Gene 83462.m00010 (T.vaginalis)

83462.m00010

Species: T.vaginalis
Alias: TvagK0376, 83462.m00010
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
83462.m00010.AA Protein None 413 None Fasta, JSON
83462.m00010.kin_dom Protein Kinase Domain None 250 None Fasta, JSON

Protein domain

Protein domains of 83462.m00010.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 83462.m00010.AA AGC 107-356 26 3.2e-142 370.3 In-house 1-395 (395) Show / Hide 
Range on Protein: 107-356
Range on HMM: 1-395/395
Sequence Identity: 26% (106 aa)

FEIISSLGRGHFGKVNLCRRI------NSQLFYAIKSIHKSQ---LMEQNKINTVIVE------------RDVLLVTR----------CPFIVH-FCFSF
||..  .|.|.|||| |.|.        .. .||.| . |.    ....|..  ...|            |..|   .          .||||.   .||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTTSK--FYLGLEYVP---------GG-DLHQRIL---SAGTIPLHDLRIYLAE-------IVLGLEDLHK-RSIVYRD-LKPENILITSEGHLKLTDFG
|. ..   |. .||.|         || .|....      |. .    |.|.||       |||.|| ||. . |..|| |||||||....||.||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKFSQNP-----------------------------------------------------LRSLCG--TMEYVAPEMVRNEPYGSSVDIWS--LGIITY
|.|   |                                                        ..||  | ||.|||..    || ..|.||  ||.. |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMAIGRTPFKRAN----------QFKTFKAIL------EEEPSIN----------SNIDSKLLDLIQKLLVKDPKKRLT----------IDEINSHPFF
|| .|..||   |          ....|. |.      .... ..          ..... . |||.|||.|||.|||.          ..|| .||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 83462.m00010.AA Akt 107-356 38 1.1e-100 322.62 In-house 1-264 (264) Show / Hide 
Range on Protein: 107-356
Range on HMM: 1-264/264
Sequence Identity: 38% (102 aa)

FEIISSLGRGHFGKVNLCRRINSQLFY-AIKSIHKSQLMEQNKINTVIVERDVLLVTRCPFIVHFCFSFQTTSKFYLGLEYVPGGDLHQRILSAGTIPLH
|...  ||.| |||| |..  ..| .| |.|.. |... ..|..  .. || .|  ...||||   .||||  | |. ..|..||.| . .  .....  
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

DLRIYLAEIVLGLEDLHKRSIVYRD-LKPENILITSEGHLKLTDFGLAK-F-SQN--PLRSLCGTMEYVAPEMVRNEPYGSSVDIWS-LGIITYEMAIGR
  | | |||.|..| ||...|.||| |||||||. ..||..||||||.|    ..     ..||| || |||.  .  .. .||.|. ||...|||  ||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFKRANQFKTFKAILEEEPSIN--SNIDSKLLDLIQKLLVKDPKKRL-----TIDEINSHPFF
 ||   .. . || |....  ..  ..|. .  ||| .|| |||||||     ...|| .||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 83462.m00010.AA S_TKc 107-356 34 1.5e-99 337.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 107-356
Range on HMM: 1-231/231
Sequence Identity: 34% (91 aa)

FEIISSLGRGHFGKVNLCRRINSQLFYAIKSIHKSQLMEQNKINTVIVERDVLLVTRCPFIVHFCFSFQTTSKFYLGLEYVPG--GDLHQRILSAGT---
.||.  .|.| |||| .|| ....  .||| |.          .... |...|   ..|.||..  .||. ...|. .||..|  |||...| . |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IPLHDLRIYLAEIVLGLEDLHKRSIVYRDLKPENILITSEGHLKLTDFGLAKFSQNPLRSLCGTMEYVAPEMVRNEPYGS-SVDIWSLGIITYEMAI
   .|  . | |...|...|| .|.. |..|||||||||...  |.|..|||||..     ...||| .|.|||..   .||  ..|.||.|.| |||. 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRTPFKRANQFKTFKAILEEEPSINSNIDSKLLDLIQKLLVKDPKKRLTIDEINS-------HPFF
|..||   .....|| |.          .. ..|.|.|.|.|||.||.|. |.         ||.|
GYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 83462.m00010.AA RSK 110-356 35 1.3e-95 323.97 In-house 1-278 (278) Show / Hide 
Range on Protein: 110-356
Range on HMM: 1-278/278
Sequence Identity: 35% (98 aa)

ISSLGRGHFGKVNLCRRI---NSQLFYAIKSIHKSQLMEQNK-INTVIVERDVLLVTR-CPFIVHFCFSFQTTSKFYLGLEYVPGGDLHQRILSAGT---
.. ||.| .||| |||..   ...  || | ..|. ..  .| . ..  ||..|. .. .||||.   .||| .|.|| .||..||.|  ...  ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

IPLHDLRIYLAEIVLGLEDLHKRSIVYRDLKPENILITS---EGHLKLTDFGLAKF-SQN---PLRSLCGTMEYVAPEMVR---NEP-YGSSVDIWSLGI
.  .. ..|.||||| .| ||.. |..||||||||| ..   |||.||||||..|  . .   .. . |.| ||.||||..    .  .. ..|.||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

ITYEMAIGRTPFKR---ANQFKTFKAILEEE--PSIN--SNIDSKLLDLIQKLLVKDPKKRLT-----IDEINSHPFF
. |||  |..||.    .|. ...| |.. .  ...   ...     |||.|.| .||.|||.     ..|| .||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 83462.m00010.AA AktR 107-356 41 3.4e-95 322.55 In-house 1-268 (268) Show / Hide 
Range on Protein: 107-356
Range on HMM: 1-268/268
Sequence Identity: 41% (111 aa)

FEIISSLGRGHFGKVNLCRRI-NSQLFYAIKSIHKSQLMEQNKINTVIVERDVLL-VTRCPFIVHFCFSFQTTSKFYLGLEYVPGGDLHQRILSAGTIPL
|...  ||.| |||| |...  ..| .||.|.|.|. . |.|..  .| ||...    . |||| . ..||| .| .. .||.|||.| | . . ...  
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

HDLRIYLAEIVLGLEDLHKR-SIVYRDLKPENILITSEGHLKLTDFGLAK--FS---QNPLRSLCGTMEYVAPEMVRN-EPYGSSVDIWSLGIITYEMAI
 . |.| |.|.|.|| ||..  |.||||||||||. ..||.|.|||||.|  |      . .|.||| ||.||||... .... |||.|..||  ||| .
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRTPFKRANQFKTFKAILEEE---PSINSNIDSKLLDLIQ-KLLVKDPKKRLT-----IDEINSHPFF
| .||   ||   |. |....   . ..|.. |.. |||| ||| |.|.|||.     ..|| |||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 83462.m00010.AA Pkinase 107-356 30 1.1e-84 292.42 Pfam 1-293 (293) Show / Hide 
Range on Protein: 107-356
Range on HMM: 1-293/293
Sequence Identity: 30% (89 aa)

FEIISSLGRGHFGKVNLCRRINSQLFYAIKSIHKSQLMEQNKINTVI-VERDVLLVTRCPFIVHFCFSFQTTSKFYLGLEYVPGG----DLHQRIL--SA
..|.. .|.| ||.| .|......  .|.| | |.   .. ... .   |  ...  ..|.|| .  .|.. .. |. .||..||    ||. .|   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GTI--PLHDLRIYLAEIVLGLEDLHKRSIVYRDLKPENILITSEGHL----KLTDFGLA----KFSQNPLRSLCGTMEYVAPEMVR-NEPYGSSVDIWSL
|..  . .... |. .|. ||| .|...|..|||||||||| ..||.    |..|||||      ..  . ..||| .|.||| .| ...||..||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIITYEMAIGRTPFKRA------NQFKTFKAILEEEPSINSNID---------------------SKLLDLIQKLLVKDPKKRLTIDEINSHPFF
|.| |||. ||.||. .      .| . .. |.. ... ..  .                     . ..|.| ..| ||||||.|...|  ||.|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 83462.m00010.AA Ciliate-E2-Unclassified 107-356 26 8.4e-84 284.72 In-house 1-352 (352) Show / Hide 
Range on Protein: 107-356
Range on HMM: 1-352/352
Sequence Identity: 26% (94 aa)

FEIISSLGRGHFGKVNLCRRINSQLFYAIKSIHKSQLMEQNKINTV---------IVERD-------------VLLVTRCPFIVHFCFSFQTTSKFYLGL
..||  .|.| |||| .|.... ...||.| ..|.|   |..|...         . ..               ||   .||||.... ||.. ..|. .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYVPGGDLHQRILSAGT-----------------IPLHDLR-----IYLAEIVLGLEDLHKRS-IVYRDLKPENILITSEG---HLKLTDFGLAKFSQNP
||..||||.| | . ..                 ..    .      |.|.|..||| ||.   |..||.||||||....|   ..|..|||..|..|..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------------LRSLCGTMEYV----APEMVRNEPYGSS----VDIWSLGIITYEMAIGRTPFKRANQFK----------------TFKAILE
                  . . ||| .|     |||. ... |. |    .||||||.| |||  |. ||.  |. .                 .. |..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

EEPSINS--------NIDSKLLDLIQ----KLLVKDPKKRLTIDEINSHPFF
 ......        ... .  |.|.    |.|.|.|.||.|...|  ||.|
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 83462.m00010.AA Ciliate-E2 107-356 23 2.7e-83 283.02 In-house 1-365 (365) Show / Hide 
Range on Protein: 107-356
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

FEIISSLGRGHFGKVNLCRR-INSQLF----------------------YAIKSIHKSQLMEQNKINTVI----------VERDVLLVTRCPFIVHFCFS
...|  .|.| ||.| .|..  . ..|                      ||.|...|.|. ...... ..           |. .|    .|.|. .  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TTSKFYLGLEYVPGGDLHQRI-------------------LSAGTIPLHDLR-------IYLAEIVLGLEDLHKRS-IVYRDLKPENILITSEGHL
||  .....|| .||. |||| ..|                     ...|  . |.        |.|.|.|.|| ||..  |..||.||||||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLAKFSQNP----------------------------------LRSLCGTMEYVAPEMVRNEP---------YGSSVDIWSLGIITYEMAIGRTP
|..||||.|. ...                                   ...||| .|.|||......         |. ..||||||.| |||  |..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FKRANQFKTFKAILEEEPSIN------------------SNIDSKLLDLIQK----LLVKDPKKRLT-IDEINSHPFF
|        .. |.. . ...                   ... .  |||.|    .|.|||.||.| ...|  ||.|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 83462.m00010.AA PKA 107-356 39 5.9e-83 281.91 In-house 1-263 (263) Show / Hide 
Range on Protein: 107-356
Range on HMM: 1-263/263
Sequence Identity: 39% (103 aa)

FEIISSLGRGHFGKVNLCRRINSQLFYAIKSIHKSQLMEQNKINTVIVERDVLLVTRCPFIVH-FCFSFQTTSKFYLGLEYVPGGDLHQRILSAGTIPLH
|||| .||.| ||.| |||  .|  .||.| . |..    . .  |. |. .|. .. ||||    ..||. .. |. .||||||..  ..   |  .  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DLRIYLA-EIVLGLEDLHKRSIVYRDLKPENILITSEGHLKLTDFGLAKFSQNPLRSLCGTMEYVAPEMVRNE-PYGSSVDIWSLGIITYEMAIGRTPFK
. ..| | .||| || ||.  |.||||||||||| ..||.|.|||| ||  ..   .|||| || |||.. .. ..| ||| |.|||. |||. | .|| 
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFY

RA--NQFKTFKAILEEEPSINSNIDSKL---LDLIQKLLVKDPKKRL-TIDE----INSHPFF
    ....... |.. .    ...||..    ||| |||..|..||. . ..    |  |..|
DHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 83462.m00010.AA MAST 107-254 39 2.7e-64 195.08 In-house 1-151 (337) Show / Hide 
Range on Protein: 107-254
Range on HMM: 1-151/337
Sequence Identity: 39% (60 aa)

FEIISSLGRGHFGKVNLCRRINSQLFYAIKSIHKSQLMEQNKINTVIVERDVLLVTRCPFIVHFCFSFQT--TSKFYLGLEYVPGGDLHQRILSAG-TIP
||.|  ...| .|.| | . ...  ..|.|.| .....  | ...|.|||..| .. .||.| .  ||||  . . .. .||. |||  . . . | . |
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

LHDLRIYLAEIVLGLEDLHKRSIVYRDLKPENILITSEGHLKLTDFGLAKF
 .  ..|.||.||.|| ||. .|| |||||.|.||.| ||.|||||||.|.
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKV
Kinase 83462.m00010.AA MAST 107-254 41 6.7e-62 198.19 In-house 1-148 (334) Show / Hide 
Range on Protein: 107-254
Range on HMM: 1-148/334
Sequence Identity: 41% (62 aa)

FEIISSLGRGHFGKVNLCRRINSQLFYAIKSIHKSQLMEQNKINTVIVERDVLLVTRCPFIVHFCFSFQTTSKFYLGLEYVPGGDLHQRILSAGTIPLHD
||.|  ...| .||| | . ...  ..|.| | ||...  | ...|.|||..| ....||.|..  ||||... .. .||. |||. . . . |. . . 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

LRIYLAEIVLGLEDLHKRSIVYRDLKPENILITSEGHLKLTDFGLAKF
 ..|.||.||.|| ||. .|| |||||.|.||.|.|| |||||||.|.
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKV
Kinase 83462.m00010.AA RSK-Unclassified 107-253 41 1.1e-59 185.91 In-house 1-149 (283) Show / Hide 
Range on Protein: 107-253
Range on HMM: 1-149/283
Sequence Identity: 41% (62 aa)

FEIISSLGRGHFGKVNLCRRINSQLFYAIKSIHKSQLMEQNKINTVIVERDVLLVTRCPFIVHFCFSFQTTSKFYLGLEYVPGGDLHQRIL--SAGTIPL
|. .  .|.| |||| | |. ..|  ||.|  ||.... .|||  |. |.... .|  ||||   .||||  . || .|| .|||. .         .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

HDLRIYLAEIVLGLEDLHKRSIVYRDLKPENILITSEGHLKLTDFGLAK
 | |.|..|... ||.|||| ..||||||.||.   ||| .||||.| .
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSI
Kinase 83462.m00010.AA RSK-Unclassified 260-356 42 1.5e-27 83.19 In-house 180-283 (283) Show / Hide 
Range on Protein: 260-356
Range on HMM: 180-283/283
Sequence Identity: 42% (44 aa)

RSLCGTMEYVAPEMVRNEPYGSSVDIWSLGIITYEMAIGRTPFKRANQFKTFKAILEEEPSIN--SNIDSKLLDLIQKLLVKDPKKRL-----TIDEINS
.| ||| ||.||||.|    .  || | |||. ||| .| .|..  |.  ||. |. .. ..   | |  .  ||| ||| . | |||       |.|  
NSFCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKR

HPFF
||||
HPFF
Kinase 83462.m00010.AA MAST 261-356 35 2.2e-25 78.53 In-house 223-334 (334) Show / Hide 
Range on Protein: 261-356
Range on HMM: 223-334/334
Sequence Identity: 35% (40 aa)

SLCGTMEYVAPEMVRNEP-YGSSVDIWSLGIITYEMAIGRTPFKRANQFKTFKAILEEE------PSI-----NSNIDSKLLDLIQKLLVKDPKKRLTID
..||| .| |||   ... .| .|| ||.||| ||  .| .||   .. ..|  || ..      |        . . .   |||.|||  ||.|||.  
QCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGAN

----EINSHPFF
    |. .||||
NGADEVKQHPFF
Kinase 83462.m00010.AA MAST 263-356 38 4.2e-23 66.84 In-house 229-337 (337) Show / Hide 
Range on Protein: 263-356
Range on HMM: 229-337/337
Sequence Identity: 38% (42 aa)

CGTMEYVAPEMVRNEP-YGSSVDIWSLGIITYEMAIGRTPFKRANQFK-TFKAILE-----EEPSI-----NSNIDSKLLDLIQKLLVKDPKKRLTID--
||| .| |||    .. || .|| ||.||| ||  .| .||   .. . .|  |.      | |..        . .   |||.||| ..|||||     
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

-EINSHPFF
 || .||||
DEIKQHPFF
Kinase 83462.m00010.AA TyrKc 107-356 18 7.6e-14 1.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 107-356
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

FEIISSLGRGHFGKVNLCRRINSQLFYAIKSIHKSQLMEQNKINTVIVERDVLLVT--RCPFIVHFCFSFQTT-------SKFYLGLEYVPGGDLHQRIL
 . .  ||.|.||.| ... .   .  |.|.....       .   . |  ..     . | || .     .           .. .||.|.|||.... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SAGT-IPLHDLRIYLAEIVLGLEDLHKRSIVYRDLKPENILITSEGHLKLTDFGLAKFSQNP---------LRS----LC---GTMEYVAPEMVRNEPYG
. .  ... ||  .   |  | | ||.. .. |||   |.|...... | .||||...  .           |.     .         |||  .   . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

SSVDIWSLGIITYEMA-IGRTPFKR-----ANQFKTFKAILEE-EPSINSN--------IDSKLLDLIQKLLVKDPKKRLTIDEINSHPFF
.  |.|| |.  .|.   | .|         . .  .. . .   . .  |          ... .....    ||..| |  ||  | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 83462.m00010.AA Pkinase_Tyr 184-253 32 0.000347 14.8 Pfam 86-159 (270) Show / Hide 
Range on Protein: 184-253
Range on HMM: 86-159/270
Sequence Identity: 32% (24 aa)

LEYVPGGDLHQRILS----AGTIPLHDLRIYLAEIVLGLEDLHKRSIVYRDLKPENILITSEGHLKLTDFGLAK
.||.|.|||.    .     . ....||  . ..|  |.| |. . .. |||   |.|.|.... | .|||||.
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 83462.m00010.AA Pkinase_Tyr 107-121 40 0.060489 7.21 Pfam 1-15 (270) Show / Hide 
Range on Protein: 107-121
Range on HMM: 1-15/270
Sequence Identity: 40% (6 aa)

FEIISSLGRGHFGKV
 ...  ||.|.||.|
ITFGKKLGEGAFGEV