Gene 83325.m00036 (T.vaginalis)

83325.m00036

Species: T.vaginalis
Alias: 83325.m00036, TvagK0375
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
83325.m00036.AA Protein None 443 None Fasta, JSON
83325.m00036.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of 83325.m00036.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 83325.m00036.AA PH 1-92 24 7.4e-10 38.19 Pfam 3-92 (92) Show / Hide 
Range on Protein: 1-92
Range on HMM: 3-92/92
Sequence Identity: 24% (23 aa)

MSGWLERKFILGFWSKRFCKLEDNRIEIWKDEECTKIDSEMEITQQTTIEILDDD-KEFRFVVETPDVDTYQLKAASKDELMKWILALRSITF
..||| .|  .. | ||.. | .|.. ..||.   .    .   .  ......|  ... |.. | | .|| ..|.| .|.  |. |..|.  
KEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK--YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
PH 83325.m00036.AA PH 1-94 22 6.6e-08 33.52 SMART 3-82 (82) Show / Hide 
Range on Protein: 1-94
Range on HMM: 3-82/82
Sequence Identity: 22% (21 aa)

MSGWLERKFILGFWSKRFCKLEDNRIEIWKDEECTKIDSEMEITQQTTIEILDDDKEFRFVVETPDVDTYQLKAASKDELMKWILALRSITFSN
..||| .|  .  | ||.. | .... ..||.   |   .. ..   |..  .      | . . |  || ... |..|. .|. |... . .|
KEGWLYKKS-K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P-----CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
Kinase 83325.m00036.AA AGC 102-353 29 1.2e-149 390.0 In-house 1-395 (395) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-395/395
Sequence Identity: 29% (118 aa)

FKILSVIGRGFYGKVMLVSKI------SNNEIFAIKSIHKSR-LIQSD--KVHTVIAE------------RNILSKAA----------HPFIIS-LKFAF
|..| |||.| .|||.|| |       ......|.| . |..  .. .  .|. ...|            ||||.|.           ||||.. |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPSK--FYLGLEYAP---------GG-ELFFHMQ---KRGAFPLEDLKIYLAE-------IALALNHLHS-IGVVYRD-LKPENVLLSAQGHIKLTDFG
|....   |. .||.|         || |||.|.|   |.| |. |  ..|.||       |.||| .|||  |...|| |||||.|| ..|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKDLYNEE---------------------------------------------------LTSTFCG--TSEYLAPEIIRHEKYGIEVDWWS--LGILTY
|.| . |..                                                   .|.||||  | ||.||||.    || ..||||  ||.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLFNKTPFCHPN----------KSRLFQNIL------EKEVQYP----------AGVQTSIIEFINGLLQKDKRKRLT----------FKQMQNLEFF
|.|. ..||.. |          .  .||.|.      ...|..|            .      .|..||.|| .|||.          ... .| ..|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 83325.m00036.AA SGK 102-353 39 1.6e-121 377.16 In-house 1-283 (283) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-283/283
Sequence Identity: 39% (111 aa)

FKILSVIGRGFYGKVMLVSKISN------------------NEIFAIKSIHKSRLI-------QSDKVHTVIAER-NILSKAAHPFIISLKFAFQTPSKF
|..|.||| | .|||..| . .                     ..|.| . |   |       .  ..  . ||| .||..  ||||..|..||||. | 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLGLEYAPGGELFFHMQKRGAFPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQGHIKLTDFGLAK-DLYNEELTSTFCGTSEYLAPEIIRHE
|. ..|. |||.|.|.|... ||    ..| |||..|| .|||. ..||||||||.|| .|||..||||||.| .   .. |.||||| ||||||..|..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

KYGIEVDWWSLGILTYELLFNKTPFCHPNKSRLFQNILEKEVQYPAGVQTSIIEFINGLLQKDKRKRLTFK----QMQNLEFF
 .. .||||.||.. ||... . || . ||. ...||. .. | | ... .  . |.||||||..|||  |    . .|  ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 83325.m00036.AA Akt 102-353 40 2.2e-121 389.83 In-house 1-264 (264) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-264/264
Sequence Identity: 40% (107 aa)

FKILSVIGRGFYGKVMLVSKISNNEIF-AIKSIHKSRLIQSDKVHTVIAERNILSKAAHPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGAFPLE
| .| |.|.| .|||.|| | ...... |.|.. |...|| ..|  ...||||| .  ||||..|...|||. | |. ..|..|||||.|.|... |. .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DLKIYLAEIALALNHLHSIGVVYRD-LKPENVLLSAQGHIKLTDFGLAK-D-LYNEELTSTFCGTSEYLAPEIIRHEKYGIEVDWWS-LGILTYELLFNK
  . | ||| ||. |||| ...||| |||||.|....|||.||||||.| . . . . | ||||| |||||||.    ..  ||||. ||...||...  
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFCHPNKSRLFQNILEKEVQYP--AGVQTSIIEFINGLLQKDKRKRL-----TFKQMQNLEFF
 || . .. ..|..|....|..|    ..     .|.|||.||. |||     . .. .. ..|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 83325.m00036.AA RSK 105-353 37 1.5e-97 330.36 In-house 1-278 (278) Show / Hide 
Range on Protein: 105-353
Range on HMM: 1-278/278
Sequence Identity: 37% (104 aa)

LSVIGRGFYGKVMLVSKI---SNNEIFAIKSIHKSRLIQSDK-VHTVIAERNILSKAA-HPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGA---
|.| |.| |||| |. |.    .. |.| | ..|. ..|..| . .. .|||||.    ||||..|. ||||..|.|| .|| .||||| | ||..    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSA---QGHIKLTDFGLAKDLYNE--ELTSTFCGTSEYLAPEIIR---HEK-YGIEVDWWSLGI
|  .. ..|.|||.||. |||. |...|||||||.|.     .|||||||||..| . ..  ..| |||.| ||.|||...   ... ..  .||||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LTYELLFNKTPFCH---PNKSRLFQNILEKE--VQYP--AGVQTSIIEFINGLLQKDKRKRLT-----FKQMQNLEFF
| ||.|. ..|| .    |.. ....|....  .  |  . . .   ..|...|..|  |||.      .. .. ..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 83325.m00036.AA S_TKc 102-353 34 1.3e-94 321.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKAAHPFIISLKFAFQTPSKFYLGLEYAPG--GELFFHMQKRGA---
..|| .||.| .|||... ... ..|.||| |.           ... |..||.|  ||.|. |. .||. ...|. .||..|  |.|| ...|||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQGHIKLTDFGLAKDLYNEELTSTFCGTSEYLAPEIIRHEKYGI-EVDWWSLGILTYEL
   ||  . . |...|..||...|| |...|||||||.||.   |||..|||||. |      .||||| .|.|||..   .||  ..||||.|.. ||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LFNKTPFCHPNKSRLFQNILEKEVQYPAGVQTSIIEFINGLLQKDKRKRLTFKQMQN-------LEFF
|  ..||.  .  ..|..|.            . ..||...|||| .||.|  .  .        ..|
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 83325.m00036.AA PKC 102-353 39 8e-94 304.49 In-house 1-262 (262) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-262/262
Sequence Identity: 39% (103 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKAA-HPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGAFPLE
|. | |.|.| .|||||. .  ..|..||| . |   || | |  . .|. .|. |. |||  .|   |||... .  .||  || | ||.|. . |..|
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

DLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQGHIKLTDFGLAKD-LYNEELTSTFCGTSEYLAPEIIRHEKYGIEVDWWSLGILTYELLFNKTPF
  . | |||..||. ||. |..||||| .|||| . ||||..|||..|. ..|.. ||||||| .|.||||.. ..||  ||||..|.| ||..  . ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

CHPNKSRLFQNILEKEVQYPAGVQTSIIEFINGLLQKDKRKRLTF--------KQMQNLEFF
   .   |||.|..... ||      . . . |...|.  |||          . ..   ||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 83325.m00036.AA AktR 102-353 39 1.4e-91 310.57 In-house 1-268 (268) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-268/268
Sequence Identity: 39% (106 aa)

FKILSVIGRGFYGKVMLVSKI-SNNEIFAIKSIHKSRLIQSDKVHTVIAERNILS-KAAHPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGAFPL
|... ..|.| .|||.|| |   |....|.|.|.|. .|.  . | .| ||||.  .. ||||. |...||| .| .. .|| ||||||.| .|.. |  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EDLKIYLAEIALALNHLHSI-GVVYRDLKPENVLLSAQGHIKLTDFGLAK---DLYNEELTSTFCGTSEYLAPEIIRH-EKYGIEVDWWSLGILTYELLF
|. ..| |.| ||| .||.   ..|||||||| ||   ||.|.|||||.|   .  ..|.. .|||| ||.|||.|.  . ..  ||||..||. ||...
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

NKTPFCHPNKSRLFQNILEKE---VQYPAGVQTSIIEFIN-GLLQKDKRKRLT-----FKQMQNLEFF
  .|| | |. ..||.|..|.   ..||. .     ..|. .||.|. .|||.     ...  .  .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 83325.m00036.AA p70 102-353 36 2e-88 300.08 In-house 1-299 (299) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-299/299
Sequence Identity: 36% (110 aa)

FKILSVIGRGFYGKVMLVSKIS---NNEIFAIKSIHKSRLIQSDK--VHTV------------------------IAERNILSKAAHPFIISLKFAFQTP
|. | |.|.| ||||..| |     .. |.| | . |   . . |   ||                          ||||||.   ||||. | .|||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

SKFYLGLEYAPGGELFFHMQKRGAFPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQGHIKLTDFGLAKDLYNE-EL----------TSTFCG
.| || ||| .||||| |  . | .. .  . ||.|| .|| |||. |..||||||||..|..|||..|||||| |   .. .           | ||||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TSEYLAPEIIRHEKYGIEVDWWSLGILTYELLFNKTPFCHPNKSRLFQNILEKE--VQYPAGVQTSIIEFINGLLQKDKRKRLT-----FKQMQNLEFF
| || ||||..   .. .|||||||.| |  |  . ||   |.      ||     .. |.    .    |. || ..  .|..      .. |  .||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 83325.m00036.AA Pkinase 102-353 30 3.3e-84 290.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIA--ERNILSKAAHPFIISLKFAFQTPSKFYLGLEYAPGG----ELFFHMQ--K
..|...||.| .|.| .  ......|.|.| | |.  . |.|  | .   |  |. .  ||.|. |. .|..... |. .||..||    .|| ...  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RGAF--PLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQGHI----KLTDFGLAKD--LYNEELTSTFCGTSEYLAPEIIR-HEKYGIEVDWWS
.|.|  . ...| |. .|. .|...|| |...|||||||.|.. .|||    |..||||||   . | . ..|||||..|.|||.|| ...|| .||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGILTYELLFNKTPFCHP------NKSRLFQNILEKEVQYPAGVQ---------------------TSIIEFINGLLQKDKRKRLTFKQMQNLEFF
.|.. ||.|. ..||..       ..  ....|..... ..                          . ..||...|.||  ||.|..|  . ..|
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 83325.m00036.AA PKA 102-353 38 3.7e-84 285.9 In-house 1-263 (263) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-263/263
Sequence Identity: 38% (102 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKAAHPFII-SLKFAFQTPSKFYLGLEYAPGGELFFHMQKRGAFPLE
|.|. ..|.| .|.|||. . .. ...|.| . |.. ..   |. |. |.|||.   ||||. .... ||.... |. .||.||||.| ...|.| |.  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DLKIYLA-EIALALNHLHSIGVVYRDLKPENVLLSAQGHIKLTDFGLAKDLYNEELTSTFCGTSEYLAPEIIRHE-KYGIEVDWWSLGILTYELLFNKTP
. |.| | .| |||  |||   .|||||||| |.  .||||.|||| || . .   |.| ||| ||||||||  .  .|  ||||.|||| ||.|. ..|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FCHP--NKSRLFQNILEKEVQYPAGVQTSI---IEFINGLLQKDKRKRL-TFKQ----MQNLEFF
|     ..  ... |.. ....|  .         .|. |||.|  ||. ..|.      | ..|
FYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 83325.m00036.AA Ciliate-E2 102-353 23 2.1e-80 273.46 In-house 1-365 (365) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)

FKILSVIGRGFYGKVMLVSKISNNE-----------------------IFAIKSIHKSRLIQSDKVHTVI----------AERNILSKAAHPFIISLKFA
.|.. .||.| .|.| .........                       |.|.|...|. ..|  ..  ..           |.|||..  ||.|| .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TPSKFYLGLEYAPGGELFFHMQKR-----------GAFPLEDLKIYLAEIAL---------------ALNHLHSIG-VVYRDLKPENVLLSAQGHI
||  . ...|| .||. ||.|| .....           . | ..  | . ..|.                ||..||| . ...||.||||.|.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLAKDLYNE--------------------------------ELTSTFCGTSEYLAPEIIRHEK---------YGIEVDWWSLGILTYELLFNKTP
|..||||.|.. ..                                ... |.||| .|.||||.. .|         |. ..|.||||.. ||.||.|.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FCHPNKSRLFQNILEKEVQYP------------------AGVQTSIIEFING----LLQKDKRKRLT-FKQMQNLEFF
|        .|.|.......|                    .  . . .|.     .||||  ||.| ..|  | ..|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 83325.m00036.AA RSK-Unclassified 102-249 41 6.8e-66 205.77 In-house 1-150 (283) Show / Hide 
Range on Protein: 102-249
Range on HMM: 1-150/283
Sequence Identity: 41% (62 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKAAHPFIISLKFAFQTPSKFYLGLEYAPGGELFFHMQ--KRGAFPL
|     ||.|  ||| || |   . |.|.|  ||...|.  |.  |. |.||..   ||||. | ..|||  . || .|| .||..| |.|  |   |  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

EDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQGHIKLTDFGLAKD
.| ..|..|. .|| .||  ...||||||.|..|   ||..||||.| ..
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQ
Kinase 83325.m00036.AA RSK-Unclassified 256-342 43 1.4e-26 80.13 In-house 179-267 (283) Show / Hide 
Range on Protein: 256-342
Range on HMM: 179-267/283
Sequence Identity: 43% (39 aa)

TSTFCGTSEYLAPEIIRHEKYGIEVDWWSLGILTYELLFNKTPFCHPNKSRLFQNILEKEVQYP--AGVQTSIIEFINGLLQKDKRKRL
|  |||| ||||||.||    .  |||| |||. ||.||  .|.   ||  .|.||. ..|. |    .     . |  |||.   |||
TNSFCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRL
Kinase 83325.m00036.AA TyrKc 102-353 19 4.3e-16 37.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 102-353
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

FKILSVIGRGFYGKVMLVSKISNNEIFAIKSIHKSRLIQSDKVHTVIAERNILSKA--AHPFIISLKFAFQTP-------SKFYLGLEYAPGGELFFHMQ
 . . ..|.|..|.|..   .   .  |.|.....       .   . | .|..|    || |. |  .  ..          .. .||.|.| |  . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRGA-FPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQGHIKLTDFGLAKDLYNE--------ELTSTF--CGTS----EYLAPEIIRHEKYG
|..  ....||  .   ||   ..||| ... |||   |.|.......| .||||..|.|..          ...   .| .      .||| |.. |. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

IEVDWWSLGILTYELL-FNKTPFCH-----PNKSRLFQNILEK-EVQYPAG--------VQTSIIEFINGLLQKDKRKRLTFKQMQNLEFF
.. | || |.. .|.. . ..|         . ....... .      |.           . . . .    . |  .| ||..    |.|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 83325.m00036.AA Pkinase_Tyr 179-254 32 8.6e-09 30.4 Pfam 86-165 (270) Show / Hide 
Range on Protein: 179-254
Range on HMM: 86-165/270
Sequence Identity: 32% (26 aa)

LEYAPGGELFFHMQK----RGAFPLEDLKIYLAEIALALNHLHSIGVVYRDLKPENVLLSAQGHIKLTDFGLAKDLYNEE
.||.|.| |  . .|    .......||  . ..|| ....|.|.. . |||   |.|.. ....| .|||||.|.||..
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD
Kinase 83325.m00036.AA S_TK_X 354-414 21 1.2e-07 32.62 SMART 1-79 (79) Show / Hide 
Range on Protein: 354-414
Range on HMM: 1-79/79
Sequence Identity: 21% (17 aa)

KGLNFNDVLA--LKVQPSFIPKCD----NQGVPSNFYTEFTTEQPADSFVMPVYGSA------------EKYPGFSYME
.|........   ...| |.||.     ...  ||| .||| |.| .. . |.  ..            ....||.|. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 83325.m00036.AA Pkinase_Tyr 266-293 39 0.389675 4.47 Pfam 181-208 (270) Show / Hide 
Range on Protein: 266-293
Range on HMM: 181-208/270
Sequence Identity: 39% (11 aa)

LAPEIIRHEKYGIEVDWWSLGILTYELL
.||| |.. |. .. | || |.| .|..
MAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase 83325.m00036.AA Pkinase_Tyr 102-118 23 0.718517 3.57 Pfam 1-17 (270) Show / Hide 
Range on Protein: 102-118
Range on HMM: 1-17/270
Sequence Identity: 23% (4 aa)

FKILSVIGRGFYGKVML
 ... ..|.| .|.|..
ITFGKKLGEGAFGEVYK