Gene MLKy_a (S.moellendorffii)

MLKy_a

Species: S.moellendorffii
Alias: MLKy_a
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKy

Sequence

Name Sequence Type Origin Length Description Download
MLKy_a.AA Protein None 387 None Fasta, JSON
MLKy_a.NA RNA None 1164 None Fasta, JSON
MLKy_a.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of MLKy_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKy_a.AA TKL 49-302 18 1.8e-19 66.75 In-house 1-364 (364) Show / Hide 
Range on Protein: 49-302
Range on HMM: 1-364/364
Sequence Identity: 18% (69 aa)

IGRGQFGDVFLASARFQS------QERQVAVKMLPLVG-----------------------SEMIETVLRRFDAALFACQGL--------KGVSV--PLG
||.| || |. .  | ..        . ||||...                          .....    ..   .  .  |        .|..   | |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VSMK----NGKVCILSPLY-EGSVGGRLAHLPDNRLSPSEALKYATDIAKGVLELHS--------RGVLSLNLKPCNFLLDPSND--------------
 |.|.     |. ||   ..  ||   .|         ..  .. | |||.|.  |||        ....  .||. | |.|  .               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AFVGDHALPLLFSGCKSFLD-----------------FKFYIGTPNYMAPEQWSVETR-------------GPLAFETDSWGYACSIVEMVTGKRPWE--
. ..|  |   .|. ..  |                     .|||..||||    ..              ..    .| . ..  . |..|..||..  
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

DKTPQEIY-------NLVVLKGDRPSVP------------SELPAAIQRVLEDCFEYDYRNRPDFRQILATL
.  |...         .|..|| || .|            .  |  . . ..|| ..| ..|| | .|| .|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc MLKy_a.AA S_TKc 43-310 19 4.2e-15 44.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 43-310
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

VRHLYRIGRGQFGDVFLASARFQSQERQVAVKMLPLVGSEMIET---VLRRFDAALFACQGLKGVSVPLGVSMKNGKVCILSPLYEG---SVGGRLAHLP
 . |  ||.| || |...  .     |.||.|...    |.|.    .|..          |..| .        .....   . .|   ..  .. . .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRG

DNR----LSPSEALKYATDIAKGVLELHSRGVLSLNLKPCNFLLDPSNDAFVGD----HALPLLFSGCKSFLDFKFYIGTPNYMAPEQWSVETRGPLAF-
 ..    ... .| .|.  |....  .||.|..   ||| | |||      ..|      |             . ..|||.|||||        .  . 
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------GYGKC

ETDSWGYACSIVEMVTGKRPWEDKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILA-TLTRRLDSRL
. | |   | . ||..|. |..  ..|.......            | |..  .. |...| ..||   ..|.  .  ...  .
KCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKy_a.AA Dicty4-Unclassified 146-302 26 1.7e-12 39.09 In-house 112-263 (263) Show / Hide 
Range on Protein: 146-302
Range on HMM: 112-263/263
Sequence Identity: 26% (42 aa)

LKYATDIAKGVLELHSRGVLSLNLKPCNFLLDPSNDAFVGDHALPLLFSGCKSFLDFKFYIG-TPNYMAPEQWSVETRGPLAFETDSWGYACSIVEMVTG
.||| |||.|   ||.| .    .|  | |.|  . . ..|  .    |   .|      |. ||   .||    |         | . ||    |..||
IKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGI----SRVIDFNFNMTTIAGTPKWESPECLMHES---YNQKSDVYSYAMMLYELATG

KRPWEDKT-PQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATL
  |. .   . ..  .|  |. || .|.  .  ...   .|.  | . || . ||   |
DEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKy_a.AA MLK 206-302 30 3.5e-12 38.68 In-house 194-291 (291) Show / Hide 
Range on Protein: 206-302
Range on HMM: 194-291/291
Sequence Identity: 30% (30 aa)

