Gene 84758.m00061 (T.vaginalis)

84758.m00061

Species: T.vaginalis
Alias: 84758.m00061, TvagK0382
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
84758.m00061.AA Protein None 297 None Fasta, JSON
84758.m00061.kin_dom Protein Kinase Domain None 146 None Fasta, JSON

Protein domain

Protein domains of 84758.m00061.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 84758.m00061.AA PH 1-92 24 6.3e-10 38.45 Pfam 3-92 (92) Show / Hide 
Range on Protein: 1-92
Range on HMM: 3-92/92
Sequence Identity: 24% (23 aa)

MSGWLERKFILGFWSKRFCKLEDNRIEIWKDEECKKIDSEMEITQQTTIEILDDD-KEFRFVVETPDVDTYQLKAASKDELMKWILALRSITF
..||| .|  .. | ||.. | .|.. ..||.  ..      .    ......|  ... |.. | | .|| ..|.| .|.  |. |..|.  
KEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
PH 84758.m00061.AA PH 1-94 22 6.4e-08 33.55 SMART 3-82 (82) Show / Hide 
Range on Protein: 1-94
Range on HMM: 3-82/82
Sequence Identity: 22% (21 aa)

MSGWLERKFILGFWSKRFCKLEDNRIEIWKDEECKKIDSEMEITQQTTIEILDDDKEFRFVVETPDVDTYQLKAASKDELMKWILALRSITFSN
..||| .|  .  | ||.. | .... ..||.   |   .. ..   |..  .      | . . |  || ... |..|. .|. |... . .|
KEGWLYKKS-K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P-----CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
Kinase 84758.m00061.AA AGC 102-248 35 4e-86 221.92 In-house 1-204 (395) Show / Hide 
Range on Protein: 102-248
Range on HMM: 1-204/395
Sequence Identity: 35% (72 aa)

FKILSVIGRGFYGKVMLVSKI------SNNEIFAIKSIHKSR-LIQSD--KVHTVIAE------------RNILSKAA----------HPFIIS-LKFAF
|..| |||.| .|||.|| |       ......|.| . |..  .. .  .|. ...|            ||||.|.           ||||.. |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPSK--FYLGLEYAP---------GG-ELFFHMQ---KRGAFPLEDLKIYLAE-------IALALNHLHS-IGVVYRD-LKPENVLLSAQTY-KLTDFG
|....   |. .||.|         || |||.|.|   |.| |. |  ..|.||       |.||| .|||  |...|| |||||.|| .. . ||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKI
|.|.
LCKE
Kinase 84758.m00061.AA Akt 102-247 44 2.8e-75 240.06 In-house 1-149 (264) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-149/264
Sequence Identity: 44% (67 aa)

FKILSVIGRGFYGKVMLVSKISNNEIF-AIKSIHKSRLIQSDKVHTVIAERNILSKAAHPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGAFPLE
| .| |.|.| .|||.|| | ...... |.|.. |...|| ..|  ...||||| .  ||||..|...|||. | |. ..|..|||||.|.|... |. .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DLKIYLAEIALALNHLHSIGVVYRD-LKPENVLLSAQTY-KLTDFGLAK
  . | ||| ||. |||| ...||| |||||.|.... . .||||||.|
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCK
Kinase 84758.m00061.AA SGK 102-247 38 5.9e-68 208.79 In-house 1-173 (283) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-173/283
Sequence Identity: 38% (66 aa)

FKILSVIGRGFYGKVMLVSKISN------------------NEIFAIKSIHKSRLI-------QSDKVHTVIAER-NILSKAAHPFIISLKFAFQTPSKF
|..|.||| | .|||..| . .                     ..|.| . |   |       .  ..  . ||| .||..  ||||..|..||||. | 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLGLEYAPGGELFFHMQKRGAFPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQTY-KLTDFGLAK
|. ..|. |||.|.|.|... ||    ..| |||..|| .|||. ..||||||||.|| .| . .||||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase 84758.m00061.AA RSK-Unclassified 102-247 40 6.1e-59 183.54 In-house 1-149 (283) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-149/283
Sequence Identity: 40% (60 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKAAHPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQ--KRGAFPL
|     ||.|  ||| || |   . |.|.|  ||...|.  |.  |. |.||..   ||||. | ..|||  . || .|| .||..| |.|  |   |  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

EDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQTY-KLTDFGLAK
.| ..|..|. .|| .||  ...||||||.|..|      .||||.| .
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSI
Kinase 84758.m00061.AA RSK 105-248 44 4.1e-57 196.05 In-house 1-156 (278) Show / Hide 
Range on Protein: 105-248
Range on HMM: 1-156/278
Sequence Identity: 44% (69 aa)

LSVIGRGFYGKVMLVSKI---SNNEIFAIKSIHKSRLIQSDK-VHTVIAERNILSKAA-HPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGA---
|.| |.| |||| |. |.    .. |.| | ..|. ..|..| . .. .|||||.    ||||..|. ||||..|.|| .|| .||||| | ||..    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSA----QTYKLTDFGLAKI
|  .. ..|.|||.||. |||. |...|||||||.|.       . ||||||..|.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQ
Kinase 84758.m00061.AA p70 102-247 41 1.4e-56 194.29 In-house 1-176 (299) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-176/299
Sequence Identity: 41% (73 aa)

