Gene 87955.m00279 (T.vaginalis)
87955.m00279
Species: T.vaginalis
Alias: 87955.m00279, TvagK0065
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 87955.m00279.AA | Protein | None | 231 | None | Fasta, JSON |
| 87955.m00279.kin_dom | Protein Kinase Domain | None | 171 | None | Fasta, JSON |
Protein domains of 87955.m00279.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 87955.m00279.AA | CAMKL | 3-174 | 35 | 4.8e-63 | 199.98 | In-house | 99-293 (297) | Show / Hide |
Range on Protein: 3-174 Range on HMM: 99-293/297 Sequence Identity: 35% (71 aa) IQEYCSGGE--MFTKV--RTGPN--IRESEIIRYSLQIISAINYLHTRNIMHRDIKLENIVLDNNGD--AKIIDFGLSEVVN------DVNLKTHCGTLI . ||||||| .| .. . ... . |.| || ||.||.||.| ..| |||||.||| ||.||. .||||||.| . |||.||.. VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP YMAPEMLSQ--RQFDGKAVDIWAIGICIYAMVTRTFPWKSTT-------DEELLHEIIQADIFFPN---FVCPTISELLHGTLVKNPSERAPAAELIS |||||... ...||..||||..|. ||||. ..|.. | . .|...| . ..|. .| |... |..||..|. . .. . YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN |
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| Kinase | 87955.m00279.AA | CAMK | 3-174 | 22 | 5.6e-59 | 188.37 | In-house | 135-421 (425) | Show / Hide |
Range on Protein: 3-174 Range on HMM: 135-421/425 Sequence Identity: 22% (64 aa) IQ---EYCSGGEM----FTKVRTGPN---------------IRESEIIRYSLQIISAINYLHTRNIMHRDIKLENIVLDNN-----------------GD . |||||||. | ... .. . |.| || ||.||..|.| .||.|||.|.||| ||.| .. VMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNN AKIIDFGLSEVVNDVN-------------------------LKTHCGTLIYMA-PEMLSQ-------------RQFDGKAVDIWAIGICIYAMVTRTFPW ||||||.. .... . .|| |||. ||| ||.|.. .. .|...|.|..|. |.|.. ..|. IKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF KST-------------TDEELLHEIIQADIFFPNFVCPT------------------------ISELLHGTLVKNPSERAPAAELIS . .|.||.. |.... || . .. |. . |...|..|. ... . YGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN |
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| Kinase | 87955.m00279.AA | AGC | 5-166 | 22 | 7.6e-54 | 136.51 | In-house | 113-373 (395) | Show / Hide |
Range on Protein: 5-166
Range on HMM: 113-373/395
Sequence Identity: 22% (59 aa)
EYCS---------GG-EMFTKVR---TGPNIRESEIIRYSLQ-------IISAINYLHT-RNIMHRD-IKLENIVLDNNGDAKIIDFGLSEVVND-----
||.. || |.|. . |... | . |..|. ||| ..| ||| .|.|||.||..| |. ||||. ....
EYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKG
-----------------------------------------------VNLKTHCG--TLIYMAPEMLSQRQFDGKAVDIWA--IGICIYAMVTRTFPWKS
. .| || | |||||.| |||.|.|. |...| |.| | .
QQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPPFYG
TTDE----------ELLHEII------QADIFFP----------NFVCPTISELLHGTLVKNPSER
... |. . |. . .. || .. | |. . |.|.|..|
DNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKR
|
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| Kinase | 87955.m00279.AA | MARK | 5-174 | 40 | 7.8e-54 | 174.42 | In-house | 82-258 (262) | Show / Hide |
Range on Protein: 5-174 Range on HMM: 82-258/262 Sequence Identity: 40% (71 aa) EYCSGGEMFTKVRTG--PNIRESEIIRYSLQIISAINYLHTRNIMHRDIKLENIVLDNNG--DAKIIDFGLSEVV-NDVNLKTHCGTLIYMAPEMLSQRQ ||.||||.. .. . |.| |. ||.||.||.| .|| |||||.||| .| || ..||||||.| . .. |.|.|||. |||||..... EYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKP FDGKAVDIWAIGICIYAMVTRTFPWKSTT--DEELLHEIIQADIFFPNFVCPTISELLHGTLVKNPSERAPAAELIS ||..||||. |. |.||. .||.. .| ..|| .| . .| .| . . |.. |. ||.||. . |. . YDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMK |
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| Pkinase | 87955.m00279.AA | Pkinase | 2-176 | 26 | 9.7e-51 | 179.68 | Pfam | 77-293 (293) | Show / Hide |
Range on Protein: 2-176 Range on HMM: 77-293/293 Sequence Identity: 26% (57 aa) VIQEYCSGG----EMFTKVR--TGPNI--RESEIIRYSLQIISAINYLHTRNIMHRDIKLENIVLDNNGDA----KIIDFGLSE---VVNDVNLKTHCGT ...||| || . |. .. . .. | |...| .||.....|.| ..|.|||.|.||| .||||. ||.||||.. |.. ..| ||| MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT LIYMAPEMLSQRQFDGKAVDIWAIGICIYAMVTRTFPWKST------TDEELLHEIIQADIFFPNFVC---------------------PTISELLHGTL . ||||| . .| .|..||.|..|. .| |... .|... .. ... .| .... |. . .. ... . | PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL VKNPSERAPAAELISI--I |.|..| |... . CKDPKKRPTAEQILQHPWF |
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| Kinase | 87955.m00279.AA | Ciliate-E2 | 3-166 | 24 | 8.8e-49 | 165.58 | In-house | 112-352 (365) | Show / Hide |
Range on Protein: 3-166 Range on HMM: 112-352/365 Sequence Identity: 24% (62 aa) IQEYCSGGEMFTKVR------------TGPNIRESEIIRYSLQIIS---------------AINYLHTRN-IMHRDIKLENIVLDNNGDAKIIDFGLSEV . |||.||..| . .. | ||.... ||.. |..||| .| |.|||||.|||.. |||||||| VMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKK VNDVNLKTH---------------------------------CGTLIYMAPEMLSQRQFDG--------KAVDIWAIGICIYAMVTRTFPWKSTTDEELL ..| | .. |||. |||||.|. . |. ...|||..|...| |.. .|. . YDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------Q HEIIQADIFFP----------------NFVCPTIS--ELLHG----TLVKNPSER .|.| .| || .. . . |. |.|.|..| QQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKR |
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| Kinase | 87955.m00279.AA | Ciliate-E2-Unclassified | 3-166 | 27 | 1.7e-48 | 166.32 | In-house | 99-340 (352) | Show / Hide |
Range on Protein: 3-166
Range on HMM: 99-340/352
Sequence Identity: 27% (67 aa)
IQEYCSGGEMFTKVRTGPN-----------------IRESEII-----RYSLQIISAINYLHTRN-IMHRDIKLENIVLDNNG---DAKIIDFGLSE---
. ||| ||... . .. . | ... .| ||.....||| | | |||||.|||..|||| ||||||.|
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ
--------------VVNDVNLKTHCGTLIYM----APEMLSQRQFDG---KAVDIWAIGICIYAMVTRTFPWKSTTDEE----------------LLHEI
. . ...| |||..|| |||.| . . |. ...|||. |...|.|.. ..| .....|. |. .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI
IQADIFFPNFVC----PTIS--------ELLHGTLVKNPSER
.| .|.||.| ..| .||. |.|||..|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKR
|
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| Kinase | 87955.m00279.AA | AMPK | 2-167 | 38 | 3.4e-47 | 138.2 | In-house | 77-243 (254) | Show / Hide |
Range on Protein: 2-167 Range on HMM: 77-243/254 Sequence Identity: 38% (64 aa) VIQEYCSGGEMFTKVRTGPNIRESEIIRYSLQIISAINYLHTRNIMHRDIKLENIVLDNNGDAKIIDFGLSEVVNDVN-LKTHCGTLIYMAPEMLSQRQF .. || |||| | . . | | |. ||||.. |.| .| ||| |.||. || | || ||||| . .| . ||| || | |||| | . MVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLY DGKAVDIWAIGICIYAMVTRTFPWKSTTDEELLHEIIQADIFFPNFVCPTISELLHGTLVKNPSERA | |||| |. |||. .. | .| |.. . | |. | ...|... | ..| .|. CGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRI |
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| Kinase | 87955.m00279.AA | ULK | 3-166 | 25 | 4.2e-40 | 137.7 | In-house | 98-317 (329) | Show / Hide |
Range on Protein: 3-166
Range on HMM: 98-317/329
Sequence Identity: 25% (56 aa)
IQEYCSGGEMFTKVR----------TGPNIRESEIIRYSLQIISAINYLHTRNIMHRDIKLENIVLDNN------------GDAKIIDFGLSEVVNDVN-
|.||| || .. .. .. |.|.| . ||... .|| .||.|||||..|| ..|. | .|| |||.. .|.. |
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM
----LKTHC------GTLIYMAPEMLS----QRQFDGKAVDIWAIGICIYAMVTRTFP---WKSTTDE-----ELLHE-------IIQADIFFP-----N
..| || .||||. |. | ... . .||| .|. .| |.. | | ... .|. | . . || .
EQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDP
FVCPTISELLHGTLVKNPSER
. | . .|. . |......|
QISPECKDLIRRMLQYDEKDR
|
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| Kinase | 87955.m00279.AA | ULK | 3-166 | 25 | 9.3e-39 | 135.08 | In-house | 95-312 (324) | Show / Hide |
Range on Protein: 3-166 Range on HMM: 95-312/324 Sequence Identity: 25% (56 aa) IQEYCSGGEMFTKVR---------TGPNIRESEIIRYSLQIISAINYLHTRNIMHRDIKLENIVLDNN------------GDAKIIDFGLSEVVND---- |.||| || .. .. .. |.|.| . ||... .|| .||.|||||..|| . |. | .|| |||.. .|.. IMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME -VNLKTHC------GTLIYMAPEMLS----QRQFDGKAVDIWAIGICIYAMVTRTFP---WKSTTDE----ELLHE-------IIQADIFFP-----NFV ..| . || .||||. |. | ... . .||| .|. .| |.. | | .... .|.. | . | || . . QQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKI CPTISELLHGTLVKNPSER | . .|. . |......| SPECKDLIRRMLQYDEKDR |
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| Kinase | 87955.m00279.AA | QIK | 2-166 | 35 | 1.9e-38 | 134.06 | In-house | 75-260 (272) | Show / Hide |
Range on Protein: 2-166 Range on HMM: 75-260/272 Sequence Identity: 35% (66 aa) VIQEYCSGGEMFTKVRT-GP-------------------NIRESEIIRYSLQIISAINYLHTRNIMHRDIKLENIVLDNNGDAKIIDFGLSEVVNDVN-L .. ||||.|||| . | . |.| | ||.||. |.| ||| |||.| ||| |||| . ||.|||.| | IVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLL KTHCGTLIYMAPEMLSQRQFDGKAVDIWAIGICIYAMVTRTFPWKSTTDEELLHEIIQADIFFPNFVCPTISELLHGTLVKNPSER .| ||. | ||||. ...|| |||| .|. |..|. .| . |...| . .. | |. .| || .|. | MTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHR |
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| S_TKc | 87955.m00279.AA | S_TKc | 1-181 | 22 | 6.8e-24 | 86.62 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 1-181 Range on HMM: 19-231/231 Sequence Identity: 22% (54 aa) MVIQ--------------------------------------------EYCSG--GEMFTKVRTGPN------IRESEIIRYSLQIISAINYLHTRNIMH . |||.| |..|. . . . | .. .| ||..|..|.| ..|.| RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIH RDIKLENIVLDNNGDAKIIDFGLSEVVNDVNLKTHCGTLIYMAPEMLSQRQFDGKAVDIWAIGICIYAMVTRTFPWKSTTDEELLHEIIQADIFFPNFVC ||.| ||| ||. ||.||||. .. .| |||. |||||.| .......|.|..|...| |... |. ..... ..| RDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------S PTISELLHGTLVKNPSERAPAAELIS----IISRSAL | ... . |.|.|..| | |. | . . PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| TyrKc | 87955.m00279.AA | TyrKc | 1-176 | 14 | 1.7e-08 | -85.43 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 1-280/280 Sequence Identity: 14% (42 aa) MVIQEYCSGGE-------------------------------MFTKV--------------------------------------------RTGPNIRES . . |. . .|. ...|.. . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK EIIRYSLQIISAINYLHTRNIMHRDIKLENIVLDNNGDAKIIDFGLSEVVNDV-------NLKTH----CGT--LIY--MAPEMLSQRQFDGKAVDIWAI . . ...|| . .||| .|. |||. |. ...|. .|| ||||| . | ... .| | . |||| . . | . |.|. DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSDVWSF GICIYAMVTRTF-PWKS-----TTDEELLHEIIQADIFFPNFV--------CPT-ISELLHGTLVKNPSERAPAAELISII |.|.. . |. |. ...|... . | . . ||. . .. .|..| .|..... GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Pkinase_Tyr | 87955.m00279.AA | Pkinase_Tyr | 1-72 | 26 | 6.9e-08 | 27.33 | Pfam | 83-158 (270) | Show / Hide |
Range on Protein: 1-72 Range on HMM: 83-158/270 Sequence Identity: 26% (20 aa) MVIQEYCSGGEMFTKVRT----GPNIRESEIIRYSLQIISAINYLHTRNIMHRDIKLENIVLDNNGDAKIIDFGLS ... ||. .| . . |. .... .... ...|| .. .||. .|. |||. |. ...|. .|| ||||. YIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA |
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