IGTPNYMAPEQWSVETRGPLAFETDSWGYACSIVEMVTGKRPWE-DKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATL
.||. .||||  .    ..     | | ..  . ||.|.. | . .  | .|   |...| || .||. |. . . ...| . | ..||.||||.  |
AGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKy_a.AA STE 206-299 23 7.4e-12 38.27 In-house 224-352 (359) Show / Hide 
Range on Protein: 206-299
Range on HMM: 224-352/359
Sequence Identity: 23% (30 aa)

IGTPNYMAPEQWSVET---RGPLAFETDSWGYACSIVEMVTGKRPWEDKTPQEIYNLVVLK--------------GDRPSVPSELP--------------
.||| .||||  . ..   ...  .  | |   | |.||.||| || | .| . . .   .              |. |. |..|               
VGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTY

-----AAIQRVLEDCFEYDYRNRPDFRQIL
        .  .. |...|...||.  | |
PHKWSPEFKDFINKCLQKDPNKRPTASQLL
Kinase MLKy_a.AA TyrKc 43-302 19 1.9e-11 -37.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-302
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

VRHLYRIGRGQFGDVFLASARFQSQERQVAVKMLPLVGSEMIETVLRRFDAALFACQG--LKGV--SVP-----LGVSMKN-------GKVCILSPLYEG
.. .  .|.|.|| |... ..     .|||||||                 . |      .. .  . |     .|| ..        . ..|.  . ..
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

SVGGRLAHLPDNR--LSPSEALKYATDIAKGVLELHSRGVLSLNLKPCNFLLDPSNDAFVGDHALPLLFSGC------KSFLDFKFYIGTP-----NYMA
  |  . .| ..|  |.... |.....||.|   |||...    |   | |..  . . ..|  |             |.  . |   |.        ||
--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEQWSVETRGPLAFETDSWGYACSIVEMVT-GKRPWED-----KTPQEIYNLVVLKGDRPSVPSE--------LPAAIQRVLEDCFEYDYRNRPDFRQIL
|| .     |   ...| | .   . |. | |. |...     ...||....|  .|.|.  | .         |... .. ..| ..|  .|| |..| 
PECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

ATL
  .
ECF
Kinase MLKy_a.AA Dicty5 206-306 25 3.4e-11 34.76 In-house 164-260 (260) Show / Hide 
Range on Protein: 206-306
Range on HMM: 164-260/260
Sequence Identity: 25% (26 aa)

IGTPNYMAPEQWSVETRGPLAFETDSWGYACSIVEMVTGKRPWEDKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATLTRR
.||...||.|     .        | . ..    || | | | .. .  .| ..|  ||.|| .|   |  |  . . |     .||| |  |.... . 
VGTQCWMACELFNGQP---YHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVM-KGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESI

L
 
I
Kinase MLKy_a.AA Pkinase 202-302 17 4.8e-11 40.13 Pfam 168-293 (293) Show / Hide 
Range on Protein: 202-302
Range on HMM: 168-293/293
Sequence Identity: 17% (23 aa)

FKFYIGTPNYMAPEQWSVETRGPLAFETDSWGYACSIVEMVTGKRPWEDK------TPQEIYNLVVLKGDRPSVPSELP-------------------AA
.. . |||.|||||   . .. .   . | |.. | . ||..|. |. ..      .........  .  . . | . .                    .
MTTFCGTPWYMAPEV--IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

IQRVLEDCFEYDYRNRPDFRQILAT--L
 . ....|...|   || ..|||    .
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLKy_a.AA ASK 205-304 33 5.5e-11 32.58 In-house 155-254 (254) Show / Hide 
Range on Protein: 205-304
Range on HMM: 155-254/254
Sequence Identity: 33% (34 aa)

YIGTPNYMAPEQWSVETRGPLAFETDSWGYACSIVEMVTGKRPW-EDKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATLT
. ||  |||||      ||      | | . | .||| ||| |. | . ||     | .  . | .|.|| |. .  .  ||| | ..|.  ...|    
FTGTLQYMAPEVIDQGQRG-YGKPADIWSFGCTMVEMATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPF

R
 
L
Kinase MLKy_a.AA UTK 244-302 25 3.9e-10 30.88 In-house 237-296 (296) Show / Hide 
Range on Protein: 244-302
Range on HMM: 237-296/296
Sequence Identity: 25% (15 aa)

GKRPWEDKTPQEIYNLVVLKG-DRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATL
|..|... . ...   |. .|  |.  | . |... |.. .| .||...||||.......
GRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase MLKy_a.AA TKL-Unique 206-302 24 1.6e-09 29.93 In-house 187-290 (290) Show / Hide 
Range on Protein: 206-302
Range on HMM: 187-290/290
Sequence Identity: 24% (26 aa)

IGTPNYMAPEQWSVETRGP-LAFETDSWGYACSIV--EMVTGKR------PWEDKTPQEIYNLVVL--KGDRPSVPSELPAAIQRVLEDCFEYDYRNRPD
.|....||||    ..|..   . . |  |. .||  |..|.|.      | .. ...... .|    .. || .|...|  ..  ...|.  |  .|| 
CGSFRWMAPE----VLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPS

FRQILATL
| .|.  |
FDEIIHRL
Kinase MLKy_a.AA TK 228-302 17 2e-09 26.99 In-house 374-486 (486) Show / Hide 
Range on Protein: 228-302
Range on HMM: 374-486/486
Sequence Identity: 17% (20 aa)

ETDSWGYACSIVEMVT-GKRPWE-----------DKTPQEIYNLVVLKGD-------------RPSVPSELP--------------AAIQRVLEDCFEYD
..| | . . . |..| |. |.            . ..||......  |              |.  |   |              ....... .|..||
KSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYD

YRNRPDFRQILATL
 . ||.|.|..  |
PEDRPTFSQLHEQL
Kinase MLKy_a.AA Pkinase_Tyr 240-302 29 1.2e-08 29.89 Pfam 206-270 (270) Show / Hide 
Range on Protein: 240-302
Range on HMM: 206-270/270
Sequence Identity: 29% (19 aa)

EMVT-GKRP-WEDKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILATL
|..| |. | ... ...|.|...  .| |   |   |. | ... .| .||  .|| |..|.  |
EIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKy_a.AA TK 43-164 10 1.5e-08 23.93 In-house 1-261 (486) Show / Hide 
Range on Protein: 43-164
Range on HMM: 1-261/486
Sequence Identity: 10% (28 aa)

VRHLYRIGRGQFG---DVFLASARFQS-----------------------QERQVAVKMLPLVGSEMIETVLR-------------RFDAALFACQG---
.. .  .|.||||   .|... .| ..                       .. .|||||| .  ..  |  .              .. ...   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-LKGVSVPLGVSMKN------------GKVCILSPLYEGSV--GGRLAHLPDNR----------------------------------------------
  . .   .||....            . ..|.  . ..    |  . .| ..|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSPSEALKYATDIAKGVLELHSR------GV
                               |.. . | .. .||.|   |||.      ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNF
Kinase MLKy_a.AA UTK 43-74 37 1.9e-08 25.0 In-house 1-35 (296) Show / Hide 
Range on Protein: 43-74
Range on HMM: 1-35/296
Sequence Identity: 37% (13 aa)

VRHLYRIGRGQFGDVFLASARFQS---QERQVAVK
|... ..|.|.||.|..|.... |   .| .||||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVK
Kinase MLKy_a.AA Dicty4 240-304 23 1.5e-07 21.41 In-house 209-277 (277) Show / Hide 
Range on Protein: 240-304
Range on HMM: 209-277/277
Sequence Identity: 23% (16 aa)

EMVTGKRPWE--DKTPQEIYNLVVLKGDRPSVPSELPAAIQRVLEDCFEYDYRNRPDFRQILAT--LTR
|..|.. |     . . .....|. |. ||..|.  |. . . ...| . |  .|| | .|.    |  
EILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKy_a.AA Pkinase_Tyr 43-76 30 9e-06 20.18 Pfam 1-36 (270) Show / Hide 
Range on Protein: 43-76
Range on HMM: 1-36/270
Sequence Identity: 30% (11 aa)

VRHLYRIGRGQFGDVFLASAR--FQSQERQVAVKML
.. .  .|.|.||.|... ..   .... .||||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML
Kinase MLKy_a.AA TKL-Unique 140-177 37 2.5e-05 14.96 In-house 107-146 (290) Show / Hide 
Range on Protein: 140-177
Range on HMM: 107-146/290
Sequence Identity: 37% (15 aa)

LSPSEALKYATDIAKGVLELHSRG--VLSLNLKPCNFLLD
|...  .| | |||.|   ||...  .. ..||. |||.|
LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVD
Kinase MLKy_a.AA Dicty4 145-215 31 0.000209 10.8 In-house 114-187 (277) Show / Hide 
Range on Protein: 145-215
Range on HMM: 114-187/277
Sequence Identity: 31% (23 aa)

ALKYATDIAKGVLELHSRG--VLSLNLKPCNFLLDPSNDAFVGDHALPLLFSGCKSFLD-FKFYIGTPNYMAPE
|...| |.|.|.  ||..   .. . ||. | | | .. . |.|  |  ..   ... |  .  .||| .||||
AMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPE
Kinase MLKy_a.AA Dicty4 43-78 36 0.001599 7.81 In-house 1-32 (277) Show / Hide 
Range on Protein: 43-78
Range on HMM: 1-32/277
Sequence Identity: 36% (13 aa)

VRHLYRIGRGQFGDVFLASARFQSQERQVAVKMLPL
     |||.| || |.... | .    .||||.|..
INIEQRIGKGSFGEVYKGTWRGK----EVAVKKLNN
Kinase MLKy_a.AA MLK 43-75 30 0.015514 4.77 In-house 1-34 (291) Show / Hide 
Range on Protein: 43-75
Range on HMM: 1-34/291
Sequence Identity: 30% (11 aa)

VRHLYRIGRGQFGDVFLASARFQSQE---RQVAVKM
 . .  || | ||.|..  .|.. ..   . ||||.
IQFHEWIGSGSFGKVWK--GRWRNKDIVAKIVAVKR
Kinase MLKy_a.AA STE 43-89 15 0.015918 4.88 In-house 1-77 (359) Show / Hide 
Range on Protein: 43-89
Range on HMM: 1-77/359
Sequence Identity: 15% (12 aa)

VRHLYRIGRGQFGDVFLA-------SARFQSQE-------RQVAVKMLPLVGS-----------------EMIETVLR
 ... .||.| || |..|             ..       . .|.| ..|  .                 | .. .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILK
Kinase MLKy_a.AA ASK 49-77 27 0.188485 0.37 In-house 2-28 (254) Show / Hide 
Range on Protein: 49-77
Range on HMM: 2-28/254
Sequence Identity: 27% (8 aa)

IGRGQFGDVFLASARFQSQERQVAVKMLP
.|.| .| |.   .| .......|.| .|
LGKGTYGIVY--AGRDMHTQVRIAIKEIP
Kinase MLKy_a.AA Pkinase 43-90 22 0.780899 4.03 Pfam 1-46 (293) Show / Hide 
Range on Protein: 43-90
Range on HMM: 1-46/293
Sequence Identity: 22% (11 aa)

VRHLYRIGRGQFGDVFLASARFQSQERQVAVKMLPLVGSEMIETVLRR
 . . .||.| || |...  .  ..  .|||| ..... .. . . .|
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHR
Kinase MLKy_a.AA Pkinase_Tyr 136-163 28 3.316968 1.32 Pfam 104-131 (270) Show / Hide 
Range on Protein: 136-163
Range on HMM: 104-131/270
Sequence Identity: 28% (8 aa)

PDNRLSPSEALKYATDIAKGVLELHSRG
....|.... |.....||||   |.|..
DKQPLTMKDLLQMCWQIAKGMEYLESKN
Kinase MLKy_a.AA Pkinase 137-177 32 8.574928 0.35 Pfam 100-142 (293) Show / Hide 
Range on Protein: 137-177
Range on HMM: 100-142/293
Sequence Identity: 32% (14 aa)

DNRL--SPSEALKYATDIAKGVLELHSRGVLSLNLKPCNFLLD
....  |. |. .|.. |..|.  .||.|..   ||| |.|.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID