Gene MLKz_j (S.moellendorffii)

MLKz_j

Species: S.moellendorffii
Alias: MLKz_j
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKz

Sequence

Name Sequence Type Origin Length Description Download
MLKz_j.AA Protein None 356 None Fasta, JSON
MLKz_j.NA RNA None 1071 None Fasta, JSON
MLKz_j.kin_dom Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of MLKz_j.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKz_j.AA TKL 51-311 24 2.2e-77 263.37 In-house 1-364 (364) Show / Hide 
Range on Protein: 51-311
Range on HMM: 1-364/364
Sequence Identity: 24% (91 aa)

IGLGAIGKVHRGTYNN----------EEVAIKLLDCSKPGLAGDGISD------------------WRRVCLMRELRIWRKLDHPNIVKLIG---ASPG-
|| |. |.|..|....          ..||.| .      .  . . .                  | | .. .|... ..|.|||||...|   ..|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VADKN-AFSNVCCLVSEYMSTGSLREYLMSQHKRLSYKLVIQLGIDIARGLEYLHSRK--------IIHRDVKTKNILLDSALR--------------A
 |  ..   .. .|.| ||.. |||..||          . ... .|||||..||||..        ||||| |.||||.|. ..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFDSARILMEADQ-------------------AMSGEIGTFGYMAPEVMDGR----------------AYDCKSDVFSFGICLLEIYSCDMAYG-LV
||.||  .| . .  .                   . . ..||...|||||..|                  |. |.||.||||.| ||...   |  . 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

CLSLA------DITKGLVYRNLRPKIP------------RSCPGELAYVMKRCWKKNPDKRPRMSEVVRML
. .        .. .. ....||| ||             .|| ...  |..||. .|.||| ..|..  |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKz_j.AA TKL-Unique 47-311 29 4.7e-67 229.08 In-house 1-290 (290) Show / Hide 
Range on Protein: 47-311
Range on HMM: 1-290/290
Sequence Identity: 29% (87 aa)

IREVIGLGAIGKVHRGTYNNEEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLD-HPNIVKLIGASPGVADKNAFSNVCCLVSEYMSTGSLREYL
. ..|| |. |.| .|... ..|||| .   . ..  . . .     . .|.... ||. |||||...|..   .|.    . .|.|.||.. |||...|
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQE-----FENEVNWMKKLHYHPNIVHYMGYC---MDHQVYPPNMCIVMEYCPGGSLYDVL

M---------SQHKRLSYKLVIQLGIDIARGLEYLHSRK--IIHRDVKTKNILLDSA-----LRAKIGDFDSARILMEADQAMSGEI---------GTFG
          .... |........ ||||.|..|||...  ||||| |..|.|.|..     ...|| ||  ....   ..  ..|.         |.| 
HQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFR

YMAPEVMDG--RAYDCKSDVFSFGICLLEIYSCDM--AYGLVCLSLADI-TKGLVYR---NLRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVRML
.|||||. .    |..||||.||||.| ||.. .    |     .....  . .|     |.||.|| .|| |.   ...||. .|..||  .|..  |
WMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKz_j.AA TK 45-311 17 2.8e-61 203.88 In-house 1-486 (486) Show / Hide 
Range on Protein: 45-311
Range on HMM: 1-486/486
Sequence Identity: 17% (83 aa)

LVIREVIGLGAIG---KVHRGTYNN---------------------------EEVAIKLLDCSKPGLAGDGIS-DWRRVC--------LMRELRIWR--K
... ...| |. |   .|..|....                           ..||.| |    .  . . .  ....          ...|. . .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD-RDGGEDFLEEAEEMKMMCHSL

LDHPNIVKLIGASPGVADKNAFS-----NVCCLVSEYMSTGS----LREYLMSQHKR-------------------------------------------
..|||||.|.|..  .. |  |.       ...| |||. |.    ||.|| . ...                                           
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

------------LSYKLVIQ-------------------LGIDIARGLEYLHSR------KIIHRDVKTKNILLDSALR-----------AKIGDFD---
            |. |  .|                      .||.|.|||||.      ...|||. . |.|... ..           .||.||    
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----SARILMEADQAMSGEIGTFGY--------------------------MAPEVMDGRA---------YDCKSDVFSFGICLLEIYS-CDMAYGLVC
      || . . |   . . .. |                           ||||....|          .  ||||.|||... ||.. ... |.   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

LS------------LADITKG---------LVYRNLRPKIPRSCPG-------------ELAYV-MKRCWKKNPDKRPRMSEVVRML
 .            .  ...|          | . .|.. |  ||              |. |  |..||...|..||..|.....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
S_TKc MLKz_j.AA S_TKc 45-314 26 9.9e-60 205.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 45-314
Range on HMM: 1-231/231
Sequence Identity: 26% (77 aa)

LVIREVIGLGAIGKVHRGTYNN--EEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLDHPNIVKLIGASPGVADKNAFSNVCCLVSEYMST--GS
  | ..|| || |||.... ..  ..|||| ..                  ..||..| .| .|||||||...           .  ..| ||...  |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGD

LREYLMSQHKR-----LSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRAKIGDFDSARILMEADQAMSGEIGTFGYMAPEVMDGRAYDC-
|..|. .. ..     ..   .  .   |...|||.||..|||||.|  |||||.  . ||.|| .||.|       .  .||  ||||||.    |.. 
LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKC

KSDVFSFGICLLEIYSCDMAYGLVCLSLADITKGLVYRNLRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVR------MLEAI
|.|. |.|..| | ..    .      .. . | ..            . |.   ...|..|.|.|||   |. .      . . .
KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKz_j.AA MLK 45-311 29 1.4e-58 200.98 In-house 1-291 (291) Show / Hide 
Range on Protein: 45-311
Range on HMM: 1-291/291
Sequence Identity: 29% (88 aa)

LVIREVIGLGAIGKVHRGTYNNEE-----VAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLDHPN----IVKLIGASPGVADKNAFSNVCCLVSEY
. . |.|| |. |||..|.. |..     ||.|  . ..   ..|  ..  .  . .| |. |.|.|||    |... |..      .   .  |.|.||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSD--TYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVC------LQPPCHFCIVMEY

MSTGSLREYLMSQHK-------------RLSYKLVIQLGIDIARGLEYLHSRK---IIHRDVKTKNILLDS------ALRAKIGDFDSARILMEADQAMS
.. ||| ..| .. .             . .  ....   ..|||..|||| .   ||||| | .|||.|        . .|| ||. .| . . .. | 
CEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM

GEIGTFGYMAPEVM---DGRAYDCKSDVFSFGICLLEIYSCDMAYGLVCLSLADITKGLVYRNLRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVRM
. .||. .|||||     .  |. |.||.|.|..| |. .. . |    .. . |  . .| .||| || .||  ..  ||.||. .| ||| ....|  
SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYK-QHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQH

L
|
L
Kinase MLKz_j.AA TyrKc 45-311 29 9.9e-57 195.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 45-311
Range on HMM: 1-280/280
Sequence Identity: 29% (88 aa)

LVIREVIGLGAIGKVHRGTYNNEEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKL--DHPNIVKLIGASPGVADKNAF--SNVCCLVSEYMSTGS
..  ...| || |.|..||.. ..||.| |  ..            |  .|||.|| .||  .|||||.|.|.      .  |  .   ..| |||. |.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGD

LREYLMSQHKRLSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRAKIGDFDSARILMEA-------DQAMS----GEI--GTFGYMAPEVM
|..|| . ...|. |  ..  ..||.| |||||...||||  . |.|... ...||.||  .| . .        |  ..    |.        ||||..
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

DGRAYDCKSDVFSFGICLLEIYS-CDMAYGLVC---LSLADITKGLVYRNLRPKIPR-------SCPGELAYVMKRCWKKNPDKRPRMSEVVRML
. . .  ||||.|||.|. ||.. ... |  .    .| ... . .  .. .|. |         || |.  .||.||. .|..||..||... .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKz_j.AA Pkinase 45-311 25 2.1e-50 178.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 45-311
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

LVIREVIGLGAIGKVHRGTYNNEE--VAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLDHPNIVKLIGAS-PGVADKNAFSNVCCLVSEYMSTG--
..| ..|| |. |.| ...  ...  ||.| .. ..     | .  ..     .|..| ..|.|||||.|...           .. ...| ||.  |  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLY

--SLREYLM-SQHKRL--SYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRA----KIGDFDSARIL-MEADQAMSGEIGTFGYMAPEVMD-
  .| .|.. ..|...  |.. ..     |.|||||.||..|||||.|  |||.|.        ||.|| .|. .    .. |..  || .||||||   
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

GRAYDCKSDVFSFGICLLEIYSCDMAYGLVCLSLAD------ITKGLVYRNLRPKIPRSCP-----------------------GELAYVMKRCWKKNPD
|. |. |.|..|.|. | | ..     |    .  .        . ...|...|......|                        |.  ..|.|..|.| 
GQYYGPKVDMWSCGCILYEMLC-----GRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

KRPRMSEVVRM--L
|||   ...    .
KRPTAEQILQHPWF
Kinase MLKz_j.AA Dicty5 105-315 33 6e-50 170.09 In-house 56-260 (260) Show / Hide 
Range on Protein: 105-315
Range on HMM: 56-260/260
Sequence Identity: 33% (73 aa)

DHPNIVKLIGASPGVADKNA-FSNVCCLVSEYMSTGSLREYLMSQHK----RLSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRAKIGDF
||||...  ||  .  ...  |      |.|| . |||..||  | |     ..| . . . ||||.....|||  |||||.|  |.|.   . .|| ||
DHPNFIRCYGA--HQYNDKYPF-----HVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDF

DSARILMEADQAMSGEIGTFGYMAPEVMDGRAYDCKSDVFSFGICLLEIYSCDMAYGLVCLSLADITKG-LVYRNLRPKIPRSCPGELAYVMKRCWKKNP
   |   ..   |  ..||  .||.|.  |. |. | ||.|||| | |.   . .|      .. .    .|    || ||  || | . . | ||   |
GTSRF-VDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYD----NINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKP

DKRPRMSEVVRMLEAIA
 .||   |.. ..| | 
HNRPSFKEICKYFESII
Kinase MLKz_j.AA Dicty4 45-248 33 1.7e-49 163.31 In-house 1-210 (277) Show / Hide 
Range on Protein: 45-248
Range on HMM: 1-210/277
Sequence Identity: 33% (73 aa)

LVIREVIGLGAIGKVHRGTYNNEEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLDHPNIVKLIGASPGVADKNA---FSNVCCLVSEYMSTGSL
..| . || |. |.|..||    |||.|.|   . ..  . ... |     .|  |  |. ||||... ||.      .|    .  .| |.|||. |.|
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFR-----KEVHIMCKIRHPNICLFMGAC------TAPRSHPGKMCIVTEYMPKGNL

REYLMS------QHKRLSYKLVIQ---LGIDIARGLEYLHSRK--IIHRDVKTKNILLDSALRAKIGDFDSARILMEAD--QA-MSGEIGTFGYMAPEVM
 . | .      | . |.. |...   ...|.|||. .||..   ||||| |. |.| |  .|.|..||  ...  .    .. ... .|| ..||||||
YSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM

DGRAYDCKSDVFSFGICLLEI
 ...|. |.||.|||| | ||
MHQPYNEKADVYSFGIVLWEI
Kinase MLKz_j.AA LRRK 96-313 29 2e-49 170.52 In-house 106-351 (351) Show / Hide 
Range on Protein: 96-313
Range on HMM: 106-351/351
Sequence Identity: 29% (75 aa)

RELRIWRKLDHPNIVKLIGASPGVADKNAFSNVCCLVSEYMSTGSLREYLMSQHK--------RLSYKLVIQLGIDIARGLEYLHSRK--IIHRDVKTKN
.|. | ..|.|||||.|.| .          . .|.| ||.. |.| ..| . ..        ..|  |.... ..||.|.|||||..  ||||| |. |
HEVWIMSHLNHPNIVSLKGFC---------IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN

ILL---D---------SALRAKIGDFDSARILMEADQA--MSGEIGTFGYMAPEVMDGR---AYDCKSDVFSFGICLLEIYSCD-MAYGLVC----LSLA
|||   .          .  |||.||   | .  ...    .|  |..|.||||.| .     |. |.|..|||. | |... .  ...       ... 
ILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWM

DITKGLVYRNLRPKIPRS-CPG-----ELAYVMKRCWKKNPDKRPRMSEVVRMLEA
 . . .. . |||.|| . ||.     ..   .. ||. .|.||| .|..|  |. 
EQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKz_j.AA Dicty4-Unclassified 45-311 31 1.5e-46 157.42 In-house 1-263 (263) Show / Hide 
Range on Protein: 45-311
Range on HMM: 1-263/263
Sequence Identity: 31% (85 aa)

LVIREVIGLGAIGKVHRGTYNNEEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLDHPNIVKLIGASPGV-ADKNAFSNVCCLVSEYMSTGSLRE
. |   || |.. |||.|     .||.| .   |     . | |       .|  |   . ||| ||. |..    . |  .    | | | |  | | |
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDF-----KKEVEILGSIQHPNLVKCYGYCINPRSHKSTM----CIVMEFMHKGNLFE

YLM----SQHKRLSYKL--VIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRAKIGDFDSARILMEADQAMSGEIGTFGYMAPEVMDGRAYDCKSD
        | . ..     .|   .|||.|. .||.| .||||.|  |||.|    .||.||  .|   .  . |    ||    .||.. . .|  |||
VIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRV-IDFNFNMTTIAGTPKWESPECLMHESYNQKSD

VFSFGICLLEIYSCDMAYGLVCLSLADITKGLVYRNLRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVRML
|.|... | |    |  | .   |  ..      . |||||| .|.  .    | ||   | ||| | ...  |
VYSYAMMLYELATGDEPY-QEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKz_j.AA LISK 50-248 30 6.1e-43 137.24 In-house 1-232 (296) Show / Hide 
Range on Protein: 50-248
Range on HMM: 1-232/296
Sequence Identity: 30% (74 aa)

VIGLGAIGKVHRGTYN--NEEVAIKLLDC--SKPGLAGDGISDWRRVCLMRELRIWRKLDHPNIVKLIGASPGVA-DKNAFSNVCCLVSEYMSTGSLREY
.|| |. ||| .||..  ....||| .     .|      . .  .  . ||. . ..|.|||||. .|..  .  |.  .     .| ||.. | |..|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDP------NDPEYQKFMLREVQMMKNLRHPNIVQFMGVC--YHNDGQLH-----IVTEYINGGDLHQY

LMSQHK---RLSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLD----SALRAKIGDFDSARILMEAD----------------------------
| .  |    |. .. . .  |||.|..||||..||||| | ||.|..    .  |.|..||  ||.. . .                            
LKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPK

-------QAMSGEIGTFGYMAPEVMDGRAYDCKSDVFSFGICLLEI
       . |.   ||   ||||.. |. || ..||||||| |.||
KCMNQRKRRMT-ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEI
Kinase MLKz_j.AA Pkinase_Tyr 45-199 31 7.5e-36 122.04 Pfam 1-155 (270) Show / Hide 
Range on Protein: 45-199
Range on HMM: 1-155/270
Sequence Identity: 31% (53 aa)

LVIREVIGLGAIGKVHRGTYN------NEEVAIKLL--DCSKPGLAGDGISDWRRVCLMRELRIWRKL-DHPNIVKLIGASPGVADKNAFSNVCCLVSEY
... ...| || |.|..||..      . .||.| |  ..... .         |  .|||..| ..| .|||||.|.|.     . |      ..| ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--------CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEY

MSTGSLREYLMSQ---HKRLSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRAKIGDF
|  |.|..|| ..    ..|. |  .|  ..||.|.|||.|...||||. ..|.|... . .||.||
MPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDF
Kinase MLKz_j.AA TK-Unique 45-248 28 1.5e-34 116.56 In-house 1-232 (294) Show / Hide 
Range on Protein: 45-248
Range on HMM: 1-232/294
Sequence Identity: 28% (70 aa)

LVIREVIGLGAIGKVHRGTYNN--------EEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLD-HPNIVKLIGASPGVADKNAFSNVCCLVSEY
|.. .||| || | |.||.. .          ||.|.|         |. .| ..  ...|... ..|. |||||...|..     |.   .  ... ||
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK--------DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCT----KSD--EPWMIIMEY

MSTGSLREYLMSQHKR-------------------------LSYKLVIQLGIDIARGLEYLHS--RKIIHRDVKTKNILLDSALRAKIGDFDSARILM-E
.. |.|. || .  .                          .|.|.... ...||.|.|||.|  .||.|||. ..|.|| . ...||.||  || .. .
CPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTN

ADQAMSGEIGTFG--YMAPEVMD--GRAY-DCKSDVFSFGICLLEI
 ...|... |.    .||||..   .. |  .|||| |||. . ||
GVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI
Kinase MLKz_j.AA Pkinase_Tyr 222-311 32 1.2e-23 80.68 Pfam 181-270 (270) Show / Hide 
Range on Protein: 222-311
Range on HMM: 181-270/270
Sequence Identity: 32% (30 aa)

MAPEVMDGRAYDCKSDVFSFGICLLEIYS-CDMA-YGLVCLSLADITKGLVYRNLRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVRML
||||..  . .  |||| |||... ||.. ...  |  .  | ... . .  .. | ..|. || |.  .||.||...|..||..||....|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM--SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKz_j.AA Dicty4 274-313 35 3.2e-13 40.61 In-house 236-277 (277) Show / Hide 
Range on Protein: 274-313
Range on HMM: 236-277/277
Sequence Identity: 35% (15 aa)

LRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVRM--LEA
|||.|| .||  ..  ...|| ..| .|| ..|..    ||.
LRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKz_j.AA TK-Unique 275-311 31 1.6e-10 32.63 In-house 257-294 (294) Show / Hide 
Range on Protein: 275-311
Range on HMM: 257-294/294
Sequence Identity: 31% (12 aa)

RPKIPRSC-PGELAYVMKRCWKKNPDKRPRMSEVVRML
|.. | .| . |. ..||.||...|..||  .... .|
RMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MLKz_j.AA LRRK 45-75 21 3.1e-07 21.65 In-house 1-60 (351) Show / Hide 
Range on Protein: 45-75
Range on HMM: 1-60/351
Sequence Identity: 21% (13 aa)

LVIREVIGLGAIG-KVHRGTYNN----------------------------EEVAIKLLD
|.| | || |. | .|.|.....                            ..|||| ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWN
Kinase MLKz_j.AA LISK 271-311 30 5.4e-05 11.95 In-house 255-296 (296) Show / Hide 
Range on Protein: 271-311
Range on HMM: 255-296/296
Sequence Identity: 30% (13 aa)

YRNLRPKIPRS-CPGELAYVMKRCWKKNPDKRPRMSEVVRML
|. ...||. . || ..  .. .| | .|..||  .|.|. |
YEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase MLKz_j.AA Dicty5 45-74 36 6.6e-05 12.81 In-house 1-30 (260) Show / Hide 
Range on Protein: 45-74
Range on HMM: 1-30/260
Sequence Identity: 36% (11 aa)

LVIREVIGLGAIGKVHRGTYNNEEVAIKLL
  . ..|  || |.|  | |.   |||| .
VSFHDWIASGASGRVYNGIYKGMDVAIKVY