Gene MLKy_c (S.moellendorffii)

MLKy_c

Species: S.moellendorffii
Alias: MLKy_c
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKy

Sequence

Name Sequence Type Origin Length Description Download
MLKy_c.AA Protein None 674 None Fasta, JSON
MLKy_c.NA RNA None 2025 None Fasta, JSON
MLKy_c.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of MLKy_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKy_c.AA TKL 84-337 18 3.7e-20 69.27 In-house 1-364 (364) Show / Hide 
Range on Protein: 84-337
Range on HMM: 1-364/364
Sequence Identity: 18% (69 aa)

IGRGQFGDVFLASARFQS------QERQVAVKMLPLVG-----------------------SEMIETVLRRFDAALFACQGL--------KGVSV--PLG
||.| || |. .  | ..        . ||||...                          .....    ..   .  .  |        .|..   | |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VSMK----NGKVCILSPLY-EGSVGGRLAHLPDNRLSLSEALKYATDIAKGVLELHSSG--------VLSLNLKPCNFLLDSSND--------------
 |.|.     |. ||   ..  ||   .|         ..  .. | |||.|.  |||..        ..  .||. | |.|. .               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AFVGDHALPLLFSGCKSFLD-----------------FKFYIGTPNYMAPEQWSVETR-------------GPLAFETDSWGYACSIVEMVTGKRPWE--
. ..|  |   .|. ..  |                     .|||..||||    ..              ..    .| . ..  . |..|..||..  
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

DKTPQEIY-------NLVVLKGDRPSVP------------SELPAAIQRVLEDCFEYDYRNRPDFRQILATL
.  |...         .|..|| || .|            .  |  . . ..|| ..| ..|| | .|| .|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc MLKy_c.AA S_TKc 78-342 19 6.6e-15 41.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 78-342
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

VRHLYRIGRGQFGDVFLASARFQSQERQVAVKMLPLVGSEMIET---VLRRFDAALFACQGLKGVSVPLGVSMKNGKVCILSPLYEG---SVGGRLAHLP
 . |  ||.| || |...  .     |.||.|...    |.|.    .|..          |..| .        .....   . .|   ..  .. . .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRG

DNR----LSLSEALKYATDIAKGVLELHSSGVLSLNLKPCNFLLDSSNDAFVGD----HALPLLFSGCKSFLDFKFYIGTPNYMAPEQWSVETRGPLAF-
 ..    ..  .| .|.  |....  .|| |..   ||| | |||.     ..|      |             . ..|||.|||||        .  . 
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------GYGKC

ETDSWGYACSIVEMVTGKRPWEDKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILA----TLTSKQT
. | |   | . ||..|. |..  ..|.......            | |..  .. |...| ..||   ..|.           
KCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKy_c.AA TKL-Unique 175-337 23 4.5e-14 46.19 In-house 107-290 (290) Show / Hide 
Range on Protein: 175-337
Range on HMM: 107-290/290
Sequence Identity: 23% (45 aa)

LSLSEALKYATDIAKGVLELHSSG--VLSLNLKPCNFLLDSS-----NDAFVGDHALPLLFS-GCKSFLDFK------FYIGTPNYMAPEQWSVETRGP-
|...  .| | |||.|   ||...  .. ..||. |||.|.      . . . |  |. . |   |...  .        .|....||||    ..|.. 
LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE----VLRMNF

LAFETDSWGYACSIV--EMVTGKR------PWEDKTPQEIYNLVVL--KGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATL
  . . |  |. .||  |..|.|.      | .. ...... .|    .. || .|...|  ..  ...|.  |  .|| | .|.  |
CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKy_c.AA Dicty4-Unclassified 175-337 25 3.1e-12 38.18 In-house 104-263 (263) Show / Hide 
Range on Protein: 175-337
Range on HMM: 104-263/263
Sequence Identity: 25% (42 aa)

LSLSE--ALKYATDIAKGVLELHSSGVLSLNLKPCNFLLDSSNDAFVGDHALPLLFSGCKSFLDFKFYIG-TPNYMAPEQWSVETRGPLAFETDSWGYAC
..| .   .||| |||.|   ||.  .    .|  | |.|  . . ..|  .    |   .|      |. ||   .||    |         | . || 
IKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGI----SRVIDFNFNMTTIAGTPKWESPECLMHES---YNQKSDVYSYAM

SIVEMVTGKRPWEDKT-PQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATL
   |..||  |. .   . ..  .|  |. || .|.  .  ...   .|.  | . || . ||   |
MLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKy_c.AA MLK 241-337 30 3.5e-12 38.68 In-house 194-291 (291) Show / Hide 
Range on Protein: 241-337
Range on HMM: 194-291/291
Sequence Identity: 30% (30 aa)

IGTPNYMAPEQWSVETRGPLAFETDSWGYACSIVEMVTGKRPWE-DKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATL
.||. .||||  .    ..     | | ..  . ||.|.. | . .  | .|   |...| || .||. |. . . ...| . | ..||.||||.  |
AGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKy_c.AA STE 241-334 23 7.4e-12 38.27 In-house 224-352 (359) Show / Hide 
Range on Protein: 241-334
Range on HMM: 224-352/359
Sequence Identity: 23% (30 aa)

IGTPNYMAPEQWSVET---RGPLAFETDSWGYACSIVEMVTGKRPWEDKTPQEIYNLVVLK--------------GDRPSVPSELP--------------
.||| .||||  . ..   ...  .  | |   | |.||.||| || | .| . . .   .              |. |. |..|               
VGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTY

-----AAIQRVLEDCFEYDYRNRPDFRQIL
        .  .. |...|...||.  | |
PHKWSPEFKDFINKCLQKDPNKRPTASQLL
Kinase MLKy_c.AA Dicty5 241-341 26 1.5e-11 35.97 In-house 164-260 (260) Show / Hide 
Range on Protein: 241-341
Range on HMM: 164-260/260
Sequence Identity: 26% (27 aa)

IGTPNYMAPEQWSVETRGPLAFETDSWGYACSIVEMVTGKRPWEDKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATLTSK
.||...||.|     .        | . ..    || | | | .. .  .| ..|  ||.|| .|   |  |  . . |     .||| |  |.... | 
VGTQCWMACELFNGQP---YHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVM-KGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESI

Q
 
I
Kinase MLKy_c.AA TyrKc 78-337 19 1.8e-11 -37.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 78-337
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

VRHLYRIGRGQFGDVFLASARFQSQERQVAVKMLPLVGSEMIETVLRRFDAALFACQG--LKGV--SVP-----LGVSMKN-------GKVCILSPLYEG
.. .  .|.|.|| |... ..     .|||||||                 . |      .. .  . |     .|| ..        . ..|.  . ..
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

SVGGRLAHLPDNR--LSLSEALKYATDIAKGVLELHSSGVLSLNLKPCNFLLDSSNDAFVGDHALPLLFSGC------KSFLDFKFYIGTP-----NYMA
  |  . .| ..|  |.... |.....||.|   ||| ..    |   | |... . . ..|  |             |.  . |   |.        ||
--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEQWSVETRGPLAFETDSWGYACSIVEMVT-GKRPWED-----KTPQEIYNLVVLKGDRPSVPSE--------LPAAIQRVLEDCFEYDYRNRPDFRQIL
|| .     |   ...| | .   . |. | |. |...     ...||....|  .|.|.  | .         |... .. ..| ..|  .|| |..| 
PECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

ATL
  .
ECF
Kinase MLKy_c.AA Pkinase 237-337 17 4.8e-11 40.13 Pfam 168-293 (293) Show / Hide 
Range on Protein: 237-337
Range on HMM: 168-293/293
Sequence Identity: 17% (23 aa)

FKFYIGTPNYMAPEQWSVETRGPLAFETDSWGYACSIVEMVTGKRPWEDK------TPQEIYNLVVLKGDRPSVPSELP-------------------AA
.. . |||.|||||   . .. .   . | |.. | . ||..|. |. ..      .........  .  . . | . .                    .
MTTFCGTPWYMAPEV--IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

IQRVLEDCFEYDYRNRPDFRQILAT--L
 . ....|...|   || ..|||    .
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLKy_c.AA ASK 240-339 33 5.4e-11 32.6 In-house 155-254 (254) Show / Hide 
Range on Protein: 240-339
Range on HMM: 155-254/254
Sequence Identity: 33% (34 aa)

YIGTPNYMAPEQWSVETRGPLAFETDSWGYACSIVEMVTGKRPW-EDKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATLT
. ||  |||||      ||      | | . | .||| ||| |. | . ||     | .  . | .|.|| |. .  .  ||| | ..|.  ...|    
FTGTLQYMAPEVIDQGQRG-YGKPADIWSFGCTMVEMATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPF

S
 
L
Kinase MLKy_c.AA UTK 279-337 25 3.9e-10 30.88 In-house 237-296 (296) Show / Hide 
Range on Protein: 279-337
Range on HMM: 237-296/296
Sequence Identity: 25% (15 aa)

GKRPWEDKTPQEIYNLVVLKG-DRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATL
|..|... . ...   |. .|  |.  | . |... |.. .| .||...||||.......
GRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase MLKy_c.AA TK 263-337 17 2e-09 26.99 In-house 374-486 (486) Show / Hide 
Range on Protein: 263-337
Range on HMM: 374-486/486
Sequence Identity: 17% (20 aa)

ETDSWGYACSIVEMVT-GKRPWE-----------DKTPQEIYNLVVLKGD-------------RPSVPSELP--------------AAIQRVLEDCFEYD
..| | . . . |..| |. |.            . ..||......  |              |.  |   |              ....... .|..||
KSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYD

YRNRPDFRQILATL
 . ||.|.|..  |
PEDRPTFSQLHEQL
Kinase MLKy_c.AA Pkinase_Tyr 275-337 29 1.2e-08 29.89 Pfam 206-270 (270) Show / Hide 
Range on Protein: 275-337
Range on HMM: 206-270/270
Sequence Identity: 29% (19 aa)

EMVT-GKRP-WEDKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATL
|..| |. | ... ...|.|...  .| |   |   |. | ... .| .||  .|| |..|.  |
EIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKy_c.AA UTK 78-109 37 1.9e-08 25.0 In-house 1-35 (296) Show / Hide 
Range on Protein: 78-109
Range on HMM: 1-35/296
Sequence Identity: 37% (13 aa)

VRHLYRIGRGQFGDVFLASARFQS---QERQVAVK
|... ..|.|.||.|..|.... |   .| .||||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVK
Kinase MLKy_c.AA TK 78-196 11 4.3e-08 22.42 In-house 1-252 (486) Show / Hide 
Range on Protein: 78-196
Range on HMM: 1-252/486
Sequence Identity: 11% (28 aa)

VRHLYRIGRGQFG---DVFLASARFQS-----------------------QERQVAVKMLPLVGSEMIETVLR-------------RFDAALFACQG---
.. .  .|.||||   .|... .| ..                       .. .|||||| .  ..  |  .              .. ...   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-LKGVSVPLGVSMKN------------GKVCILSPLYEGSV--GGRLAHLPDNR----------------------------------------------
  . .   .||....            . ..|.  . ..    |  . .| ..|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSLSEALKYATDIAKGVLELHS
                               |.. . | .. .||.|   |||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHS
Kinase MLKy_c.AA Dicty4 275-339 23 7.7e-08 22.41 In-house 209-277 (277) Show / Hide 
Range on Protein: 275-339
Range on HMM: 209-277/277
Sequence Identity: 23% (16 aa)

EMVTGKRPWE--DKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILAT--LTS
|..|.. |     . . .....|. |. ||..|.  |. . . ...| . |  .|| | .|.    | .
EILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKy_c.AA Pkinase_Tyr 78-111 30 9e-06 20.18 Pfam 1-36 (270) Show / Hide 
Range on Protein: 78-111
Range on HMM: 1-36/270
Sequence Identity: 30% (11 aa)

VRHLYRIGRGQFGDVFLASAR--FQSQERQVAVKML
.. .  .|.|.||.|... ..   .... .||||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML
Kinase MLKy_c.AA Dicty4 180-250 31 8.2e-05 12.18 In-house 114-187 (277) Show / Hide 
Range on Protein: 180-250
Range on HMM: 114-187/277
Sequence Identity: 31% (23 aa)

ALKYATDIAKGVLELHS--SGVLSLNLKPCNFLLDSSNDAFVGDHALPLLFSGCKSFLD-FKFYIGTPNYMAPE
|...| |.|.|.  ||.  . .. . ||. | | | .. . |.|  |  ..   ... |  .  .||| .||||
AMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPE
Kinase MLKy_c.AA Dicty4 78-113 36 0.001599 7.81 In-house 1-32 (277) Show / Hide 
Range on Protein: 78-113
Range on HMM: 1-32/277
Sequence Identity: 36% (13 aa)

VRHLYRIGRGQFGDVFLASARFQSQERQVAVKMLPL
     |||.| || |.... | .    .||||.|..
INIEQRIGKGSFGEVYKGTWRGK----EVAVKKLNN
Kinase MLKy_c.AA MLK 78-110 30 0.015514 4.77 In-house 1-34 (291) Show / Hide 
Range on Protein: 78-110
Range on HMM: 1-34/291
Sequence Identity: 30% (11 aa)

VRHLYRIGRGQFGDVFLASARFQSQE---RQVAVKM
 . .  || | ||.|..  .|.. ..   . ||||.
IQFHEWIGSGSFGKVWK--GRWRNKDIVAKIVAVKR
Kinase MLKy_c.AA STE 78-124 15 0.015918 4.88 In-house 1-77 (359) Show / Hide 
Range on Protein: 78-124
Range on HMM: 1-77/359
Sequence Identity: 15% (12 aa)

VRHLYRIGRGQFGDVFLA-------SARFQSQE-------RQVAVKMLPLVGS-----------------EMIETVLR
 ... .||.| || |..|             ..       . .|.| ..|  .                 | .. .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILK
Kinase MLKy_c.AA ASK 84-112 27 0.188485 0.37 In-house 2-28 (254) Show / Hide 
Range on Protein: 84-112
Range on HMM: 2-28/254
Sequence Identity: 27% (8 aa)

IGRGQFGDVFLASARFQSQERQVAVKMLP
.|.| .| |.   .| .......|.| .|
LGKGTYGIVY--AGRDMHTQVRIAIKEIP
Kinase MLKy_c.AA Pkinase 78-125 22 0.780899 4.03 Pfam 1-46 (293) Show / Hide 
Range on Protein: 78-125
Range on HMM: 1-46/293
Sequence Identity: 22% (11 aa)

VRHLYRIGRGQFGDVFLASARFQSQERQVAVKMLPLVGSEMIETVLRR
 . . .||.| || |...  .  ..  .|||| ..... .. . . .|
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHR
Kinase MLKy_c.AA Pkinase_Tyr 171-196 30 5.911139 0.47 Pfam 104-129 (270) Show / Hide 
Range on Protein: 171-196
Range on HMM: 104-129/270
Sequence Identity: 30% (8 aa)

PDNRLSLSEALKYATDIAKGVLELHS
....|.... |.....||||   |.|
DKQPLTMKDLLQMCWQIAKGMEYLES