FKILSVIGRGFYGKVMLVSKIS---NNEIFAIKSIHKSRLIQSDK--VHTV------------------------IAERNILSKAAHPFIISLKFAFQTP
|. | |.|.| ||||..| |     .. |.| | . |   . . |   ||                          ||||||.   ||||. | .|||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

SKFYLGLEYAPGGELFFHMQKRGAFPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQTY-KLTDFGLAK
.| || ||| .||||| |  . | .. .  . ||.|| .|| |||. |..||||||||..|..|   .|||||| |
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCK
Kinase 84758.m00061.AA AktR 102-247 44 5.8e-53 182.27 In-house 1-150 (268) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-150/268
Sequence Identity: 44% (67 aa)

FKILSVIGRGFYGKVMLVSKI-SNNEIFAIKSIHKSRLIQSDKVHTVIAERNILS-KAAHPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGAFPL
|... ..|.| .|||.|| |   |....|.|.|.|. .|.  . | .| ||||.  .. ||||. |...||| .| .. .|| ||||||.| .|.. |  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EDLKIYLAEIALALNHLHSI-GVVYRDLKPENVLLSAQTY-KLTDFGLAK
|. ..| |.| ||| .||.   ..|||||||| ||    . |.|||||.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK
Kinase 84758.m00061.AA RSK 102-247 37 1.4e-51 177.71 In-house 1-153 (271) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-153/271
Sequence Identity: 37% (58 aa)

FKILSVIGRGFYGKVMLVSKI---SNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKAAHPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGAFP
. ....||.| ..|| .. |.    .|  .|.| | |. .  .|.     .||.||.   ||||. |. .||.  | |. .. . ||.|| ...| . |.
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

LEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQ-----TYKLTDFGLAK
 .. |.|.||||||...||| |.|.|||||||.|....     . |..|||.||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAK
Kinase 84758.m00061.AA PKA 102-247 40 2.1e-49 170.46 In-house 1-149 (263) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-149/263
Sequence Identity: 40% (60 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKAAHPFII-SLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGAFPLE
|.|. ..|.| .|.|||. . .. ...|.| . |.. ..   |. |. |.|||.   ||||. .... ||.... |. .||.||||.| ...|.| |.  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DLKIYLA-EIALALNHLHSIGVVYRDLKPENVLLSAQTY-KLTDFGLAK
. |.| | .| |||  |||   .|||||||| |.  . . |.|||| ||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK
Kinase 84758.m00061.AA PKC 102-247 41 6.1e-48 153.39 In-house 1-148 (262) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-148/262
Sequence Identity: 41% (62 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKAA-HPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGAFPLE
|. | |.|.| .|||||. .  ..|..||| . |   || | |  . .|. .|. |. |||  .|   |||... .  .||  || | ||.|. . |..|
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

DLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQTY-KLTDFGLAK
  . | |||..||. ||. |..||||| .|||| .    |..|||..|
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCK
Kinase 84758.m00061.AA Pkinase 102-247 32 1.9e-41 147.6 Pfam 1-160 (293) Show / Hide 
Range on Protein: 102-247
Range on HMM: 1-160/293
Sequence Identity: 32% (52 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIA--ERNILSKAAHPFIISLKFAFQTPSKFYLGLEYAPGG----ELFFHMQ--K
..|...||.| .|.| .  ......|.|.| | |.  . |.|  | .   |  |. .  ||.|. |. .|..... |. .||..||    .|| ...  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RGAF--PLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLS-AQTY----KLTDFGLAK
.|.|  . ...| |. .|. .|...|| |...|||||||.|..   .     |..||||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase 84758.m00061.AA S_TKc 102-248 23 2.1e-15 48.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 102-248
Range on HMM: 1-231/231
Sequence Identity: 23% (57 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKAAHPFIISLKFAFQTPSKFYLGLEYAPG--GELFFHMQKRGA---
..|| .||.| .|||... ... ..|.||| |.           ... |..||.|  ||.|. |. .||. ...|. .||..|  |.|| ...|||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQTYKLTDFGLAK----------------------------------------------
   ||  . . |...|..||...|| |...|||||||.||.  . |..|||||.                                              
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQM

--------------------------------------------I
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QMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 84758.m00061.AA TyrKc 102-248 12 1.4e-05 -132.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 102-248
Range on HMM: 1-280/280
Sequence Identity: 12% (37 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKA--AHPFIISLKFAFQTP-------SKFYLGLEYAPGGELFFHMQ
 . . ..|.|..|.|..   .   .  |.|.....       .   . | .|..|    || |. |  .  ..          .. .||.|.| |  . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRGA-FPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQT-YKLTDFGL------------------------AK-------------------
|..  ....||  .   ||   ..||| ... |||   |.|....   | .||||                        .|                   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

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TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF