVTALHFLHQNDIIYRDLKPENILLAQDGHIKLTDFGFAKDLSQSEVTKTFCGTNEYLAPEVISRV-NYGPAVDWWTLGILLYEMLFQTTP
.|..||| .|| || .||. .||||||||||||. ..||||.||||||| .    .|.| ||| ||||||.|..   .| .||||.|||| ||||.  .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FFHQ--NTSRMFTRILMDPVVFPKGADPDV---CSLI
|.    ..  .. .|.   . ||   |.|.    .||
FYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLI
Kinase TVAG_359220.AA RSK 55-281 39 1.5e-87 297.14 In-house 1-251 (278) Show / Hide 
Range on Protein: 55-281
Range on HMM: 1-251/278
Sequence Identity: 39% (100 aa)

LSVLGRGNYGKVMLAEKI---DSGELFAIKSVHKKRLALAGK-VHTMLSERNTLINAS-NPFIVKLFYAFQNATKFYLVLEYVPGGEMFNYMSTNGA---
|.|||.| |||| |  |.   |.| ..| | ..|. .. . | . . . ||| |      ||||.|.||||  .|.||..||..|||.|   .. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

VPLEDARIYAAEIVTALHFLHQNDIIYRDLKPENILLAQ---DGHIKLTDFGFAKDLSQS--EVTKTFCGTNEYLAPEVIS----RVNYGPAVDWWTLGI
   ..|..|.|||| |. .||| .||.|||||||||...   .||||||||||.| .. .  . |.|||.| ||.|||..     .. .. |.|||.||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMLFQTTPFFH---QNTSRMFTRILMDP--VVFP--KGADPDVCSLIT
|.||||.  .|| .   .| .  ..||.     . .|  .   ..  .||.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIR
Kinase TVAG_359220.AA RSK-Unclassified 52-269 37 3.4e-87 273.89 In-house 1-242 (283) Show / Hide 
Range on Protein: 52-269
Range on HMM: 1-242/283
Sequence Identity: 37% (91 aa)

FKVLSVLGRGNYGKVMLAEKIDSGELFAIKSVHKKRLALAGKVHTMLSERNTLINASNPFIVKLFYAFQNATKFYLVLEYVPGGEMFNYMS--TNGAVPL
| .   .|.|  ||| | .| |.  ..|.|  ||...    |.   . |.| .     ||||.|...||   . ||..|| .||..|  .       .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

EDARIYAAEIVTALHFLHQNDIIYRDLKPENILLAQDGHIKLTDFGFAKDL----------------------SQSEVTKTFCGTNEYLAPEVISRVNYG
.|.|.||.|.. ||  ||  |.|||||||.||.| |.||..||||.  ..                       . .  |. |||| ||||||.| |   .
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

PAVDWWTLGILLYEMLFQTTPFFHQNTSRMFTRILMDPVVFP
 |||||||||..|||||  .|.   |.  .|. |.  .| ||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFP
Kinase TVAG_359220.AA PKC 52-270 41 2.8e-82 266.46 In-house 1-221 (262) Show / Hide 
Range on Protein: 52-270
Range on HMM: 1-221/262
Sequence Identity: 41% (91 aa)

FKVLSVLGRGNYGKVMLAEKIDSGELFAIKSVHKKRLALAGKVHTMLSERNTLINASN-PFIVKLFYAFQNATKFYLVLEYVPGGEMFNYMSTNGAVPLE
|. | |||.|..|||||||. .. |..||| . |        |   . |.  |  |.. || ..|.  ||   . . |.||| ||     .   .  ..|
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

DARIYAAEIVTALHFLHQNDIIYRDLKPENILLAQDGHIKLTDFGFAKD-LSQSEVTKTFCGTNEYLAPEVISRVNYGPAVDWWTLGILLYEMLFQTTPF
 || |||||. ||.|||...||||||| .|.|| ..||||..||| .|. . . . |.||||| .|.|||...   ||..|||| .|.|.|||.    ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

FHQNTSRMFTRILMDPVVFPK
  ..   .|  |..| ...|.
HGEDEDELFQSIMHDNPHYPR
Kinase TVAG_359220.AA p70 52-243 40 6.4e-79 268.5 In-house 1-232 (299) Show / Hide 
Range on Protein: 52-243
Range on HMM: 1-232/299
Sequence Identity: 40% (94 aa)

FKVLSVLGRGNYGKVMLAEKID---SGELFAIKSVHKKRLALAGK--VHTM------------------------LSERNTLINASNPFIVKLFYAFQNA
|. | |||.| ||||..  |     .| ..| |   |       |   ||                         . ||| |     |||..|.||||  
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

TKFYLVLEYVPGGEMFNYMSTNGAVPLEDARIYAAEIVTALHFLHQNDIIYRDLKPENILLAQDGHIKLTDFGFAK-DLSQSEV----------TKTFCG
 | ||.||| .||| |      |  . . |. |..||. || .||| .||||||||||..| | ||..|||||  |  .  ..|          | ||||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TNEYLAPEVISRVNYGPAVDWWTLGILLYEML
| || |||...|. .. ||||| ||.|.| ||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDML
Kinase TVAG_359220.AA RSK 52-262 35 3.9e-77 262.58 In-house 1-218 (271) Show / Hide 
Range on Protein: 52-262
Range on HMM: 1-218/271
Sequence Identity: 35% (78 aa)

FKVLSVLGRGNYGKVMLAEKI---DSGELFAIKSVHKKRLALAGKVHTMLSERNTLINASNPFIVKLFYAFQNATKFYLVLEYVPGGEMFNYMSTNGAVP
. .....|.| ..|| .  |.   |.. ..|.| . |. .. . .      ||. | .   ||||||.|.|| ..| |....   ||..|  ..  .  .
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

LEDARIYAAEIVTALHFLHQNDIIYRDLKPENILLAQD----GHIKLTDFGFAKDL-SQSEVTKTFCGTNEYLAPEVISRVNYGPAVDWWTLGILLYEML
 .....|.|||  |. .||. .|..|||||||||.. .    ||||..|||||| | .. . ..|||.| .|.||||..|  .. |.||| .|.|.||||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

FQTTPFFHQNTSRMFTRIL
  .||| ...  .... |.
TGCTPFQNKPRDTPMNIIQ
Kinase TVAG_359220.AA S_TKc 52-280 32 7.1e-74 252.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 52-280
Range on HMM: 1-231/231
Sequence Identity: 32% (85 aa)

FKVLSVLGRGNYGKVMLAEKIDSGELFAIKSVHKKRLALAGKVHTMLSERNTLINASNPFIVKLFYAFQNATKFYLVLEYVPG--GEMFNYMSTNGA---
...| ..|.| .|||... ....|...||| ..           ....|.. | .   |.||||...||. ...|.|.||..|  |..| |.  .|    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VPLEDARIYAAEIVTALHFLHQNDIIYRDLKPENILLAQDGHIKLTDFGFAKDLSQSEVTKTFCGTNEYLAPEVISRVNYGP-AVDWWTLGILLYEM
    |  .|| |...|. || ..|.. ||.|||||||||| .  |||..|||.|. |      .||||| .|.||||.    ||. ..||| .|..||||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LFQTTPFFHQNTSRMFTRILMDPVVF----------PK---GADPDVC--------SLI
|   .||   .  .|| .|. .| .           |.   .|               .
LCGYPPFP--QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TVAG_359220.AA Pkinase 52-281 29 3.3e-73 254.34 Pfam 1-271 (293) Show / Hide 
Range on Protein: 52-281
Range on HMM: 1-271/293
Sequence Identity: 29% (80 aa)

FKVLSVLGRGNYGKVMLAEKIDSGELFAIKSVHKKRLALAGKVHTML-SERNTLINASNPFIVKLFYAFQNATKFYLVLEYVPGG----EMFNYMS--TN
.......|.|..|.| .. ....|...|.| . |..     ...  . ||   . . . |.||.|...|.. .. |.|.||..||    . | |.|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GAV--PLEDARIYAAEIVTALHFLHQNDIIYRDLKPENILLAQDGHI----KLTDFGFAKD--LSQSEVTKTFCGTNEYLAPEVIS-RVNYGPAVDWWTL
|..  . .... |. .|. .| ..|.. ||.|||||||||. ..|||    |..|||.||   .  .. ..||||| .|.|||||  .  |||.||.| .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILLYEMLFQTTPFFHQ------NTSRMFTRILMDPVVFPKGAD---------------------PDVCSLIT
|..|||||.  .|| ..      .   |. ||.. |. |.   .                     .. ...|.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK
Kinase TVAG_359220.AA TyrKc 52-280 14 6.1e-13 -13.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 52-280
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)

FKVLSVLGRGNYGKVMLAEKIDSGELFAIKSVHKKRLALAGKVHTMLSERNTLINA--SNPFIVKLFYAFQNA-------TKFYLVLEYVPGGEMFNYMS
 . . .||.|..|.|.... .   .  |.|....        .  ...| . . .   ..| ||.|. .              ..|.||.|.|   .|  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

TNGA-VPLEDARIYAAEIVTALHFLHQNDIIYRDLKPENILLAQDGHIKLTDFGFAKDLSQS-------EVTKTFC--GTNE-----YLAPEVISRVNYG
 ..  ....|   ..  |     .||.. .| |||   |.|.. ....| .||| ..|.          .. ..    |..       .|||.|    . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PAVDWWTLGILLYEMLFQTTPFFHQ-----NTSRMFTRILMDPVVFPKGAD-------------------------------PDVCSLI
.. | |  |....|..    .          . .   . ...    |. ..                                ......
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TVAG_359220.AA Pkinase_Tyr 52-200 21 1.3e-08 29.81 Pfam 1-161 (270) Show / Hide 
Range on Protein: 52-200
Range on HMM: 1-161/270
Sequence Identity: 21% (35 aa)

FKVLSVLGRGNYGKVMLAEKI----DSGELFAIKSVHKKRLALAG-KVHTMLSERNTLINA-SNPFIVKLFYAFQ-NATK--FYLVLEYVPGGEMFNYMS
 . . .||.|..|.|....      . .   |.|.. |        .   ...| ... .  ..| ||.|  .          |.|.||.|.| . .|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

T----NGAVPLEDARIYAAEIVTALHFLHQNDIIYRDLKPENILLAQDGHIKLTDFGFAKDL
.    .......|   ....|  .. .|... .| |||   |.|.. ....| .||| |.|.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI