Gene 92788.m00019 (T.vaginalis)
92788.m00019
Species: T.vaginalis
Alias: 92788.m00019, TvagK0764
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
92788.m00019.AA | Protein | None | 376 | None | Fasta, JSON |
92788.m00019.kin_dom | Protein Kinase Domain | None | 283 | None | Fasta, JSON |
Protein domains of 92788.m00019.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 92788.m00019.AA | GSK | 40-322 | 31 | 2.7e-78 | 238.58 | In-house | 1-328 (328) | Show / Hide |
Range on Protein: 40-322 Range on HMM: 1-328/328 Sequence Identity: 31% (102 aa) FHPIQILGRGEYGIAFQVQLN----DGSFF-----VIKRVLDDPKIK-SRELAILKRL---NSRYILSLKGHFYTPGPTPHS--RYLN-LVTDFYPENLE .. .. |.| | .| ..| . . .||.|. |.. | .||| |.|.| . | .|| .||. . .. .|.| || .. |..|. YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY QYCQPYFQRGIPIPIFYAKLFSFQMFAGLDVLHKFQIVHRDISPKNLFVDSKYGRLIVGDFGNAKQILSTT-EKNVTYIIERKYRPPELIYGSEKYGPPI |. |. . ..|| . ||...||| || ||.. |.|||| |.|. || . |.| |||.|||. .. |.|..|| | ||.|||| |...|. | QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI DIWAGGAVLAELLLGKPLFNGSSAVSLLHDMVRILGPPSK----EIIDSYGGTLKV-----SLARHNKTT-------------------LDKELANIEPS |.| | |.||.|.|.||| | |.| | ...|| |.| .. || . . . .|.... . | . .... DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD GIQLLKQIFNWDPSKRIKANEILDSRFY |.|..... ||.||... |.. . |. WIDLISKCLVYDPKKRLSPLEACAHPFF |
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Kinase | 92788.m00019.AA | CMGC | 40-322 | 16 | 1.5e-66 | 217.37 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 40-322 Range on HMM: 1-513/513 Sequence Identity: 16% (84 aa) FHPIQILGRGEYGIAFQVQL---------------NDGSFFVIKRVLDDPKIKS----------------RELAILKRLN-----------------SRY .. |. .|.| ||. .. . ... . ||.. .. . ||. |||.|| . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN ILSLKGHFYTPGPTPHS-----------RYLNLVTDFYPENLEQYCQPYFQ-----RGIP-------------------IPIFYAKLFSFQMFAGLD--V |..|. .||...... ..|.||... . .| || . . . |..| ..| . . ...|.. ||. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY LHKFQ--IVHRDISPKNLFVDSKY-------------------GRLIVGDFGNAKQILST---------------------TEKNVTYIIERKYRPPELI .|. |.|||. | |. .... ||| ..|||.|... . .. . .|. | ||.||.. CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL YGS---------EKYGPPIDIWAGGAVLAELLLG--------KPLFNGSSA-----------VSLLHDMVRILGPPS---------------KE----II |. .|..|||.|. | ..||...| |||| |.| . |. ....||.|. .| .| LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI DSYGGTLKVS------------------------LARHNKTTLDKELAN-----------------------------------IEPSGIQLLKQIFNWD . .. .. . . .... .. . . . | .| |||... .| KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD PSKRIKANEILDSRFY |.|||.| ..|. . PDKRITAEQALQHPYF |
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Kinase | 92788.m00019.AA | S_TKc | 40-322 | 20 | 2.8e-52 | 180.93 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 40-322 Range on HMM: 1-231/231 Sequence Identity: 20% (62 aa) FHPIQILGRGEYGIAFQVQLND-GSFFVIKRVLDDPKIKSRELAILKRLNSRYILSLKGHFYTPGPTPHSRYLNLVTDFYPE---NLEQYCQPYFQRG-- .. ....|.| .| .... .. | . ||.. . ||..|||. . .| |...|.. .| .|... . .| .| . . .| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR IPIPIFYAKLFSFQMFAGLDVLHKFQIVHRDISPKNLFVDSKYGRLIVGDFGNAKQILSTTEKNVTYIIERKYRPPELIYGSEKYGP-PIDIWAGGAVLA |.| |. . |.. .|. .|. .|.|||. | |...|. .. ..||| |.|. |.. . |..||.. .||. ..|.|. | .|. FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY ELLLGKPLFNGSSAVSLLHDMVRILGPPSKEIIDSYGGTLKVSLARHNKTTLDKELANIEPSGIQLLKQIFNWDPSKRIKANEILD-------SRFY |.| |.|.| .. | ...| |............||.||. | |.| . EMLCGYPPFP------QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 92788.m00019.AA | Pkinase | 40-322 | 21 | 5.5e-48 | 170.53 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 40-322 Range on HMM: 1-293/293 Sequence Identity: 21% (69 aa) FHPIQILGRGEYGIAFQVQLNDGS-FFVIKRVLDDPKIKSR--------ELAILKRLNSRYILSLKGHFYTPGPTPHSRYLNLVTDFYPENLEQYCQPYF .| ....|.| .| .. . . . ...|.. . . .. |..|.||||. .|. |.. |.. .... .|... . |. .. | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLY--VMDLF -----QRGIPI--PIFYAKLFSFQMFAGLDVLHKFQIVHRDISPKNLFVDSKYGR---LIVGDFGNAKQI-LSTTEKNVTYIIERKYRPPELIYGSEKYG .|. .. . .| . |.. ||. .|. |.|||. | |...|... . ..||| |||. . . . |. . |..||.| |...|| DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG PPIDIWAGGAVLAELLLGKPLFNGS----SAVSLLHDMVRILGPPSKEIIDSY----------GGTLKVSLARHNKTTLDKELANIEPSGIQLLKQIFNW |..|.|. | .|.|.|.|.|.| |. . .. .. ..||.||| .. .. . . . . |.........| .... PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-H----------F-HWTF-HNWSEECKDFIKWCLCK DPSKRIKANEILDSRFY ||.||. | .|| . . DPKKRPTAEQILQHPWF |
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Kinase | 92788.m00019.AA | CDC2 | 79-322 | 27 | 2.4e-34 | 102.6 | In-house | 49-301 (301) | Show / Hide |
Range on Protein: 79-322 Range on HMM: 49-301/301 Sequence Identity: 27% (73 aa) RELAILKRLN-SRYILSLKGHFYTPGPTPHSRYLNLVTDFYPENLEQYCQPYFQRGIPIPIFYAKLFSFQMFAGLDVLHKFQIVHRDISPKNLFVDSKYG ||. .|| |. | .|. .. . | .|.... .| .| ... . ..| . | . .|. |.. .| .|.|||. | |...|.| | REISCLKELKDHPNIVKLHDVIHQ-------NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKK-G RLIVGDFGNAKQILSTTEKNVT---YIIERKYRPPELIYGSEKYGPPIDIWAGGAVLAEL---LLGKPLFNGSSAVSLLHDMVRILGPPSKEIIDSYGGT .. ..||| |. . .. .. | .. . ||.||. |...| |.|.|. | ..||. |||| | | | . |||| |. .. . NIKIADFGLARAF-GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQL L--KVSLARHNKTTLDKELAN---------IEPSGIQLLKQIFNWDPSKRIKANEILDSRFY | . | ... | | . | ..| ||.||.|. ||.|||.| |.|. .. PDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF |
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Kinase | 92788.m00019.AA | CDK | 40-322 | 22 | 1.2e-32 | 101.69 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 40-322 Range on HMM: 1-284/284 Sequence Identity: 22% (72 aa) FHPIQILGRGEYGIAFQVQLND-G-----SFFVIKRVLDDP--------KIKS---RELAILKRLNSRYILSLKGHFYTP-------GPTPHSRYLNLVT . .. .|.| ||. . . . | . .|.. . . . || ..|| | .| .|. ..| . | . | .| YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDK--HENKLYMVF DFYPENLEQYCQPYFQRGIPIPIFYAKLFSFQMFAGLDVLHKFQIVHRDISPKNLFVDSKY----GRLIVGDFGNAKQILS------TTEKNVTYIIERK .. . | .| | . .|. ||. .|. |.|||. | |. .... ||| ..||| |. . . . .. . EYMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLW YRPPELIYGSEKYG--PPIDIWAGGAVLAELLL---GKPLFNGSSAVSLLHDMVRILGPPSKEI---IDSYGGTLKVSLARHNKTTLDKELANIEPSGIQ ||.||| ||..|. .|||.|. | ..||... .|||| |.| |. ||.| |. .. . .. . . YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------D LLKQIFNWDPSKRIKANEILDSRFY || . . ||.|||.| . |.. . LLNKMLCYDPKKRISAEQALQHPYF |
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Kinase | 92788.m00019.AA | Ciliate-E2 | 40-322 | 14 | 1.6e-30 | 101.95 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 40-322 Range on HMM: 1-365/365 Sequence Identity: 14% (60 aa) FHPIQILGRGEYGIAFQVQL------------------------NDGSFFVIKRV-LDDPKIKSRELAILK----------------RLNSRYILSLKGH . |...|.| .|. .... ...... .|.. .. .....|. |.. .||. .|. .. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FY--TPGPTPHSRYLNLVTDFYPE-NLEQYCQ--PYFQRGI-----PIPIFYAKLFSFQMFA---------------GLDVLHKFQ-IVHRDISPKNLFV |. . .. ||.... .|..|.. . .. . .. .. .| .. | . .| ||. |.|||| | |... FQEKD------DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF DSKYGRLIVGDFGNAKQI--------------LSTTEKNVTYIIER------------------KYRPPELIYG--------SEKYGPPIDIWAGGAVLA . . |||..|.. . . || |.. . | .|| . | .. |. .|||. | .| ------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY ELLLGKPLFNGSSAVSLLHDMVRILGPPSKEIIDSYGGTLKVSLARHNKTTLDKEL-------ANIEPSGIQLLKQ----IFNWDPSKRIK-ANEILDSR |.| ||| | .. . .. . . .| .. . ........|.|. ... ||.||| ...||. EMLFGKPPF----------------------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP FY . WF |
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Kinase | 92788.m00019.AA | ERK7 | 146-322 | 28 | 1.4e-29 | 98.12 | In-house | 107-292 (292) | Show / Hide |
Range on Protein: 146-322 Range on HMM: 107-292/292 Sequence Identity: 28% (53 aa) FQMFAGLDVLHKFQIVHRDISPKNLFVDSKYGRLIVGDFGNAKQILSTT-----EKNVT-YIIERKYRPPELIYGSEKYGPPIDIWAGGAVLAELLLGKP .|.. . .| ...|||. | |. .||. .. | ||| | | .. . .| |. | || || ||..| . .| | | .|.|.| ||| YQLLRAIKYMHSGNVIHRDLKPSNILLDSE-CMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKP LFNGSSAVSLLHDMVRILGPPSKEIIDS----YGGTLKVSLARHNKTTLDKELANIEPSGIQLLKQIFNWDPSKRIKANEILDSRFY .| |.| . . ..... |..| | . |. .. .. .... |||. . . . .| |||.. | ||. |.. | .. MFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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Kinase | 92788.m00019.AA | nmo | 142-322 | 31 | 5.6e-29 | 85.75 | In-house | 105-292 (292) | Show / Hide |
Range on Protein: 142-322 Range on HMM: 105-292/292 Sequence Identity: 31% (59 aa) KLFSFQMFAGLDVLHKFQIVHRDISPKNLFVDSKYGRLIVGDFGNAKQILSTTEKNVTY-IIERKYRPPELIYGSEKYGPPIDIWAGGAVLAELLLGKPL | | .|. || || .|.|||| | || |.| | . ||| |. ..|..| .. || ||.. |. .| .|||. | . |||| . | KVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNC-VLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRRIL FNGSSAVSLLHDMVRILGPPSKEII-DSYGGTLKVSLARHNKTTLDKELANIEP------SGIQLLKQIFNWDPSKRIKANEILDSRFY | | . |. .. .|| || | . | | . | . | .. ..||... .||.||| ... | .. FQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL |
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Kinase | 92788.m00019.AA | CDK10 | 142-322 | 32 | 1.3e-26 | 89.44 | In-house | 103-285 (285) | Show / Hide |
Range on Protein: 142-322 Range on HMM: 103-285/285 Sequence Identity: 32% (59 aa) KLFSFQMFAGLDVLHKFQIVHRDISPKNLFVDSKYGRLIVGDFGNAKQILSTTEKNVTYIIERKYRPPELIYGSEKYGPPIDIWAGGAVLAELLLGKPLF | || || ||. ..|||. || . | | . | ||| |.. .. || |||..|. . ||.|| | .|.|||..|||. KCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDK-GCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPLM NGSSAVSLLHDMVRILGPPSKEIIDSYGGTLKV---SLARHNKTTLDKELANIEPSGIQLLKQIFNWDPSKRIKANEILDSRFY |.| . . .. .|| || .| . | .| . | . . || .||. .| ..| || |.| |.|... PGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF |
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Kinase | 92788.m00019.AA | CDKL | 146-259 | 39 | 1.3e-26 | 87.98 | In-house | 105-218 (286) | Show / Hide |
Range on Protein: 146-259 Range on HMM: 105-218/286 Sequence Identity: 39% (45 aa) FQMFAGLDVLHKFQIVHRDISPKNLFVDSKYGRLIVGDFGNAKQILSTTEKNVT-YIIERKYRPPELIYGSEKYGPPIDIWAGGAVLAELLLGKPLFNGS .| ... .|| ..|||| | |... | |.. .||| |. .|. . ..| | | || ||| | .||.|.|||| | |.||.. | ||. |. WQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLWPGQ SAVSLLHDMVRILGP | . .|. .. ||| SDIDQLYHIQKCLGP |
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Kinase | 92788.m00019.AA | ERK5 | 144-322 | 26 | 1.8e-24 | 86.49 | In-house | 108-295 (295) | Show / Hide |
Range on Protein: 144-322 Range on HMM: 108-295/295 Sequence Identity: 26% (50 aa) FSFQMFAGLDVLHKFQIVHRDISPKNLFVDSKYGRLIVGDFGNAKQILS--TTEKNV---TYIIERKYRPPELIYGSEKYGPPIDIWAGGAVLAELLLGK | .|. || .| |..|||. | || | | .|||| |. . . .. . |. | || |||.. |. | ||.|. | .. |.. . FLYQILRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMIARR PLFNGSSAVSLLHDMVRILGPPSKEIIDSYGGT-----LKVSLARHNKTTLDKELANIEPSGIQLLKQIFNWDPSKRIKANEILDSRFY .| | . | .. .|| |. .| . . .. .. . ..| .. ...|| .. ..||.|| .|. | | QMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL |
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Kinase | 92788.m00019.AA | TyrKc | 40-325 | 16 | 2.9e-07 | -105.12 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 40-325 Range on HMM: 1-280/280 Sequence Identity: 16% (54 aa) FHPIQILGRGEYGIAFQVQLNDGSFFV-IKRVLDDPKIKS--RELAILKRL--NSRYILSLKGHFYTP-------GPTPHSRYLNLVTDFYPE-NLEQYC . ...||.|..|. .. ... | .| . .| .. ||. |...| . |. | | .. .| | .|. . | .| .| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEP------LMIVMEYMPHGDLKDYL QPYFQRGIPIPIFYAKLFSFQMFAGLDVLHKFQIVHRDISPKNLFVDSKYGRLIVGDFGNAKQILST-------TEKNVTY-IIER-----KYRPPELIY . . . .. |..| .| . ||. ...|||. | |.... . ..||| .. | . . .. .. . .|| | RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI- GSEKYGPPIDIWAGGAVLAELL-LGKPLFNG-----SSAVSLLHDMVRILGPPSKEI---IDSYGGTLKVSLARHNKTTLDKELANIEPSGIQLLKQIFN |. . |.|. | .. |.. .|.. | |. .... . .| . . . |. || . NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------FVCCPDEMYQIMKQCWH WDPSKRIKANEILDSRFYDEL ||..| .|| .... EDPEDRPTFSEI-----HECF |
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Kinase | 92788.m00019.AA | CDKL | 283-322 | 17 | 3.5e-05 | 13.69 | In-house | 246-286 (286) | Show / Hide |
Range on Protein: 283-322 Range on HMM: 246-286/286 Sequence Identity: 17% (7 aa) TLDKELANIE-PSGIQLLKQIFNWDPSKRIKANEILDSRFY .| | . |. . . ..|. . ||..|. . . ... . PLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF |