Gene 91412.m00124 (T.vaginalis)

91412.m00124

Species: T.vaginalis
Alias: TvagK0414, 91412.m00124
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
91412.m00124.AA Protein None 453 None Fasta, JSON
91412.m00124.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of 91412.m00124.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 91412.m00124.AA PH 8-106 19 3.4e-05 24.52 SMART 1-82 (82) Show / Hide 
Range on Protein: 8-106
Range on HMM: 1-82/82
Sequence Identity: 19% (19 aa)

DDMTGEFYKKGSKYGFWHKRFCVLRIQDMKLLVYIDKEKTKLDRAITITSDTECILDDDHKHPSFTISGNNIKSIRLSTDDLGIVNSWVTTIRTITMQT
  . |  |||.     |.||..||.     |. | ||   |.   | ...  ..   .     .|.|.  .  .. .....    ..|.. |.  . . 
VIKEGWLYKKS--K-RWKKRWFVLFN--DCLYYYKDK---KPKGSIPLSDC-TVRE-P-----CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
Kinase 91412.m00124.AA AGC 114-365 27 2.7e-134 349.33 In-house 1-395 (395) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-395/395
Sequence Identity: 27% (108 aa)

FKVISVIGRGFYGKVTLCELK------KTHDVYAIKSVHKSR---LLKEHKSSTVITE------------RNILMHID----------HPFIVH-IYFAF
|... |||.| .||| |.. |       | ..||.| . |..   ..|...   ..||            ||||....          |||||.  ...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTSSK--VYMGFEYIP---------GG-DLAFHLN---NTSKFTFNDIKLFIAE-------LALAIDYIHQ-RKIVYRD-LKPENILIDEEGHLKLTDFG
|. ..  .|.  ||.|         || .| .||    .  .|. . .. ..||       ..||..|.|. ..|..|| |||||||.||.||.||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

L-VKNIAYSNG--------------------------------------------------TKSFCG--TPEYIAPEVIRGEKYGTKIDWWA--LGILAF
|  ... . .                                                   |..|||  ||||.|||..    ||   |||.  ||.| .
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

NLLYGKTPWNDEN----------QDKLFNMIL------NDKIIFP----------DNAKPNEIDLITHLLNKDPSQRKDMKY----------LVHHPFF
 .|.|..| ...|          ....|. |.      |.|. ||          ..  |.  |||..||.|||..|   .           .  ||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 91412.m00124.AA Akt 114-365 40 8.99999999999e-101 322.86 In-house 1-264 (264) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-264/264
Sequence Identity: 40% (108 aa)

FKVISVIGRGFYGKVTLCELKKTHDVY-AIKSVHKSRLLKEHKSSTVITERNILMHIDHPFIVHIYFAFQTSSKVYMGFEYIPGGDLAFHLNNTSKFTFN
| .. |.|.| .||| |.. |.| ..| |.|.  |.....  .   ..|||||| |..|||||  ...|||. | |.  .|..||.| .||    .|. .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DIKLFIAELALAIDYIHQRKIVYRD-LKPENILIDEEGHLKLTDFGLVK-N-IAYSNGTKSFCGTPEYIAPEVIRGEKYGTKIDWWA-LGILAFNLLYGK
 .. ..||. |||.. |.. |.||| |||||||.|..||..|||||| | | | .   ||.|||||||.|||.. |  .. . |||. ||.. . ...| 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPWNDENQDKLFNMILNDKIIFP--DNAKPNEIDLITHLLNKDPSQRK-----DMKYLVHHPFF
 |  .......|  |.| .. ||  |.  |.  |||. ||||||..|      | . .  ||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 91412.m00124.AA SGK 114-365 36 1.1e-99 308.55 In-house 1-283 (283) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-283/283
Sequence Identity: 36% (102 aa)

FKVISVIGRGFYGKVTLCELKKT------------------HDVYAIKSVHKSRLL-------KEHKSSTVITER-NILMHIDHPFIVHIYFAFQTSSKV
|. ..||| | .||| . . |..                   ..||.|   |   .       |  .   . .|| .||  . |||||   .||||  | 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YMGFEYIPGGDLAFHLNNTSKFTFNDIKLFIAELALAIDYIHQRKIVYRDLKPENILIDEEGHLKLTDFGLVK-NIAYSNGTKSFCGTPEYIAPEVIRGE
|.  .|. ||.. .||.   .|     .   ||...|..| |  .|.|||||||||| | .||..|||||| | .|. ...|..||||||| ||||.|..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

KYGTKIDWWALGILAFNLLYGKTPWNDENQDKLFNMILNDKIIFPDNAKPNEIDLITHLLNKDPSQR---K-DMKYLVHHPFF
 ..   ||| ||.. . ..||. |  . |   ..  |.| .. .| .  .   |||. ||.|||..|   | |      ||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 91412.m00124.AA S_TKc 114-365 32 9.1e-98 332.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-231/231
Sequence Identity: 32% (86 aa)

FKVISVIGRGFYGKVTLCELKKTHDVYAIKSVHKSRLLKEHKSSTVITERNILMHIDHPFIVHIYFAFQTSSKVYMGFEYIPG--GDLAFHLNNTSK---
.... .||.| .||| .|  |||. ..||| ..           ... |..||.. .||.||..| .||. ...|| .||..|  |||  .. .  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTFNDIKLFIAELALAIDYIHQRKIVYRDLKPENILIDEEGHLKLTDFGLVKNIAYSNGTKSFCGTPEYIAPEVIRGEKYGT-KIDWWALGILAFNL
   |.  ... .......|..|.|...|..|||||||||.||  |.|..|||| . .      ..|||||.|.||||.   .||. |.|||..|.. . .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LYGKTPWNDENQDKLFNMILNDKIIFPDNAKPNEIDLITHLLNKDPSQRKDMKYLVH-------HPFF
|.|..|.   .....|..|.           |  .|.| ..|.|||..|     . .       ||.|
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 91412.m00124.AA AktR 114-365 38 9.4e-93 314.45 In-house 1-268 (268) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-268/268
Sequence Identity: 38% (103 aa)

FKVISVIGRGFYGKVTLCELK-KTHDVYAIKSVHKSRLLKEHKSSTVITERNILM-HIDHPFIVHIYFAFQTSSKVYMGFEYIPGGDLAFHLNNTSKFTF
|.|. ..|.| .||| |.. | .. ..||.|...|. . .. . . .||||||.  ...|||||  ...||| .| .   ||.|||.| .||..  ||. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

NDIKLFIAELALAIDYIHQR-KIVYRDLKPENILIDEEGHLKLTDFGLVK--NIA-YSNGTKSFCGTPEYIAPEVIRG-EKYGTKIDWWALGILAFNLLY
.... ..|.  ||..| ||. .|.||||||||||.||.||.|.||||| |  ..  |.  ..||||||||.|||.|.  . ..  .||||.||. . ...
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GKTPWNDENQDKLFNMILNDK-IIFPDNAKP--NEIDLIT-HLLNKDPS-----QRKDMKYLVHHPFF
| .| ...||  .| .|..   . ||.....  .  |||.  ||.|.|      .... . .  ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 91412.m00124.AA PKA 114-365 39 2.2e-90 306.58 In-house 1-263 (263) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-263/263
Sequence Identity: 39% (104 aa)

FKVISVIGRGFYGKVTLCELKKTHDVYAIKSVHKSRLLKEHKSSTVITERNILMHIDHPFIVH-IYFAFQTSSKVYMGFEYIPGGDLAFHLNNTSKFTFN
|. | ..|.| .|.| ||  |.. . ||.|   |..  ..     |..|.|||. |.|||||   |. ||.... || .||.|||..  .| .  .|.  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DIKLFIA-ELALAIDYIHQRKIVYRDLKPENILIDEEGHLKLTDFGLVKNIAYSNGTKSFCGTPEYIAPEVIRGE-KYGTKIDWWALGILAFNLLYGKTP
. |. .| .  ||..|.|.  |.||||||||||||..||.|.|||| .|..     |.. ||||||.|||.| ..  .|  .|||||||| . .| |..|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

WNDE--NQDKLFNMILNDKIIFPDNAKPNE---IDLITHLLNKDPSQRK-DMKY----LVHHPFF
 .|.  .. .... |.| || || .  ...    ||| .||..|...|   ||       .|..|
FYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 91412.m00124.AA RSK-Unclassified 114-365 36 1.6e-89 281.33 In-house 1-283 (283) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-283/283
Sequence Identity: 36% (102 aa)

FKVISVIGRGFYGKVTLCELKKTHDVYAIKSVHKSRLLKEHKSSTVITERNILMHIDHPFIVHIYFAFQTSSKVYMGFEYIPGGDLAFHLN--NTSKFTF
| ..  ||.|  ||| | . |.|  .||.|  ||.....  |   |.||.||.   .|||||  |..|||. . |.  || .|||.  ||    . .|. 
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

NDIKLFIAELALAIDYIHQRKIVYRDLKPENILIDEEGHLKLTDFGLVKNI----------------------AYSNGTKSFCGTPEYIAPEVIRGEKYG
.|.. ...|  .|  | | | ..||||||.||. . ||| .||||.| .                          . .|.||||| ||.|||.||.   .
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

TKIDWWALGILAFNLLYGKTPWNDENQDKLFNMILNDKIIFP-DNAKPNEI-DLITHLLNKDPSQRKDMKYL-----VHHPFF
  .||| |||. . .| | .|.  .|.. .|. |.  .. || |.   |.  |||  ||.. |. |   |         ||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 91412.m00124.AA PKC 114-365 35 4.8e-87 282.16 In-house 1-262 (262) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-262/262
Sequence Identity: 35% (92 aa)

FKVISVIGRGFYGKVTLCELKKTHDVYAIKSVHKSRLLKEHKSSTVITERNILMHID-HPFIVHIYFAFQTSSKVYMGFEYIPGGDLAFHLNNTSKFTFN
|. . |.|.| .||| | |.|.|  .|||| . |   .. .    . ||. .|     ||| .| .  ||| .. .   ||. |||| ||  .  .|   
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

DIKLFIAELALAIDYIHQRKIVYRDLKPENILIDEEGHLKLTDFGLVK-NIAYSNGTKSFCGTPEYIAPEVIRGEKYGTKIDWWALGILAFNLLYGKTPW
  .   || ..|  . |.. |.||||| .|.|.|.||| |..|||. | |. . . |..|||||.|||||......||  .||||.|.| . .. |. | 
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

NDENQDKLFNMILNDKIIFPDNAKPNEIDLITHLLNKDPSQRKDM--------KYLVHHPFF
  |. | ||. |..|.. .|        .... ...|.|..|  .        .    ||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 91412.m00124.AA RSK 117-365 35 7.8e-86 291.47 In-house 1-278 (278) Show / Hide 
Range on Protein: 117-365
Range on HMM: 1-278/278
Sequence Identity: 35% (99 aa)

ISVIGRGFYGKVTLCELK---KTHDVYAIKSVHKSRLLKEHK-SSTVITERNILMHID-HPFIVHIYFAFQTSSKVYMGFEYIPGGDLAFHLNNTSK---
..| |.| |||| ||  .   .|  .|| | ..|. . .  |   .. ||||||...  |||||. . |||| .|.|.  ||..||.|  || .      
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTFNDIKLFIAELALAIDYIHQRKIVYRDLKPENILIDE---EGHLKLTDFGLVKN-IAY-SNGTKSFCGTPEYIAPEVIR---GEK-YGTKIDWWALGI
|. .. .  .||..||....||..|..||||||||| |.   |||.||||||. |   .  .. |..||.| ||.|||...   ... ..   ||| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LAFNLLYGKTPWND---ENQDKLFNMILNDK--IIFP--DNAKPNEIDLITHLLNKDPSQRKD-----MKYLVHHPFF
| . .| |..|      .|...... |.. |    .|  ..  ..  |||...| .||..|       .. .  ||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 91412.m00124.AA Pkinase 114-365 29 6.5e-85 293.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

FKVISVIGRGFYGKVTLCELKKTHDVYAIKSVHKSRLLKEHKSSTVI-TERNILMHIDHPFIVHIYFAFQTSSKVYMGFEYIPGG----DLAFHLN--NT
......||.| .|.| .|  |.| ...|.| . |..  .. . . .  .|  |. ...||.|| .| .|......|| .|| .||    ||. ..   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SKF--TFNDIKLFIAELALAIDYIHQRKIVYRDLKPENILIDEEGHL----KLTDFGLVKNI-AYSNGTKSFCGTPEYIAPEVIR-GEKYGTKIDWWALG
 .|  . ...| .. ... ...|.|...|..|||||||||||..||.    |..|||| | .   .|....|||||.|.|||||| |..||.|.|.|..|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG

ILAFNLLYGKTPWNDE------NQDKLFNMILNDKIIFPDNAK---------------------PNEIDLITHLLNKDPSQRKDMKYLVHHPFF
.. . .| |..|. ..      .|......|.  .. |.   .                     .. .|.|. .|.|||..|   . ...||.|
CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 91412.m00124.AA Ciliate-E2-Unclassified 114-365 26 5.6e-82 278.67 In-house 1-352 (352) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-352/352
Sequence Identity: 26% (93 aa)

FKVISVIGRGFYGKVTLCELKKTHDVYAIKSVHKSRLLKEHKSSTV---------ITERN-------------ILMHIDHPFIVHIYFAFQTSSKVYMGF
.|.| .||.| .||| .|. ||.  .||.|  .|..  | ..  ..         . ...             || ...|||||. ...||.  ..|.  
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYIPGGDLAFHLNNTSK-----------------FTFNDIK-----LFIAELALAIDYIHQRK-IVYRDLKPENILIDEEG---HLKLTDFGLVKNIAYS
||..|||| ..... .|                 || . .|      ..|.. ....|.|. . |..||.||||||.|..|   ..|..|||. |.. ..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

NG----------------TKSFCGTPEYI----APEVIRGEKYG----TKIDWWALGILAFNLLYGKTPWNDENQDK----------------LFNMILN
|.                ...|||||.|.    ||||..|..|.     |.|.|.||.... .|.|. | .|.|...                |.. |..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

DKIIFP--------DNAKPNEIDLIT----HLLNKDPSQRKDMKYLVHHPFF
 .| ||        ..  |. .|.|.     .|.|.|..| ... .  ||.|
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 91412.m00124.AA MAST 114-258 44 4.3e-56 179.18 In-house 1-145 (334) Show / Hide 
Range on Protein: 114-258
Range on HMM: 1-145/334
Sequence Identity: 44% (65 aa)

FKVISVIGRGFYGKVTLCELKKTHDVYAIKSVHKSRLLKEHKSSTVITERNILMHIDHPFIVHIYFAFQTSSKVYMGFEYIPGGDLAFHLNNTSKFTFND
|. | .|..| |||| | . ||| | .|.| . || ... .  ..|..|||||  .. ||.|... .||| ....|  ||  |||.|..|..   |  . 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

IKLFIAELALAIDYIHQRKIVYRDLKPENILIDEEGHLKLTDFGL
 |. |||..|...|.|.  || |||||.|.||| .|| |||||||
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase 91412.m00124.AA MAST 269-365 37 1.7e-30 95.23 In-house 222-334 (334) Show / Hide 
Range on Protein: 269-365
Range on HMM: 222-334/334
Sequence Identity: 37% (44 aa)

KSFCGTPEYIAPEVIRGEK-YGTKIDWWALGILAFNLLYGKTPWNDENQDKLFNMILNDK---IIFPDN--------AKPNEIDLITHLLNKDPSQR---
|. ||||.||||||| |.  .|  .|||..||  . .| | .| ||......|. |||..   | .|.           |  .|||  ||. ||..|   
KQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGA

K----DMKYLVHHPFF
.    ..|    ||||
NNGADEVK---QHPFF
Kinase 91412.m00124.AA TyrKc 114-365 20 6e-16 35.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 114-365
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

FKVISVIGRGFYGKVTLCELKKTHDVYAIKSVHKSRLLKEHKSSTVITERNILMHI--DHPFIVHIYFAFQTS-------SKVYMGFEYIPGGDLAFHLN
 . . ..|.|..|.| ....|      |.|.....           . | .|....  .|| || .| .  ..         ... .|| |.|||  .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NTSK-FTFNDIKLFIAELALAIDYIHQRKIVYRDLKPENILIDEEGHLKLTDFGLVKNIAYS--------NGTKSF--CGTP----EYIAPEVIRGEKYG
.. . ..  |   |    |   .|.|..... |||   |.|..|... | .|||| ..|             .|.   .|         |||.|.  |. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

TKIDWWALGILAFNLL-YGKTPWND-----ENQDKLFNMILND-KIIFPDN--------AKPNEIDLITHLLNKDPSQRKDMKYLVHHPFF
|| | |. |.. . .. ||..|. .      . . ... . .      |.|        . .   ....   . ||..|  .. .  | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 91412.m00124.AA Pkinase_Tyr 114-300 25 1.2e-12 43.49 Pfam 1-203 (270) Show / Hide 
Range on Protein: 114-300
Range on HMM: 1-203/270
Sequence Identity: 25% (52 aa)

FKVISVIGRGFYGKVTLCELK----KTHDVYAIKSVHKSRLLKEHK--SSTVITERNILMHI-DHPFIVHIYFAFQ-TSSK--VYMGFEYIPGGDLAFHL
 . . ..|.| .|.| ....|    .|.   |.|.. |     ..   .   . | .|.... .|| ||  | .    .    .|. .|| |.|||  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

NN----TSKFTFNDIKLFIAELALAIDYIHQRKIVYRDLKPENILIDEEGHLKLTDFGLVKNI----AY-SNGTKSFCGTPEYIAPEVIRGEKYGTKIDW
 .      ..|  |.  . .. | . .| ...... |||   |.|..|... | .|||| . |     |   ....        |||.|.  |. || | 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDV

WALGIL
|. |.|
WSFGVL
Kinase 91412.m00124.AA Pkinase_C 394-428 34 1.3e-05 23.12 Pfam 10-46 (46) Show / Hide 
Range on Protein: 394-428
Range on HMM: 10-46/46
Sequence Identity: 34% (13 aa)

NFDREFLDEPIIDSL---GTPVQQEMNAFDGFSFVADP
||| || |||  |.        ... ..| ||..|.. 
NFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase 91412.m00124.AA S_TK_X 366-426 21 0.000213 13.87 SMART 1-79 (79) Show / Hide 
Range on Protein: 366-426
Range on HMM: 1-79/79
Sequence Identity: 21% (18 aa)

EGLDFNSVLE--MKYQHDFRPIII----NLNVATNFDREFLDEPIIDSLGTPV--------QQEM-------NAFDGFSFVA
 |.|.. ..   ....  |.| |     .   . ||| || .|..     ||.        .|..       . | ||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM---LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF